Dab tsi yog cov tshuaj zoo li protamine sulfate? Cov lus qhia rau nws siv, nrog rau daim ntawv thiab cov lus qhia ntawm cov cuab yeej no yuav raug qhia hauv qab no.
Composition, piav qhia, daim ntawv
Protamine sulfate yog dab tsi? Nws yog ib qho kev daws teeb meem uas tsim nyob rau hauv daim ntawv ntawm cov kua daj daj los yog xim tsis muaj xim pob tshab, npaj rau kev tswj hwm txoj hlab ntshav. Cov tshuaj raws li cov tshuaj no muaj tib lub npe thiab tseem muaj dej rau txhaj tshuaj.
Protamine sulfate mus muag hauv ampoules, uas tau muab tso rau hauv cov hlwb ua los ntawm polyvinyl chloride zaj duab xis, uas tau ntim rau hauv cov thawv ntawv. Lub pob kuj muaj cov lus qhia siv thiab rab riam ampoule.
Drug action
Protamine sulfate yog dab tsi? Cov lus qhia hais tias nws yog heparin antagonist (tshwj xeeb). 1 mg ntawm cov tshuaj no muaj peev xwm ua rau nruab nrab txog 80-115 units ntawm heparin hauv tus neeg mob cov ntshav.
Qhov kev txiav txim ntawm tus neeg sawv cev hauv qab kev txiav txim siab tom qab txhaj tshuaj tau tshwm sim tam sim ntawd thiab kav ntev li ob teev. Lub complex tsim ntawm cov tshuaj no yog vim muaj ntau ntawm cationic pawg uas khi rau anionic.heparin chaw.
Raws li cov lus qhia, protamine sulfate nyob rau hauv tib neeg lub cev tsim ib tug protamine-heparin complex, uas yog rhuav tshem nrog kev tso tawm tom kawg.
Thaum tus neeg siv tshuaj ntau dhau ntawm tus neeg sawv cev no, tus neeg mob cov ntshav txhaws tuaj yeem txo qis, vim tias cov tshuaj nquag ntawm cov tshuaj hauv nqe lus nug pom muaj kev ua haujlwm anticoagulant siab.
Pharmacokinetics ntawm cov tshuaj
Dab tsi yog cov khoom kinetic ntawm heparin protamine sulfate? Raws li cov kws tshaj lij, cov yam ntxwv pharmacokinetic ntawm cov tshuaj no tsis tau kawm. Yog li ntawd, lawv tsis tau nthuav tawm hauv cov lus qhia.
Qhia rau kev teem caij ntawm kev daws
Yuav ua li cas tus neeg mob tuaj yeem muab tshuaj rau hauv cov tshuaj "Protamine sulfate"? Kev siv cov tshuaj no yog qhia:
- ua ntej kev phais hauv cov neeg noj tshuaj heparin rau kev kho mob;
- nrog hyperheparinemia;
- rau ntshav vim yog heparin overdose;
- tom qab kev phais ntawm cov hlab ntsha thiab lub plawv nrog cov hlab ntsha ntxiv.
txwv tsis pub sau tshuaj
Cov tshuaj "Protamine sulfate" (tsuas yog kws kho mob yuav tsum sau ib daim ntawv tshuaj rau nws qhov kev yuav khoom) yog contraindicated rau siv nyob rau hauv cov nram no:
- thrombocytopenia;
- siab rhiab heev rau cov tshuaj yam tshuaj;
- mob ntshav siab ntshav siab;
- congenital los yogidiopathic hyperheparinemia (nyob rau hauv cov xwm txheej no, cov tshuaj tsis muaj txiaj ntsig, thiab tuaj yeem ua rau los ntshav ntau ntxiv);
- noj tshuaj insulin thiab lwm yam tshuaj uas muaj protamine sulfate;
- ua xua rau cov khoom ntses, suav nrog keeb kwm;
- adrenal cortex insufficiency.
Tsis txhob hais tias muaj kev txwv kev kho mob nrog cov tshuaj no rau cov menyuam yaus.
Thaum cev xeeb tub thiab pub mis "Protamine sulfate" tuaj yeem siv. Txawm li cas los xij, qhov no tsuas yog yuav tsum tau ua yog tias qhov kev xav tau ntawm kev kho mob loj dua qhov kev pheej hmoo rau tus menyuam hauv plab lossis menyuam yaus.
Cov tshuaj "Protamine sulfate": cov lus qhia rau kev siv
Cov tshuaj nyob rau hauv nqe lus nug yuav tsum tau muab maj mam intravenously los ntawm drip los yog dav hlau. Hauv qhov no, tus nqi ntawm kev tswj hwm yuav tsum tsis txhob siab dua 5 mg ntawm cov tshuaj ib feeb. Kev tswj hwm cov tshuaj sai dua tuaj yeem ua rau muaj qhov tshwm sim anaphylactoid hauv tus neeg mob.
Qhov ntau npaum li cas ntawm cov tshuaj no nyob ntawm seb nws siv li cas. Cov koob tshuaj suav nrog yuav tsum tau yaj hauv 300-500 ml ntawm 0.9% sodium chloride tov. Nws yog txwv tsis pub txhaj ntau dua 150 mg ntawm cov tshuaj hauv 60 feeb.
- Nrog rau kev txhaj tshuaj bolus, qhov ntau npaum ntawm protamine sulfate raug txo nyob ntawm lub sijhawm uas tau dhau los ntawm kev qhia txog heparin. Qhov no yog vim qhov tseeb tias tom kawg raug tshem tawm tas li ntawm tib neeg lub cev.
- Yog tias heparin tau muab tso rau hauv cov hlab ntsha, ces nws yog qhov tsim nyognres nws cov infusion thiab siv li 20-30mg protamine sulfate.
- Thaum txhaj tshuaj heparin subcutaneously, qhov koob tshuaj ntawm protamine sulfate yog 1-1.5 mg rau 100 IU ntawm heparin. Nyob rau hauv cov ntaub ntawv no, thawj 25-50 mg yuav tsum tau maj mam intravenously, thiab cov seem - drip intravenously tshaj 8-17 teev. Fractional tswj kuj tseem ua tau, tab sis qhov no yuav xav tau kev tswj hwm nruj ntawm APTT.
- Thaum lub sij hawm phais nyob rau hauv cov ntaub ntawv ntawm extracorporeal ncig, qhov ntau npaum ntawm cov kev txiav txim siab yog 1.5 mg ib 100 IU ntawm heparin.
Lub sijhawm ntev tshaj plaws ntawm kev kho nrog tus neeg sawv cev hauv nqe lus nug yog 3 hnub.
Side action
Puas protamine sulfate ua rau muaj kev phiv tshwm sim? Cov lus qhia hais tias, feem ntau, cov tshuaj no kuj zoo rau cov neeg mob. Txawm li cas los xij, qee zaum, nws tseem tuaj yeem ua rau muaj kev cuam tshuam tsis zoo rau lub cev tiv thaiv kab mob, cov hlab plawv thiab lub plab zom mov, nrog rau daim tawv nqaij:
- bradycardia, txo cov ntshav siab;
- ntuav thiab xeev siab;
- khaus, pob khaus ntawm daim tawv nqaij, kev loj hlob ntawm cov tshuaj tiv thaiv anaphylactoid;
- xav kub, ua tsis taus pa thiab liab ntawm daim tawv nqaij.
Cov neeg mob ntau dhau thiab kev cuam tshuam tshuaj yeeb
Cov tshuaj hauv nqe lus nug, npaj rau kev txhaj tshuaj hauv cov hlab ntsha, tsis sib haum nrog penicillins thiab cephalosporins. Vim lub fact tias nws yog ib tug antagonist ntawm tsawg molecular hnyav heparins, cov tshuaj noTej zaum yuav ua rau kom lub sij hawm thiab kev siv ntawm cov leeg tsis depolarizing.
Kev noj tshuaj ntau dhau tuaj yeem ua nrog los ntshav. Qhov no yog vim lub fact tias cov tshuaj nyob rau hauv nqe lus nug muaj ib tug siab anticoagulant kev ua si. Hauv qhov no, yuav tsum tau kho cov tsos mob.
Special Information
Kuv yuav tsum paub dab tsi ua ntej txhaj tshuaj xws li protamine sulfate? Cov kws tshaj lij hais tias kev siv cov tshuaj no yuav tsum tau tswj hwm nruj los ntawm tus kws kho mob uas yuav tsum tau ua tib zoo saib xyuas tus neeg mob cov ntshav txhaws.
Ua ntej muab cov tshuaj no, xyuas kom tus neeg mob cov ntshav ntim txaus. Qhov no yog vim hypovolemia ua rau muaj kev pheej hmoo ntawm kev tawg.
khaws cia, xa tawm ntawm cov chaw muag tshuaj, hnub tas sijhawm
Puas yog cov tshuaj "Protamine sulfate" muag dawb hauv khw muag tshuaj? Daim ntawv tshuaj nyob rau hauv Latin los yog Lavxias teb sab yuav tsum tau muab rau tus kws muag tshuaj, txwv tsis pub cov tshuaj yuav tsis muab faib.
Khaws tus neeg sawv cev rau lo lus nug kom deb ntawm cov menyuam yaus thiab tiv thaiv los ntawm tshav ntuj, qhov chaw huab cua kub ntawm 4 txog 10 degrees. Nws tseem yuav tsum tau muab sau tseg tias cov tshuaj txhaj "Protamine sulfate" yuav tsum tsis txhob khov.
Lub txee lub neej ntawm cov tshuaj no yog 4 xyoos txij li hnub tsim khoom. Nws yuav tsum tsis txhob siv tom qab lub sijhawm no.
Analogues ntawm cov tshuaj thiab tshuaj xyuas txog nws
Analoguestsis muaj ntau qhov kev pab cuam raws li xav tau. Cov tshuaj tua kab mob tuaj yeem hloov nrog cov tshuaj xws li Protamine thiab Protamine-Ferein.
Raws li cov neeg siv khoom tawm tswv yim, yuav luag txhua tus ntawm lawv yog qhov zoo. "Protamine sulfate" yog ib qho tshuaj zoo heev thiab muaj txiaj ntsig zoo rau txhua tus neeg. Qhov no yog qhov kev xav ntawm cov neeg mob feem ntau. Lawv thov tias cov tshuaj no tsis tso cai rau cov tshuaj heparin ua rau cov txheej txheem ntawm cov ntshav txhaws, ua kom tus neeg mob tus mob los ntshav hnyav.
Tsis tas li, qhov zoo ntawm cov tshuaj no suav nrog nws qhov ua tau sai thiab ntev. Tsis tas li ntawd, kom ua tiav cov txiaj ntsig kho mob, tus neeg mob tsis tas yuav tsum tau kho lub sijhawm ntev. Lub sijhawm siab tshaj plaws ntawm kev siv tshuaj no yog peb hnub.
