Cov tshuaj "Avastin" yog suav tias yog tshuaj tua kab mob, uas yog hais txog cov tshuaj tiv thaiv kab mob monoclonal. Thaum siv cov tshuaj, muaj qhov txo qis hauv metastatic kev loj hlob ntawm pathology thiab microvascular permeability nyob rau hauv ntau yam malignant neoplasms, tshwj xeeb tshaj yog cov muaj feem xyuam rau cov qog mammary nyob rau hauv cov poj niam, cov nyuv, raws li zoo raws li lub txiav thiab prostate qog.
Cov tshuaj
Avastin muaj nyob rau hauv daim ntawv ntawm kev mloog zoo, uas yog npaj rau kev npaj cov tshuaj rau infusion, tej zaum yuav tsis muaj xim los yog nrog ib tug maj mam brownish tint.
Cov tshuaj tseem ceeb ntawm cov tshuaj yog bevacizumab. Cov cuab yeej no muaj nyob rau hauv pob ntawm 100 mg, qhov twg 4 ml ntawm cov tshuaj nquag, thiab 400 mg / 16 ml.
Pharmacological action
"Avastin" - tshuaj tiv thaiv cov qog uas ua rau qeeb ntawm kev tsim cov tshiabcov hlab ntsha muab cov as-ham thiab oxygen rau cov ntaub so ntswg ntawm neoplasm, thiab yog li tso cai rau kev hloov ntawm cov qog nqaij hlav los ntawm qhov hnyav mus rau ib qho mob ntev. "Avastin" (kev tshuaj xyuas ntawm cov neeg mob thiab kws kho mob - kev pom zoo ntawm qhov no) muaj kev cuam tshuam loj heev ntawm metastases ntawm ntau yam malignant neoplasms.
Nws yog ib qho tseem ceeb rau tus neeg sawv cev no kis tau los ntawm cov ntaub so ntswg hauv qhov tsawg kawg nkaus, ntxiv rau, nws tau tawm hauv lub cev mus ntev, uas tso cai rau koj kom tswj tau qhov xav tau ntawm cov khoom tseem ceeb ntawm cov tshuaj., tswj nws nruj me ntsis raws li cov lus qhia - ib zaug txhua 14-20 hnub. Cov tshuaj no tawm tsis tau los ntawm lub siab los yog raum, tab sis los ntawm tag nrho cov hlwb ntawm lub cev rau 18 hnub nyob rau hauv cov txiv neej, thiab cov poj niam - 20.
Tab sis yog Avastin zoo tiag tiag? Cov neeg mob tshuaj xyuas hais tias qhov no yog ib qho tshuaj zoo heev yog tias ua ke nrog kev kho mob rau ntau hom qog noj ntshav. Cov cuab yeej no ua rau lub sijhawm muaj sia nyob hauv txhua pab pawg neeg mob, thaum qhov kev loj hlob ntawm tus kab mob tsis tshwm sim.
"Avastin": cov lus qhia rau kev siv
Cov tshuaj no tau siv dav hauv kev kho mob qog noj ntshav. Cov kws kho mob sau nws:
- Kev mob qog nqaij hlav hauv plab hnyuv loj. Cov tshuaj tau pom zoo kom siv nrog rau kev kho mob raws li "Fluoropyrimidine".
- Kev mob qog noj ntshav mis metastatic. Siv ua thawj kab kev kho mob ua ke nrog Paclitaxel.
- ThaumKev siv tsis tau, muaj ntau yam metastatic, lossis tsis yog squamous, tsis yog mob qog noj ntshav ntawm tes me me raws li kev kho thawj kab ua ke nrog kev kho mob platinum-based chemotherapy.
- Rau qhov mob qog noj ntshav siab lossis mob qog noj ntshav cuam tshuam rau lub raum hlwb - raws li kev kho thawj zaug ua ke nrog "Interferon alfa-2a".
- Glioblastoma nrog kev kho hluav taws xob thiab Temozolomide hauv cov neeg mob tshiab, ib leeg lossis nrog Irinotecan hauv cov neeg mob uas rov tshwm sim glioblastoma lossis mob qog noj ntshav.
- Cov neeg mob tau kuaj pom tus poj niam qhov chaw mos malignancy thiab thawj kab mob qog noj ntshav peritoneal. Hauv qhov no, nws raug nquahu kom sau tshuaj Avastin ua thawj txoj kev kho mob ua ke nrog Carboplatin thiab Paclitaxel.
Ntxiv rau, cov tshuaj tau muab tshuaj ua ke nrog Carboplatin thiab Gemcitabine rau cov kab mob loj zuj zus lossis cov neeg mob platinum-sensitive nrog mob qog noj ntshav ntawm cov poj niam hauv nruab nrog cev lossis peritoneum uas tsis tau txais kev kho mob yav dhau los nrog cov tshuaj no lossis lwm yam inhibitor VEGF.
Yuav ua li cas ntaus "Avastin" kom raug?
"Avastin" (kev tshuaj xyuas ntawm cov neeg mob thiab kws kho mob paub tseeb tias qhov no) yog ib qho tshuaj zoo, tab sis nws yuav tsum tau muab tshuaj kom raug, thiab tsuas yog nyob rau hauv kev saib xyuas ntawm kws kho mob. Nws yog txwv tsis pub nkag musdav hlau - tsuas yog intravenously, thiab ces maj mam li sai tau. Kev suav yog 5 mg rau 1 kg ntawm lub cev hnyav ib zaug txhua ob lub lis piam.
Qhov xav tau ntawm cov concentrate yog diluted hauv 100 ml ntawm 0.9% sodium chloride. Thawj koob tshuaj yog pom zoo kom muab ib thiab ib nrab teev tom qab kws khomob, ces txhaj tshuaj Avastin yog muab ua ntej los yog tom qab cov txheej txheem. Yog tias tus neeg mob tau txais kev txhaj tshuaj thawj zaug yam tsis muaj teeb meem, ces nws tuaj yeem muab tshuaj ntxiv hauv ib teev, thiab txhua qhov kev txhaj tshuaj tom qab ib nrab teev, tab sis tsuas yog tias qhov kev txhaj tshuaj thib ob tau txais txiaj ntsig zoo los ntawm tus neeg mob.
Cov koob tshuaj, txawm tias muaj qhov tsis zoo, tsis pom zoo kom txo qis, yog tias tsim nyog, kev kho mob raug ncua lossis tso tseg.
Yog tias tus neeg mob tau kuaj pom tias muaj mob qog noj ntshav lossis mob qog noj ntshav, ces thawj koob tshuaj pom zoo yog 5 mg rau ib kg ntawm lub cev hnyav ib zaug txhua 14 hnub lossis 7.5 mg / kg, tab sis txhua 21 hnub. Yog tias txoj kab thib ob ntawm kev kho mob, ces koob tshuaj tau nce 2 zaug.
Yog hais tias ib tug poj niam tau kuaj mob cancer mis, qhov no, raws li kev txhaj tshuaj thawj zaug, nws raug nquahu kom suav cov tshuaj ntawm 10 mg / kg thiab txhaj ib zaug txhua ob lub lis piam. Los yog ntawm peb, tab sis qhov no, 15 mg ib kg ntawm lub cev hnyav yog noj.
Yog tias muaj cov tsos mob ntawm kev loj hlob ntawm pathology, kev kho mob yuav tsum nres.
Yog tias muaj kev ua tsis tau zoo, metastatic lossis rov tshwm sim tsis yog-squamous lossis tsis yog me me ntawm lub ntsws qog noj ntshav, kev kho mob yog ua tiav nrog kev kho mob nrog cov tshuaj Pt (tsis pub ntau tshaj 6 lub voj voog), thiab tom qab ntawdCov tshuaj yog siv raws li monotherapy.
Thaum cov tsos mob ntawm kev mob qog noj ntshav tshwm sim, Avastin yuav tsum raug txiav tawm. Cov lus qhia rau kev siv hais tias: yog tias tsis muaj kev vam meej, ces qhov kev suav yog 7.5 mg / kg txhua 14 hnub, lossis cov koob tshuaj tau muab faib ua ob zaug thiab muab ib zaug txhua peb lub lis piam ntxiv rau Cisplatin lossis Carboplatin.
Rau lub raum mob qog noj ntshav, koob tshuaj yuav tsum tsis pub ntau tshaj 10 mg / kg txhua 15 hnub. Yog tias muaj cov tsos mob tshwm sim ntawm tus kab mob, kev kho mob yuav tsum nres.
Cov neeg laus tsis tas yuav kho cov koob tshuaj.
Avastin Overdose
Kev noj tshuaj ntau dhau feem ntau tshwm sim yog tias tus neeg mob tau txais koob tshuaj loj - 20 mg ib kg ntawm tus neeg mob lub cev hnyav ib zaug txhua 14 hnub.
Nyob rau hauv cov ntaub ntawv no, migraine tawm tsam tej zaum yuav tshwm sim nyob rau hauv ib tug complex daim ntawv, ntxiv rau, muaj ib tug nce nyob rau hauv lub undesirable teebmeem tau piav qhia hauv qab no. Tsis muaj tshuaj tiv thaiv tshwj xeeb, tsuas yog siv cov tsos mob kho.
"Avastin" phiv
"Avastin" yog ib qho tshuaj zoo heev, feem ntau nws yuav pab txo qis kev loj hlob ntawm tus kab mob loj, tab sis feem ntau cov neeg mob ntsib qhov tshwm sim tsis zoo. Muaj tsawg zaus, lawv tuaj yeem hnyav heev:
- Kev mob plab thiab hnyuv.
- Internal los ntshav.
- Arterial thromboembolism.
- ntshav siab nce thiabproteinuria tsim. Feem ntau yuav, qhov no yog qhov tshwm sim ntawm kev noj tshuaj ntawm tus neeg mob.
Tsis tas li ntawd, cov neeg mob uas tau muab tshuaj Avastin muaj lwm yam kev mob tshwm sim:
- dub vein thrombosis, complex plawv tsis ua hauj lwm, supraventricular tachycardia, los ntshav;
- leukopenia, neutropenia, qis hemoglobin, thrombocytopenia;
- peritoneal tsis xis nyob, plab zom mov, ntshav hauv cov quav, kis kab mob hauv qhov ncauj, cov pos hniav los ntshav, plab hnyuv;
- nosebleed, tsis muaj oxygen, pulmonary thromboembolism;
- daim tawv nqaij qhuav, tshuaj pleev ib ce, cov tawv nqaij ntawm daim tawv;
- poob saj, poob ceeb thawj, syncope, migraine, stroke, pw tsaug zog;
- pom qhov tsis pom kev;
- mob qhov twg txhaj tshuaj;
- uterine los ntshav, urinary tract infections, qaug zog, lub cev qhuav dej.
Contraindications rau kev siv
Puas yog Avastin rau txhua tus? Kev tshuaj xyuas cov neeg mob hais tias qhov no yog ib qho tshuaj zoo heev, tab sis nws tseem muaj contraindications rau kev siv, thiab ua ntej pib kho, tus kws kho mob yuav tsum tham txog lawv. Cov tshuaj yuav tsum tsis txhob muab tshuaj rau hauv cov xwm txheej hauv qab no:
- yog tias muaj qhov tsis txaus siab tshwj xeeb rau cov khoom tseem ceeb;
- muaj kab mob kis ntawm qhov muag thiab thaj chaw periocular;
- muaj intraocularCov txheej txheem inflammatory;
- qis dua 18;
- Y cev xeeb tub thiab lactation.
Ntxiv rau, yog tias tus neeg mob muaj kev pheej hmoo ntawm kev mob stroke, ces kev txhaj tshuaj Avastin tsuas yog tom qab tus neeg mob tau ua tib zoo tshuaj xyuas thiab nws tau txiav txim siab tias cov tshuaj yuav muaj txiaj ntsig.
Cov lus qhia tshwj xeeb
Kev kho nrog tshuaj yuav tsum tsuas yog ua los ntawm tus kws kho mob uas muaj kev paub txog kev txhaj tshuaj intraocular.
Tom qab kev kho tau raug qhia, nws tsis pom zoo kom tsav tsheb thiab ua haujlwm cuam tshuam nrog cov txheej txheem rau qee lub sijhawm, thiab tag nrho vim tias qhov tsis pom kev tsis pom kev tuaj yeem tshwm sim.
"Avastin" (cov chaw tsim khoom qhia qhov no hauv cov lus qhia) yuav tsum khaws cia hauv lub tub yees nkaus xwb, thiab tsis muaj qhov yuav tsum tau khov. Muaj los ntawm kev sau ntawv nkaus xwb.
Avastin cuam tshuam nrog lwm yam tshuaj li cas?
Tshuaj "Avastin" tsis sib haum nrog cov tshuaj dextrose. Tsis tas li ntawd, cov tshuaj yuav ua rau muaj kev pheej hmoo ntawm kev phiv yog tias noj ua ke nrog cov tshuaj no:
- "Sunitinib malate" - microangiopathic hemolytic anemia tuaj yeem tsim;
- platinum thiab taxanes - tuaj yeem txhim kho cov teeb meem ntawm cov kab mob sib kis, mob hnyav neutropenia, nce kev pheej hmoo ntawm kev tuag;
- "Panitumumab" thiab "Cetuximab" - ua rau muaj tshuaj lom thiab ua rau tuag taus.
"Avastin" hauv ophthalmology
Tsis ntev los no, cov xov xwm tshaj tawm tias cov tshuaj "Avastin" yog siv los ntawm kws kho qhov muag los kho cov kab mob qhov muag thiab muab cov txiaj ntsig zoo heev. Tab sis yog nws? Cov neeg tsim khoom hais li cas txog qhov no? Cov tshuaj no puas tuaj yeem tsis tsuas yog txwv tsis pub cov qog loj hlob, tab sis kuj kho cov kab mob ntawm lub cev ntawm qhov muag?
Yog, qhov tseeb, muaj cov ntaub ntawv hais tias qee cov neeg mob, tau hnov txog cov txiaj ntsig ntawm cov tshuaj rau lub qhov muag, txiav txim siab thiab txhaj tshuaj "Avastin" rau hauv lub cev vitreous, tab sis cov txiaj ntsig tau poob siab. Cov tshuaj tsis tau coj lawv los kho, ntawm qhov tsis sib xws, nws coj mus rau qhov tseeb tias tib neeg tsuas yog dig muag. Roche tau hais ntau zaus tias Avastin tsis tuaj yeem siv rau hauv kev kho qhov muag, nws lub hom phiaj txawv.
Cov tshuaj no yog tsim los txo qhov kev siv ntawm kev loj hlob ntawm cov hlab ntsha uas pub cov malignant neoplasm, yog li txo qhov kev siv ntawm cov qog loj hlob. Tias yog vim li cas ua ntej pib kho thiab mloog cov lus pom zoo uas tsis txhawb nqa, nws yog qhov zoo dua mus ntsib kws kho mob.
"Avastin": analogues
Raws li seb puas muaj cov tshuaj hloov pauv uas yuav muaj tib yam tshuaj hauv lawv cov muaj pes tsawg leeg, Avastin tsis muaj lawv. Muaj cov analogues raws li cov txheej txheem ntawm kev ua, thiab lawv kuj muab cov txiaj ntsig zoo hauv kev ua kom qeeb ntawm cov hlab ntsha thiab kev loj hlob ntawm cov qog nqaij hlav cancer. Cov no suav nrog:
- "Arzerru".
- "Campas".
- "Rituximab".
- "Mabtheru" thiab lwm tus
Tab sis nws yuav tsum nco ntsoov tias tus kws kho mob yuav tsum xaiv qhov analogue.
"Avastin": tshuaj xyuas ntawm cov neeg mob thiab kws kho mob
"Avastin" (cov lus qhia rau kev siv lees paub qhov no) yog tib cov tshuaj uas muaj bevacizumab hauv nws cov khoom, pab ua kom qeeb ntawm cov hlab ntsha uas pub cov qog thiab ua rau qeeb zuj zus ntawm cov kab mob. Feem ntau ntawm cov kws kho mob uas tau soj ntsuam cov kev mob ntawm tus kab mob nyob rau hauv ib tug tshwj xeeb cov neeg mob hais tias tom qab ob peb txhaj tshuaj, ib tug slowdown nyob rau hauv lub qog loj hlob yog pom, qhov tseem ceeb tshaj plaws yog noj cov tshuaj kom raug thiab tsis ua ke nrog cov tshuaj, nyob rau hauv lem. kev sib xyaw ua ke, tuaj yeem ua rau mob hnyav rau tus neeg mob.
suav nrog, peb tuaj yeem hais tseeb tias "Avastin" (chaw tsim khoom - F. Hoffmann-La Roche) yog qhov zoo heev, uas pab ua kom lub neej ntev ntawm cov neeg mob qog nqaij hlav cancer. Tab sis tsuas yog nws yuav tsum tau siv nyob rau hauv kev saib xyuas nruj ntawm kws kho mob, txwv tsis pub cov txiaj ntsig yuav rov qab tsis tau thiab xaus tu siab.
