Hyperandrogenism hauv cov poj niam tsim tawm tsam keeb kwm ntawm kev cuam tshuam hormonal tshuav. Tshwj xeeb yog vim yog ib qho tshuaj hormones. Txawm li cas los xij, nws tsis txaus kom paub nws lub npe. Nws tseem ceeb dua kom nkag siab tias nws yog dab tsi - DHEA-S hormone? Cia peb sim ua kom tiav. Cias muab, nws yog ib tug txiv neej cov tshuaj hormones uas yuav provoke ob sab hauv thiab sab nrauv hloov. Txawm li cas los xij, qhov no tuaj yeem sib txuas tau, thiab muaj qee yam cim qhia ntawm kev nce hauv DHEA-S cov tshuaj hormones hauv cov poj niam.
Dehydroepiandrosterone hauv ib nrab zoo nkauj
Tshuaj los ntawm ntau cov tshuaj steroids, feem ntau yog tsim los ntawm cov qog adrenal, thiab tus so yog coj los ntawm zes qe menyuam. Qhov loj tshaj ntawm qhov concentration ntawm no androgen nyob rau hauv tib neeg cov ntshav yuav qhia tau hais tias inflammatory txheej txheem tshwm sim nyob rau hauv lub qog adrenal. Raws li txoj cai, cov qog tau nce lub zog hauv cov qog endocrine.
DHEA-S hormone, yog dab tsi? Sulfate yog ib qho tshuaj tiv thaiv nruab nrab. Rau cov qauv ntawm cov tshuaj hormone DHEA thiab nws cov tsim, cov roj cholesterol yog xav tau nyob rau hauv kom muaj nuj nqis txaus. Thaum hloov los ntawm daim ntawv steroid,estrogens, tshwj xeeb tshaj yog estradiol.
Nyob ntawm tus nqi ntawm DHEA-S cov tshuaj hormones, lub hauv paus rau kev tso tawm cov kev hloov pauv hloov. Ntawd yog, ntawm qhov txo qis, nws yog tsim nyob rau hauv zes qe menyuam, thiab nce qib hauv adrenal cortex. Ib yam li ntawd.
Thaum DHEA-S cov tshuaj hormones nce siab hauv ib tug ntxhais, nws cuam tshuam tsis zoo rau cov txheej txheem ntawm lub cev. Thiab tseem ntawm kev ua haujlwm ntawm adrenal, kev xeeb tub, kev ruaj ntseg ntawm tag nrho cov huab hwm coj thiab cov xwm txheej ntawm cov epidermis. Thaum pom cov tsos mob tshwm sim, tus poj niam yuav tsum tam sim ntawd nrhiav qhov laj thawj rau qhov nce hauv cov tshuaj hormone DHEA-S.
Ib qho tseem ceeb ua kom nrawm nrawm ntawm thaj chaw qog adrenal txhawm rau txhawm rau kuaj pom muaj qog lossis lwm yam txheej txheem, yog tias muaj.
YDHEA Synthesis
Vim tias Dehydroepiandrosterone (DHEA) yog ntau hom tshuaj steroid-hom tshuaj, nws ua rau androgen receptors. Nws lub npe lag luam thoob ntiaj teb yog prasterone.
DHEA-S hormone, yog dab tsi? Nws cov synthesis hauv peb lub cev yog ua nrog kev koom tes ntawm enzyme 17-alpha-hydroxylase. Pregnenolone, uas yog thawj zaug los ntawm cov roj cholesterol, yog hloov los ntawm cov enzyme no mus rau 17-hydroxypregnenolone, uas hloov mus rau DHEA los ntawm tib enzyme.
Cov tom kawg yog cuam tshuam los ntawm lwm cov enzymes - steroidogens, thiab dhau los ua androstenediol, androstenedione thiab dehydroepiandrosterone sulfate.
Vim lub cev
Tus qauv ntawm DHEA-S cov tshuaj hormones cuam tshuam ntau yam txheej txheem, suav nrog:
- kev ua kom lub cev tiv thaiv kab mob;
- tsim kom muaj txiaj ntsig zoo rau kev sib sau ua ke ntawm estrogen;
- txo qis cov roj cholesterol phem;
- tiv thaiv kev rog;
- libido regulation;
- tuav lub voj voog ntawm kev coj khaub ncaws;
- kev ua kom zoo ntawm cov haujlwm ntawm cov qog sebaceous;
- txo qis kev pheej hmoo ntawm kev nyuaj siab;
- khaws cov elasticity ntawm epidermis.
Cov poj niam feem ntau xav tias kev tso tawm ntawm cov txiv neej cov tshuaj hormones yog qhov tsis tseem ceeb uas qhov nce hauv testosterone concentration yuav luag tsis cuam tshuam dab tsi. Txawm hais tias qhov tseeb, ntau dhau ntawm cov tshuaj steroids ua rau muaj zog androgenism. Thiab nrog rau tag nrho cov txiaj ntsig tsis zoo.
Tus qauv ntawm cov tshuaj hormone DHEA
Txij cuaj mus rau kaum tsib, qhov txwv qis dua yog 1, thiab sab saud yog 9.7. Ntxiv mus, qhov txwv nce, thiab los ntawm kaum tsib mus rau peb caug, qhov qis qis yog 2.4, thiab qhov txwv siab tshaj yog 14.5. poj niam mus txog lub hnub nyoog ntawm peb caug, androgen ntau lawm pib txo, thiab los ntawm peb caug mus rau plaub caug, cov nqi yog raws li nram no: 1.8 mus rau 9.7. Thiab los ntawm plaub caug mus rau tsib caug: los ntawm 0.6 mus rau 7.2.
Nyob rau yav tom ntej, cov ntsiab lus ntawm cov tshuaj txo qis dua thiab ntau dua thiab los ntawm tsib caug mus rau rau caum, cov qauv sib txawv ntawm 0.9 txog 3.3. Tag nrho cov txiaj ntsig ntawm cov qauv tau qhia hauv µmol / l. Yog xav paub ntxiv, nws zoo dua mus nrog koj tus kws kho mob.
Thaum cev xeeb tub, tus nqi ntawm DHEA-S cov tshuaj hormones hauv cov poj niam siab dua. Thaum lub sij hawm thawj peb lub hlis twg, nws txawv ntawm 3.12 mus rau 12.48, thiab nyob rau hauv lub thib ob - los ntawm 1.7 mus rau 7. Lub sij hawm mus txog kev yug me nyuam qib qis qis: 0, 09 thiab 3, 7.
Cas thiab tsos mob
Thaum cov poj niam tau nce DHEA-S cov tshuaj hormones, qhov ua rau muaj feem ntau pom nyob rau hauv lub chaw ua haujlwm ntawm gynecologist thiab endocrinologist. Feem ntau, nce concentration tshwm sim rau cov laj thawj hauv qab no:
- Tsis muaj enzymes uas inhibit qhov kev tso tawm ntawm cov tshuaj hormones, suav nrog cov tshuaj steroid.
- Syndrome thiab Cushing's disease. Tumor formation.
- Txij hnub tim kaum ob mus rau kaum tsib lub lim tiam ntawm cev xeeb tub, cov placenta ua haujlwm tsis zoo.
- Amenorrhoea thiab Galactorrhea Syndromes.
- polycystic zes qe menyuam
- Kev txhim kho ntawm cov qog ua haujlwm hormonally hauv adrenal cortex, uas tsim cov txiv neej hormone.
- Addison tus kab mob.
- Cancers cuam tshuam cov tshuaj hormones.
- Osteoporosis nyob rau theem zuj zus.
- Pathology nyob rau hauv lub caj pas pituitary.
Cov kev hloov pauv feem ntau pom nrog nce DHEA cov tshuaj hormones hauv cov poj niam. Dab tsi yog qhov tseeb. Tab sis nws tsim nyog qhia meej tias thaum nws nce siab, kev ntxhov siab ntau dhau tshwm sim thiab cov hlab ntsha "ua si pranks", lub cev muaj zog thiab kev ua siab ntev, lub cev plaub hau loj hlob nyob qhov twg nws yuav tsum tsis txhob, antennae kuj tshwm sim saum daim di ncauj, pob txuv thiab pob khaus tshwm sim vim. ua rau cov mob hnyav zuj zus tuaj, qhov tso tawm ntawm cov qog sebaceous nce ntxiv, kev xeeb tub tsis zoo, nchuav menyuam lossis yug ntxov ntxov, qhov zoo tshaj plaws kev coj khaub ncaws raug ua txhaum cai,txhim kho kev muaj menyuam.
Ntseeg ntawm kev sib txawv
Tom qab tus neeg mob tham nrog tus kws kho mob thiab tom qab ntawd pom cov tsos mob ntawm androgenism nce, muaj ib lub sij hawm muaj teeb meem nrog DHEA-S cov tshuaj hormones, thaum nws twb tsim nyog mus kuaj. Tus neeg yuav tsum nco ntsoov mus kawm, suav nrog ultrasound thiab MRI.
Qhov tseem ceeb tshaj plaws rau tus kws kho mob yuav yog txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm chim siab thiab ntshai tawm tsam, thiab tseem muaj teeb meem fertility.
Rau qhov kev ntsuas tseeb ntawm qhov kawg, nws yog qhov yuav tsum tau ua kom paub meej qhov concentration ntawm ntau yam tshuaj hormones, uas yog: progesterone, dihydrotestosterone, thyroxine, dawb testosterone, FSH, LH, TSH thiab triiodothyronine.
Npaj rau tag nrho cov no raws li hauv qab no: ntshav tawm ntawm cov hlab ntsha txij hnub thib tsib mus rau xya hnub ntawm kev coj khaub ncaws, ntawm lub plab khoob, nws yog qhov tsim nyog, koj yuav tsum tsis txhob haus dej kom pom tseeb dua. Lwm cov txheej txheem tsis tuaj yeem ua ua ntej kev tshuaj ntsuam.
Kev sib deev, mus ntsib lub gym yuav tsum tau nres ob peb hnub ua ntej mus ntsib chav kuaj. Kev ntxhov siab yuav tsum tiv thaiv. Ua ntej cov txheej txheem kuaj ntshav rau DHEA-S cov tshuaj hormones, haus luam yeeb thiab kib cov zaub mov ntsim thiab rog, cawv thiab kas fes muaj zog yuav tsum raug tshem tawm ntawm kev noj haus.
Nyob hauv cov qog
Normalization ntawm androgen qib tam sim no ua tsis tau yam tsis tau tshem tawm qhov ua raudab tsi ua rau hormonal imbalance. Siv cov txiaj ntsig ntawm kev sim rau Dhea-so4, tus kws kho mob endocrinologist xaiv cov kev kho mob uas tsim nyog tshaj plaws.
Nrog rau txoj kev loj hlob ntawm lub paj hlwb txheej txheem, kev cuam tshuam ntawm neurosurgeon yog qhov tsim nyog. Kev cuam tshuam nrog kev tshem tawm cov qog hauv lub hlwb thiab cov qog adrenal nyob rau hauv cov neoplasm siab heev yog qhov yuav tsum tau, vim tias qhov tso tawm ntawm DHEA-S yuav tsis rov qab mus rau qhov qub thaum cov qog nyob hauv lub cev, vim nws tsim cov tshuaj steroid ntxiv.
qib siab heev ntawm DHEA sulfate (tshaj 800 mcg / dl) tuaj yeem qhia tau tias muaj kev loj hlob zoo li no. Nyob rau hauv cov ntaub ntawv uas tus txheej txheem yog malignant, tus neeg mob tau mus rau ib tug chav kawm ntawm kev tiv thaiv chemotherapy nyob rau hauv thiaj li yuav tiv thaiv metastases los ntawm tsim. Tag nrho cov no, tau kawg, tsuas yog tom qab cov neoplasm raug tshem tawm.
Txoj kev kho no haum rau cov poj niam laus uas tsis xav muaj menyuam. Cov tshuaj hormonal raug sau tseg yog tias tus neeg mob muaj contraindications rau kev kho tus kab mob nrog kev pab ntawm radial therapy.
Tom qab kawm tiav ntawm kev kho cov tshuaj hormones, qhov concentration ntawm cov tshuaj hormones steroid rov zoo li qub rau ib ntus, txawm li cas los xij, tom qab ib ntus nws yuav pib nce ntxiv.
Diana tau ua kom pom qhov ua tau zoo tshaj plaws ntawm kev kho tshuaj hormonal, vim nws muaj qhov zoo tshaj plaws concentration ntawm antiandrogens. Txawm li cas los xij, pom muaj txiaj ntsig zoo duaKev sib xyaw ua ke ntawm "Androkura" nrog cov tshuaj tiv thaiv qhov ncauj.
Txoj kev tawm tsam
Hauv cov poj niam tom qab tsib caug xyoo, kev tso tawm ntawm dehydroepiandrosterone poob qis, thiab tom qab qee lub sijhawm, qhov kev txo qis hauv cov concentration ntawm DHEA-S yuav zoo li. Nyob rau hauv cov ntaub ntawv ntawm ib tug txheej txheem ntawm ib tug benign los yog malignant qog, nyob rau hauv tsis muaj cov ntaub ntawv koj yuav tsum ncua nrog ib tug kev khiav hauj lwm kom tshem tawm cov tsim los yog hormonal kho, tshwj xeeb tshaj yog thaum tus txheej txheem yog malignant.
Yog tias kuaj pom cov kab mob qog adrenal ntawm hyperandrogenism, tom qab ntawd kev siv glucocorticoids ("Dexamethasone", "Prednisolone") hauv cov koob tshuaj me me yuav ua rau muaj txiaj ntsig zoo. Qhov no yuav pab txhim kho kev tsim cov tshuaj hormones. Nyob rau hauv cov ntaub ntawv ntawm hirsutism nyob rau hauv cov poj niam, cov kws kho mob kuaj adrenogenital syndrome nyob rau hauv 2-4% ntawm cov neeg mob.
txhawm rau ua kom cov qib ntawm cov tshuaj hormones normalizes, tus kws kho mob endocrinologist yuav qhia tus neeg mob kom tsis txhob noj cov rog thiab kib zaub mov kom ntau, nrog rau txo qis ntawm haus luam yeeb, nqaij liab, nplooj ntsuab, pickles thiab nqaij nruab deg hauv kev noj haus.
kev ua si thiab cov tshuaj hormones
Txo tus naj npawb ntawm cov xwm txheej ntxhov siab thiab nrhiav sijhawm rau kev so kom zoo thiab pw tsaug zog thaum hmo ntuj, nrog rau kev tsis lees paub lub cev hnyav ntawm lub cev thiab kev tshem tawm cov tshuaj anabolic steroids thaum ua si - tag nrho qhov no yog qhov yuav tsum tau ua thaum ua haujlwm. Kev kho kom muaj zog androgenism.
Ua kom koj lub sijhawm ua haujlwm zoo yogLwm qhov tseem ceeb uas yuav muaj feem cuam tshuam rau kev ua haujlwm androgenic. Kev saib xyuas ntau dhau rau cov leeg nqaij loj tuaj yeem ua rau nce qib ntawm testosterone hauv cov ntshav, thiab qhov no yog txiv neej androgen nquag tshaj plaws.
Nyob ntau dhau ntawm cov roj txheej mus rau qhov tsawg kawg nkaus tso cai tuaj yeem ua rau tsis muaj tshuaj estrogen thiab muaj menyuam tsis taus ntawm qib hormonal. Txawm hais tias qhov tseeb ntawm kev ua haujlwm ntawm cov qog adrenal, androgenital syndrome tuaj yeem tshwm sim, nrog kev tso tawm ntau ntxiv ntawm steroids.
Hmoob hauv Teb Chaws Asmeskas
Ib daim nqi hauv US Senate, uas tau tshaj tawm thaum Lub Peb Hlis 2009, tau sim cais cov tshuaj hormone DHEA raws li cov tshuaj tswj tau muaj nyob rau hauv qeb ntawm anabolic-type steroids.
Tus neeg siv khoom yog Senator los ntawm Republican Party los ntawm lub xeev Iowa - Grassley Charles. Nyob rau hauv lem, cov neeg koom nrog ces yog Senator los ntawm Democratic Party ntawm Illinois thiab lwm Republican Senator ntawm lub xeev Arizona - Richard Durbin thiab John McCain, feem. Daim nqi no tau xa mus rau Pawg Neeg Saib Xyuas Kev Cai lij choj Senate.
Nyob rau xyoo 2007, thaum Lub Kaum Ob Hlis, Grassley Charles tau qhia txog nws daim Bill S. 2470, DHEA Abuse Reduction Act of 2007, uas tau npaj los hloov kho Cov Tshuaj Tiv Thaiv Cov Ntawv Sau. Qhov no yuav ua rau qhov tseeb tias cov khoom uas muaj dihydroepiandrosterone tsis tuaj yeem, raws li txoj cai, raug muag kom paub txog lossis tsim cov xwm txheej rau kev muag khoom ntawm qhov no.cov khoom rau cov neeg muaj hnub nyoog qis dua 18 xyoo, tag nrho cov no suav nrog kev muag hauv Internet.
Txawm li cas los xij, raws li daim ntawv qhia, cov khoom lag luam zoo li no, tau kawg, yuav raug xa tawm. Raws li kev rau txim, ib qho tshwj xeeb tsis yog kev ua txhaum cai (civil) kev nplua yuav raug muab. Daim nqi no tau nyeem ob zaug thiab kuj tau hais hauv Pawg Neeg Saib Xyuas Kev Cai Lij Choj.
Tab sis nws yeej tsis tau txais yuav, thiab niaj hnub no kev muag khoom ntawm cov khoom muaj dihydroepiandrosterone raug cai, thaum cov khoom no raug txwv tsis pub siv los ntawm cov neeg koom nrog ntau yam kev sib tw kis las. Txawm li cas los xij, hauv Canada koj tseem yuav xav tau daim ntawv xaj yuav khoom DHEA.
Nyob rau lwm hom
DHEA-S hormone, yog dab tsi? Nws yog tsim nyog sau cia lwm qhov tseeb nthuav. Nws yog hais tias ob qho tib si cov tshuaj hormones thiab sulfate yog tsim los ntawm cov qog adrenal tsuas yog nyob rau hauv cov neeg sawv cev ntawm qhov kev txiav txim ntawm primates, uas yog, nyob rau hauv qis thiab siab dua liab, raws li zoo raws li nyob rau hauv tib neeg. Qhov kev txiav txim ntawm qhov kev tsim khoom no yog raws li nram no: Cov roj (cholesterol), pregnenolone, 17-hydroxypregnenolone thiab DHEA.
Cov qog adrenal ntawm lwm hom tsiaj, suav nrog nas thiab nas, tsis tuaj yeem tsim cov tshuaj hormone no. Nyob rau tib lub sijhawm, qee lub hlwb cov qauv ntawm tsis tsuas yog qis thiab siab dua liab, nrog rau tib neeg, tab sis kuj muaj lwm yam tsiaj muaj peev xwm ntawm de novo synthesis ntawm DHEA thiab nws cov precursors, uas txhais tau tias yog neurosteroids.
Purkinje hlwb, uas ua lub luag haujlwm tseem ceeb hauv kev tsim kev nco thiab kev kawm, tau raug pov thawj tias yog qhov chaw tsim khoom tseem ceeb tshaj plaws rau cov tsiaj txhu thiab lwm yam vertebrate neurosteroids.
rauTxhawm rau kom paub qhov muaj hnub nyoog muaj feem cuam tshuam txog kev ncig ntawm dihydroepiandrosterone, nrog rau lwm yam steroids hauv tib neeg, kev tshawb fawb ntawm nws cov concentration tau ua nyob rau ntau lub sijhawm ntawm kev tsim tom qab yug menyuam. Nws tau txiav txim siab tias lub ncov ntawm nws cov concentration yog hnub nyoog nees nkaum-tsib rau peb caug xyoo. Tom qab nws poob.
Cortisol qib hauv cov ntshav tsis hloov nrog lub hnub nyoog, thiab qhov no ua rau muaj qhov tsis sib xws hauv qhov piv ntawm Dhea / cortisol. Lub luag haujlwm tseem ceeb tshaj plaws ntawm cov tshuaj hormones ua ntej ntawm bioactive kev sib deev steroids xws li testosterone, estrone thiab estradiol hauv cov ntaub so ntswg peripheral tau raug pov thawj.
