Ntawm cov tshuaj antispasmodic "Papaverine" yog ib qho ntawm cov tshuaj muaj kev nyab xeeb tshaj plaws siv rau ntau yam pathologies. Raws li cov kab mob dab tsi thiab yog vim li cas "Papaverine" raug sau tseg, nws yuav paub meej yog tias koj nkag siab txog cov txheej txheem ntawm nws qhov kev ua. Zoo li txhua yam tshuaj, cov tshuaj no tsuas yog muab los ntawm kws kho mob xwb.
papaverine yog dab tsi
Papaverine hydrochloride yog ib yam tshuaj uas muaj vasodilating thiab antispasmodic nyhuv. Pom nyob rau hauv poppy nroj tsuag. Dab tsi yog papaverine, tib neeg tau kawm nyob rau hauv nruab nrab ntawm lub xyoo pua 19th, txawm hais tias cov ntaub ntawv Roman thaum ub tham txog kev sib xyaw cov khoom nrog lub npe zoo sib xws rau hauv cov zaub mov. Thaum pib ntawm lub xyoo pua 20th, papaverine tau ua ke, thiab tam sim no nws yog ib qho tshuaj siv dav hauv tshuaj.
Kev ua papaverine
Qhov kev txiav txim ntawm papaverine ntawm cov leeg nqaij leeg yog txuam nrog cov txheej txheem enzymatic, uas thaum kawg txocov calcium nyob rau hauv lub cell, vim hais tias cov leeg du. Qhov no muaj peev xwm txuas mus rau lub plab zom mov, kab mob biliary, cov hlwb hauv cov hlab ntsha, cov zis, cov hlwb ntawm cov hlab ntsha, cov leeg plawv, thiab cov leeg nqaij ntawm lub tsev menyuam. Piav txog cov nyhuv sedative me me thaum cuam tshuam lub hlwb ntawm cov neeg mob.
Kev nqus thiab tshem tawm
Cov tshuaj muaj peev xwm nqus tau los ntawm 54%. Cov tshuaj khi zoo rau plasma proteins (90%). Nyob rau hauv lub cev, nws kis tau sai heev ntawm cov ntshav thiab cov ntaub so ntswg, nkag mus rau tag nrho cov hlwb ntawm lub cev, nrog rau lub hlwb. Papaverine hloov dua siab tshiab tshwm sim nyob rau hauv daim siab hlwb. Nws raug tshem tawm los ntawm lub cev sai heev: ib nrab-lub neej yog los ntawm peb caug feeb mus rau ob teev, tab sis nrog cov kab mob siab, kev tshem tawm cov tshuaj ntev dua yog ua tau. Cov tshuaj raug tshem tawm los ntawm ob lub raum, yog li nws yog ib qho tseem ceeb kom paub tias cov neeg mob lim ntshav tuaj yeem ua kom papaverine tawm sai sai (nws yog dab tsi, koj twb paub lawm) hauv cov zis.
Cov lus qhia rau kev siv
Dab tsi pab papaverine, nws ua kom pom tseeb, raws li nws cov txheej txheem ntawm kev ua. Cov tshuaj muaj cov nyhuv antispasmodic thiab siv:
- Kho kom mob plab mob los ntawm kev qaug cawv, mob plab (gastritis), peptic ulcer thiab kev ua haujlwm ntawm lub paj hlwb.
- Kev tshem tawm ntawm cov kab mob hauv lub plab hauv plab cholecystitis, cholangitis, kev ua haujlwm tsis zoo vim tsis txausKev tswj ntawm lub paj hlwb, cholelithiasis.
- Nyob rau hauv kev kho cov txheej txheem spastic nyob rau hauv cov hnyuv txuam nrog inflammatory kab mob ntawm cov hnyuv me thiab loj, ua hauj lwm spasms.
- Txhim kho bronchospasm hauv mob ntsws thiab mob ntsws, mob ntsws asthma, mob ntsws.
- Thaum tshem tawm qhov ua rau spasm ntawm cov phab ntsa ntawm cov zis thiab cov hlab ntsha ntawm ob lub raum vim muaj cov txheej txheem sib kis, kev ua haujlwm tsis zoo ntawm kev so vim yog pathology ntawm peripheral paj hlwb.
- Txhim kho cov hlab ntsha hauv cov txheej txheem inflammatory hauv cov hlab ntsha, ua haujlwm spasms ntawm lub hlwb uas ua rau mob taub hau, arterial hypertension.
- Ua ke nrog lwm cov tshuaj angina.
- "Papaverine" thaum ntxov cev xeeb tub yog siv los txo cov suab nrov hauv tsev menyuam.
- Kom txo cov leeg nqaij ntawm lub tsev menyuam thiab txo qhov mob thaum cev xeeb tub hauv poj niam.
- Nyob rau hauv kev npaj rau kev phais kom muab cov nyhuv hypnotic me me nrog rau lwm cov tshuaj sedatives.
Khoom "Papaverine"
Cov tshuaj yog siv rau hauv 40 mg ntsiav tshuaj, 20 mg suppositories thiab 40 mg txhaj.
Cov koob tshuaj "Papaverine" rau cov neeg laus yog ob ntsiav tshuaj (tswj tswm ciab) lossis ib qho ampoule intramuscularly peb zaug hauv ib hnub. Qhov koob tshuaj ntau tshaj yog ua tau mus txog 240 mg ib hnub twg nrog mob hnyav spasmodic rhiab heev. Kev taw qhia ntawm cov tshuaj los ntawm ib txoj kev yuav tsum tau nqa tawm tsis pub ntau tshaj plaubteev.
Tshuaj tsis yog nyob ntawm zaub mov. Qhov kev nqis tes ua sai sai txaus, cov tshuaj pib txo qhov mob spasmodic li ntawm peb caug feeb tom qab siv.
Lub sijhawm ntawm kev noj "Papaverine" yog tus kheej thiab tuaj yeem ntev rau qhov mob ntev.
Siv thaum yau
Cov menyuam mos hnub nyoog qis dua rau lub hlis ntawm cov tshuaj yog contraindicated. Pib txij hnub nyoog rau lub hlis thiab txog li ob xyoos, koj tuaj yeem muab 5 mg peb zaug ib hnub. Cov menyuam yaus hnub nyoog 3-4 xyoos tau muab 5-10 mg peb zaug ib hnub. Thaum muaj hnub nyoog tsib thiab rau rau - 10 mg, uas yog, 1/4 ntsiav tshuaj peb zaug ib hnub twg. Los ntawm xya mus rau cuaj xyoo, 10-15 mg peb zaug ib hnub twg. Cov menyuam yaus hnub nyoog 10-14 xyoos - 15 mus rau 20 mg peb zaug ib hnub. Txij thaum muaj hnub nyoog 15 xyoos, qhov koob tshuaj sib raug rau cov neeg laus, uas yog 40 mg peb zaug ib hnub.
Siv thaum cev xeeb tub
Nyob rau hauv thawj peb lub hlis twg ntawm cev xeeb tub, cov poj niam feem ntau muaj kev nce uterine suab, uas yog, cov leeg nqaij spasm. Qhov no tuaj yeem ua rau kev nchuav menyuam ntxov. Pathology feem ntau nrog rau qhov mob hauv plab thiab hauv lub sacrum, qee zaum kuj muaj qhov tso tawm, xws li thaum cev xeeb tub. Cov neeg mob zoo li no tau mus pw hauv tsev kho mob hauv chav kho mob pathology ntawm cev xeeb tub thiab "Papaverine" raug tshuaj rau kev txhaj tshuaj. Nyob rau hauv cov ntaub ntawv no, cov tshuaj zoo kawg nkaus so cov nqaij ntshiv ntawm lub tsev menyuam, txhim kho cov ntshav ncig, tsis muaj kev cuam tshuam rau tus me nyuam loj hlob.
tswm ciab "Papaverine" nyob rau theem pib muaj qhov zoo tib yam. Siv lawv 3-4 zaug hauv ib hnub, nyob ntawm qhov xwm txheej. Cov kev kho mob zoo li no yuav tsum tau ua raws li kev saib xyuas ntawm tus kws kho mob kom tsis txhob muaj kev so hnyav ntawm cov leeg ntawm lub tsev menyuam.
siv ntshav siab
Arterial hypertension, uas yog nrog los ntawm cov hlab ntsha hauv hlwb thiab nce ntshav siab, tuaj yeem nres nrog kev pab ntawm "Papaverine" nrog "Dibazol" ua ke. "Dibazol" yog ib tug antispasmodic uas tshem tawm spasm ntawm peripheral hlab ntsha thiab cov nqaij ntshiv ntawm lub cev. Kev sib xyaw ua ke ntawm ob cov tshuaj antispasmodics tso cai rau koj kom muaj feem yuav txo qis ntshav siab thiab txhim kho tus neeg mob sai. Ib ampoule ntawm "Dibazol" nyob rau hauv 2 ml muaj 10 mg ntawm active ingredient.
Hauv kev kub ntxhov siab, 1-2 ampoules ntawm txhua yam tshuaj tau muab tshuaj intramuscularly lossis maj mam tso rau hauv ib lub koob txhaj tshuaj. "Papaverine" thiab "Dibazol" nyiam kev sib koom ua ke. Nws yog undesirable siv xws li kev sib xyaw ua ke rau cov neeg laus uas muaj teeb meem plawv. "Dibazol" yog contraindicated nyob rau hauv qaug dab peg thiab convulsive qaug dab peg ntawm lwm yam etiology, nrog rau cov hypersensitivity rau cov tshuaj no.
YContraindications
Kawm seb "Papaverine" yog dab tsi, koj yuav tsum paub seb leej twg yuav tsum tsis txhob noj cov tshuaj no:
- Cov me nyuam mus txog rau lub hlis.
- Cov neeg laus dua 70,muaj mob plawv, uas tsis muaj peev xwm nqus tau cov ntshav ncig lub cev.
- Rau cov muaj sia nyob ntawm myocardial infarction.
- Rau cov neeg mob uas muaj atrioventricular block, uas ua rau qeeb ntawm kev ua haujlwm ntawm lub siab ntawm lub ventricle thiab atrium, uas ua rau lub plawv dhia qeeb thiab txo qis ntawm cov ntshav tawm mus rau hauv aorta.
- Nrog qhov muag siab.
- mob siab ua tsis taus pa.
- Nrog cov kab mob ua pa, obstructive pulmonary txheej txheem.
- Nyob rau hauv cov neeg mob uas tsis nco qab (nyob rau hauv lub coma thiab soporous xeev).
- Nyob rau hauv cov ntaub ntawv ntawm tus kheej rhiab heev.
Cov lus qhia tshwj xeeb
"Papaverine" feem ntau zam tau zoo, tab sis yuav tsum tau siv nrog ceev faj hauv cov xwm txheej hauv qab no:
- Nyob rau ntshav siab thiab bradycardia.
- Txo cov thyroid ua haujlwm.
- Kev tsim cov tshuaj hormones adrenal tsis txaus.
- mob raum tsis ua haujlwm.
- Dishormonal prostatic hyperplasia hauv cov txiv neej.
- mob hlwb.
- Cov xwm txheej poob siab.
- ECG cov cim qhia ntawm supraventricular tachycardia.
- Thaum tsav tsheb thiab ua haujlwm ntawm qhov siab, qhov cuam tshuam ntawm "Papaverine" ntawm lub cev yuav tsum raug coj mus rau hauv tus account.
Side effects
Dab tsi "Papaverine" yog siv rau, peb tau piav qhia saum toj no, tab sis nws tsis yog ib txwm coj cov txiaj ntsig zoo xwb. Qee lub sij hawm tsis xav tau qhov tshwm sim tuaj yeem ua tau:
- Npaj, plab tsis xis nyob, qhov ncauj qhuav, cem quav, raws plab, tsam plab, qab los noj mov.
- Txo cov ntshav siab nce mus rau qhov vau, extrasystoles, arrhythmias, tachycardia, bradycardia, thaiv, kiv taub hau.
- Drowsiness, lethargy, qhov muag tsis pom kev, mob taub hau, rhiab heev rau lub teeb.
- nce eosinophils hauv cov ntshav peripheral.
- Ua kom lub cev kub siab dua 37 degrees (feem ntau hauv cov menyuam yaus thiab cov neeg laus).
- Npauj ntsaug.
- daim tawv nqaij daj thiab sclera.
- ua xua pob khaus, angioedema.
- Kev kub nyhiab ntawm qhov chaw txhaj tshuaj.
- Vim thrombosis nrog ib tug nyiam thrombosis.
Ntau tshaj
Tshaj qhov koob tshuaj "Papaverine" tuaj yeem ua rau muaj kev tsis zoo nyob hauv tus mob. Tus neeg mob yuav yws yws ntawm qhov muag tsis pom kev, mob rhiab heev rau lub teeb, qaug zog, tsaug zog, tsis xis nyob hauv plawv cheeb tsam, lub plawv dhia qis, kiv taub hau. Muaj peev xwm txhim kho kev ua pa nres.
Kev pab yuav tsum muab tam sim ntawd. Thaum ua pa nres, cardiopulmonary resuscitation yog qhia. Hauv cov mob me me, thaum noj cov ntsiav tshuaj, ua rau plab zom mov, sorbents (activated charcoal) tau noj. Nrog rau kev txhaj tshuaj ntau dhau, kev lim ntshav tuaj yeem siv los ntxuav lub cev sai sai.
Kev Sib Tham Tshuaj
Nws yuav tsum tau qhia meej seb "Papaverine" tuaj yeem siv nrog lwm yam tshuaj.
Contraindicatedkev siv cov dej cawv thaum lub sij hawm kho nrog cov tshuaj no vim muaj kev cuam tshuam ntau ntxiv rau cov kab mob siab. Nicotine txo cov nyhuv ntawm "Papaverine", yog li kev haus luam yeeb yuav tsum raug tso tseg lossis txo kom tsis txhob txo cov txiaj ntsig ntawm kev kho mob.
Cov tshuaj Anticholinergic ("Atropine", "Cyclodol", "Ipratropium bromide"), thaum noj ua ke nrog "Papaverine", tuaj yeem ua rau lub zog ntau dua, yog li lawv cov tshuaj yuav tsum tau kho.
Txo cov nyhuv ntawm Levodopa (ib tshuaj rau cov neeg mob Parkinsonism), Methyldopa thiab Dopegyt.
Tej zaum yuav ua rau mob plawv ntau dua thaum siv nrog 3-adrenergics (Reserpine, Octadine).
Cov nyhuv sedative yog txhim kho thaum noj ua ke nrog cov tshuaj tsaug zog, tshuaj, tshuaj tiv thaiv kev ntxhov siab, tshuaj tiv thaiv kev ntxhov siab, tshuaj tiv thaiv kev puas hlwb thiab tshuaj kho mob.
Thaum noj tshuaj kom txo cov ntshav siab, lawv cov koob tshuaj yuav tsum tau hloov kho vim qhov muaj feem ntau ntawm kev tsim cov ntshav siab.
hom thiab cov npe lag luam
Hauv daim ntawv ntsiav tshuaj, cov tshuaj yog tsim los ntawm cov npe hauv qab no nkaus xwb los ntawm cov tuam txhab hauv tsev:
- Papaverine yog cov khoom siv tshuaj uas tsim los ntawm Pharmstandard-Tomkhimfarm OJSC.
- "Papaverine" hauv cov ntsiav tshuaj ntawm 40 mg, tsim los ntawm OJSC "Irbitsky CPP".
- "Papaverine" ntawm PJSC "Biosintez".
- "Papaverine hydrochloride MS", tsim los ntawm kev lag luam CJSCMedisorb.
Nyob rau hauv daim ntawv ntawm lub qhov quav suppositories, cov tshuaj nyob rau hauv Russia yog sawv cev los ntawm domestic tshuaj:
- "Papaverine" suppositories ntawm 20 mg, tsim los ntawm OJSC "Biochemist".
- "Papaverine" rectal suppositories ua los ntawm JSC "Nizhpharm".
- "Papaverine" rectal suppositories ua los ntawm Tula Pharmaceutical Factory.
- "Papaverine hydrochloride" tswm ciab PJSC "Biosintez".
- "Papaverine hydrochloride" suppositories JSC "Dalchimpharm".
Cov tshuaj rau txhaj tshuaj ntawm 2 ml yog tsim nyob rau hauv Lavxias teb sab tuam txhab raws li lub npe:
- Papaverine, manufacturers: Novosibkhimfarm OJSC, Grotex LLC, Veropharm JSC, Biochemist OJSC, Biosynthesis PJSC, Ellara LLC.
- "Papaverine Bufus", tsim los ntawm CJSC "PFC Rov Ntxiv".
- "Papaverine hydrochloride" cov lag luam: OJSC "Moskhimfarmpreparaty im. N. A. Semashko, Atoll LLC, Slavyanskaya Apteka LLC, Dalkhimfarm OJSC, FKP Armavir Biofactory.
Thiab kuj tau xa tawm "Papaverine" hauv kev daws teeb meem los ntawm Republic of Belarus, ua ntawm JSC "Borisov Plant of Medical Preparations".
