Gamma-aminobutyric acid. Cov cim qhia ntawm qhov tsis muaj peev xwm ntawm lub cev

Cov txheej txheem:

Gamma-aminobutyric acid. Cov cim qhia ntawm qhov tsis muaj peev xwm ntawm lub cev
Gamma-aminobutyric acid. Cov cim qhia ntawm qhov tsis muaj peev xwm ntawm lub cev

Video: Gamma-aminobutyric acid. Cov cim qhia ntawm qhov tsis muaj peev xwm ntawm lub cev

Video: Gamma-aminobutyric acid. Cov cim qhia ntawm qhov tsis muaj peev xwm ntawm lub cev
Video: Mob nrob qaum/ Mob duav yog vim li cas? 2024, Lub Xya hli ntuj
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Lub ntsiab tswj hwm ntawm peb lub cev tag nrho yog lub hlwb. Ua tsaug rau nws, kev ua haujlwm ntawm txhua lub tshuab ua haujlwm sib koom ua ke. Nrog kev pab ntawm lub hlwb thiab txha caj qaum, peb tuaj yeem txav mus, pom, hnov, hais lus, hnov thiab nkag siab. Lawm, lub hauv nruab nrab thiab peripheral paj hlwb nqa tawm lawv qhov kev ua los ntawm cov qauv tshwj xeeb - neurotransmitters. Cov no suav nrog ntau yam khoom uas pab lub hlwb xa cov cim.

Kev ua ntawm neurotransmitters hauv lub cev

gamma aminobutyric acid
gamma aminobutyric acid

Yuav kom ua tiav kev sib kis ntawm cov paj hlwb, nrog rau cov leeg nqaij, xav tau cov pab. Lawv yog cov intermediaries uas ua rau hluav taws xob impulse los ntawm qhov chaw synaptic. Cov impulses mus raws cov hlab ntsha xaus thiab, mus txog qhov kawg, ua rau tso tawm cov neurotransmitter. "Helpers" poob rau hauv qhov sib txawv thiab cuam tshuam rau cov neeg nyob sib ze neuron, uas dhau los ua permeable rau lub teeb liab. Yog li, kev sib kis ntawm tag nrho cov hluav taws xob impulses nyob rau hauv lub cev yog nqa tawm. Neurotransmitters yog cov khoom siv tshuaj lom neeg uas tuaj yeem ua rau ob qho tib siexcitation thiab inhibition hauv CNS. Lawv muab faib ua 3 pawg: amino acids, catecholamines thiab peptides. Cov neeg sawv cev tshaj plaws yog epinephrine thiab norepinephrine, gamma-aminobutyric acid, glycine, dopamine, serotonin, glutamate, acetylcholine.

GABA ua haujlwm hauv lub cev

Gamma aminobutyric acid tshuaj xyuas
Gamma aminobutyric acid tshuaj xyuas

Gamma-aminobutyric acid (los ntawm lus Askiv GABA) yog hais txog cov neeg nruab nrab uas cuam tshuam rau lub paj hlwb. Nws yog ib yam tshuaj muaj nyob rau hauv lub cev ntawm tib neeg thiab tsiaj txhu. GABA yog ib qho ntawm cov amino acids tsis tseem ceeb uas tsis muaj peev xwm ntawm kev tsim cov protein molecules. Txawm li cas los xij, nws qhov tseem ceeb hauv lub cev yog siab heev. Gamma-aminobutyric acid ua 2 lub luag haujlwm tseem ceeb:

  1. Mediator action. Vim nws cov nyhuv inhibitory, GABA muaj hypotensive, sedative, anticonvulsant teebmeem. Tsis tas li ntawd, nws txhawb kev pw tsaug zog, tswj lub cev muaj zog, txhim kho kev nco thiab kev xav.
  2. Metabolic muaj nuj nqi. GABA txhim kho cov txheej txheem metabolic hauv lub hlwb thiab nws cov ntshav ncig, muab cov paj hlwb nrog lub zog. Ua tsaug rau cov tshuaj no, ib qho ntawm cov teebmeem tseem ceeb tshaj plaws yog nqa tawm - antihypoxic, uas yog, tiv thaiv kev tshaib plab oxygen. Qhov kev txiav txim tom ntej ntawm GABA yog tshem tawm cov khoom lag luam metabolic ntawm lub cev thiab cov txiaj ntsig ntawm kev tsim cov tshuaj hormones loj hlob los ntawm cov qog pituitary anterior.

Sources of GABA

nicotinoyl gamma aminobutyric acid
nicotinoyl gamma aminobutyric acid

GABA yog ib qho ntawm cov khoom ntawm cov ntshav thiab lub hlwb. Nrog rau qhov tsis muaj natural reserves, nws yog ib qho tsim nyog yuav tau txais los ntawm lwm qhov chaw. Gamma-aminobutyric acid muaj nyob hauv qee cov zaub mov cog. Cov no suav nrog tshuaj yej thiab kas fes nplooj, filamentous nceb, thiab kua txiv ntawm cov nroj tsuag cruciferous. Tsis tas li ntawd, GABA tau txais tshuaj siv cov txheej txheem microbiological. Rau nws txoj kev loj hlob, tib neeg cov kab mob, xws li E. coli, yog siv. Qee cov tshuaj muaj cov ntsiab lus tseem ceeb - nicotinoyl gamma-aminobutyric acid. Nws hais txog cov analogues tau txais hauv chav kuaj.

Cov cim qhia ntawm GABA deficiency hauv lub cev

Nrog tsis muaj gamma-aminobutyric acid, ntau cov txheej txheem pathological tshwm sim. Cov tseem ceeb yog kev nyuaj siab, ntxhov siab vim thiab mob leeg. Qhov no yog vim qhov txo qis hauv kev ua haujlwm uas gamma-aminobutyric acid ua hauv lub cev. GABA xav tau los muab lub hlwb nrog lub zog, tswj cov txheej txheem tshwm sim hauv nws. Yog li ntawd, nrog nws qhov tsis muaj peev xwm, ntau yam teeb meem ntawm lub hauv nruab nrab paj hlwb tsim. Cov no suav nrog:

gamma aminobutyric acid gamma
gamma aminobutyric acid gamma
  1. Vascular pathologies ntawm lub hlwb - kub siab, atherosclerosis, kev loj hlob ntawm strokes thiab plawv nres.
  2. Heev, qaug zog, kiv taub hau, pw tsaug zog, nco, mloog.
  3. Alzheimer's disease.
  4. Cerebral palsy.
  5. Encephalopathies.
  6. Npaj loj hlob cov tshuaj hormones.
  7. Dementia tom qab mob hlwb.
  8. Kab mobParkinson tus kab mob.
  9. xeev kev nyuaj siab.
  10. Underdevelopment of mental processes in me.
  11. Txoj kev puas siab puas ntsws tsis ruaj khov.
  12. mob hiav txwv thiab huab cua.

Txhua yam mob no yuav tsum tau kho mob ntxiv ntawm gamma-aminobutyric acid, nrog rau kev noj zaub mov ntau ntxiv.

Tshuaj muaj GABA

Yuav ua kom tsis muaj gamma-aminobutyric acid, koj yuav tsum mus ntsib kws kho mob. Nws yuav muab cov kev kho mob hloov txaus. Cov khoom tseem ceeb ntawm txhua yam tshuaj yog gamma-aminobutyric acid. Nws cov analogues muaj cov additives nyob rau hauv daim ntawv ntawm calcium, nicotinoyl, thiab kuj yog derivatives ntawm GABA. Cov tshuaj tseem ceeb suav nrog Aminalon, Picamilon, Phenibut, Neurobutal, GABA tshuaj. Cov lus qhia rau kev siv tag nrho cov tshuaj no yog cov teeb meem tshwm sim los ntawm qhov tsis muaj gamma-aminobutyric acid hauv lub cev. Cov tshuaj uas muaj GABA yog contraindicated rau cov menyuam yaus hnub nyoog qis dua 1 xyoos, cov poj niam cev xeeb tub (hauv thawj peb lub hlis twg), nrog rau qhov tsis txaus siab rau lub ntsiab lossis cov khoom ntxiv thiab hauv lub raum tsis ua haujlwm.

Gamma aminobutyric acid analogues
Gamma aminobutyric acid analogues

Gamma-aminobutyric acid: tus neeg mob tshuaj xyuas

Thaum muab tshuaj GABA lossis nws cov tshuaj analogues, cov neeg mob ua kom lawv lub peev xwm ua haujlwm tau zoo, tswj kev pw tsaug zog thiab tsaug zog, txhim kho kev nco thiab txo qis kev nyuaj siab, tsis txhob mob plab. Ntawm cov kev mob tshwm sim, qee cov neeg mob nco ntsoov dyspepticmob, nce libido, tsaug zog.

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