Lub xya xyoo txij li thaum lub lag luam tau tshwm sim ib qho kev kho mob zoo rau kev kho mob ntshav qab zib, kev txais tos uas tsis ua rau cov kab mob uas twb muaj lawm ntawm cov hlab plawv, ob lub raum thiab daim siab, hais tias kev tshuaj xyuas ntawm cov ntshav qab zib. "Trajenta", uas yog raws li enzyme blocker dipeptidyl peptidase-4 linagliptin, hais txog cov tshuaj hypoglycemic. Lub pharmacological kev txiav txim ntawm cov tshuaj yog tsom txo cov synthesis ntawm cov tshuaj hormonal glucagon, nrog rau kev tsim cov tshuaj insulin. Cov tshuaj no tam sim no tau lees paub tias yog ib qho kev cog lus zoo tshaj plaws rau kev tswj cov kab mob txaus ntshai ntawm hom 2 mob ntshav qab zib.
Dab tsi yog ntshav qab zib?
Qhov no yog pathology ntawm cov kab mob endocrine, vim tias qhov concentration ntawm cov piam thaj hauv cov ntshav ntawm tus neeg nce ntxiv, vim lub cev tsis muaj peev xwm nqus tau cov tshuaj insulin. Cov txiaj ntsig ntawm tus kab mob no hnyav heev - cov txheej txheem metabolic tsis ua haujlwm, cov hlab ntsha, cov kabmob thiab cov kab ke cuam tshuam. Ib qho txaus ntshai tshaj plaws thiab insidious yog hom 2 mob ntshav qab zib. Tus kab mob no hu ua kev hem thawj rau tib neeg.
Ntawm qhov ua rau tuag ntawm cov pejxeem nyob rau ob lub xyoo dhau los, nws tau tawm los rau saum. Lub ntsiab provocative yam nyob rau hauv txoj kev loj hlob ntawm tus kab mob yog tsis ua hauj lwm ntawm lub cev tiv thaiv kab mob. Lub cev tsim cov tshuaj tiv thaiv uas muaj kev puas tsuaj rau cov hlwb ntawm cov txiav. Raws li qhov tshwm sim, cov piam thaj hauv cov khoom loj tuaj yeem nkag mus rau hauv cov ntshav, muaj kev cuam tshuam tsis zoo rau lub cev thiab lub cev. Raws li qhov tshwm sim ntawm qhov tsis sib xws, lub cev siv cov rog los ua lub zog, uas ua rau muaj kev nce ntxiv ntawm ketone lub cev, uas yog cov tshuaj lom. Yog li ntawd, txhua yam txheej txheem metabolic tshwm sim hauv lub cev raug cuam tshuam.
Yog li ntawd, nws yog ib qho tseem ceeb tshwj xeeb tshaj yog thaum kuaj pom muaj mob, xaiv txoj kev kho kom raug thiab siv cov tshuaj zoo, piv txwv li, Trazhent, tshuaj xyuas cov kws kho mob thiab cov neeg mob uas tuaj yeem pom hauv qab no. Kev phom sij ntawm ntshav qab zib yog tias nws yuav tsis ua rau muaj kev tshwm sim nyob rau lub sijhawm ntev, thiab kev kuaj pom cov piam thaj ntau dhau tau raug kuaj pom los ntawm lub sijhawm thaum lub sijhawm tshuaj xyuas tom ntej.
Txoj Kev Mob Ntshav Qab Zib
Cov kws tshawb fawb thoob ntiaj teb tau tshawb fawb tas li txhawm rau txheeb xyuas cov qauv tshiab los tsim cov tshuaj uas tuaj yeem kov yeej tus kab mob txaus ntshai. Nyob rau hauv 2012, ib tug tshwj xeeb tshuaj tau sau npe nyob rau hauv peb lub teb chaws, uas xyaum tsis ua rau muaj kev phiv thiab yog zoo zam los ntawm cov neeg mob. Tsis tas li ntawd, nws raug tso cai rau noj los ntawm cov tib neeg uas muaj lub raum thiab lub siab tsis txaus -yog li nws tau sau rau hauv kev tshuaj xyuas txog Trajent.
Cov teeb meem hauv qab no ntawm ntshav qab zib yog qhov txaus ntshai:
- txo qis hauv qhov pom kev pom mus txog qhov poob tag;
- tsis ua haujlwm rau lub raum;
- kab mob vascular thiab lub plawv - myocardial infarction, atherosclerosis, coronary artery disease;
- nres kab mob - cov txheej txheem purulent-necrotic, ulcerative lesions;
- tshwm sim ntawm abscesses ntawm dermis;
- daim tawv nqaij fungus;
- neuropathy, uas yog tshwm sim los ntawm convulsions, tev tawm thiab txo qis rhiab ntawm daim tawv nqaij;
- coma;
- nqi qis qis tsis ua haujlwm.
"Txoj Kev": piav qhia, muaj pes tsawg leeg
Cov tshuaj yog tsim nyob rau hauv ntsiav tshuaj ntau npaum daim ntawv. Round biconvex ntsiav tshuaj nrog beveled npoo muaj lub teeb liab plhaub. Ntawm ib sab muaj lub cim ntawm lub tuam txhab tsim khoom, nthuav tawm hauv daim ntawv engraving, ntawm qhov tod tes - tus lej cim npe D5.
Cov khoom xyaw nquag yog linagliptin, vim nws cov txiaj ntsig siab, tsib milligrams txaus rau ib koob. Cov tshuaj no, los ntawm kev tsim cov tshuaj insulin, txo cov synthesis ntawm glucagon. Cov nyhuv tshwm sim ib puas thiab nees nkaum feeb tom qab noj - nws yog tom qab xws li lub sij hawm uas nws siab tshaj plaws concentration nyob rau hauv cov ntshav yog pom. Excipients xav tau rau kev tsim cov ntsiav tshuaj:
- magnesium stearate;
- pregelatinized thiab pob kws hmoov nplej;
- mannitol yog diuretic;
- copovidone yog nqus tau.
Lub plhaub muaj hypromellose, talc, xim liab (hlau oxide), macrogol, titanium dioxide.
Txoj kev tshuaj
Raws li kws kho mob cov kev xav, Trazhenta tau ua pov thawj nws cov txiaj ntsig hauv kev kho mob ntshav qab zib hom 2 hauv tsib caug lub tebchaws, suav nrog Russia, hauv kev kho mob. Kev tshawb fawb tau ua nyob rau hauv nees nkaum-ob lub teb chaws, uas ntau txhiab tus neeg mob ntshav qab zib hom 2 tau koom nrog hauv kev sim tshuaj.
Vim qhov tseeb tias cov tshuaj tau tawm ntawm lub cev ntawm tus neeg los ntawm txoj hnyuv, thiab tsis yog los ntawm ob lub raum, yog tias lawv ua haujlwm tsis zoo, tsis tas yuav kho cov tshuaj noj. Qhov no yog ib qho ntawm qhov sib txawv tseem ceeb ntawm Trazhenta thiab lwm yam tshuaj antidiabetic. Cov txiaj ntsig tom ntej yog raws li hauv qab no: tus neeg mob tsis muaj kev mob ntshav qab zib hauv cov ntshav thaum noj tshuaj, ob qho tib si nrog Metformin thiab ua monotherapy.
About tshuaj manufacturers
Kev tsim cov tshuaj Trazhenta, tshuaj xyuas uas muaj pub dawb, yog ua los ntawm ob lub tuam txhab tshuaj.
- Eli Lilly tau ua tus thawj coj thoob ntiaj teb hauv kev muab cov kev daws teeb meem tshiab los txhawb cov neeg mob ntshav qab zib rau 85 xyoo. Lub tuam txhab tab tom nthuav dav nws cov ntau yam, siv cov kev tshawb fawb tshiab tshaj plaws.
- Boehringer Ingelheim tau ua nws keeb kwm txij li xyoo 1885. Koom nrog hauv kev tshawb fawb, kev tsim kho, tsim khoom, thiab muag tshuaj. Lub tuam txhab no yog ib qho ntawm nees nkaum tus thawj coj hauv ntiaj teb hauv kev lag luam tshuaj.
Early 2011Ob lub tuam txhab tau kos npe rau daim ntawv cog lus kev koom tes hauv kev tiv thaiv kab mob ntshav qab zib, ua tsaug rau qhov kev vam meej tseem ceeb tau ua tiav hauv kev kho tus kab mob insidious. Lub hom phiaj ntawm kev sib cuam tshuam yog tshawb nrhiav kev sib xyaw tshiab ntawm plaub yam tshuaj uas yog ib feem ntawm cov tshuaj tsim los tshem tawm cov tsos mob ntawm tus kab mob.
Cov lus qhia rau kev siv
Raws li kev tshuaj xyuas thiab cov lus qhia rau kev siv, Trazhenta tau pom zoo siv rau hauv kev kho mob ntawm hom 2 mob ntshav qab zib mellitus ob qho tib si raws li kev kho mob monotherapy thiab ua ke nrog lwm cov tshuaj tiv thaiv kab mob, nrog rau kev npaj insulin. Hauv thawj kis, nws tau sau tseg ntawm:
- contraindications rau noj Metformin lossis raum puas;
- tswj glycemic tsis txaus vim kev tawm dag zog thiab noj zaub mov tshwj xeeb.
Yog tias tsis muaj txiaj ntsig ntawm kev kho mob monotherapy nrog cov tshuaj hauv qab no, nrog rau kev pab ntawm kev noj zaub mov noj thiab kev ua si lub cev, kev kho nyuaj yog qhia.
- Nrog sulfonylurea derivatives, Metformin, thiazolidinedione.
- YNrog insulin lossis Metformin, pioglitazone, sulfonylurea derivatives thiab insulin.
- Nrog Metformin thiab sulfonylurea derivatives.
YContraindications
Raws li kev tshuaj xyuas thiab cov lus qhia, "Trazhent" raug txwv tsis pub noj thaum tos tus menyuam, nrog rau kev pub niam mis. Hauv kev tshawb fawb preclinical, nws tau pom tias cov tshuaj nquag (linagliptin) thiab nws cov metabolites nkag mus rau hauv cov kua mis. Yog li ntawd, nws tsis yooj yim suatshem tawm qhov cuam tshuam tsis zoo rau tus menyuam hauv plab thiab crumbs uas pub niam mis. Yog tias nws tsis tuaj yeem tshem tawm cov tshuaj thiab hloov nws nrog ib qho zoo sib xws, cov kws kho mob hais kom hloov los ntawm ntuj mus rau khoom noj khoom haus.
Kev noj tshuaj kuj yog contraindicated raws li cov hauv qab no:
- underteen8;
- mob ntshav qab zib ketoacidosis;
- mob ntshav qab zib hom 1;
- tus neeg intolerance rau cov khoom xyaw uas ua rau Trazhenta.
Hauv kev tshuaj xyuas ntawm cov kws kho mob, nrog rau cov lus qhia rau kev siv cov tshuaj no, muaj cov ntaub ntawv hais tias nws yuav tsum tau siv nrog ceev faj los ntawm cov neeg muaj hnub nyoog yim caum xyoo thaum noj cov tshuaj insulin thiab (lossis) tshuaj. Raws li sulfonylurea. Kev tshawb fawb txog cov nyhuv ntawm cov tshuaj ntawm lub peev xwm ntawm kev tsav tsheb mechanisms thiab tsheb tsis tau ua. Txawm li cas los xij, vim muaj qhov tshwm sim ntawm hypoglycemia, tshwj xeeb tshaj yog thaum tau txais kev kho mob ua ke, yuav tsum tau saib xyuas. Yog tias mob pancreatitis raug kuaj pom, cov tshuaj yuav tsum tau txiav. Hauv qhov no, tus kws kho mob yuav xaiv lwm txoj kev kho.
Cov lus qhia tshwj xeeb
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias kev kho mob ntawm hom 1 mob ntshav qab zib ketoacidosis, Trazhenta raug txwv. Hauv kev tshuaj xyuas ntawm cov neeg mob ntshav qab zib, cov lus ceeb toom zoo li no muaj ntau heev. Tsis tas li ntawd, nws tau muab sau tseg tias qhov kev pheej hmoo ntawm pathologies ntawm cov hlab plawv system tsis nce. Cov tib neeg uas muaj lub siab tsis zoo thiab lub raum ua haujlwm tuaj yeem noj tshuaj zoo ntawm cov tshuaj ib txwm,tsis tas yuav hloov kho.
Hauv pab pawg hnub nyoog ntawm xya caum txog yim caum xyoo, kev siv linagliptin pom tau zoo. Muaj qhov txo qis:
- glycosylated hemoglobin;
- Plasma qab zib theem ntawm lub plab khoob.
Kev siv tshuaj los ntawm cov neeg muaj hnub nyoog yim caum xyoo yuav tsum tau ua nrog ceev faj, vim tias kev siv tshuaj hauv pab pawg no tsawg heev.
Qhov tshwm sim ntawm hypoglycemia tsawg tsawg thaum noj ib qho Trazhenta nkaus xwb. Kev tshuaj xyuas tus neeg mob kuj lees paub qhov tseeb no. Tsis tas li ntawd, hauv lawv cov lus, lawv tau sau tseg tias ua ke nrog lwm cov tshuaj rau kev kho mob ntshav qab zib mellitus, kev txhim kho glycemia yog qhov tsis txaus ntseeg. Hauv cov xwm txheej no, yog tias tsim nyog, tus kws kho mob tuaj yeem txo cov koob tshuaj insulin lossis sulfonylurea derivatives. Noj Trajenta tsis ua rau muaj kev pheej hmoo ntawm lub plawv nres lossis mob stroke, uas yog qhov tseem ceeb thaum noj nws thaum muaj hnub nyoog laus dua.
kev tawm tsam tsis zoo
Ntau cov tshuaj siv los kho cov ntshav qab zib mellitus tuaj yeem ua rau muaj kab mob pathological uas cov piam thaj hauv cov ntshav poob qis, uas ua rau muaj kev phom sij loj rau tus kheej. Trazhenta, nyob rau hauv kev tshuaj xyuas uas nws tau hais tias noj nws tsis ua rau hypoglycemia, yog ib qho kev zam rau txoj cai. Qhov no suav hais tias yog qhov txiaj ntsig tseem ceeb tshaj li lwm cov chav kawm ntawm cov neeg ua haujlwm hypoglycemic. Ntawm qhov tsis zoo tshwm sim uas yuav tshwm sim thaum kho nrog Trazhenta,cov hauv qab no:
- pancreatitis;
- hnoos fits;
- nasopharyngitis;
- kev nyuaj siab;
- nce hauv plasma amylase;
- rash;
- thiab lwm tus.
Thaum siv tshuaj ntau dhau, kev ntsuas niaj hnub raug qhia kom tshem tawm cov tshuaj uas tsis tau nqus los ntawm txoj hnyuv thiab kho cov tsos mob.
"Trajenta": tshuaj xyuas cov ntshav qab zib thiab cov kws kho mob
Qhov kev ua tau zoo ntawm cov tshuaj tau rov qab lees paub los ntawm kev kho mob thiab kev tshawb fawb thoob ntiaj teb. Cov kws kho mob endocrinologist hauv lawv cov lus pom zoo siv nws hauv kev kho mob ua ke lossis ua thawj kab kev kho mob. Yog hais tias ib tug neeg muaj ib tug nyiam rau hypoglycemia, uas yog provoked los ntawm kev noj haus tsis txaus thiab kev ua si lub cev, nws yog advisable mus muab tshuaj Trazhent es tsis txhob ntawm sulfonylurea derivatives. Nws tsis yog ib txwm ua tau los ntsuas qhov ua tau zoo ntawm cov tshuaj yog tias nws tau noj hauv txoj kev kho mob, tab sis feem ntau cov txiaj ntsig tau zoo, uas kuj tau sau tseg los ntawm cov neeg mob. Muaj kev tshuaj xyuas ntawm Trazhenta thaum nws tau pom zoo rau kev rog thiab insulin tsis kam.
Qhov zoo ntawm cov tshuaj tiv thaiv kab mob ntshav qab zib no yog tias lawv tsis ua rau qhov hnyav nce, tsis ua rau muaj kev loj hlob ntawm hypoglycemia, thiab tsis ua rau mob raum hnyav. Trazhenta tau nce kev nyab xeeb, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib. Yog li ntawd, muaj ntau qhov kev tshuaj xyuas zoo txog qhov cuab yeej tshwj xeeb no. Ntawm cov minuses yogtus nqi siab thiab tus neeg intolerance.
Analogues ntawm "Trajents"
Kev tshuaj xyuas los ntawm cov neeg mob noj cov tshuaj no feem ntau yog qhov zoo. Txawm li cas los xij, rau qee tus neeg, vim yog qhov tsis txaus siab lossis tsis kam lees, cov kws kho mob pom zoo cov kev kho zoo sib xws. Cov no suav nrog:
- "Sitagliptin", "Januvia" - cov neeg mob noj cov tshuaj no ua ib qho ntxiv rau kev tawm dag zog, noj zaub mov noj, txhawm rau txhim kho glycemic tswj; Tsis tas li ntawd, cov tshuaj tau nquag siv hauv kev kho mob ua ke;
- "Alogliptin", "Vipidia" - feem ntau cov tshuaj no tau pom zoo thaum tsis muaj cov txiaj ntsig ntawm kev noj zaub mov noj, kev ua si lub cev thiab kev kho mob monotherapy;
- "Saxagliptin" - yog tsim los ntawm lub npe lag luam "Ongliza" rau kev kho mob ntawm hom 2 mob ntshav qab zib mellitus, siv ob qho tib si hauv kev kho mob monotherapy thiab nrog rau lwm cov tshuaj ntsiav, nrog rau inulins.
Kev xaiv ntawm ib qho analogue tsuas yog ua los ntawm tus kws kho mob endocrinologist, kev hloov pauv ntawm cov tshuaj yog txwv tsis pub.
Cov neeg mob lub raum tsis ua haujlwm
"Cov tshuaj zoo heev" - cov lus no feem ntau pib rave tshuaj xyuas txog Trazhent. Cov tib neeg uas muaj lub raum tsis ua haujlwm, tshwj xeeb tshaj yog cov uas tau txais hemodialysis, yeej ib txwm muaj kev txhawj xeeb loj thaum noj cov tshuaj tiv thaiv kab mob. Nrog rau qhov tshwm sim ntawm cov tshuaj no hauv lub khw muag tshuaj, cov neeg mob raum pathologies zoo siab rau nws, txawm tias tus nqi siab.
Vim yog qhov tshwj xeeb ntawm kev ua tshuaj, cov piam thaj txo qis thaum noj cov tshuaj ib hnub ib zaug ntawm kev kho tshuaj ntawm tsib milligrams. Ntxiv mus, lub sij hawm noj cov tshuaj tsis muaj teeb meem. Cov tshuaj yog absorbed sai sai tom qab nkag mus rau hauv lub plab zom mov, qhov siab tshaj plaws concentration yog pom ib thiab ib nrab los yog ob teev tom qab noj. Nws raug tso tawm hauv cov quav, piv txwv li lub raum thiab lub siab tsis koom nrog cov txheej txheem no.
Zoo kawg
Raws li kev tshuaj xyuas ntawm cov neeg mob ntshav qab zib, "Trajent" tuaj yeem noj txhua lub sijhawm yooj yim, tsis hais zaub mov thiab tsuas yog ib hnub ib zaug, uas suav tias yog ib qho ntxiv. Tib yam uas yuav tsum nco ntsoov yog tias koj tsis tuaj yeem noj ob zaug ib hnub. Nrog kev sib xyaw ua ke, qhov ntau npaum ntawm Trazhenta tsis hloov. Tsis tas li ntawd, nws txoj kev hloov kho tsis tas yuav muaj teeb meem nrog raum. Cov ntsiav tshuaj tau txais txiaj ntsig zoo, qhov tsis zoo tshwm sim yog qhov tsawg heev. "Trajenta", kev tshuaj xyuas uas muaj kev txaus siab heev, muaj cov khoom xyaw tshwj xeeb nrog kev ua haujlwm siab. Nws tseem yog ib qho tseem ceeb uas cov tshuaj muaj nyob rau hauv daim ntawv teev cov tshuaj uas raug tshem tawm nyob rau hauv lub khw muag tshuaj raws li cov tshuaj dawb.
