Alendronic Acid yog dab tsi? Koj yuav kawm tau cov lus teb rau lo lus nug kho mob no los ntawm cov ntaub ntawv ntawm kab lus no. Tsis tas li ntawd, peb yuav qhia koj yuav ua li cas noj cov tshuaj no, thaum nws tsis pom zoo kom siv, thiab yog tias nws muaj kev phiv. Koj tseem yuav kawm txog daim ntawv uas cov tshuaj uas peb tab tom xav txog yog tsim, txawm tias nws muaj cov analogues, cov neeg mob hais txog nws.
Kev sib xyaw ntawm cov khoom siv tshuaj, nws daim ntawv tso tawm thiab ntim
"Alendronic acid", lossis cov tshuaj hu ua "Alendronate", mus muag hauv daim ntawv ntawm cov ntsiav tshuaj dawb. Cov khoom xyaw nquag ntawm cov tshuaj no yog alendronate sodium trihydrate, los yog alendronic acid.
Raws li cov ntsiab lus ntxiv, qhov kev npaj no suav nrog cov hauv qab no: monohydrate, povidone, microcrystalline cellulose, croscarmellose sodium thiab magnesium stearate.
Hauv khw muag tshuaj, "Alendronic acid" tuaj yeem pom hauv cov pob hlwv ntawm 4 ntsiav tshuaj txhua.
tshuaj kho mobtshuaj
Alendronic Acid yog dab tsi? Cov lus qhia ntawm cov tshuaj hais tias cov tshuaj no yog ib qho inhibitor ntawm pob txha resorption. Cov txheej txheem ntawm kev ua ntawm cov tshuaj no yog txuam nrog kev txo qis hauv kev ua haujlwm ntawm osteoclasts. Nws nce pob txha (mineral) ceev thiab txhawb kev tsim cov pob txha.
Pharmacokinetics ntawm cov tshuaj
Alendronic Acid Absorbed li cas? Cov lus qhia rau kev siv cov tshuaj no muaj cov ntaub ntawv hais tias thaum noj qhov ncauj, ntawm lub plab khoob (2 teev ua ntej noj tshais), ntawm qhov ntau npaum li 70 mg, bioavailability ntawm cov khoom nquag hauv kev sib deev ncaj ncees yog li 0.65%, thiab hauv kev sib deev muaj zog - txog 0.6%.
Yog tias koj noj cov tshuaj ib nrab teev lossis ib teev ua ntej noj mov, ces nws cov bioavailability yuav txo qis (rau 0.45% thiab 0.4% raws li).
Kev noj tshuaj 2 teev tom qab noj mov tsis cuam tshuam rau nws cov bioavailability. Txawm li cas los xij, tom qab haus kua txiv kab ntxwv thiab kas fes, bioavailability txo qis li ntawm 60%.
Kev khi ntawm cov tshuaj nquag ntawm cov tshuaj rau cov ntshav protein yog kwv yees li 78%.
Tom qab noj tshuaj, nws yog thawj zaug faib rau cov ntaub so ntswg, thiab tom qab ntawd mus rau pob txha, qhov twg, qhov tseeb, nws raug kho, thiab cov seem raug tso tawm los ntawm lub raum.
Qhov concentration ntawm cov tshuaj hauv cov ntshav tom qab noj cov tshuaj yog qis dua qhov kev ntsuas (tsawg dua 5 ng / ml).
Cov tshuaj tsis yog biotransformed. Nws yog tawm los ntawm lub cev tsis hloovdaim ntawv. Cov tshuaj yog tus cwj pwm los ntawm kev txo qis hauv cov ntshav sai, nrog rau kev tso tawm qeeb heev los ntawm cov pob txha.
Cov lus qhia rau kev siv cov ntsiav tshuaj
Tam sim no koj paub tias Alendronic Acid yog dab tsi. Cov cuab yeej no yog dab tsi? Raws li cov lus qhia txuas mus, cov tshuaj no muaj cov lus qhia hauv qab no rau kev siv:
- osteoporosis hauv cov poj niam tom qab yug menyuam (raws li kev tiv thaiv pob txha pob txha, suav nrog tus txha nraub qaum thiab lub duav);
- pob txha hauv kev sib deev muaj zog;
- osteoporosis, uas yog tshwm sim los ntawm kev siv cov tshuaj glucocorticosteroid mus ntev;
- Page's disease.
"Alendronic acid": contraindications rau kev siv
Thaum twg siv tsis tau cov tshuaj peb tab tom txiav txim siab? Cov lus qhia rau kev siv tshuaj hais tias cov tshuaj no muaj cov nram qab no contraindications:
- hypocalcemia;
- mob siab rau tus neeg mob rau cov tshuaj ntawm cov tshuaj;
- tsis muaj peev xwm ntawm cov neeg mob sawv ntsug (sawv ntsug lossis sawv ntsug) ib nrab teev;
- mob hnyav hauv cov metabolism hauv cov ntxhia;
- mob raum tsis ua haujlwm;
- hypoparathyroidism hnyav;
- achalasia lossis nruj ntawm txoj hlab pas, nrog rau lwm yam mob uas ua rau nyuaj rau kev txav zaub mov los ntawm txoj hlab pas;
- glucose-galactose malabsorption, lactase deficiency lossis lactose intolerance;
- lactation;
- calcium malabsorption;
- xeeb tub;
tshuaj kho mob
Nyob rau hauv dab tsi yog "Alendronic acid" sau nrog ceev faj heev? Raws li kev saib xyuas nruj ntawm cov kws kho mob, yuav tsum muaj cov neeg mob uas muaj qhov txawv txav ntawm lub plab zom mov (piv txwv li, cov kab mob xws li esophagitis, dysphagia, duodenitis, gastritis, peptic ulcer ntawm duodenum thiab plab). Tsis tas li ntawd, cov tshuaj yuav tsum tau siv nrog ceev faj heev rau cov neeg mob uas tsis muaj vitamin D.
"Alendronic acid": cov lus qhia rau kev siv tshuaj
Tshuaj "Alendronat" yuav tsum tsuas yog noj hauv qhov ncauj ntawm 1 ntsiav tshuaj. Hauv qhov no, cov tshuaj tsis pom zoo kom zom lossis yaj. Nws noj ntawm lub plab khoob, 2 teev ua ntej noj tshais (tsawg ib nrab teev ua ntej noj mov, dej lossis lwm yam tshuaj).
Cov tshuaj yuav tsum tau ntxuav nrog dej. Qhov no yog vim qhov tseeb tias lwm yam dej qab zib (xws li dej ntxhia, tshuaj yej, kas fes, kua txiv kab ntxwv) txo qhov nqus ntawm cov tshuaj nquag.
Cov tshuaj pom zoo yog 1 ntsiav tshuaj (los yog 10 mg) qhov ncauj ib hnub ib zaug. Qee zaum, cov kws kho mob muab cov koob tshuaj sib txawv rau tus neeg mob, uas yog raws li hauv qab no: 1 ntsiav tshuaj (los yog 70 mg) ib zaug ib lub lim tiam.
Kev kho pob txha ntawm cov txiv neej thiab poj niam (postmenopausal), nrog rau cov pob txha pob txha, uas yog tshwm sim los ntawm kev siv mus ntev. Cov tshuaj glucocorticosteroid, cov tshuaj no yog noj ntawm 10 mg ib hnub twg lossis 70 mg ib lim piam ib zaug.
Nrog rau qhov mob xws li Paget's kab mob, cov tshuaj uas peb tab tom txiav txim siab tau muab tshuaj ntawm 40 mg ib hnub twg. Lub sijhawm kho yog 6 lub hlis.
Yog tias koj tsis siv tshuaj ib zaug ib lim piam, ces cov tshuaj yuav tsum tau noj thaum sawv ntxov hnub tom qab. Hauv qhov no, nws txwv tsis pub siv cov tshuaj li ob ntsiav tshuaj ib hnub ib zaug.
Tshuaj ntau dhau
Yuav ua li cas yog tias tus neeg mob pib tswj tsis tau cov tshuaj xws li "Alendronic acid"? Cov tshuaj ntawm hom no muaj ntau cov tsos mob xws li hypophosphatemia, kub siab, hypocalcemia, erosive thiab ulcerative lesions ntawm lub plab zom mov, esophagitis, raws plab.
Yog tias muaj qhov tshwm sim tshwm sim, tus neeg mob yuav tsum tau muab cov mis nyuj tag nrho lossis cov tshuaj antacids uas muaj calcium. Qhov no yog qhov tsim nyog los khi cov tshuaj. Vim muaj kev pheej hmoo siab ntawm kev tsim khaus ntawm txoj hlab pas, nws raug nquahu kom tsis txhob ntuav ntuav. Nyob rau hauv cov ntaub ntawv ntawm overdose, tus neeg mob yuav tsum tsuas yog nyob rau hauv ib tug upright txoj hauj lwm.
Cov kev mob tshwm sim tom qab noj tshuaj
Alendronic Acid puas tuaj yeem ua rau tsis zoo? Kev tshuaj xyuas ntawm cov neeg mob thiab kws kho mob hais tias cov tshuaj no muaj ntau yam kev phiv. Qhov twg, peb yuav txiav txim siab me ntsis ntxiv.
Y Digestive system: esophagitis, raws plab, dysphagia, dyspepsia, mob plab, flatulence,cem quav thiab kub siab. Tsis tshua muaj, tom qab noj cov tshuaj, cov neeg mob tau ntsib: ntuav, melena, xeev siab, esophageal stricture, gastritis, esophageal ulcer, rwj ntawm mucous daim nyias nyias ntawm lub pharynx thiab qhov ncauj kab noj hniav, perforation ntawm esophageal rwj nrog los ntshav.
Nws kuj yuav tsum tau hais tias cov tsos mob tshwm sim thaum pib ntawm kev kho tshuaj yog cov hauv qab no: malaise, myalgia thiab kub taub hau.
Kev sib tham nrog lwm yam tshuaj
Ua ke nrog cov tshuaj dab tsi uas cov neeg mob tsis tau sau "Alendronic acid", nws cov lus txhais?
Raws li cov lus qhia, nws tsis pom zoo kom noj cov tshuaj no ib txhij nrogCov tshuaj uas muaj calcium thiab antacids (vim muaj peev xwm txo qhov nqus ntawm cov tshuaj nquag ntawm cov tshuaj).
Lub sijhawm nruab nrab ntawm kev noj Alendronate thiab noj lwm yam tshuaj yuav tsum yog tsawg kawg ib nrab teev.
cov tshuaj uas tsis yog tshuaj steroidal, nrog rau acetylsalicylic acid, tuaj yeem ua rau muaj kev phiv ntawm cov tshuaj hauv plab zom mov.
Kev sib xyaw ua ke ntawm "Alendronic acid" (tab sis tsis yog tib lub sijhawm) nrog cov tshuaj estrogens tsis tuaj yeem nrog kev hloov pauv hauv lawv cov kev ua thiab kev txhim kho ntawm cov kev mob tshwm sim.
Ib tshuaj xws li Prednisolone tsis ua rau muaj kev hloov pauv tseem ceeb hauv acid bioavailability.
cov lus qhia tshwj xeeb rau kev noj tshuaj
Koj yuav tsum paub dab tsi ua ntej koj pib noj tshuaj zoo li Alendronic Acid? Analogues thiab cov tshuaj nyob rau hauv nqe lus nug nws tus kheej yuav adversely cuam tshuam lub digestive ib ntsuj av. Yog li ntawd, txhawm rau txo qhov ua rau khaus, nws raug nquahu kom noj cov tshuaj thaum sawv ntxov, ntawm lub plab khoob, nrog ib khob dej.
Tom qab noj cov tshuaj, koj yuav tsum nyob twj ywm ib nrab teev. Kev siv cov khoom nyob rau hauv txoj hauj lwm kab rov tav los yog thaum pw tsaug zog ua rau muaj kev pheej hmoo ntawm kev tsim mob xws li esophagitis.
Tus neeg mob yuav tsum tau ceeb toom txog kev txiav tshuaj ntxiv thaum kub siab, mob tom qab sternum thiab thaum nqos, nrog rau kev txhim kho ntawm dysphagia.
Hypocalcemia yuav tsum tau kho ua ntej pib kho. Nws kuj pom zoo kom tshem tawmCov zaub mov metabolism tsis zoo uas ua rau qhov sib txawv no.
Thaum siv bisphosphonates, tus neeg mob yuav tsum xyuas kom lub cev tau txais cov vitamin D thiab calcium txaus.
Thaum lub sijhawm kho, vim muaj cov txiaj ntsig zoo ntawm cov kua qaub ntawm cov pob txha pob txha pob txha, tus neeg mob yuav muaj kev txo qis hauv cov concentration ntawm phosphate thiab calcium hauv cov ntshav.
Cov neeg uas muaj kev pheej hmoo ntawm cov kab mob sib kis (mob qog noj ntshav, tshuaj khomob, kho hluav taws xob, thiab lwm yam) yuav tsum tau kuaj hniav ua ntej kho nrog bisphosphonates.
Nqe thiab analogues ntawm cov tshuaj
Tam sim no koj paub yuav ua li cas noj tshuaj zoo li Alendronic Acid. Los ntawm cov tshuaj no yog kws kho mob tau sau tseg, peb kuj pom. Txawm li cas los xij, feem ntau cov neeg mob uas tau txais cov tshuaj no ib txwm muaj ib lo lus nug: nws raug nqi pes tsawg?
Hnub no "Alendronic acid" tuaj yeem yuav tau rau 350 rubles (4 ntsiav tshuaj). Xav txog kev noj tshuaj (ib zaug hauv ib lub lis piam), tus nqi no tsis siab heev.
Yog tias vim li cas cov tshuaj uas peb tab tom txiav txim siab tsis haum rau koj, ces nws tuaj yeem hloov nrog cov tshuaj analogues. Cov no suav nrog cov tshuaj xws li Tevanat, Ostalon, Alendronat, Strongos, Alendrokern, Ostealen, Lindron, Alental, Foroza, Osterepar, Fosamax » thiab lwm yam.
Kev tshuaj xyuas cov neeg mob thiab kws kho mob txog tshuaj
Cov neeg mob thiab kws kho mob hais li cas txog kev kho mob zoo li Alendronic Acid? Raws li lawvtshuaj xyuas, cov tshuaj ua haujlwm zoo heev nrog rau txoj haujlwm. Nws txhawb cov pob txha zoo, kho pob txha thiab Paget tus kab mob.
Txawm li cas los xij, ib tus tsis tuaj yeem tsis nco qab qhov tseeb tias cov tshuaj no muaj cov kev phiv loj heev. Hauv qhov no, cov tshuaj yuav tsum tau noj tsuas yog raws li kws kho mob tau sau tseg. Ntxiv mus, tom kawg yuav tsum tau qhia tus neeg mob txog cov contraindications uas twb muaj lawm.
Cov kev tshuaj xyuas tsis zoo tshaj plaws txog "Alendronic acid" yog los ntawm cov neeg mob uas muaj teeb meem nrog lub plab zom mov. Qhov no yog vim qhov tseeb tias cov tshuaj no tuaj yeem cuam tshuam rau lub plab, txoj hlab pas thiab cov hnyuv.
