Hauv kab lus, peb yuav xav txog cov kev mob tshwm sim ntawm Amoxicillin, nrog rau cov lus qhia rau nws. Nws yog ib tug semi-synthetic broad-spectrum tshuaj tua kab mob los ntawm pharmacological qeb ntawm penicillins. Cov cuab yeej no zoo tiv thaiv kab mob gram-positive thiab gram-negative anaerobic microorganisms. Hais txog nws cov khoom siv tshuaj, lub ntsiab tseem ceeb nyob ze rau ampicillin, txawm li cas los xij, nws muaj bioavailability ntau dua thaum noj qhov ncauj.
Cov tshuaj feem ntau yog muab rau cov neeg mob thaum muaj ntau yam kab mob sib kis. Ntau tus neeg tsis txaus siab txog kev txhim kho ntau yam kev mob tshwm sim los ntawm Amoxicillin. Feem ntau cov tshuaj tiv thaiv ntawm lub cev muaj xws li dryness nyob rau hauv lub qhov ncauj, kev loj hlob ntawm urticaria, thiab raws plab. Cov neeg mob qhia tias: “Kuv xav tias zoo li tus neeg quav yeeb tshuaj tom qab Amoxicillin. Txawm li cas los, ua ntejkom paub tseeb tias cov tsos mob no tshwm sim thaum noj cov tshuaj no, nws yog ib qho tsim nyog yuav tsum paub meej nws cov yam ntxwv tseem ceeb thiab xyuas seb nws ua haujlwm li cas ntawm lub cev, nrog rau cov tshuaj twg los ntawm nws cov muaj pes tsawg leeg tuaj yeem ua rau lub cev zoo sib xws.
Composition
Tshuaj "Amoxicillin" ntawm koob tshuaj 500 mg yog tsim nyob rau hauv ob daim ntawv: tshuaj ntsiav thiab ntsiav tshuaj.
Ib lub tshuaj ntsiav muaj cov khoom nquag - amoxicillin ntawm koob tshuaj 500 mg (hauv daim ntawv ntawm amoxicillin trihydrate) thiab cov khoom siv xws li sodium lauryl sulfate, magnesium stearate, sodium starch glycolate. Gelatin capsule muaj dej huv, sodium lauryl sulfate, bronopol, povidone, gelatin, Ponceau 4 R (E124), ci ntsa iab xiav FCF (E133), titanium dioxide (E171), quinoline daj (E104).
Ib ntsiav tshuaj muaj amoxicillin trihydrate ua cov khoom xyaw nquag, nrog rau cov khoom ntxiv: talc, qos starch, tween, magnesium stearate.
tshuaj muaj txiaj ntsig
Raws li cov lus qhia siv rau Amoxicillin 500 mg ntsiav tshuaj, qhov no yog cov tshuaj tua kab mob acid-resistant bactericidal broad-spectrum tus neeg saib xyuas los ntawm qeb ntawm semi-synthetic penicillins. Nws pab txhawb rau kev tawm tsam ntawm transpeptidase, cuam tshuam ntawm kev sib txuas ntawm peptidoglycan (cov protein txhawb nqa ntawm cov phab ntsa ntawm tes) thaum lub sijhawm loj hlob thiab kev faib tawm, provokes lysis ntawm cov kab mob hlwb. Clinically tseem ceeb gram-negative microorganisms rhiab heev rau cov khoom tseem ceeb ntawm cov tshuaj no: Escherichia coli, Klebsiellaspp., Salmonella, Proteus mirabilis, Shigella, Haemophilus influenzae, Campylobacter, Leptospira, Neisseria gonorrhoeae, Chlamydia, Neisseria meningitidis.
Ntxiv rau, cov tshuaj no muaj zog tiv thaiv kab mob gram-zoo aerobic: Streptococcus spp., Staphylococcus spp. (tshwj tsis yog hom kab mob uas tsim penicillinase). "Amoxicillin" kuj muaj kev ua haujlwm tawm tsam Helicobacter pylori, tab sis tsis cuam tshuam rau indole-zoo Proteus hom. Mycoplasmas, rickettsia, thiab kab mob kuj tiv taus nws qhov kev ua. Cov kab mob uas muaj peev xwm tsim tau penicillinase tiv taus amoxicillin. Cov nyhuv ntawm cov tshuaj no tshwm sim 15-30 feeb tom qab noj thiab kav li ntawm 8 teev.
Cov khoom nquag nqus tau sai sai tom qab noj. Cov nyhuv ntawm cov zaub mov ntawm kev nqus ntawm amoxicillin tau kawm ib nrab. Amoxicillin nkag mus rau feem ntau ntawm cov kua thiab cov ntaub so ntswg, tshwj tsis yog cov kua cerebrospinal thiab lub hlwb, tshwj tsis yog cov membranes ntawm lub hlwb raug cuam tshuam los ntawm cov txheej txheem inflammatory. Ib nrab-lub neej ntawm amoxicillin yog 1 teev. Qhov tseem ceeb yog tawm hauv cov zis, khi rau plasma proteins los ntawm 20%. Qhov siab tshaj plaws hauv cov ntshav tau pom tom qab 1-2 teev thiab yog kwv yees li 3.5 μg / ml - 5 μg / ml. Kwv yees li 60% ntawm cov khoom raug tso tawm los ntawm lub raum.
Cov lus qhia rau kev siv
Dab tsi ntxiv koj tuaj yeem kawm los ntawm cov lus qhia siv rau cov ntsiav tshuaj "Amoxicillin" 500 mg? Cov tshuaj yog muab rau inflammatory kab mob ntawm tus kab mobgenesis, xws li:
- kis kab mob ntawm cov kab mob ENT thiab cov kav dej ua pa sab saud (sinusitis, pharyngitis, tonsillitis, mob otitis media);
- kis kab mob ntawm cov kwj deg ua pa (mob ntsws thiab mob ntsws, mob ntsws);
- kis kab mob ntawm cov kab mob genitourinary (pyelitis, mob ntev thiab mob pyelonephritis, cystitis, gonorrhea, urethritis);
- kab mob gynecological (cervicitis, endometritis);
- kis kab mob hauv plab hnyuv (typhoid fever, enterocolitis, salmonellosis, shigellosis, salmonella carriage);
- peptic ulcer, mob plab, ua rau Helicobacter pylori ua ib feem ntawm kev kho mob ua ke;
- kab mob ntawm cov kab mob hauv cov ducts (cholecystitis, cholangitis);
- kab mob ntawm cov nqaij mos thiab tawv nqaij (impetigo, erysipelas, thib ob kis kab mob dermatosis);
- leptospirosis;
- latent thiab mob listeriosis;
- Yborreliosis (Lyme disease);
- endocarditis ntawm tus kab mob kis ntawm keeb kwm, piv txwv li enterococcal.
Kev noj tshuaj thiab kev tswj hwm
Cov lus qhia thiab ntau npaum ntawm "Amoxicillin" yuav tsum tau ua nruj me ntsis. Cov tshuaj yog noj ntawm qhov ncauj. Cov menyuam yaus tom qab 10 xyoo (lub cev hnyav dua 40 kg) thiab cov neeg laus cov neeg mob tau muab 500 mg 3 zaug hauv ib hnub; nrog ib tug complex txoj kev ntawm tus kab mob - 1 g 3 zaug ib hnub twg. Lub ncua sij hawm ntawm koob tshuaj yuav tsum tau nruj me ntsis soj ntsuam - 8 teev. Qhov siab tshaj plaws koob tshuaj ib hnub yuav tsum tsis txhob ntau tshaj 6 g. Cov kev kho mob ntawm cov tshuaj yog los ntawm 5 mus rau 12 hnub. Nws raug nquahu kom noj cov tshuaj ntxiv rau lwm 48-72 teev tom qab kev ruaj khovlub cev kub los yog txhim khu kev puas tsuaj ntawm tus kab mob.
Nyob rau hauv cov mob gonorrhea tsis yooj yim, cov txiv neej tau muab tshuaj 3 g ib zaug. Cov poj niam raug qhia kom noj cov tshuaj no ob zaug nrog lub sijhawm ntawm 10-12 teev vim qhov tshwm sim ntawm ntau qhov txhab thiab muaj cov txheej txheem ascending inflammatory nrog kev hloov mus rau cov kabmob uas nyob hauv lub plab me me.
koob tshuaj me nyuam
Thaum muaj hnub nyoog qis dua 10 xyoo, cov tshuaj no feem ntau yog muab rau hauv daim ntawv ntawm kev ncua, vim tias kev siv tshuaj hauv cov tshuaj ntsiav nyuaj.
Hauv kev kho menyuam yaus, "Amoxicillin" hauv daim ntawv encapsulated tsuas yog siv tau yog tias noj txhua hnub tsawg kawg yog 500 mg. Yog tias qhov koob tshuaj no tau noj thaum sawv ntxov thiab yav tsaus ntuj, nws yog qhov zoo tshaj plaws los siv cov ntsiav tshuaj uas muab faib ua ob ntu - 250 mg txhua.
Yog tias tsis noj tshuaj, noj kom sai li sai tau, tsis tas tos koob tshuaj ntxiv, thiab saib xyuas lub sijhawm sib npaug ntawm cov koob tshuaj.
Kev mob tshwm sim ntawm Amoxicillin
Thaum noj tshuaj pharmacological, cov kev mob tshwm sim hauv qab no yuav tshwm sim:
- Kev ua xua tshwm sim: tawm ntawm daim tawv nqaij, urticaria, erythema, rhinitis, angioedema, conjunctivitis, mob pob qij txha, febrile syndrome, kub taub hau, eosinophilia, exudative erythema multiforme, Stevens-Johnson syndrome, anaphylactic shock. Urticaria tom qab "Amoxicillin" yog ib qho tshwm sim zoo heev. Qhov no tau lees paub los ntawm ntau qhov kev tshuaj xyuas.hais txog tshuaj. Thiab nws tshwm sim rau cov menyuam yaus thiab cov neeg laus. Tsis tas li ntawd, kev ua xua dermatitis tshwm sim tom qab "Amoxicillin", uas kuj tsis zoo siab.
- digestive system: hloov hauv saj, dysbacteriosis, xeev siab, ntuav, glossitis, stomatitis, ua txhaum ntawm lub luag haujlwm ntawm lub siab, kev nce qib hauv kev ua haujlwm ntawm daim siab transaminases, khaus hauv qhov quav, pseudomembranous colitis. Ntau tus neeg mob tau raws plab tom qab "Amoxicillin". Cas cov tshuaj no muaj kev cuam tshuam tsis zoo rau lub plab zom mov.
- Nervous system: psychomotor agitation lossis agitation, ntxhov siab vim, ataxia, insomnia, tsis meej pem, kev nyuaj siab, kev coj cwj pwm hloov, cephalalgia, peripheral neuropathy, kiv taub hau, aseptic-type meningitis, convulsions. Puas muaj lwm yam kev phiv ntawm Amoxicillin tshwm sim?
- Urinary system: mob interstitial nephritis, crystalluria.
- Lab qhov tseem ceeb: neutropenia, leukopenia, agranulocytosis, anemia, thrombocytopenic purpura.
- Lwm cov kev mob tshwm sim: ua tsis taus pa luv, candidiasis ntawm qhov ncauj thiab qhov chaw mos mucosa, tachycardia, superinfection (feem ntau nyob rau hauv cov neeg mob uas muaj kab mob ntev los yog txo lub cev tsis kam), kev hloov ntawm cov hniav hauv cov menyuam yaus.
Tom ntej, nrhiav seb Amoxicillin puas muaj contraindications.
npe ntawm contraindications
Cov tshuaj yog contraindicated rau siv nyob rau hauv xws li mob:
- lymphocytic leukemia;
- kab mob ntawm lub plab zom mov hauv anamnesis (tshwj xeeb yog colitis vim sivtshuaj tua kab mob);
- kis kab mob mononucleosis;
- siab rhiab heev rau cov khoom ntawm cov muaj pes tsawg leeg (xws li lwm yam penicillins, carbapenems, cephalosporins).
Thaum cev xeeb tub thiab lactation
Cov lus qhia txwv tsis pub siv "Amoxicillin" thaum pub niam mis. Cov tshuaj tua kab mob nkag mus rau hauv cov mis nyuj thiab tuaj yeem ua mob rau tus menyuam. Yog tias xav tau kev kho mob, kev pub mis yuav tsum raug ncua. Kev siv cov tshuaj thaum cev xeeb tub muaj nws tus yam ntxwv. Penicillins tuaj yeem hla cov placenta thiab khaws cia rau ntawd. Qhov concentration ntawm "Amoxicillin" hauv cov kua amniotic nce mus txog 25-30 feem pua ntawm cov ntshav plasma ntawm tus poj niam cev xeeb tub, qhov no yog qhov txaus ntshai rau kev loj hlob ntawm fetus.
Kev Sib Tham Tshuaj
Yog hais tias muaj kev phiv tshwm sim, nws yuav tsum tau coj mus rau hauv tus account tsis yog tsuas yog cov nyhuv ncaj qha rau lub cev ntawm cov tshuaj no, tab sis kuj nws cuam tshuam nrog lwm yam tshuaj.
Lub ntsiab lus tseem ceeb ntawm cov tshuaj no tsis raug puas tsuaj nyob rau hauv ib puag ncig acidic gastric. Glucosamine, antacids, laxatives, aminoglycosides txo thiab txo qis kev nqus ntawm "Amoxicillin", thiab vitamin C txhim kho nws.
Cov tshuaj tua kab mob bactericidal (tshwj xeeb, cephalosporins, aminoglycosides, rifampicin, vancomycin) muaj cov nyhuv synergistic, cov tshuaj bacteriostatic (macrolides, sulfonamides, lincosamides, chloramphenicol, tetracyclines) muajantagonistic nyhuv.
Cov tshuaj no ua kom cov nyhuvindirect anticoagulants (suppresses lub plab hnyuv microflora, txo cov prothrombin Performance index thiab synthesis ntawm vitamin K), txo cov nyhuv ntawm qhov ncauj estrogen-muaj cov tshuaj tiv thaiv kab mob.
"Amoxicillin" txo qhov kev tshem tawm thiab ua rau muaj tshuaj lom ntawm methotrexate, txhim kho qhov nqus ntawm digoxin.
Allopurinol, diuretics, oxyphenbutazone, cov tshuaj uas tsis yog-steroidal anti-inflammatory, phenylbutazone, tubular secretion blockers nce qib ntawm amoxicillin hauv cov ntshav. Allopurinol ua rau muaj qhov tshwm sim ntawm daim tawv nqaij ua pob khaus.
Special Recommendations
Tau kawg, nws yog ib qho tseem ceeb kom paub txhua yam txog contraindications ntawm Amoxicillin ua ntej pib txais tos. Tab sis muaj lwm cov lus pom zoo ib yam. Raws li cov lus qhia rau kev siv, cov tshuaj no yuav tsum tau siv nrog ceev faj nyob rau hauv lub xub ntiag ntawm allergic pathologies, siab rhiab heev rau penicillins, carbapenems, cephalosporins, los ntshav thiab keeb kwm ntawm lub raum tsis ua hauj lwm.
Nrog rau kev kho mob mus sij hawm ntev, nws raug nquahu kom saib xyuas lub sijhawm ua haujlwm ntawm lub siab, lub raum, thiab kuaj ntshav. Hauv cov neeg mob lub raum tsis ua haujlwm thiab cov neeg laus, qhov tso tawm ntawm cov khoom tseem ceeb ntawm lub cev tuaj yeem ua rau qeeb, yog li yuav tsum tau saib xyuas qee qhov thaum muab tshuaj rau cov pab pawg no. Hauv cov neeg mob uas txo cov zis tso zis, crystalluria tuaj yeem tshwm sim, thiab yog li nws raug nquahu kom noj cov kua dej ntau thaum txais tos.
Thaum kho nrog cov tshuaj no, nws tseem yuav tsum tau coj mus rau hauv tus accountQhov tshwm sim ntawm superinfection nrog cov kab mob thiab cov kab mob mycotic. Hauv qhov no, nws raug nquahu kom thim cov tshuaj thiab sau ntawv kho kom tsim nyog.
Cov txiaj ntsig tsis zoo yuav tshwm sim thaum kho yog tias siv tshuaj siv los ntsuas cov piam thaj hauv zis.
Ntau tshaj
Xaiv cov tsos mob ntawm kev noj tshuaj ntau dhau ntawm cov tshuaj no lossis cov tshuaj ntawd, tib neeg yuam kev rau kev phiv. Thaum nce koob tshuaj, tsis pom zoo nrog tus kws kho mob, cov xwm txheej hauv qab no yuav tshwm sim:
- Cov kab mob dyspeptic (ntuav, xeev siab), raws plab, hloov pauv hauv dej thiab electrolyte tshuav (vim ntuav thiab raws plab).
- Nws tsis yog qhov txawv rau cov neeg mob kub taub hau. Qhov ncauj qhuav tom qab Amoxicillin kuj tshwm sim.
Thaum noj tshuaj ntau dhau, tus neeg mob yuav tsum tau txais kev pabcuam khomob uas tsim nyog, uas suav nrog kev ua pa sai sai, noj charcoal, saline laxatives, tshuaj los tswj cov electrolyte. Hauv qhov xwm txheej hnyav, hemodialysis yog siv.
Analogues
Cov tshuaj analogues tseem ceeb ntawm cov tshuaj "Amoxicillin 500 mg" tuaj yeem yog tshuaj los ntawm pawg fluoroquinolones thiab macrolides, suav nrog:
- Azithromycin;
- "Sumamed";
- Fromilid;
- Erythromycin;
- YMacrofoam.
Cov tshuaj no kuj tau sau tseg yog tias kev kho mob nrog "Amoxicillin" tsis tau muab qhov txiaj ntsig zoo, uas yog, cov tshuaj tua kab mob no tsis tuaj yeem ua rau cov kab mob.kab mob. Tsis tas li ntawd, nws raug hloov nrog cov tshuaj analogues thaum tus neeg mob muaj kev phiv loj heev.
Tus kws kho mob hais li cas?
Cov kws kho mob nco ntsoov tias cov neeg mob cov lus tsis txaus siab txog kev phiv los ntawm kev noj Amoxicillin yog ib qho tshwm sim tsis tu ncua. Qhov no yog vim qhov tseeb tias txhua yam tshuaj tua kab mob yog tshuaj lom, thiab tib neeg lub cev ua rau nws mob heev. Nrog rau kev siv tshuaj tua kab mob ntev, dysbacteriosis tuaj yeem tshwm sim, uas yog nrog los ntawm kev tsis txaus siab ntawm qhov mob plab thiab mob raws plab. Kev tsis txaus siab tsis tu ncua - tom qab noj "Amoxicillin" cov pob liab liab tshwm. Qee lub sij hawm muaj kev phiv xws li kev ua txhaum ntawm cov txheej txheem digestive, uas tshwm sim nws tus kheej hauv daim ntawv ntawm kub siab, xeev siab, thiab belching. Feem ntau, cov neeg mob tau mob raws plab, uas yog tshwm sim los ntawm kev tuag ntawm cov kab mob uas muaj txiaj ntsig hauv plab hnyuv mucosa.
Qee tus neeg mob mob raum tom qab "Amoxicillin". Raws li kws kho mob, cov neeg uas tsis muaj teeb meem nrog rau cov zis, raws li txoj cai, zam qhov kev kho no zoo. Yog tias muaj kab mob raum, tus neeg mob yuav hnov mob hauv nraub qaum, tso zis tsis zoo, thiab lwm yam. Qhov no yog vim qhov tseeb tias cov txheej txheem tshem tawm cov tshuaj tawm hauv lub cev nyuaj.
Ntau tus neeg txaus siab rau lo lus nug ntawm seb puas yog qhov qub uas tom qab noj "Amoxicillin" kub tau nce. Cov kws tshaj lij taw qhia tias hyperthermia yog cov tshuaj tiv thaiv ntawm lub cev tiv thaiv kab mob rau cov kab mob. Yog li ntawd, cov tshuaj nws tus kheej tsis tuaj yeem nce qhov kub ntawm qhov ncaj qha, tab sis nws muaj peev xwm provoketshuaj tsis haum.
