txhawm rau tiv thaiv thiab kho cov kab mob kis, siv interferon inducers. Cov txheej txheem ntawm lawv cov kev ua yog txuam nrog kev tsim cov tshuaj protein uas tiv thaiv kev tsim cov kab mob pathogenic. Kev npaj raws li inductors tso cai rau koj los tawm tsam cov kab mob ua pa, kab mob herpetic thiab kab mob siab, mob khaub thuas.
Kev txiav txim siab ntawm interferon
Nov yog lub npe ntawm ib pawg ntawm cov tebchaw ntawm cov protein. Lawv yog tsim los ntawm cov hlwb uas kis tus kab mob.
Cov tshuaj Interferon yog yam tsis muaj kev tiv thaiv tshwj xeeb hauv lub cev tiv thaiv kab mob, chlamydial, kab mob fungal, cellular qauv ntawm cov qog. Lawv kuj ua lub luag haujlwm ntawm regulators ntawm intercellular kev sib cuam tshuam ntawm kev tiv thaiv kab mob. Lawv kuj hu ua immunomodulators nrog endogenous xwm.
Muaj ntau hom ntawm tib neeg interferonCov tshuaj: leukocyte, lossis a-interferon, fibroblast, lossis b-interferon, thiab tiv thaiv kab mob, lossis g-interferon.
Lub tswv yim ntawm cov txheej txheem ntawm lawv txoj haujlwm pib nrog kev sib txuas ntawm cov proteins thiab cov receptors ntawm cov xwm txheej tshwj xeeb hauv cov hlwb. Nrog rau qhov kev sib cuam tshuam no, cov protein molecules yog synthesized nyob rau hauv peb kaum. Nrog kev pab los ntawm kev tswj peptides, kev ua haujlwm ntawm T-hom lymphocytes thiab cov qauv macrophage tau txhawb nqa, cov kab mob raug tiv thaiv kom tsis txhob nkag mus rau hauv cov cell membrane thiab sib npaug. Nws yog lawv uas txiav txim siab txog kev tiv thaiv.
Natural interferon inducers yog cov kab mob kis tau nkag mus rau hauv cov kab mob muaj sia. Lawv muaj zog thiab tsis muaj zog stimulants ntawm zus tau tej cov protein tiv thaiv. Feem ntau cov kab mob ntawm cov kab mob loj yog cov tsis zoo inducers. Cov no suav nrog cytomegalovirus thiab kab mob HIV, kab mob herpes, kab mob siab C thiab B. Ntawm qhov tod tes, ntau cov kab mob pathogenic uas ua rau cov kab mob ua pa yog suav tias yog cov tshuaj txhawb zog rau kev tsim cov protein tiv thaiv.
Interferon inducers (tshuaj): nws yog dab tsi
Feem ntau qhov no yog lub npe ntawm cov tshuaj ntawm cov chav kawm ntawm cov tshuaj immunomodulators. Lawv tsim los ntawm cov tuam txhab tshuaj. Interferon inducers (cov tshuaj) muaj nyob rau hauv cov chav kawm loj ntawm cov tebchaw nrog cov qauv tshuaj sib txawv. Cov khoom xyaw nquag tuaj yeem yog cov khoom siv qis- thiab siab molecular, ntawm cov khoom siv hluavtaws lossis ntuj tsim. Lawv koom ua ke los ntawm cov cuab yeej cuab tam uas tso cai rau lawv ua rau lawv tus kheej los yog endogenous interferon hauv cov hlwb ntawm lub cev. Cov tshuaj no ua tauCov tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob.
Yuav ua li cas lawv ua haujlwm
Endogenous interferon inductors yog cov tshuaj tsom rau feem ntau ntawm kev tawm tsam tus kab mob. Cov txheej txheem ntawm lawv qhov kev ua yog raws li kev sib cuag ntawm cov tshuaj nquag ntawm cov tshuaj nrog cov cellular thiab cov ntaub so ntswg, uas ua rau tsim cov protein tiv thaiv.
Interferon inductors yog cov tshuaj tshuaj uas ua kom muaj protein ntau ntxiv. Lawv qhov kev ua zoo ib yam li cov tshuaj stimulants, uas suav nrog cov kab mob, kab mob hlwb thiab ntau yam tshuaj.
Kev siv cov interferon inductors tuaj yeem ua rau muaj qhov tsis zoo. Hauv lub xeev no, nrog kev rov ua haujlwm ntawm cov tshuaj, tsis muaj cov lus teb ntawm kev tiv thaiv cov protein, nws raug pom zoo. Nyob rau theem no, nws tsis pom zoo los tswj cov tshuaj. Lub sijhawm ntawm xws li lub xeev yog txiav txim los ntawm inductor nws tus kheej. Hloov cov tshuaj nquag, nrog rau kev cuam tshuam kev kho mob nrog tib tus neeg sawv cev, pab txhawb kev tshem tawm ntawm hyporeactivity.
Cov tshuaj uas txhawb kev tsim cov protein tiv thaiv tsis ua rau muaj kev cuam tshuam loj heev uas yuav tsum tau tshem tawm.
qhov kom zoo dua ntawm endogenous protein inducers
Muaj ob txoj hauv kev los txhawb kev tiv thaiv interferon. Cov tshuaj no tuaj yeem ua rau exogenously lossis ncaj qha rau lub cev. Lwm txoj hauv kev cuam tshuam nrog endogenous interferonization nrog kev qhia txog cov tshuaj uas txhawb kev tsim khoomtus kheej interferon. Xws li cov protein tsis qhia antigenicity, uas tsis tuaj yeem hais txog recombinant interferon. Kev tswj hwm ntev ntev ntawm cov protein ua tiav hauv daim ntawv tshuaj ua rau muaj kev cuam tshuam tsis zoo.
Inducers ntawm endogenous interferon, thaum kawm txog lawv cov kev ua tau zoo, pom cov tshuaj pharmacological hauv ntau yam kab mob. Lawv cov cuab yeej bifunctional tau tsim, muaj cov yam ntxwv los ntawm cov tshuaj tiv thaiv kab mob thiab cov tshuaj tiv thaiv immunomodulatory.
Qhov kev txiav txim ntawm interferon inducers ua rau cov synthesis ntawm cov protein, uas nyob rau hauv lawv cov dej num zoo ib yam li npaj txhij-ua proteins. Cov txheej txheem zoo li no suav hais tias muaj kev sib npaug, nws tau tswj hwm los ntawm cov txheej txheem uas ntseeg tau los tiv thaiv lub cev los ntawm kev tsim ntau dhau ntawm cov tebchaw.
Nrog rau kev siv ib zaug ntawm cov tshuaj uas ua rau muaj kev cuam tshuam interferon, muaj kev sib raug zoo mus sij hawm ntev ntawm cov protein tiv thaiv hauv cov tshuaj uas xav tau. Txhawm rau kom tau txais cov koob tshuaj zoo li no thaum muab cov tshuaj exogenous protein, nws yuav tsum tau rov ua dua hauv cov ntim loj. Kev kho mob zoo li no suav tias yog kim dua.
Drug List
Tam sim no, cov kws kho mob tau siv cov tshuaj interferon inducers - cov tshuaj, cov npe uas tau muab ntxiv txhua xyoo nrog cov tshuaj tshiab. Ntau tus neeg ua haujlwm immunomodulating tso cai rau koj los tua ntau yam kab mob.
Lub cev tiv thaiv kab mob muaj cov khoom sib txuas ua haujlwm uas tshem tawm cov khoom sib txawv txawv rau lub cevantigenic keeb kwm. Txhua lub ntsiab ntawm kev tiv thaiv kab mob muaj cov kab mob tshwj xeeb. Qhov no piav qhia txog ntau yam tshuaj uas txhawb kev tsim cov protein tiv thaiv.
Muaj ntau yam interferon inducers (tshuaj), cov npe ntawm cov tshuaj "Poludan". Cov cuab yeej no suav hais tias yog thawj qhov kev txhawb nqa ntawm cov protein tiv thaiv, uas tau pib siv rov qab rau xyoo 70s. Nws suav nrog polyadenylic thiab polyuridic acids. Nws cov txiaj ntsig hauv kev tsim cov tshuaj interferon tsawg. Qhov muag tee thiab txhaj tshuaj "Poludan" kho herpetic keratitis thiab keratoconjunctivitis. Daim ntawv thov rau kev kho mob ntawm colpitis thiab herpetic vulvovaginitis yog tsim los ntawm kev daws cov tshuaj.
Interferon inductors - npaj "Actaviron", "Lavomax", "Tilaxin", "Tylorone dihydrochloride", "Amiksin", "Tiloram" - muaj cov tshuaj tiv thaiv tilorone.
Tshuaj "Ridostin" thiab "Sodium ntsev ntawm ob-stranded ribonucleic acid" yog tsim nrog cov khoom xyaw nquag sodium ribonucleate.
Cov tshuaj umifenovir yog ib feem ntawm cov tshuaj "Arbidol", "Arbivir", "Immust" thiab "Arpeflu"
Tseem muaj cov interferon inducers, cov kev npaj uas muaj npe tom qab lub npe ntawm cov tshuaj nquag. Cov no suav nrog Kagocel thiab Tiloron ntsiav tshuaj.
Raws li meglumine acridone acetate, Meglumine Acridonacetate thiab Cycloferon tshuaj yog tsim, thiab sodium oxodihydroacridinyl acetate muaj nyob rau hauv cov tshuaj Neovir.
Y Yodantipyrin muaj 1-phenyl-2, 3-dimethyl-4-iodopyrazolone, thiabCov ntsiav tshuaj Alpizarin muaj cov ntsev magniferrin.
Interferon inductors rau menyuam yaus, lawv piav qhia
Muaj ntau cov tshuaj rau cov neeg laus tuaj yeem muab rau tus menyuam, tab sis tsuas yog los ntawm ib lub hnub nyoog. Piv txwv li, cov tshuaj "Cycloferon" pib kho cov menyuam yaus hnub nyoog plaub xyoos, thiab cov tshuaj "Ridostin" raug tshuaj txij li hnub nyoog xya xyoo. Ob yam tshuaj muaj ntau yam teebmeem. Lawv tsim nyog rau kev kho mob ntawm cov kab mob ua pa ntawm tus kab mob, kab mob khaub thuas, kab mob siab ntev, herpes. Lawv qhov tsis zoo yog qhov tshwm sim tsis xav tau.
Interferon inductors yog tshuaj rau cov menyuam yaus hauv daim ntawv tshwj xeeb, tsim tshwj xeeb rau menyuam yaus. Ntawm lawv, cov tshuaj "Arbidol" yog qhov txawv. Nws tau siv txij thaum muaj hnub nyoog ob xyoos. Cov me nyuam daim ntawv ntawm cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm capsules rau kev siv sab hauv. Cov tshuaj muaj antiviral thiab immunomodulatory teebmeem.
Nws yog hais txog cov tshuaj tiv thaiv kab mob khaub thuas uas txwv hom B thiab hom A kab mob. Nrog nws txoj kev koom tes, kev tsim cov tshuaj interferon yog txhawb nqa, uas tiv thaiv kev sib cuag thiab nkag mus rau hauv lub cell. Raws li qhov kev txiav txim ntawm cov protein tiv thaiv, lub hnab ntawv viral lipid tsis tuaj yeem txuas mus rau lub cell membrane.
Interferon inductors rau cov menyuam yaus txhim kho kev lom zem hom kev tiv thaiv, thaum lawv ua, lub cev tiv taus ntau dua rau cov kab mob sib kis, cov teeb meem txo qis.
Cov tshuaj "Kagocel" muajcov nyhuv zoo sib xws rau lub cev ntawm tus menyuam. Nws yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj rau kev siv sab hauv. Lub hnub nyoog tso cai siv tshuaj yog txij li peb xyoos.
Kev kho cov kab mob ua pa
Interferon inducers yog cov tshuaj rau kev kho mob ntawm cov kab mob ua pa nyuaj, uas ua rau tsim cov protein tiv thaiv hauv cov hlwb ntawm lub cev. Lawv kuj raug tshuaj rau tus mob npaws.
Qhov txhais tau zoo tshaj plaws yog cov tshuaj raws li tilorone, uas suav nrog cov ntsiav tshuaj "Tiloron" thiab "Amixin". Rau kev kho mob khaub thuas thiab mob ua pa nyuaj ntawm tus kab mob, cov neeg laus raug pom zoo kom siv 125 mg ntawm qhov ncauj ib zaug. Qhov koob tshuaj no siv rau thawj ob hnub, tom qab ntawd 125 mg yog noj txhua hnub. Tus nqi ntawm cov tshuaj yog 750 mg.
Rau kev tiv thaiv, 125 mg yog siv ib zaug, tom qab ntawd so rau 6 hnub. Hoob no rov hais dua li ntawm rau lub lis piam.
Tshuaj raws li tilorone yog contraindicated nyob rau hauv cov ntaub ntawv ntawm ib tug neeg intolerance, thaum cev xeeb tub thiab thaum pub niam mis rau me nyuam.
Cov tshuaj no tuaj yeem ua rau xeev siab, ua npaws, thiab ua xua.
Cov tshuaj "Umifenovir" muaj kev cuam tshuam ntawm kev ua haujlwm, txhawb kev tiv thaiv ntawm tes, ua rau muaj kev tiv thaiv ntawm tag nrho cov kab mob mus rau cov kab mob.
Rau kev tiv thaiv kev tiv thaiv kev sib cuag nrog cov neeg mob, ib hnub koob tshuaj 200 mg yog muab rau ib lub lis piam. Mob khaub thuas raws caij nyoog thiab kab mob ua paSiv ib koob tshuaj 100 mg ib hnub twg, tom qab ntawd so ob hnub. Hoob no muaj peb lub lis piam. Rau kev kho mob khaub thuas, 200 mg yog muab 4 zaug hauv ib hnub, rau peb hnub.
Tshuaj nrog umifenovir tsis siv nrog tus neeg tsis kam lees, thaum muaj mob hnyav heev. Kev noj cov tshuaj no tuaj yeem ua rau muaj kev tsis haum tshuaj.
Kev kho mob autoimmune
Cov kab mob no suav nrog cov kab mob pathological uas tsim cov tshuaj tiv thaiv kab mob los yog nws tus kheej-aggressive clones ntawm killer cell multily teb rau cov ntaub so ntswg noj qab haus huv. Qhov no ua rau kev puas tsuaj thiab kev puas tsuaj ntawm cov ntaub so ntswg noj qab haus huv, ua rau autoimmune o.
Feem ntau, interferon inducers yog siv rau kev kho mob. Cov tshuaj rau cov kab mob autoimmune yog sau rau cov uas muaj kev tiv thaiv kab mob.
Rau kev kho mob ntau yam sclerosis, cov tshuaj "Amixin" yog siv. Ntawm qhov tshwm sim me ntsis ntawm tus kab mob ua pa nyuaj, uas ua rau tus mob hnyav dua, koob tshuaj 125 mg lossis 250 mg ntawm cov tshuaj tau muab tom qab noj mov. Cov ntsiav tshuaj haus cawv txhua hnub, lub sijhawm tswj hwm yog los ntawm 6 txog 12 hnub.
Rau kev tiv thaiv exacerbation ntawm ntau yam sclerosis, 125 mg ntawm cov tshuaj tau muab, 2 zaug hauv 7 hnub.
Hauv kev kho mob nyuaj ntawm theem nquag ntawm tus kab mob nrog cov cim qhia ntawm exacerbation, cov tshuaj tau noj 125 mg 10 zaug txhua 30 hnub rau 6 lub hlis. Cov tshuaj "Amixin" tau sau ua ke nrog peptide bioregulators,Cov txiaj ntsig dav dav uas txo qhov kev nkag siab ntawm lub cev mus rau myelin protein ntau.
Kev kho nyuaj nrog cov tshuaj "Cycloferon" tso cai rau koj los tawm tsam kev mob caj dab thiab rheumatoid, kab mob uas cuam tshuam rau cov ntaub so ntswg. Nws txoj haujlwm yog tsom rau kev txo qis cov txheej txheem autoimmune, uas muab cov nyhuv anti-inflammatory thiab analgesic. Nrog kev pab los ntawm cov cuab yeej, lub cev tiv thaiv kab mob yog tswj rau ntau yam kev tiv thaiv kab mob. Cov tshuaj "Cycloferon" yog tsim nyob rau hauv daim ntawv ntsiav tshuaj, nyob rau hauv daim ntawv ntawm kev txhaj tshuaj thiab liniment.
Rau kev kho mob caj dab, cov tshuaj yog siv intravenously lossis intramuscularly 1 zaug hauv ib hnub. Cov koob tshuaj ntawm 250 mg yog siv los ntawm thawj hnub mus rau hnub thib kaum ob ntawm cov hnub. Hauv cov kab mob hnyav, thawj koob tshuaj 500 mg yog siv.
Kev kho kab mob kis kab mob
Cov tshuaj "Amiksin" yog hais txog interferon inducers ntawm fluoreon qis molecular hnyav chav kawm. Nrog nws cov kev koom tes, txhua hom kev tiv thaiv cov proteins raug tsim, theem uas ib hnub tom qab siv cov tshuaj nce mus txog tus nqi siab tshaj plaws hauv plasma.
Cov tshuaj muaj ntau yam tshuaj tiv thaiv kab mob. Ntxiv nrog rau cov kab mob ua pa, nws yog siv rau mob siab thiab mob siab C thiab B, rov tshwm sim ntawm qhov chaw mos herpes, cytomegalovirus thiab kab mob chlamydia.
Ntau yam tshuaj tiv thaiv kab mob yog interferon inducers, Neovir tsis muaj qhov zam. Nrog nws txoj kev koom tes, ntau cov protein tiv thaiv yog tsim, tshwj xeeb tshaj yoghom fibroblast, uas piav qhia txog kev tiv thaiv kab mob, tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob ntawm cov tshuaj no. Neovir yog siv los kho encephalitis, kab mob siab C thiab B, urethritis, cervicitis, salpingitis tshwm sim los ntawm chlamydia.
Lwm yam zoo sib xws inducer ntawm qhov hnyav molecular yuag tiv thaiv protein yog cov tshuaj "Cycloferon", rau cov synthesis ntawm carboxymethylenecridone methylglucamine ntsev yog siv. Nrog nws kev koom tes, alpha-interferon yog tsim, cov ntsiab lus ntawm cov ntaub so ntswg lymphoid tseem nyob rau peb hnub.
Hauv T thiab B hom lymphocytes, macrophages, cov protein tiv thaiv yog tsim, cov qauv qia yog qhib rau hauv cov pob txha pob txha, thiab kev tsim cov granulocytic units yog stimulated. Cov tshuaj no yog siv rau zuam-borne encephalitis, herpes, kab mob siab, cytomegalovirus, human immunodeficiency virus thiab papillomas.
Ntxiv rau cov tshuaj tiv thaiv kab mob, tus neeg sawv cev ua haujlwm hauv cov kab mob chlamydia, erysipelas, bronchitis, mob tom qab phais, kab mob ntawm cov kab mob genitourinary, peptic ulcer..
Cov tshuaj "Lavomax" tau tshwm sim hauv khw muag tshuaj, nws yog tsim los ntawm lub tuam txhab "Nizhpharm". Nws muaj cov nyhuv immunomodulatory, muaj peev xwm induce interferons, thiab ntau yam tshuaj tiv thaiv kab mob.
Lavomax ntsiav tshuaj muaj 125 mg ntawm tilorone ua cov tshuaj nquag. Cov tshuaj yog ib qho analogue ntawm cov tshuaj "Amixin". Nws cov dej num yog tsom rau stimulatingKev tsim tawm ntawm peb hom interferon nyob rau hauv T-lymphocytes, hepatocytes, cell ntawm epithelial plab hnyuv phab ntsa.
Kev cuam tshuam ntawm immunomodulatory teebmeem tshwm sim vim kev rov qab los ntawm kev sib npaug ntawm cov hlwb immunocompetent thiab normalization ntawm cov tshuaj tiv thaiv kab mob. Cov txheej txheem ntawm kev ua haujlwm tshuaj tiv thaiv kab mob yog ua raws li inhibition ntawm synthesis ntawm cov protein tshwj xeeb rau cov kab mob hauv cov kab mob hauv lub cev. Qhov no cuam tshuam lawv cov kev tsim tawm ntxiv.
Cov tshuaj tau zoo kho mob khaub thuas, kab mob ua pa, kab mob siab viral thiab kab mob herpes.
nrawm nrawm inductors
Feem ntau, kev qhia txog cov tshuaj no ua rau kev tsim cov protein tiv thaiv sai.nrawm nrawm inducers ntawm endogenous interferon li ntawm ob peb teev nyob rau hauv lub cev tuaj yeem ua rau tsim cov protein., uas ua pov thawj lawv cov txiaj ntsig.
Cov tshuaj Tiloron tom qab siv sab hauv ua kom cov protein ntau ntxiv rau qhov siab tshaj plaws tom qab 4 teev. Muaj ib qho kev tsim ua ntu zus ntawm interferon, thawj zaug hauv cov hnyuv, tom qab ntawd hauv daim siab, thiab ib hnub tom qab - hauv cov ntshav.
Cov tshuaj "Cycloferon" induces protein tom qab 4 teev, thiab lub ncov yog pom tom qab 8 teev, tom qab uas muaj ib tug maj mam txo nyob rau hauv concentration.
