Thrombosis yog hu ua intravital tsim ntawm cov ntshav txhaws lossis cov ntshav txhaws hauv cov hlab ntsha. Lawv tiv thaiv kev ywj pheej ntawm plasma los ntawm tib neeg txoj hlab ntshav, uas tuaj yeem ua rau muaj kev puas tsuaj loj.
Thaum cov hlab ntsha puas lawm, lub cev siv cov fibrin thiab platelets los ua ib hom "plug" uas tiv thaiv cov ntshav poob. Txawm li cas los xij, nyob rau hauv qee yam mob, cov ntshav txhaws tau tsim yam tsis muaj kev puas tsuaj rau cov hlab ntsha. Thaum cov hlab ntsha npog ntau dua 75% ntawm tag nrho cov cheeb tsam ntawm cov hlab ntsha lumen, cov pa oxygen ntws mus rau cov ntaub so ntswg txo qis heev uas tus neeg mob pom cov cim ntawm kev txuam nrog cov khoom metabolic hauv lub cev thiab hypoxia.
Cov kws tshaj lij txheeb xyuas cov hauv qab no uas ua rau muaj kev loj hlob ntawm thrombosis:
- kev puas tsuaj rau phab ntsa;
- ntshav muaj pes tsawg leeg (thrombophilia lossis hypercoagulability);
- tus cwj pwm ntawm cov ntshav ntws (ua rau muaj kev kub ntxhov, stasis).
Yuav siv tshuaj dab tsi rau thrombosis? Ib qho ntawm feem nrov txhais tau tias yog Heparin-Akrikhin 1000 gel. Cov lus qhia rau kev siv cov tshuaj no, nws muaj pes tsawg leeg, pharmacological nta, phiv thiab lwm yam ntaub ntawv qhia hauv qab no.
Kev sib xyaw, ntim tshuaj, piav qhia
"Heparin-Akrikhin" - gel npaj rau kev siv sab nraud. Cov khoom zoo li no yog pob tshab lossis yuav luag pob tshab, tsis muaj xim lossis daj me ntsis, nrog cov ntxhiab tsw tshwj xeeb.
Cov tshuaj Heparin-Akrikhin muaj dab tsi? Cov muaj pes tsawg leeg ntawm cov cuab yeej no suav nrog xws li cov khoom muaj xws li sodium heparin. Raws li excipients, cov tshuaj nyob rau hauv nqe lus nug muaj xws li: methyl parahydroxybenzoate, lavender roj, carbomer, purified dej, trometamol, 96% ethanol (rectified ethyl cawv), txiv kab ntxwv paj roj (los yog neroli roj).
Heparin-Akrikhin gel mus muag hauv cov raj txhuas, uas tau muab tso rau hauv cov thawv ntawv.
tshuaj kho mob
Heparin sodium yog dab tsi? Lub active tivthaiv ntawm tus neeg sawv cev nyob rau hauv nqe lus nug yog ib tug ncaj-acting anticoagulant. Nws belongs rau nruab nrab molecular hnyav heparins. Ib zaug nyob rau hauv cov ntshav plasma, cov tshuaj no muaj peev xwm mus qhib antithrombin III, yog li ua rau nws cov anticoagulant zog.
Gel nrog sodium heparin inhibits cov haujlwm ntawm thrombin, cuam tshuam kev hloov pauv ntawm prothrombin rau thrombin, thiab kuj txoplatelet aggregation (rau qee qhov).
Lwm yam khoom
Dab tsi lwm yam khoom muaj nyob hauv cov tshuaj "Heparin-Akrikhin"? Raws li cov lus qhia, cov tshuaj no muaj peev xwm ua kom lub raum cov ntshav khiav, ua kom cov hlab ntsha hauv hlwb, txo cov kev ua ntawm hyaluronidase, qhib lipoprotein lipase thiab nthuav tawm cov teebmeem lipid-txo. Tsis tas li ntawd, tus neeg sawv cev hauv kev saib xyuas zoo txo qhov kev ua ntawm surfactant hauv tus neeg mob lub ntsws, inhibits cov synthesis ntawm aldosterone nyob rau hauv adrenal cortex, tsub kom cov kev ua ntawm parathyroid hormone, khi adrenaline, thiab kuj modulates lub zes qe menyuam teb rau cov tshuaj hormone stimuli.
Thaum cuam tshuam nrog cov enzymes, cov tshuaj no tuaj yeem ua rau muaj kev ua haujlwm ntawm pepsinogen, hlwb tyrosine hydroxylase, DNA polymerase thiab txo cov haujlwm ntawm pyruvate kinase, myosin ATPase, pepsin thiab RNA polymerase. Tseem muaj pov thawj ntawm kev tiv thaiv kab mob hauv sodium heparin gel.
cuam tshuam nta
tshuaj "Heparin-Akrikhin" cuam tshuam rau tus neeg mob lub cev li cas? Hauv cov neeg uas muaj tus kab mob coronary artery (ua ke nrog ASA), kev siv cov tshuaj no txo qhov kev pheej hmoo ntawm kev tsim thrombosis (mob) ntawm cov hlab ntsha, kev tuag sai thiab myocardial infarction. Tsis tas li ntawd, kev siv cov tshuaj no txo qhov zaus ntawm kev tuag thiab rov tshwm sim plawv nres. Nyob rau hauv ntau npaum li cas, cov gel nyob rau hauv nqe lus nug yog zoo nyob rau hauv venous thrombosis thiab pulmonary embolism, thiab nyob rau hauv me me koob tshuaj nws nquag siv rau kev tiv thaiv ntawm venous thromboembolism, suav nrog.tom qab phais.
Thaum siv sab nraud, "Heparin-Akrikhin" muaj cov nyhuv antiexudative, antithrombotic thiab anti-inflammatory (mob nruab nrab). Cov tshuaj no muaj kev nyuaj siab rau kev ua haujlwm ntawm hyaluronidase, thaiv kev tsim cov thrombin, thiab tseem ua rau cov khoom fibrinolytic ntawm plasma.
Heparin, nkag mus rau ntawm daim tawv nqaij, txo qhov mob thiab muaj cov nyhuv antithrombotic. Tsis tas li ntawd, cov tshuaj no ua rau cov ntaub so ntswg metabolism thiab txhim kho microcirculation, yog li ua kom cov txheej txheem ntawm resorption ntawm cov ntshav txhaws thiab hematomas, thiab txo cov ntaub so ntswg o.
Pharmacokinetic zog
Ib qho me me ntawm cov tshuaj nquag ntawm cov tshuaj tau nqus los ntawm daim tawv nqaij mus rau hauv lub cev. Tib lub sijhawm, nws qhov siab tshaj plaws tau sau tseg 8 teev tom qab thov.
Kev tso tawm ntawm heparin sodium tshwm sim los ntawm lub raum. Ib nrab-lub neej ntawm cov tshuaj yog 12 teev. Vim qhov hnyav molecular loj, cov active tivthaiv ntawm cov gel tsis nkag mus rau lub placenta zoo, thiab kuj tsis nkag mus rau hauv lub mis niam.
Cov lus qhia rau cov tshuaj
Heparin-Akrikhin siv rau dab tsi? Cov lus qhia rau kev siv cov tshuaj no yog cov hauv qab no (rau kev tiv thaiv thiab kev kho mob):
- deep vein thrombosis;
- thrombophlebitis;
- pulmonary embolism (tshwj xeeb tshaj yog nyob rau hauv kab mob peripheral leeg);
- DIC;
- thrombosis ntawm coronary hlab ntsha;
- myocardial infarctionntse;
- tsis ruaj tsis khov angina;
- atrial fibrillation (tshwj xeeb yog nrog los ntawm embolism);
- microcirculation tsis meej, microthrombosis;
- kab mob endocarditis;
- -Lub raum plab hlaub thrombosis;
- hemolytic uremic syndrome;
- Yglomerulonephritis;
- kab mob plawv, thrombosis;
- Ylupus nephritis.
Tsis tas li, cov tshuaj hauv nqe lus nug tau raug sau tseg rau kev tiv thaiv cov ntshav txhaws thaum lub sijhawm phais kev phais siv cov txheej txheem kev ua haujlwm ntawm lub cev, thaum lub sij hawm hemosorption, hemodialysis, yuam diuresis, peritoneal dialysis, citapheresis thiab thaum lub sij hawm ntxuav ntawm venous catheters.
Qee lub sij hawm xws li kev npaj yog tsim nyog rau kev npaj cov qauv ntawm cov ntshav uas tsis yog-clotting thaum lub sij hawm hloov thiab rau lub hom phiaj kuaj.
txwv tsis pub sau tshuaj gel rau kev siv sab nraud
Hauv qhov xwm txheej twg tsis tuaj yeem siv Heparin-Akrikhin? Cov xwm txheej hauv qab no yog contraindications rau kev siv cov tshuaj no:
- los ntshav, antiphospholipid syndrome, cov kab mob uas nrog los ntawm kev ua txhaum ntawm cov ntshav coagulation;
- erosive thiab ulcerative lesions ntawm lub plab zom mov, intracranial hemorrhage los yog xav tias nws, cerebral aneurysm;
- dissecting aortic aneurysm, hemorrhagic stroke, siab cirrhosis nrog varicose veins, malignant arterial hypertension;
- kab mob endocarditissubacute, siab rhiab heev rau heparin, mob siab heev parenchymal lesions, poob siab tej yam kev mob;
- Malignant neoplasms nyob rau hauv txoj hlab pas thiab daim siab, hem nchuav menyuam, qhov muag tsis ntev los no, prostate, hlwb, biliary tract, daim siab, kev coj khaub ncaws, mob tom qab txha caj qaum, yug me nyuam (tsis ntev los no).
Nws tseem yuav tsum tau sau tseg tias Heparin-Akrikhin gel tsis yog siv rau cov txheej txheem necrotic ulcerative thiab tsis siv rau cov mucous membranes thiab qhib qhov txhab.
Kev siv tus neeg sab nraud
Qhov ntau npaum li cas ntawm cov tshuaj hauv nqe lus nug yog tus kheej thiab nyob ntawm qhov chaw kho mob, qhia thiab hnub nyoog ntawm tus neeg mob. Cov gel yog siv rau sab nraud, hauv ib txheej nyias (ntawm tus nqi ntawm 3-5 cm ntawm gel rau ntawm daim tawv nqaij mus txog 3-5 cm inch) thiab maj mam rubbed rau hauv.
Siv cov tshuaj 1-3 zaug hauv ib hnub txhua hnub kom txog thaum cov kab mob tshem tawm tag nrho. Cov ntsiab lus ntawm kev kho mob yog txiav txim los ntawm cov kws tshwj xeeb (qhov nruab nrab ntawm 3 hnub mus rau ib lub lis piam).
Side Effects
Cov txiaj ntsig tsis zoo dab tsi tuaj yeem ua rau kev siv tshuaj "Heparin-Akrikhin"? Cov kev mob tshwm sim ntawm cov tshuaj no suav nrog:
- xeev siab, los ntshav ntawm cov kab mob urinary thiab gastrointestinal ib ntsuj av, dej ntws tawm ntawm daim tawv nqaij, los ntshav nyob rau hauv cov cheeb tsam uas raug lub siab (los ntawm phais qhov txhab), hnov kub nyob rau hauv cov leeg, hematuria, tsis qab los noj mov, thrombocytopenia;
- ntuav, tshuaj kub cev, pruritus, raws plab, bronchospasm, siab siab transaminases, cev qhuav dej, osteoporosis;
- urticaria, spontaneous fractures, rhinitis, mos mos calcification, anaphylactic shock, thrombocytopenia, daim tawv nqaij necrosis, daim ntawv thov chaw khaus khaus, arterial thrombosis;
- ntuav alopecia, gangrene, flushing, myocardial infarction, hematoma, stroke, hypoaldosteronism, mob thiab ulceration ntawm qhov chaw thov.
"Heparin-Akrikhin": kev sib cuam tshuam tshuaj
Thyroxine, ergot alkaloids, tshuaj tiv thaiv kab mob, nicotine thiab tetracycline txo cov teebmeem ntawm sodium heparin.
Cov khoom tiv thaiv coagulant ntawm "Heparin-Akrikhin" tau txhim kho nrog kev siv tib lub sijhawm ntawm cov tshuaj tiv thaiv kab mob, tshuaj tiv thaiv coagulants thiab NSAIDs.
Cov neeg mob ntau dhau
Dab tsi yog qhov tshwm sim ntawm kev noj tshuaj ntau dhau ntawm Heparin-Akrikhin? Raws li cov lus qhia, kev siv tshuaj ntau dhau, tshwj xeeb tshaj yog nrog tus neeg sawv cev sab nraud, tsis zoo li vim qhov nqus ntawm cov khoom siv gel. Txawm li cas los xij, hauv qee kis, kev siv tshuaj ntau dhau yog nrog los ntshav ntau ntxiv. Nyob rau hauv cov xwm txheej zoo li no, nws yog qhov zoo dua los tsis kam siv cov tshuaj (los ntshav tawm los ntawm kev siv tshuaj antagonist).
Nws yog ib qho tseem ceeb rau sawv daws paub
Nrog kev ceev faj heev, cov tshuaj hauv nqe lus nug yuav tsum tau muab rau cov neeg uas muaj kev tsis haum tshuaj polyvalent, nrog rau cov hlab ntshav siab, ntshav qab zib mellitus, cov txheej txheem kho hniav, mob ntsws, mob endocarditis, hluav taws xob kho mob, pericarditis, muaj cov kab mob hauv lub cev. kev tiv thaiv kab mob, daim siab tsis ua haujlwm, lub raum tsis ua haujlwm ntev,hauv cov neeg mob laus.
Nrog ceev faj, Heparin-Akrikhin gel yog siv sab nraud rau thrombocytopenia thiab nce los ntshav.
Thaum lub sijhawm kho nrog heparin, yuav tsum tau saib xyuas cov txheej txheem ntawm cov ntshav coagulation.
Qhov kev pheej hmoo ntawm los ntshav tuaj yeem txo qis nrog kev soj ntsuam ceev faj ntawm kev siv cov gel, noj kom txaus thiab saib xyuas cov txheej txheem ntshav coagulation.
