Peb lub cev, tej zaum, tuaj yeem suav hais tias yog "cov thev naus laus zis siab tshaj" uas Niam Xwm tau tsim. Nyob rau hauv nws, txhua lub cev yog qhov tshwj xeeb hauv nws "tsim", thiab nrog nws cov peev xwm nws tsis yog qhov xav tsis thoob li nws tau tawm tsam. Thiab yog tias koj delve rau hauv txoj kev kawm ntawm tag nrho cov kab mob, koj tuaj yeem nrhiav tau ntau cov ntsiab lus nyuaj. Feem ntau hauv kev sim koj ua, koj tuaj yeem pom cov kab lus hais tsis tau zoo li aspartate aminotransferase nce. Thiab lub sijhawm no, qhov no cuam tshuam rau lub ntsiab lus ntawm kev faib cov amino acids. Yuav tsum tau paub lo lus no los ze zog me ntsis.
lub sij hawm yog dab tsi?
Lo lus no yog hais txog ib qho enzyme tshwj xeeb uas koom nrog hauv kev sib cais ntawm yuav luag txhua cov amino acid hauv peb lub cev. Nws yog abbreviated li AST los yog denoted los ntawm cov tsiaj ntawv loj AST. Cov enzyme muaj nyob rau hauv cov ntaub so ntswg ntawm ntau lub cev, xws li:
- siab;
- siab;
- paj ntaub;
- raum;
- muscles;
- pancreas;
- spleen;
- light;
- paj hlwb.
Ntxiv mus, feem ntau ntawm cov enzyme muaj nyob rau hauv cov ntaub so ntswg ntawm lub plawv, ob lub raum, paj hlwb, siab.
Yog li, kev kuaj mob ntawm txhua yam kab mob cuam tshuam nrog cov kabmob no qhia qhov tseeb tias aspartate aminotransferase nce siab. Nyob rau hauv lub ntsws, spleen thiab pancreas, tus nqi ntawm cov enzyme tsis yog li ntawd. Tib lub sijhawm, tus txiv neej lub cev txawv ntawm poj niam lub cev hauv kev ua haujlwm siab ntawm AST.
Lub hom phiaj ntawm ASAT
Ib enzyme yog ib qho protein molecule uas tsim los ntawm cov ntaub so ntswg ntawm lub cev. Nws cov qauv tau tsim los ntawm cov kws tshawb fawb Lavxias rov qab rau xyoo 70s. Lub luag haujlwm ntawm ib qho enzyme yog txhawm rau ua kom cov tshuaj lom neeg biochemical uas tshwm sim hauv cov hlwb. Nrog kev koom tes ntawm vitamin B6, kev sib pauv ntawm cov amino acids ua tau. Thaum lub sij hawm txoj kev hloov ntawm ntau cov amino acids, nrog rau aspartic, ib tug tshiab compound yog tsim. Nws yog ua tsaug rau nws uas lub synthesis ntawm qabzib yog nqa tawm, uas yog heev tsim nyog rau peb lub cev.
Txoj kev ntawm AST
Peb txhua tus sai lossis tom qab tau hla cov kab lus xws li aspartate aminotransferase nce. Qhov no txhais li cas, tsis yog txhua tus paub. Nrog rau qhov ntawd, cia peb qhib daim ntaub. Nyob rau hauv lub cev noj qab haus huv, lub enzyme yog muaj nyob rau hauv lub hlwb ntawm lub sab hauv lub cev, uas yog tus qauv. Tsuas yog ib feem me me ntawm AST tuaj yeem nkag mus rau hauv cov ntshav. Rau koj cov ntaub ntawv - qhov concentration ntawm enzyme nyob rau hauv lub plawv tshaj nws cov nyiaj nyob rau hauv cov hlab ntsha los ntawm 10txhiab zaug.
Tab sis yog tias cov ntaub so ntswg ntawm ib yam khoom raug puas tsuaj, ces aspartate aminotransferase, raug tso tawm, nkag mus rau hauv cov ntshav thiab cov enzyme pib nce. Qhov kev loj hlob yog nyob ntawm qib ntawm cov ntaub so ntswg puas. Piv txwv li, nrog kev kuaj mob ntawm myocardial infarction, qhov concentration ntawm AST yuav ncav cuag qhov siab tshaj plaws hauv ib hnub.
Qee zaum, qib ntawm cov enzyme tuaj yeem dhau qhov kev cai los ntawm 5 zaug, thiab daim duab no tuaj yeem kav ntev li 7 hnub. Thiab ntawm no ib tug neeg yuav xav tias: yog tias aspartate aminotransferase (AST) nce siab, qhov no txhais li cas? Qhov kev ua haujlwm siab no yog ib qho cim qhia ntawm tus neeg mob hnyav, uas feem ntau xaus rau qhov txiaj ntsig tsis zoo.
Yog tias qhov nce hauv qhov concentration ntawm cov enzyme tshwm sim ntawm maj mam thiab nce nrawm, qhov no txhais tau tias thaj tsam infarct nce ntxiv. Aspartate aminotransferase kev ua haujlwm tuaj yeem tshwm sim los ntawm kev tuag ntawm daim siab.
Dab tsi tuaj yeem ua rau AST siab hem nrog?
Nws yog myocardial infarction uas feem ntau ua rau muaj siab ntawm aspartate aminotransferase hauv cov ntshav. Nyob rau hauv rooj plaub no, tus nqi ntawm enzyme tuaj yeem yog 10 npaug ntau dua li qhov qub, thiab qhov siab dua, qhov loj dua qhov chaw ntawm kev puas tsuaj rau cov leeg nqaij. Hnub plaub ntawm kev kho mob, ib qho kev soj ntsuam thib ob feem ntau yog muab. Nws cov txiaj ntsig yuav pom tias aspartate aminotransferase nce siab lossis tsis. Nyob rau hauv rooj plaub ntawm kev kho kom zoo, nws cov concentration yuav tsum tau txo.
Cov qib AST tuaj yeem pom nrogdaim siab puas vim yog kev cuam tshuam ntawm qee yam:
- kab mob oncological.
- cawv lom.
- Kev rog.
- Kev muaj kab mob siab.
Tsuas yog qhov no, txhawm rau txhawm rau kuaj xyuas qhov tseeb, nws yog qhov yuav tsum tau kuaj xyuas ntxiv. Tab sis kev nce qib ntawm cov enzyme tuaj yeem ua rau cov neeg noj qab nyob zoo. Yog li, qhov haujlwm yuav yog:
- Nyob rau hauv cov me nyuam muaj mob.
- Cov poj niam thaum lub caij cev xeeb tub thawj zaug.
- Thaum haus cawv ntau dhau.
- Thaum noj qee yam tshuaj: valerian, ntau yam tshuaj tua kab mob lossis paracetamol.
Kev ua lub cev zoo kuj muaj qhov cuam tshuam tsis zoo rau qhov no. Tsis tas li ntawd, yog tias aspartate aminotransferase nce siab, cov laj thawj yuav nkaum hauv kev siv tshuaj raws li barbituric acid, noj cov tshuaj tiv thaiv kab mob kuj tuaj yeem ua rau muaj kev nce hauv AST..
Vim li cas thiaj nce AST
Yog vim li cas rau qib nce ntawm cov enzyme, raws li tau hais los saum no, tej zaum yuav yog myocardial infarction. Nrog rau qhov kev kuaj mob no, 95-98% ntawm tag nrho cov neeg mob muaj kev ua haujlwm siab aspartate aminotransferase. Hauv qhov no, tus nqi tuaj yeem ncav cuag 3000 units / l. Hauv lwm qhov xwm txheej, qib siab ntawm cov enzyme tau pom nrog lub siab necrosis. Tus kab mob no, nyob rau hauv lem, tuaj yeem tshwm sim los ntawm kab mob siab ntawm ntau hom. Qib ntawm AST nyob rau tib lub sij hawm tshaj qhov qub qhov tseem ceeb los ntawm 10-100 zaug.
Nrog rau lwm yam kab mob tsim nyog sau ciaangina pectoris, mob pancreatitis, cuam tshuam ntawm cov ducts, cov qog nqaij hlav cancer lossis daim siab metastases. Cov concentration ntawm cov enzyme kuj tuaj yeem nce ntxiv vim kev raug mob, kub hnyiab, pib ntawm cov txheej txheem ntawm cov leeg nqaij tuag, nyob rau hauv lub zog ntawm tshav kub stroke. Qhov no tuaj yeem suav nrog tus neeg mob tus mob hauv lub sijhawm tom qab phais.
Qhov tseeb tias aspartate aminotransferase nce siab hauv tus menyuam yuav qhia tau tias muaj kab mob siab, mob plab, mob myocarditis, jaundice.
Yog vim li cas thiaj txo AST
Qib ntawm cov enzyme tuaj yeem tsis tsuas yog nce, tab sis kuj txo. Qhov no tshwm sim rau ntau yam. Nws feem ntau tshwm sim hauv cov poj niam cev xeeb tub. Hauv lwm qhov xwm txheej, hauv cov menyuam yaus thiab cov neeg laus, vim cov leeg nqaij dystrophy, kev raug mob ntawm qhov sib txawv ntawm qhov hnyav, cerebral infarction, hypothyroidism lossis mob pancreatitis, qhov txo qis ntawm aspartate aminotraferase tau pom. Vim tias tsis muaj vitamin B6 lossis lub siab tawg, qhov tsis txaus ntawm cov protein molecule kuj raug kuaj pom.
Indications for analysis
Kev tshuaj xyuas txhawm rau txiav txim siab qib ntawm AST enzyme yuav tsum tau ua txhawm rau txhawm rau txheeb xyuas qhov muaj qee yam mob hnyav:
- ua cov txheej txheem oncological tshwm sim hauv daim siab hlwb;
- puas muaj metastases;
- nce ntshav aspartate aminotransferase tuaj yeem qhia tias muaj kab mob mononucleosis lossis kis kab mob ntawm cov kab mob lymphatic;
- kab mob ntawm hom kab mob autoimmune (piv txwv li, Duchenne-Becker myodystrophy);
- myocardial infarction;
- cirrhosis;
- kuj qhov kev tshuaj ntsuam yuav qhia pom muaj kab mob siab ntawm txhua hom,suav nrog daim siab necrosis.
Tsis tas li ntawd, kev txheeb xyuas qhov txawv txav ntawm cov leeg thiab daim siab, yam tsawg kawg, yuav tsum ua rau koj xav txog kev dhau qhov kev tshuaj ntsuam.
Tsuas yog cov txiaj ntsig tau tuaj yeem lees paub lossis tsis lees paub qhov kev kuaj mob. Qhov no yuav tso cai rau koj los ntsuas qhov tsim nyog raws sijhawm. Yog tias tsis muaj kev hloov pauv loj, ces qhov no tsuas yog qhov zoo dua.
Kev npaj yog qhov tseem ceeb
Raws li qee qhov kev sim, kev sim yuav tsum tau ua kom zoo, vim tias kev noj tshuaj, txawm tias nws yog tshuaj kho mob los ntawm kws kho mob lossis tshuaj ntsuab decoction, tuaj yeem cuam tshuam tsis zoo rau cov txiaj ntsig ntawm kev tshuaj ntsuam, uas yuav tsis raug..
Yog li ntawd, txhawm rau paub tseeb tias aspartate aminotransferase nce siab lossis tsis, nws yuav tsum tsis txhob noj tshuaj. Yog tias vim li cas qhov no tsis tuaj yeem ua tau, tus kws kho mob tuaj koom yuav tsum tau ceeb toom, leej twg yuav tsum tau muab tag nrho cov ntaub ntawv hais txog cov tshuaj. Namely, qhov ntau npaum thiab lub sij hawm ntawm nws noj. Rau cov poj niam, kev kuaj sim tuaj yeem ua rau cev xeeb tub.
Kev ntsuas thiab ntsuas ib txwm
Cov khoom siv rau kev kawm tsuas yog cov ntshav venous lossis ntshav. Nws lub laj kab yog ua rau ntawm lub plab khoob thaum sawv ntxov. Tag nrho cov txheej txheem tsis siv sijhawm ntau thiab tsis mob. Cov txiaj ntsig yuav npaj tau tom qab 6-10 teev. Serum tuaj yeem khaws cia rau 48 teev ntawm 15-25 teevqib. Hauv qhov txias txias (2-8 ° C) nws yuav khaws cia li 6 hnub.
Rau lo lus nug ntawm qhov twg koj tuaj yeem ua qhov kev tshuaj ntsuam no, koj yuav tsum hu rau cov chaw kuaj mob tshwj xeeb uas ua cov tshuaj ntsuam biochemical. Qee qhov xwm txheej, txhawm rau txhawm rau txhawm rau paub AST (aspartate aminotransferase) nce lossis ib txwm muaj, koj tuaj yeem mus kawm hauv tsev kho mob ntawm qhov chaw sau npe lossis ib lub tsev kho mob hauv xeev. Tsuas yog yuav tsum xub paub seb nws lub chaw kuaj mob puas muaj cov cuab yeej tsim nyog thiab cov cuab yeej rau kev tshuaj xyuas.
Cov ntsuas ib txwm rau txhua pab pawg neeg sib txawv. Piv txwv li, nyob rau hauv cov me nyuam mos, qhov concentration ntawm AST yog 25-75 U / l, thaum nyob rau hauv me ntsis laus cov me nyuam (1-18 xyoo) nws yog 15-60 U / l. Tus nqi ib txwm muaj rau cov poj niam nyob ntawm 10 txog 36 U / l, thiab rau cov txiv neej - los ntawm 14 txog 20 U / l.
