Raws li cov qauv tshuaj, phosphatidic acid yog qhov yooj yim tshaj plaws phospholipid.
Cov tshuaj no yog ib qho ntawm cov theem nrab hauv cov metabolism hauv phosphoglycerides hauv cov kab mob muaj sia.
chav kawm ntawm cov tshuaj no tau txais kev saib xyuas ntau thaum kawm cov teeb liab ua haujlwm ntawm cov tshuaj lom neeg.
Hnub no, tsis yog txhua qhov txuas hauv cov metabolism ntawm phosphatidic acids tau meej meej, tshwj xeeb, cov lus nug ntawm lub tshuab hluav taws xob xa hluav taws xob los ntawm cov tebchaw no tseem raug txiav txim siab, nrog rau muaj cov khoom ionophoric hauv phosphatidic acids..
YSynthesis ntawm phosphatidic acid
Kev tsim ntawm phosphatidic acid tshwm sim los ntawm kev cuam tshuam ntawm phospholipase D. Cov enzymes no ua lub luag haujlwm tseem ceeb hauv kev tsim cov phosphatidic acids. Ua ib qho tshuaj tiv thaiv luv luv, cov tshuaj no tau tom qab hydrolyzed rau diglyceride nyob rau hauv kev cuam tshuam ntawm phosphohydrolase (raws li qhov tshwm sim ntawm dephosphorylation tshuaj tiv thaiv).
Thaum cuam tshuam nrog tib lub enzyme, phosphatidic acid kuj tuaj yeem hloov mus rau hauv diacylglycerol, uas ua haujlwm ntawm cov protein kinase C enzyme nyob rau hauv lub voj voog ntawm cov tshuaj biochemical.
Cov synthesis ntawm phosphatidic acid tshwm sim hauv cov ntaub so ntswg adipose. Cov txheej txheem pib nrog kev nkag mus rau hauv adipocytes (cov ntaub so ntswg adipose) ntawm fatty acids tsim los ntawm hydrolysis ntawm cov rog (tsuas yog cov lipoproteins tsawg heev). Hauv cov hlwb, cuam tshuam nrog glycerol-tri-phosphate, fatty acids yog thawj zaug hloov mus rau hauv lysophosphatidic acid, los ntawm cov phosphatidic acid tom qab tsim.
Cov mis ntawm glycerophospholipids tsim los ntawm nws muaj cov seem ntawm phosphoric thiab fatty acids, glycerol, nrog rau nitrogen-muaj kua qaub residues.
Tus nqi ntawm phosphatidic acid
Nws tau raug tsim tsa tias phosphatidic acid belongs rau lub npe hu ua cov teeb liab sib txuas, uas yog, cov uas ua haujlwm ntawm cov neeg kho kom haum xeeb hauv kev xa cov ntaub ntawv hauv cov teeb liab txoj hauv kev. Tshwj xeeb, nws yog qhov txuas tseem ceeb hauv kev sib kis ntawm cov teeb liab hauv qab no hauv cov nroj tsuag ntawm tes:
- cytokinin;
- osmotic, uas yog ib qho tseem ceeb hauv kev tsim cov cellular teb rau hom kev ntxhov siab no.
Thaum lub sijhawm kev sim nws tau pom tias theem ntawm cov tshuaj no hauv cov hlwb ntawm cov kab mob hauv cov kab mob hauv qab ntawm cov kab mob pathogenic nce ntau. Cov tshuaj tiv thaiv no yog tshwm sim los ntawm:
- Osmotic stress.
- raug rau qhov txias txias.
- Kev cuam tshuam ntawm qee yam tshuaj lom neeg lom neeg ntawm cov nroj tsuag keeb kwm (phytohormones).
Yog li, peb tuaj yeem xaus tias phosphatidic acid thiab nws cov metabolites koom nrog hauv cov kev cuam tshuam ntawm lub luag haujlwm rau lub cev hloov mus rau kev ntxhov siab.xwm txheej.
Ntxiv rau, nws paub tias phosphatidic acid yog qhov tsim nyog rau cov tshuaj tiv thaiv ntawm kev thauj cov protons thiab calcium ions los ntawm daim nyias nyias ntawm cov neurons thiab cov leeg nqaij. Raws li qhov no, ib qho kev ua haujlwm ionophore kuj raug ntaus nqi rau phosphatidic acid (xaiv: rau calcium ions thiab protons).
Kev hloov pauv mechanism
Txawm hais tias lub hom phiaj ntawm phosphatidic acid tau raug tsim los, txoj kev (mechanism) ntawm cov teeb liab kis tau tus kheej tseem tab tom tham thiab yuav tsum tau qhia meej.
Txawm li cas los xij, tsis muaj qhov tsis ntseeg tias kev hloov pauv tau ua tiav vim muaj peev xwm ntawm phosphatidic acid, ua haujlwm ntawm cov qauv ntawm cov cell membrane, tswj kev ua haujlwm ntawm daim nyias nyias enzymes, thiab tseem koom nrog kev sib cuam tshuam ntawm cov protein. molecules nrog cell membranes.
YSiv cov phosphatidic acid
Kev tshawb fawb ntawm cov tshuaj tiv thaiv antioxidant ntawm phosphatidic acid derivatives, ua ob qho tib si hauv kev kawm ntawm cov qauv txheej txheem thiab nrog kev koom tes ntawm cov khoom lom neeg, pom tau tias lub npe hu ua phosphatidic acid mimetics muaj ntau lub tswv yim ntawm kev ua haujlwm antioxidant.
Cov ntaub ntawv qhia ntxaws txog kev coj ua ntawm phosphatidic acid ua rau nws siv tau thiab nws cov metabolites hauv kev tsim cov tshuaj lom neeg lom neeg tsim los ua kom muaj txiaj ntsig thiab ua kom lub cev muaj zog.
Ua haujlwm ntawm qib cellular, cov khoom sib txuas no tsis txhawb nqa, tab sis tsuas yog normalize cov haujlwm ntawm cov hlwb; qhov nolub ntsiab lus tseem ceeb txo qis qhov tshwm sim ntawm qhov tshwm sim tsis zoo.
