Trospium chloride yog ib qho m-anticholinergic blocker uas muaj qee qhov ganglioblocking thiab antispasmodic teebmeem. Cov tshuaj tsis muaj qhov cuam tshuam hauv nruab nrab.
Cov tshuaj muaj peev xwm thaiv m-cholinergic receptors. Tawm tsam keeb kwm yav dhau los ntawm nws qhov kev noj haus, lub suab ntawm cov leeg nqaij pob txha ntawm cov kab mob urinary txo qis, thiab nce kev ua haujlwm ntawm lub zais zis ntawm lub zais zis. Nws yog ib tug antispasmodic, muaj ib tug me me ganglioblocking nyhuv. Tsis muaj kev cuam tshuam hauv nruab nrab.
Pharmacokinetics ntawm cov tshuaj no
Nyob hauv lub cev ntawm trospium chloride yog nqus los ntawm tsawg dua 10%, qhov nqus tau txo qis yog tias cov tshuaj tau noj ua ke nrog cov zaub mov muaj roj. Lub ntim ntawm kev faib tawm yog hais txog 365 litres, nws nkag mus rau hauv lub hauv paus paj hlwb me ntsis. Nws khi rau plasma proteins los ntawm 50-85%.
Biotransformed hauv daim siab cov ntaub so ntswg. Ib nrab-lub neej yog mus txog 20 teev. Qhov nruab nrab plasma concentration yog li 3.5 ng / ml. 85% ntawm cov metabolites raug tshem tawm ua ke nrog quav,5,8% - nrog zis. Hauv cov neeg mob uas mob raum tsis ua haujlwm, kev tshem tawm ib nrab-lub neej yog ob npaug.
Cov lus qhia rau kev siv
Trospium chloride yog qhia rau siv hauv cov xwm txheej hauv qab no:
- Hnub, nocturnal enuresis.
- Nicturia, pollakiuria.
- Detrusor-sphincter-dyssynergy tshwm sim los ntawm kev sib tshuam catheterism.
- Cov kab mob spastic ntawm kev ua haujlwm ntawm lub zais zis ntawm cov kab mob neurogenic (nrog rau neurogenic hyperreflexia, detrusor hyperactivity uas tshwm sim tawm tsam keeb kwm ntawm parkinsonism, mob stroke, kis tau thiab congenital pathologies ntawm tus txha caj qaum, kev raug mob ntawm tus txha caj qaum, ntau yam sclerosis).
- Cov ntaub ntawv sib xyaw ntawm urinary incontinence.
- Hyperactivity ntawm lub zais zis, nrog rau qhov nce ntawm qhov tso zis ntau zaus, qhov tseem ceeb tshaj plaws, tso zis tsis ua haujlwm.
Contraindications rau kev siv
Trospium chloride yog contraindicated nyob rau hauv cov neeg mob uas muaj physiological thiab pathological mob xws li:
- Nyob rau hauv cov tshuaj nquag.
- Glucose-galactose malabsorption, lactase deficiency, lactose intolerance.
- Lub raum tsis ua haujlwm yuav tsum tau lim ntshav.
- Cov menyuam yaus, cov tub ntxhais hluas hnub nyoog qis dua 14 xyoos.
- Kev qeeb qeeb ntawm kev khiav tawm ntawm lub plab, nrog rau cov xwm txheej uas ua rau lawv txoj kev loj hlob.
- tso zis tso quav.
- Myasthenic mob.
- Tachyarrhythmia.
- Angle-kaw glaucoma.
Ntxiv rau, muaj ntau tus neeg mob uas yog cov txheeb ze contraindications rau kev siv cov tshuaj. Uas yog, nyob rau hauv lub xub ntiag ntawm xws pathologies, tshuaj raws li trospium chloride yuav tsum tau noj raws li cov lus qhia nrog ceev faj heev. Ntawm lawv:
- Pathologies ntawm vascular system thiab lub plawv, uas nce lub plawv dhia yog undesirable.
- Mob ntshav siab, ntshav siab, mitral stenosis, IHD, mob plawv tsis ua haujlwm, tachycardia, atrial fibrillation.
- YThyrotoxicosis.
- Hiatal hernia, uas ua ke nrog reflux esophagitis, reflux esophagitis.
- Fever.
- YPyloric stenosis, achalasia.
- Kev mob plab hnyuv ntawm tus neeg tuag tes tuag taw, plab hnyuv atony hauv cov neeg laus, hauv cov neeg mob debilitated.
- Hnub nyoog tshaj 40, lub kaum sab kaw glaucoma, qhib-angle glaucoma.
- Ulcerative colitis.
- rau lub raum, lub siab tsis ua haujlwm.
- Qub qhov ncauj.
- Cov ntaub ntawv mob ntsws ntev, tshwj xeeb hauv cov neeg mob uas tsis muaj zog thiab cov menyuam yaus hnub nyoog qis dua.
- Tachycardia, central paralysis hauv cov neeg mob menyuam yaus.
- Nkauj kab mob.
- Head hlwb puas rau menyuam yaus.
- Preeclampsia.
- Pathologies nrog rau kev hloov pauvkab mob urinary.
- tso zis tso quav, tso quav tso rau nws.
- Prostate hypertrophy thaum tsis muaj qhov cuam tshuam ntawm cov zis hloov.
- Autonomic neuropathy.
Siv lub sijhawm lactation, thaum cev xeeb tub
Tshwj xeeb kev sim tshuaj hauv cov pab pawg neeg mob no tsis tau ua. Kev ntsuam xyuas tsiaj tau pom tias muaj kev cuam tshuam tsis zoo ntawm cov tshuaj ntawm tus menyuam hauv plab, ua rau txo qis hauv kev muaj peev xwm. Tsis muaj pov thawj tias cov tshuaj nkag mus rau hauv cov kua mis ntawm cov poj niam, tab sis nws tau raug pov thawj tias nws raug tso tawm hauv cov mis nyuj hauv nas.
Kev siv cov khoom tsim nyog tsuas yog tias qhov txiaj ntsig xav tau rau leej niam tshaj qhov pheej hmoo rau tus menyuam.
Kev siv trospium chloride
Cov neeg laus thiab cov menyuam yaus hnub nyoog qis dua 14 xyoos yuav tsum tau noj tshuaj ntawm qhov ncauj. Cov ntsiav tshuaj nrog koob tshuaj 15 mg yuav tsum tau noj peb zaug hauv ib hnub, 1 daim txhua. Lub sijhawm nruab nrab ntawm cov koob tshuaj yuav tsum yog 8 teev. Qhov siab tshaj plaws ib hnub tau tso cai noj 45 mg.
Cov ntsiav tshuaj nrog koob tshuaj 30 mg tau qhia tias yuav tsum tau noj peb zaug hauv ib hnub, ½ daim, lossis thaum sawv ntxov - tag nrho cov ntsiav tshuaj, thiab yav tsaus ntuj - ½. Qhov koob tshuaj txhua hnub yuav tsum tsis pub tshaj 45 mg.
Thaum kho cov neeg mob uas mob raum tsis ua haujlwm, tsis pub ntau tshaj 15 mg ntawm cov tshuaj siv rau ib hnub.
Lub sijhawm nruab nrab ntawm qhov kev kho mob yog 2-3 lub hlis. Yog tias xav tau kev kho mob ntev dua, tus kws kho mob yuav tsum tshuaj xyuas cov txheej txheem. Kev kho mob txhua 3-6 lub hlis.
Cov tshuaj trospium chloride yuav tsum tau ua nruj me ntsis saib.
Qhov tsis zoo ntawm cov tshuaj
Thaum kho, tus neeg mob tuaj yeem tsim cov kev mob tshwm sim hauv qab no:
- Hypertensive crisis, tachyarrhythmia, fainting, retrosternal mob - los ntawm vascular system thiab lub plawv.
- Ntau lossis me ntsis nce hauv kev ua haujlwm transaminase, gastritis (tej zaum tsawg), tsam plab, raws plab, mob plab, xeev siab, cem quav, dyspeptic tshwm sim, qhov ncauj qhuav - los ntawm txoj hnyuv.
- Ua tsis taus pa - los ntawm ib sab ntawm txoj hlab pa.
- Kev tsis meej pem, tsis meej pem - los ntawm sab ntawm National Assembly.
- Kev hloov pauv tsis zoo hauv cov leeg pob txha (tej zaum tsawg) - los ntawm cov leeg nqaij thiab pob txha.
- Kev ua txhaum ntawm kev pab - los ntawm lub cev qhov muag.
- tso zis tso tseg, ua tsis taus pa ntawm lub zais zis - los ntawm cov zis.
- Stevens-Johnson syndrome, anaphylactic tshuaj tiv thaiv, daim tawv nqaij pob.
Special Recommendations
Yog tias muaj kev ua txhaum ntawm kev ua haujlwm ntawm sphincter, nws yog qhov tsim nyog los xyuas kom meej tias lub zais zis ua tiav. Qhov no yog ua tiav nrog lub catheter. Thaum cov kab mob vegetative ua rau lub zais zis tsis ua haujlwm, qhov no yuav tsum tau txiav txim siab ua ntej pib kho. Nws tseem yog ib qho tseem ceeb kom txiav txim siab tawm tsam kab mob urinary thiab carcinoma, xws li nws yuav tsum tau kho etiotropic. Yuav tsum tau cais tawmCov dej num uas muaj kev phom sij uas yuav tsum tau ua kom muaj kev saib xyuas thiab pom kev pom (qhov chaw pw tuag tes tuag taw tshwm sim).
Kev sib tham nrog lwm yam tshuaj
Amantadine, tricyclic antidepressants, Quinidine, antihistamines thiab beta-adrenergic stimulants tau zoo dua tiv thaiv keeb kwm ntawm kev noj tshuaj.
Chaw khaws tshuaj - qhuav, tiv thaiv los ntawm lub teeb thiab siv tsis tau rau cov menyuam yaus, kub 15-25 ° C. Txee lub neej 5 xyoo.
Analogues
Lub ntsiab analogues ntawm trospium chloride yog "Spazmolit" thiab "Spazmeks". Cov tshuaj muaj qee yam contraindications thiab tuaj yeem ua rau muaj qhov tshwm sim tsis zoo, thiab yog li ntawd qhov muaj peev xwm siv tau los hloov pauv yuav tsum tau tham nrog tus kws kho mob.
Trospium chloride tshuaj xyuas
Cov neeg mob nco txog qhov ua tau zoo ntawm cov tshuaj hauv kev kho mob urinary incontinence thiab enuresis. Cov tshuaj yog heev zam, txawm li cas los, cov neeg mob muaj xws li ib tug drawback raws li ib tug dav daim ntawv teev cov ncaj qha thiab txheeb ze contraindications. Txawm li cas los xij, nrog kev ua tib zoo ua raws li cov lus pom zoo kho mob thiab ua raws li cov tshuaj noj, cov tshuaj tuaj yeem tshem tawm qhov teeb meem uas tau tshwm sim. Nws yog ib qho tseem ceeb kom nco ntsoov tias txhua yam tshuaj yuav tsum tau noj tsuas yog raws li kws kho mob tau sau tseg. Peb tau tshuaj xyuas cov lus qhia siv rau trospium chloride.
