Cov tshuaj tiv thaiv rov ua dua tau dhau los ua ib kauj ruam tshiab hauv tshuaj thiab tshuaj tiv thaiv. Tam sim no, hom tshuaj tiv thaiv no tau siv dav tshaj plaws, tiv thaiv kab mob siab B. Cia peb xav txog cov yam ntxwv ntawm cov tshuaj ntawm cov chav kawm no, lawv qhov sib txawv tseem ceeb. Cia peb mloog rau cov khoom nto moo tshaj plaws.
cov ntaub ntawv dav dav
Kev tsim cov tshuaj tiv thaiv recombinant yuav tsum xub cloning cov noob caj noob ces los tsim cov antigen, tom qab ntawd qhia cov khoom siv raw rau hauv vector, qhia cov vector rau hauv cov neeg tsim khoom. Cov kauj ruam tom ntej yog kev sim cog qoob loo, tom qab ntawd cov antigen raug cais tawm thiab ua kom huv. Lwm qhov kev xaiv yog siv cov neeg tsim khoom ua ib feem ntawm cov tshuaj tiv thaiv.
Cov khoom npaj yuav tsum tau kawm ua ntej. Txhawm rau ua qhov no, siv cov tshuaj siv uas tau ua tiav cov kev sim ntawm qib preclinical thiab nyob rau theem kho mob. Qhov sib txawv ntawm cov series sib txawv qhia tias tsis ruaj khov vectors thiab poob ntawm cov vectors los ntawm cov khoom siv cellular hauv chav ua haujlwm. Nyob rau theem kawg ntawm kev ua haujlwm, nws yuav tsum tau xyuas seb qhov feem pua ntawm cov cell loj npaum li cas nrog rau cov vector. Rau tus kab mob vectortsim cov kev cai nruj. Attenuation yuav tsum siab, thaum cov kev ua ntawm oncogenic yog tsis tsim nyog. Nws yog qhov tsim nyog siv cov khoom uas ua rau muaj kev cuam tshuam tsis zoo ntxiv.
Yam tshuaj yav tom ntej?
Cov tshuaj tiv thaiv rov ua dua muaj kev nyab xeeb tag nrho, cov kws tshawb fawb tau hais. Cov nyiaj no qhia txog kev ua tau zoo. Cov txheej txheem tsim khoom ntawm cov khoom lag luam tshuaj no suav nrog kev siv cov txheej txheem zoo tshaj plaws thiab niaj hnub thiab cov thev naus laus zis. Cov khoom tiav yog siv los tsim cov kev npaj nyuaj rau kev txhaj tshuaj tiv thaiv ntawm cov pejxeem. Lawv siv tso cai rau tib neeg los txhim kho kev tiv thaiv ntau yam kab mob tib lub sijhawm.
About cov khoom nto moo: "Bubo-Kok"
Cov tshuaj tiv thaiv Bubo-Kok yog tsim los ntawm kev ncua kev npaj rau kev txhaj tshuaj rau cov leeg nqaij. Cov tshuaj no tsis yog siv nrog kev ua rau lub cev muaj zog, kev ua rau lub paj hlwb loj zuj zus, cov teeb meem loj uas yav tas los tshwm sim tom qab txhaj tshuaj tiv thaiv. Tsis txhob siv cov tshuaj yog tias tus neeg mob yav tas los raug mob febrile convulsions. Cov tshuaj tiv thaiv tsis yog siv rau hauv lub sijhawm mob hnyav ntawm tus kab mob, thaum lub sijhawm rov tshwm sim ntawm cov kab mob ntev. Hauv cov xwm txheej zoo li no, kev txhaj tshuaj tiv thaiv raug ncua mus txog thaum tus neeg xav tau rov zoo.
Cov tshuaj tiv thaiv Bubo-Kok txhaj rau hauv cov leeg, rau hauv pob tw. Yuav tsum tau siv lub quadrant sab nraud. Nws tso cai rau nkag mus rau hauv lub anterior lateral femoral nto. Ib koob tshuaj yog ib nrab milliliter. Cov tshuaj tiv thaiv yog muab raws li lub sijhawm txhaj tshuaj tiv thaiv hauv tebchaws. Yog tus menyuam muaj hnub nyoog qis dua peb lub hlishnub nyoog tseem tsis tau txais cov tshuaj tiv thaiv kab mob siab B, nws yog ib qho tsim nyog yuav tsum txhaj "Bubo-Kok" peb zaug. Thaum pib, kev txhaj tshuaj yog muab thaum muaj hnub nyoog peb hlis, tom qab ntawd rov ua ob zaug nrog ib thiab ib hlis ib nrab ncua.
Daim ntawv thov nta
Yog tias yuav tsum tau siv tshuaj tiv thaiv Bubo-Kok recombinant, nws yog txwv tsis pub ua kom luv luv ntawm kev txhaj tshuaj. Qee zaum yuav tsum tau nce lub sijhawm tos. Nyob rau hauv cov ntaub ntawv no, cov tshuaj yog siv sai li sai tau raws li cov me nyuam txoj kev noj qab haus huv tso cai txhaj tshuaj. Yog tias tau txhaj tshuaj DTP yav dhau los ib zaug lossis ob zaug, thiab tsis muaj kev tiv thaiv kab mob siab B, yuav tsum tau txhaj tshuaj monovaccine ntxiv. Lawv siv cov tshuaj Bubo-Kok los ua kom tiav cov kev txhaj tshuaj tiv thaiv kab mob, uas yuav tsum suav nrog kev txais cov tshuaj tiv thaiv peb zaug.
Kev txhaj tshuaj rov yog ua los ntawm kev qhia txog DTP ib zaug thaum muaj hnub nyoog 18 hli. Yog hais tias cov txheej txheem raug ua txhaum cai, kev txhaj tshuaj thib ob yog 12-13 lub hlis tom qab thawj chav kawm. Yog tias tseem tsis tau txhaj tshuaj tiv thaiv kab mob hauv lub hnub nyoog plaub xyoos, muab tshuaj toxoid ADS rau cov menyuam yaus hnub nyoog qis dua rau xyoo lossis ADS-M rau cov neeg laus.
Kev ua haujlwm yam ntxwv
Yog koj nug tus kws kho mob tias "cov tshuaj tiv thaiv rov qab" txhais tau li cas, nws ua haujlwm li cas, tus kws kho mob yuav teb tias nws yog cov khoom lag luam tshwj xeeb uas tsim los tiv thaiv kev mob hnyav. Cov txheej txheem tsim khoom tau piav qhia saum toj no. Lub pharmacology ntawm cov tshuaj yog xws li hais tias ib tug neeg muaj ib tug tshwj xeeb kev tiv thaiv uas tiv thaivKab mob tetanus, tsis suav nrog hnoos hawb pob, diphtheria thiab kab mob siab B.
Kev siv cov tshuaj no los nrog qee yam txaus ntshai. Recombinant txhaj tshuaj tiv thaiv tuaj yeem ua rau lub sijhawm luv luv, cov tshuaj tiv thaiv hauv zos. Qhov kub thiab txias tuaj yeem nce, qhov xwm txheej ntawm tus menyuam tsis muaj zog, qhov chaw txhaj tshuaj teb nrog qhov mob thiab kub rau qhov kov. Muaj qhov ua tau ntawm lub zos edema. Feem ntau qhov no tshwm sim thawj ob hnub tom qab kev taw qhia. Tsis tshua muaj, kev txhaj tshuaj ua rau qaug dab peg, ua xua, thiab qw nrov nrov.
Recombinant Poov Tshuaj Vaccine
Cov khoom no yog tsim los ntawm lub tuam txhab kws tshuaj hauv tsev Combiotech. Nws muaj cov tshuaj formula ntawm aluminium-sorbed protein uas ua los ntawm cov poov xab recombinant. Cov muaj pes tsawg leeg muaj cov tshuaj tiv thaiv antigen, uas muab kev tiv thaiv kab mob siab B. Cov tshuaj tiv thaiv muaj 20 micrograms ntawm cov protein, ib nrab milligram ntawm ib qho txhuas compound. Nws muaj peev xwm suav nrog cov khoom siv tshuaj tiv thaiv - merthiolate. Yog tias muaj ib qho, nws yog siv los ntawm 50 mcg. Koj tuaj yeem tshawb xyuas qhov muaj cov tshuaj tiv thaiv nyob rau hauv cov lus qhia uas nrog rau kev tso tawm tshwj xeeb.
Cov tshuaj tiv thaiv yog tsim los txhaj rau hauv cov leeg nqaij. Koj tsis tuaj yeem siv cov tshuaj nyob rau hauv cov kab mob hnyav, ua npaws, rhiab heev rau cov khoom xyaw ntawm cov khoom. Tsis txhob siv yog tias koj ua xua rau cov khoom uas muaj cov poov xab. Ib daim ntawv teev cov contraindications zoo sib xws yog muaj nyob rau hauv cov tshuaj tiv thaiv Bubo M, uas yog suav hais tias yog ib qho kev ntseeg tau zoo ntawm cov tshuaj tiv thaiv kab mob sib kis.
Txoj Kevapps
Kev qhia txog tshuaj tiv thaiv kab mob poov xab tuaj yeem ua rau muaj qhov nce hauv lub cev tag nrho. Qee tus neeg mob taub hau. Tus me nyuam yuav hnov xeev siab. Qhov chaw txhaj tshuaj yog qee zaum cuam tshuam los ntawm qhov mob, nws dhau los ua me ntsis denser. Cov khoom yog npaj rau cov menyuam yaus thiab cov neeg laus. Thaum muab tshuaj, koj yuav tsum tau coj los ntawm lub teb chaws txhaj tshuaj tiv thaiv daim ntawv qhia hnub thiab cov lus qhia rau cov tshuaj.
Cov npe tshuaj tiv thaiv rov ua dua, ntxiv rau cov uas tau piav qhia, kuj suav nrog RDNA. Qhov no yog ib qho khoom siv recombinant tsim los tiv thaiv kab mob siab B. Nyob rau hauv tib daim ntawv teev npe, koj tuaj yeem pom cov kev tsim kho tshuaj Engerix B, Eberbiovak. Cov khoom "Euvax B", belongs rau cov chav kawm ntawm kev txhaj tshuaj tiv thaiv raws li kev txiav txim siab, paub zoo.
Regevac B
Cov khoom no kuj yog recombinant, raws li tau hais nyob rau hauv cov lus qhia nrog rau kev siv. "Regevak B" yog tsim nyob rau hauv daim ntawv ntawm cov kua dawb, me ntsis tig mus rau hauv grey. Yuav tsum tsis muaj qhov pom kev suav nrog. Ib koob tshuaj yog ib nrab milliliter. Nws muaj 10 µg ntawm cov kab mob thiab cov khoom tsis sib xws, 25 µg ntawm cov tshuaj tua kab mob thiab txhuas sorbent. Lub preservative tivthaiv tej zaum yuav ploj lawm. Txhawm rau kom meej meej nws muaj, koj yuav tsum kawm cov ntaub ntawv nrog rau ib qho ampoule tshwj xeeb. Cov me nyuam koob tshuaj - 0.5 mg. Rau cov neeg laus, ob zaug lub ntim yog teem.
tshuaj kho mob
Regevac B yog cov khoom lag luam tshuaj tsim los tiv thaiv tus mob kab mob siab B. Nws muaj cov tshuaj tiv thaiv kab mob tshwj xeeb uas huv huv. Khoom tsimrecombinantly siv cov poov xab kab lis kev cai. Txoj kev tswj hwm tshuaj tiv thaiv tso cai tsim cov antigens tshwj xeeb hauv tib neeg. Kev tiv thaiv titer yog ua tiav hauv qhov nruab nrab ntawm 90% ntawm cov neeg tau txais tshuaj tiv thaiv.
Cov tshuaj yog siv thaum tsim nyog los txhaj tshuaj tiv thaiv raws li daim ntawv qhia hnub lub teb chaws. Cov tshuaj tau qhia rau cov neeg uas tau ntsib nrog cov khoom muaj kab mob siab B, nrog rau txhua tus neeg ua haujlwm noj qab haus huv ua haujlwm nrog ntshav. Nws yog ib qho tsim nyog los tswj cov tshuaj tiv thaiv rau cov neeg ua haujlwm hauv kev tsim cov khoom siv tshuaj tiv thaiv kab mob los ntawm tib neeg cov ntshav.
Cas thiab xyaum
Cov chaw tsim tshuaj tiv thaiv Regevac B qhia txog kev siv tshuaj no rau cov neeg uas muaj kev pheej hmoo kis tus kab mob siab B. Cov no yog cov neeg ntawm txhua lub hnub nyoog uas nyob hauv tib lub tsev uas muaj tus kab mob los yog tus neeg mob ntev nrog kab mob siab.. Cov qeb uas muaj kev pheej hmoo siab suav nrog cov neeg nyob hauv tsev menyuam ntsuag, cov tsev kawm ntawv nce qib, nrog rau cov neeg uas tau txais cov khoom siv ntshav tas li, ncaj qha ntshav. Tib qhov kev pheej hmoo yog tshwm sim hauv cov neeg mob uas muaj kab mob ntshav siab thiab cov uas raug yuam kom ua siab ntev hemodialysis.
Kev txhaj tshuaj tiv thaiv yog pom zoo rau cov tub ntxhais kawm cuv npe hauv tsev kawm kho mob theem nrab, qib siab dua. Qhov no muaj tseeb tshwj xeeb rau cov kawm tiav. Yuav tsum txhaj tshuaj tiv thaiv rau cov neeg txhaj tshuaj lawv tus kheej.
Daim ntawv thov nta
"Regevak B" raug tso cai muab rau tus menyuam thawj hnub, tom qab ib hlis ntawm lub neej, ua raws li lwm tusnyob rau hauv ib lub hlis thiab thaum muaj hnub nyoog ib xyoos, yog hais tias leej niam tau kuaj pom muaj kab mob siab B los yog ib tug kab mob xws li mob. Yog tias ib tug neeg tsis tau txhaj tshuaj tiv thaiv yav dhau los, tau ntsib nrog cov khoom siv biomaterial, nws yuav tsum tau muab tus neeg sawv cev ua ntej, tom qab ntawd ib hlis thiab ob tom qab thawj zaug txhaj tshuaj.
Nws raug tso cai los tswj hwm "Regevak B" thiab cov tshuaj tau sau tseg raws li daim ntawv qhia hnub lub tebchaws nyob rau tib hnub. Hauv qhov no, cov koob txhaj tshuaj sib txawv yog siv. Cov tshuaj tau txhaj rau ntau qhov chaw ntawm lub cev xav tau.
