Calcineurin inhibitors nthuav tawm hauv cov khw muag tshuaj niaj hnub no yog cov lactones uas yog hom macrolide. Cov yam ntxwv tseem ceeb yog kev nyuaj siab zoo ntawm lub cev tiv thaiv kab mob. Ntawm cov nto moo tshaj plaws, thawj qhov chaw rightfully belongs rau cyclosporine. Nws yog ua tsaug rau A-hom ntawm cov khoom no uas hloov lub cev los ua tau. Cov tshuaj, raws li qhia los ntawm kev ntsuam xyuas thiab paub tseeb los ntawm kev paub ntawm kev siv, zoo tiv thaiv tsis kam ntawm cov ntaub so ntswg transplanted. Muaj tseeb tiag, qhov ntev ntawm cov molecule tau dhau los ua qhov uas tsuas yog siv cov txheej txheem ua tau. Cia peb xav txog dab tsi yog calcineurin inhibitory tshuaj, dab tsi yog qhov nuances ntawm lawv cov txiaj ntsig.
cov ntaub ntawv dav dav
Tam sim no, calcineurin inhibitors (tshuaj pleev tshuaj) tsis yog tsuas yog cyclosporine A, tab sis kuj muaj lwm cov macrolides, cov molecules uas me dua. Pimecrolimus thiab tacrolimus feem ntau yog siv los ua immunomodulators. Cov kev tshawb fawb tau pom tias cov tshuaj no tuaj yeem dhau ntawm daim tawv nqaij, yog li ntawd, nws muaj peev xwm tsim taucov tshuaj pleev zoo. Tacrolimus yog siv rau zus tau tej cov tshuaj ointments, lub concentration ntawm active tshuaj nyob rau hauv uas txawv ntawm 0.03-0.1%. Pimecrolimus yog siv los ua 1% tshuaj pleev. Muaj ob peb yam khoom lag luam uas tseem nyob hauv kev sim tshuaj. Cov no suav nrog sirolimus, tseem hu ua Rifampicin.
Tshuaj calcineurin inhibitors (TCIs) cuam tshuam rau tus neeg mob lub cev ntawm qib cellular. Cov complexes yog tsim nyob rau hauv xws li cov qauv. Cyclosporine kuj reacts nrog cyclophilin, lwm yam ob yam uas hais los saum toj no reacts nrog kaum ob macrophilin. Vim muaj cov txheej txheem khi, dephophorylation ntawm nucleus thiab lymphocytes yog inhibited, kev tsim tawm ntawm IL-2 thiab lwm yam cytokines raug tiv thaiv. T-lymphocytes tsis qhib, kev loj hlob qeeb qeeb, kev tsim cov cytokines raug thaiv.
Txoj kev siv
Kev npaj raws li cov tshuaj calcineurin inhibitors yog siv tshuaj pleev ib ce thiab ua haujlwm. Rau kev siv sab nraud, cov tshuaj muaj pimecrolimus, tacrolimus feem ntau xaiv. Cov kev kho no tau ua haujlwm zoo rau atopic eczema. Cov kev tshawb fawb random tau ua nrog rau kev siv cov tshuaj no nyob rau hauv ntau yam inflammatory pathologies. Cov tshuaj tau siv rau lichen erythematosus, thaj chaw ntawm cov mucous daim nyias nyias, pyoderma, nrog rau gangrene, lupus erythematosus. Cov neeg mob tau sau tseg ib qho kev hnov mob me ntsis hauv thaj chaw ntawm daim ntawv thov ntawm cov tshuaj formulations nyob rau hauv thawj hnub, maj mam undesirable nyhuv.dhau. Tsis muaj qhov kev soj ntsuam pom pom cov txheej txheem atrophic hauv daim tawv nqaij.
Txhawm rau kom muaj kev nyab xeeb siab tshaj plaws ntawm kev siv, nws yog ib qho tseem ceeb kom tsis txhob muaj hluav taws xob ultraviolet thaum lub sijhawm kho. Calcineurin inhibitors tau pom tias yuav ua rau muaj kev pheej hmoo ntawm mob qog noj ntshav yog tias ib tus neeg raug cov rays.
Siv nuances
Rau kev siv lub cev, tsuas yog cov tshuaj raws li cov tshuaj calcineurin inhibitor cyclosporine tam sim no. Nws yog siv rau mob psoriasis, nrog atopic eczema uas tsis kho los ntawm lwm txoj kev. Feem ntau cov neeg mob uas muaj npe pathologies tau txais kev kho mob phototherapy, uas txhais tau hais tias lawv muaj kev pheej hmoo loj ntawm kab mob oncological.
Systemically calcineurin inhibitors raug tshuaj rau Behçet tus kab mob thiab SLE. Koj tuaj yeem siv cyclosporine rau pyoderma nrog cov cim qhia ntawm gangrene, lichen planus, txhim kho raws li qhov xwm txheej dav dav. Xav txog tias kev kho mob hauv lub cev muaj feem yuav ua rau hypertrichosis thiab ntshav siab, gingival hyperplasia, raum tsis ua haujlwm.
Kev phom sij ntawm kev kho mob
Kev tshawb fawb tau pom tias calcineurin inhibitors ua rau muaj kev pheej hmoo ntawm squamous cell ntawm daim tawv nqaij los ntawm kwv yees li ib puas npaug tom qab hloov lub cev. Ua kom muaj kev pheej hmoo ntawm kev tsim metastases hauv lub sijhawm luv tshaj plaws. Txhawm rau txo qhov tsis zoo, koj yuav tsum ua tib zoo tiv thaiv tus neeg los ntawm ultraviolethluav taws xob. Kev siv txuas ntxiv ntawm pawg tshuaj no txwv tsis pub siv tshuaj kho mob rau yav tom ntej.
Azathioprine
Cov tshuaj no muaj cov txiaj ntsig zoo ntawm kev tiv thaiv tib neeg lub cev. Qhov tshwm sim ntawm qhov kev txiav txim no tau piav qhia los ntawm cov nyhuv inhibitory ntawm iosine monophosphate dehydrogenase. Raws li kev cuam tshuam ntawm cov tshuaj calcineurin inhibitor, cov txheej txheem tshwm sim hauv lub cell raug cuam tshuam, tiam DNA raug cuam tshuam, thiab kev loj hlob ntawm hom T thiab B lymphocytes yog inhibited. Mycophenolate mofetil muaj qhov zoo sib xws.
Cov nyiaj no yog ib qho ntawm cov kev kho mob ntawm ntau yam kab mob autoimmune. Cov tshuaj calcineurin inhibitors tuaj yeem siv rau dermatomyositis thiab bullous pob, thaj chaw ntawm daim tawv nqaij, nrog rau gangrene. Cov tshuaj yog siv nyob rau hauv kev sib ntaus tawm tsam lupus erythematosus, hnyav eczema. Koj tuaj yeem siv nyiaj los ua ib feem ntawm kev kho mob nyuaj rau lichen planus. Thaum xaiv cov ntsiav tshuaj nrog azathioprine, thawj koob tshuaj yog 100-150 mg ib kilogram ntawm tus neeg mob qhov hnyav. Txhawm rau kom muaj txiaj ntsig zoo dua, chav kawm yog ntxiv nrog cov tshuaj hormonal los tiv thaiv kab mob, cov ntim uas tau xaiv, tsom rau tus neeg mob lub cev hnyav - 0.5-1 mg / kg. Kev txo koob tshuaj yog tso cai tom qab kev txhim kho tseem ceeb ntawm tus neeg mob. Qhov tsawg kawg nkaus yog 50 mg; yuav tsum tau muab nrog rau lwm yam tshuaj rau kev kho mob ntawm ib tug kab mob.
Usage nuances
Nrog rau cov chav kawm ntawm calcineurin inhibitorsCov tshuaj yuav tsum tau nruj me ntsis ua raws li cov cai ntawm kev siv - qhov no yog vim lub peculiarities ntawm cov hauj lwm zoo ntawm formulations. Hauv particular, cov lus hais azathioprine qhia tau hais tias cov nyhuv tsuas yog tom qab siv ntev - los ntawm ib hlis mus rau ib thiab ib nrab. Thawj kauj ruam yog hu ua latent.
Cov tshuaj yuav ua rau muaj kev phiv. Cov kev tshawb fawb tau pom tias muaj kev pheej hmoo ntawm kev mob ntshav qab zib ntau ntxiv raws li qhov xwm txheej macrocytic, nrog rau kev ua haujlwm tsis zoo ntawm lub hauv nruab nrab lub paj hlwb thiab lub plab zom mov. Cov tsos mob zoo li mob khaub thuas yuav tshwm sim. Qee cov neeg mob tsim cov plaub hau tsis zoo. Kev siv azathioprine tsis zoo cuam tshuam rau daim siab hlwb, ua rau kev tuag ntawm hepatocytes. Tej zaum txoj kev loj hlob ntawm leukopenia. Thawj kauj ruam ntawm kev kho mob yuav tsum tau saib xyuas kom meej txog kev ua haujlwm ntawm daim siab, suav ntshav. Kev txo qis hauv thiopurine methyltransferase kev ua haujlwm tuaj yeem ua tau, yog li cov qib no yuav tsum tau txiav txim siab ua ntej txhawm rau txheeb xyuas qhov tsis muaj thiab sib piv nrog cov thawj zaug. Tsis txhob siv allopurinol thiab cov tshuaj hauv nqe lus nug tib lub sijhawm.
YMycophenolate mofetil
Calcineurin inhibitor-based tshuaj raws li cov tshuaj no yog cov tshuaj tiam tom ntej piv rau yav dhau los piav txog azathioprine. MMF yog siv yog tias qhov tshwm sim ntawm kev tsis lees txais cov ntaub so ntswg hloov pauv tau raug ntsuas siab txaus. Tsis muaj tshuaj lom neeg cov tshuaj tiv thaiv ntawm kev sib cuam tshuam nrog allopurinol tau sau tseg. Tsis tas li ntawd, cov nuances ntawm kev ua yeeb yam tsis muaj kev sib txuas nrog thiopurine methyltransferase. Cov tshuaj ntawm cov chav kawm no tsis tshua muaj kev phom sij rau lub siab. Muaj tseeb, lawv muaj cov lus qhia ntau dua myelotoxic zoo,tshaj tshuaj nrog azathioprine.
Imuran
Cov tshuaj muaj nyob rau hauv daim ntawv ntsiav tshuaj, ib lub tshuaj ntsiav muaj 50 mg, ib lub thawv - 100 daim ntawv thiab cov lus qhia. Azathioprine yog lub ntsiab active ingredient ntawm cov tshuaj. Ntxiv rau nws, cov chaw tsim khoom siv cov khoom sib txuas ntxiv - starches, acids, lactose. Cov tshuaj belongs rau cov khoom hloov pauv ntawm 6-mercaptopurine thiab tau muab cais ua hom imidazole. Tsis ntev tom qab noj, cov tshuaj tau hloov mus rau hauv methylnitroimidazole, 6-mercaptopurine. Qhov thib ob qhov chaw nkag mus los ntawm cov cell membranes, qhov twg kev hloov pauv hloov mus rau hauv purine analogues, suav nrog nucleotides, pib. Tus nqi ntawm kev hloov pauv txawv txawv ntawm rooj plaub mus rau rooj plaub, nyob ntawm qhov nuances ntawm tus neeg mob lub cev.
Hauv cov lus qhia uas tuaj nrog cov ntsiav tshuaj azathioprine, cov chaw tsim khoom qhia tias qhov tsis muaj peev xwm ntawm nucleotides dhau los ntawm cov cell membrane, uas ua rau nws tsis yooj yim rau cov tebchaw nkag mus rau hauv cov kua dej organic. 6-mercaptopurine yog tshem tawm nyob rau hauv daim ntawv ntawm ib tug inactive metabolite - cov khoom ntawm oxidation cov tshuaj tiv thaiv uas tshwm sim nrog kev koom tes ntawm lub enzyme keeb xanthine oxidase inhibited los ntawm allopurinol. Kev tshawb fawb txog kev ua haujlwm ntawm methylnitroimidazole tseem tsis tau muab cov duab meej meej ntawm cov tshuaj ua haujlwm li cas, tab sis nws tau raug tsim los tias kev ua haujlwm ntawm azathioprine yuav nyob ntawm nws.
Thaum twg yuav pab tau?
Azathioprine, ua lag luam raws li lub npe lag luam Imuran, tau tshaj tawm los muab cov txiaj ntsig zoo raws li lub hauv pauskev sib xyaw ua ke, txawm hais tias nws provokes undesirable txim. Cov kws kho mob feem ntau tau sau ntau chav kawm uas suav nrog cov tshuaj hormonal los tiv thaiv kab mob thiab lwm yam tshuaj los tiv thaiv kev ua haujlwm ntawm lub cev tiv thaiv kab mob. Lub hom phiaj tseem ceeb ntawm qhov kev zov me nyuam yog txhawm rau txo qhov kev pheej hmoo ntawm kev tsis lees txais cov ntaub so ntswg hloov pauv. Cov tshuaj yog siv nyob rau hauv kev hloov ntawm lub plawv, siab, raum. Txoj kev kho mob tsim tau zoo pab txo qhov xav tau tshuaj hormonal.
Hauv foci ntawm qhov mob ntawm txoj hnyuv (Crohn's disease, colitis), azathioprine, nthuav tawm nyob rau hauv lub npe "Imuran" hauv cov khw muag tshuaj, yog siv yog tias tus neeg mob tau qhia rau ib chav kawm ntawm corticosteroids, tab sis tus neeg mob zam nws. nyuaj heev. Lawv mus rau Imuran yog tias cov txheej txheem tshuaj tsis muab qhov xav tau.
Reception nta
Raws li tib txoj kev kho mob "Imuran" raug xaiv yog tias tus neeg mob muaj mob rheumatoid mob caj dab, nrog rau pemphigus vulgaris. Koj tuaj yeem siv cov tshuaj rau polyarteritis nodosa, hemolytic anemia ntawm hom autoimmune, SLE, dermatomyositis, polymyositis. Cov tshuaj no tau sau tseg rau idiopathic purpura, ntau yam sclerosis, nyiam rov qab (azathioprine cuam tshuam kev nco).
Calcineurin inhibitor yuav tsum tsis txhob noj yog tias muaj qhov tsis haum rau azathioprine, cov tshuaj pabcuam suav nrog hauv cov tshuaj. Kev kho mob yuav raug txwv los ntawm qib siab ntawm rhiab heev rau 6-mercaptopurine.
Kuaj thiab kuaj mob
Yog tias "Imuran" raug tshuaj yog tias tsim nyog los tiv thaiv kev tsis lees txais cov ntaub so ntswg hloov pauv, thawj hnub cov koob tshuaj raug xaiv raws li qhov hnyav: txog li 5 mg / kg. Cov ntim txhua hnub tau muab faib ua 2-3 servings. Kev saib xyuas ntau npaum li cas sib txawv hauv qhov txwv ntawm 1-4 mg / kg. Cov txiaj ntsig tshwj xeeb raug xaiv, ntsuas qhov ua tau zoo ntawm chav kawm yav dhau los, kev ua siab ntev ntawm cov ntaub so ntswg hauv ib kis.
Kev soj ntsuam thiab kev tshawb fawb ua pov thawj tias kev kho mob ntev ntev tuaj yeem ua tau. Qhov no pab tiv thaiv cov ntaub so ntswg tsis lees paub yav tom ntej, vim tias qhov kev pheej hmoo ntawm cov txheej txheem no tseem nyob ntev tom qab kev phais.
Yog tias "Imuran" raug tshuaj tiv thaiv keeb kwm yav dhau los ntawm ntau yam sclerosis, cov tshuaj tau siv thawj zaug hauv qhov nyiaj ntawm 2-3 mg / kg. Cov ntim txhua hnub tau muab faib ua 2-3 servings. Qee lub sij hawm cov txiaj ntsig ntawm kev kho mob pom tau los ntawm qhov kawg ntawm thawj xyoo ntawm kev kho mob, lwm yam - tom qab ob xyoos ntawm kev siv cov tshuaj tas mus li.
Nyob rau hauv rooj plaub ntawm lwm yam kab mob pathological, thaum xub thawj Imuran raug tshuaj nyob rau hauv tus nqi ntawm 1-3 mg / kg. Kev hloov tshuaj yog ua los ntawm kev saib xyuas lub cev cov lus teb rau cov kev xaiv ntawm kev kho mob. Qee zaum qhov no tuaj yeem pom tsuas yog lub hlis tom qab pib qhov program. Tau pom cov txiaj ntsig kho mob, qhov ntim ntawm tus neeg sawv cev siv tau maj mam txo kom txog thaum nws tuaj yeem txheeb xyuas qhov qis tshaj plaws, tseem siv tau rau hauv ib rooj plaub tshwj xeeb. Yog tias peb lub hlis tom qab pib siv "Imuran" tseem tsis muaj kev txhim kho, qhov kev xav tau ntawm cov tshuaj no yuav tsum tau rov ntsuas dua. Nrog rau kev tsom mus rau qhov mob ntawm txoj hnyuv, kev kho mob yuav kav ntev li ib xyoos. Nrog xws liKev kuaj mob coj mus rau hauv tus account tias cov txiaj ntsig tseem ceeb ntawm kev kho yog qee zaum pom tsuas yog thaum kawg ntawm plaub lub hlis ntawm chav kawm.
Nyob zoo ib tsoom niam txiv kwv tij neej tsas sawv daws.
Tsuas muaj cov ntaub ntawv txwv ntawm kev siv Imuran los ntawm cov neeg mob laus. Qhov zaus ntawm qhov tshwm sim ntawm qhov tsis xav tau cov lus teb ntawm lub cev, raws li tau pom los ntawm kev txheeb cais, tsis txawv ntawm tus yam ntxwv ntawm cov neeg mob hluas. Cov chaw tsim khoom pom zoo kom koj ua raws li qhov tsawg tshaj plaws tau noj. Nws yog ib qho tseem ceeb kom tsis tu ncua xyuas cov duab ntshav thiab txo qhov ntim ntawm cov khoom siv, yog tias ua tau.
Kev phom sij: Neoplasms
Raws li tau hais los saum toj no, raws li calcineurin inhibitor tshuaj pleev, cov ntsiav tshuaj uas muaj qhov ua tau zoo tuaj yeem dhau los ua qhov tseem ceeb ntawm kev tsim cov cell. Imuran yuav tsis muaj kev zam. Cov kev tshawb fawb tau pom tias cov kev kho mob yog nrog los ntawm kev pheej hmoo ntawm kev tsim cov qog nqaij hlav uas tsis yog Hodgkin, melanoma, thiab sarcoma. Tus neeg mob tuaj yeem tsim myelodysplasia, mob qog nqaij hlav ntawm lub caj dab, myeloid leukemia.
Qhov phom sij ntawm tus kab mob malignant yog qhov tshwj xeeb tshaj yog thaum noj tshuaj tiv thaiv kab mob tiv thaiv keeb kwm yav dhau los ntawm kev hloov pauv ntawm cov ntaub so ntswg organic. Txhawm rau txo qhov kev pheej hmoo, koj yuav tsum siv "Imuran" hauv qhov qis tshaj qhov ua tau. Los ntawm cov ntaub ntawv kho mob nws tau paub tias kev siv cov lus piav qhia rau kev mob caj dab rheumatoid cuam tshuam nrog kev phom sij ntau dua ntawm cov qog ntshav qog ntshav uas tsis yog Hodgkin tshaj qhov nruab nrab ntawm tag nrho cov tib neeg.
Tau heev
Yog tias koj siv "Imuran" ntau npaum li cas, hematomas, foci ntawm los ntshav, rwj yuav tshwm simnyob rau hauv lub caj pas. Tus neeg mob raug kev txom nyem los ntawm kev kis tus kab mob tsis zoo. Cov tsos mob cuam tshuam nrog inhibition ntawm cov pob txha pob txha ua haujlwm tshwm sim ib thiab ib nrab mus rau ob lub lis piam tom qab pib noj ntau dhau. Nws paub tias kev siv ib zaug ntawm 7.5 g ntawm azathioprine ua rau ntuav, quav quav, xeev siab, leukopenia, thiab daim siab tsis ua haujlwm.
Cov tshuaj tsis muaj tshuaj tiv thaiv. Yog tias pom tias muaj kev noj tshuaj ntau dhau, nws yuav tsum tau ntxuav lub plab, coj tus neeg mob lub cev kom tswj tau, thiab tsis tu ncua xyuas cov haujlwm ntawm cov kab mob hemolytic. Nws tseem tsis tau paub tias kev lim ntshav zoo npaum li cas, tab sis nws tau pom tias cov khoom nquag ntawm Imuran tuaj yeem raug tshem tawm ib nrab ntawm txoj kev no.
Atopic dermatitis thiab nws txoj kev kho
Rau kev kho sab nraud, calcineurin inhibitors yog siv, raws li txoj cai, yog tias tus neeg mob muaj atopic dermatitis.
Lo lus hais txog tus kab mob uas tuaj yeem rov qab los, cuam tshuam nrog kev tsim foci ntawm o ntawm daim tawv nqaij. Nrog rau qhov kev kuaj mob zoo li no, ib tus neeg raug yuam kom siv tshuaj tua kab mob, tshem tawm cov tsos mob rau kev kawm ntev - atopic dermatitis yog ib qho ntawm cov kab mob kho tsis tau. Kev nyiam huv thiab kev saib xyuas kom zoo yog qhov tseem ceeb ntawm txhua theem - daim tawv nqaij yuav tsum tau moisturizing li niaj zaus, softening los ntawm emollients. Txog tam sim no, nws tseem tsis tuaj yeem txheeb xyuas cov yam ntxwv ntawm kev ua tau zoo ntawm cov tshuaj no, tab sis ntseeg tau tias lawv tsis tuaj yeem tiv thaiv kev ua mob.
Undoubtedly, zoo nyob rau hauv atopic dermatitis yoghormonal anti-inflammatory tshuaj, tab sis cov no muaj feem yuav ua rau muaj kev phiv. Qee qhov xwm txheej, kev ua haujlwm qeeb dhau. Kev tshem tawm ntawm glucocorticosteroids feem ntau yog nrog kev ua tsis zoo ntawm cov neeg mob. Cov teeb meem no yuam kom cov kws tshawb fawb nrhiav txoj hauv kev tshiab los tawm tsam tus kab mob, thiab qhov no yog txoj hauv kev uas siv niaj hnub no rau kev kho mob atopic dermatitis calcineurin inhibitors.
Subtleties ntawm qhov teeb meem
tshuaj tiv thaiv kab mob yog raug sau tseg thaum atopic dermatitis tshwm sim hauv daim ntawv hnyav, ua rau tawv ncauj. Cyclosporine, methotrexate, azathioprine yog siv. Cov classic version yog npaj nrog cyclosporine ntawm polypeptide xwm. Cov tshuaj nquag yog thawj zaug tau los ntawm cov kab mob tshwj xeeb. Kev soj ntsuam tau pom tias kev siv cyclosporine pab ua kom qeeb ntawm degranulation ntawm cellular mast daim tawv nqaij qauv, tiam ntawm leukotrienes. Cov tshuaj no inhibits zus tau tej cov cytokines, cov kev ua ntawm T-lymphocytes, tsis muaj kev cuam tshuam cov kev tsis haum tshuaj ntawm lub cev. Txawm li cas los xij, kev siv cov tshuaj pleev tau zoo txo qhov khaus.
Tus mob atopic dermatitis hnyav tuaj yeem cuam tshuam nrog cov tshuaj uas tsim los ntawm Staphylococcus aureus. Kev siv cyclosporine pab txo qis cov tsos mob ntawm tus kab mob, txo cov concentration ntawm cov kab mob ntawm daim tawv nqaij. Txoj kev tshawb no koom nrog cov neeg mob me. Ua ntej pib siv cov tshuaj tiv thaiv kab mob, qee cov kws tshawb fawb tau sib cav tias qhov kev kawm ntawmtshuaj tua kab mob.
Official thiab ntseeg tau
Yuav luag ob xyoo dhau los, cov kws tshawb fawb Askiv tau kos npe pom zoo tswj kev siv cyclosporine tiv thaiv keeb kwm ntawm atopic dermatitis. Tshwj xeeb mloog yog them rau cov xwm txheej ntawm lub reserve. Cyclosporine tsuas yog siv rau hauv cov mob hnyav thiab tsis muaj txiaj ntsig ntawm cov txheej txheem. Kev nce qib ntawm toxicity yuav tsum tau saib xyuas tus neeg mob tus mob, kuaj lub raum ua haujlwm, ntsuas ntsuas siab. Nws yog txwv tsis pub siv cyclosporine rau kev kho mob dermatitis hauv kab mob siab, mob raum, mob kis kab mob.
Lawv tuaj yeem sau tsis tau tsuas yog tshuaj pleev, tab sis kuj yog ib qho kev daws qhov ncauj. Ua ntej, cov koob tshuaj yog xam raws li 5 mg / kg, muab faib ua ob koob, ces halved. Lub sijhawm ntawm chav kho mob txawv ntawm ib thiab ib nrab mus rau ob peb lub hlis.
Kev siv cyclosporine yog nrog los ntawm kev txo qhov khaus thiab tshem tawm ntawm hyperemia ntawm daim tawv nqaij. Cov teebmeem zoo li no tuaj yeem pom tau nyob rau thawj ob peb hnub ntawm kev pabcuam tshuaj. Kev txo qis ntawm cov tshuaj uas cuam tshuam rau lub cev tiv thaiv kab mob ua rau muaj kev cuam tshuam ib ntus los ntawm cov tsos mob ntawm tus kab mob dermatitis, tab sis kwv yees li txhua tus neeg mob thib ob yws yws txog qhov tshwm sim ntawm tus kab mob no zuj zus los ntawm qhov kawg ntawm lub lim tiam thib ob tom qab kawm tiav. Qhov nruab nrab, tsuas yog txhua tus neeg thib rau hauv qhov zoo mus txog rau ib xyoos. Ib txoj kev tshawb fawb tshwj xeeb ntawm cov neeg mob uas tau xaiv los xaiv, koom nrog yav dhau los tsis ntev los no, qhia tias kev siv cyclosporine tsis cuam tshuam rau lub neej zoo ntawm cov neeg mob atopic dermatitis.
