Cov kab mob autoimmune yog ib pab pawg ntawm cov kab mob pathological uas muaj kev ua haujlwm ntxiv ntawm kev tiv thaiv kab mob rau koj lub cev. Txhawm rau txo qhov kev tiv thaiv kab mob, cov tshuaj uas ua rau lub cev tsis muaj zog yog raug sau tseg. Cov tshuaj no yog indispensable nyob rau hauv transplantation los tiv thaiv kev hloov pauv tsis kam. Cia peb saib cov tshuaj xws li Azathioprine, analogues ntawm cov tshuaj no, cov lus qhia rau kev siv thiab nws cov nta.
tshuaj yam ntxwv
Hauv nws cov khoom xyaw, cov tshuaj "Azathioprine" muaj cov khoom xyaw nquag ntawm tib lub npe. Cov tshuaj lom neeg no yog ib qho derivative ntawm cov khoom tsim nyog rau kev sib txuas ntawm DNA thiab RNA. Nkag mus rau hauv lub cev, azathioprine cuam tshuam DNA synthesis thiab, raws li, inhibits cov txheej txheem ntawm cell faib hauv cov ntaub so ntswg. Kev txo qis hauv kev ua haujlwm ntawm lub cev tiv thaiv kab mob yog vim muaj cov tshuaj "Azathioprine" ntawm cov ntaub so ntswg lymphoid.
Nyob rau hauv cov ntaub ntawv no, cov txheej txheem ntawm kev faib cell thiab lub cellular teb ntawm kev tiv thaiv yog inhibited. Tom qab kev qhia ntawm cov tshuaj "Azathioprine" nyob rau hauv lub cev, muaj ib tug txo nyob rau hauv tus naj npawb ntawm atypical phagocytes thiab txo nyob rau hauv lub synthesis ntawm immunoglobulins. Cia peb txheeb xyuas cov ntaub ntawv ntxiv: Dab tsi yog cov yam ntxwv ntawm cov tshuaj "Azathioprine", analogues, nqe, cov lus qhia rau kev siv.
YPharmacokinetics
Cov tshuaj no tau zoo heev absorbed rau hauv lub cev, thiab nws qhov siab tshaj plaws concentration yog pom twb 2 teev tom qab kev tswj qhov ncauj. Cov tshuaj tsis yog tshwj xeeb yog tropic rau plasma proteins: nws khi rau lawv mus txog 30%. Azathioprine yog tus cwj pwm los ntawm cov txiaj ntsig ntawm cov metabolism hauv thawj, lossis thawj qhov kev nkag mus hauv lub siab.
Hla dhau los ntawm hepatocytes, cov tshuaj yog metabolized rau cov khoom nquag - mercaptopurine, uas muaj cov tshuaj pharmacodynamic. Yuav luag tag, cov tshuaj tau tawm ntawm lub cev nrog cov kua tsib. Tsis pub ntau tshaj 2% ntawm cov tshuaj tawm hauv cov zis.
Cov lus qhia rau kev siv
Cov tshuaj "Azathioprine", analogues nrog tib cov khoom xyaw nquag tau qhia rau siv hauv kev hloov pauv kom tsis txhob hloov pauv.
Tsis tas li, cov tshuaj no tau siv zoo hauv kev xyaum rheumatological rau kev kho mob rheumatoid mob caj dab thiab kab mob autoimmune xws li kab mob siab, kab mob lupus erythematosus, psoriasis, thrombocytopenic.purpura, pemphigus, thiab ntau ntxiv.
YContraindications
Azathioprine yog contraindicated rau siv rau cov neeg uas muaj hypersensitivity rau ib feem ntawm cov tshuaj. Vim lub fact tias cov tshuaj inhibits tag nrho cov hematopoiesis, Azathioprine yog contraindicated nyob rau hauv cov ntshav cov kab mob (anemia, leukocyto- thiab lymphopenia, thrombocytopenia), raws li zoo raws li nyob rau hauv cev xeeb tub thiab lactating cov poj niam.
Siv thaum cev xeeb tub thiab pub niam mis
Cov tshuaj nquag nkag mus rau hauv cov kua mis thiab dhau ntawm cov kab mob hematoplacental. Yog li ntawd, nws tsis pom zoo siv rau cov poj niam cev xeeb tub thiab pub niam mis. Yog tias tsim nyog los sau cov tshuaj los yog nws cov analogues hauv pawg neeg no, nws yog ib qho tsim nyog los ntsuas qhov kev pheej hmoo los ntawm cov txiaj ntsig ntawm kev siv tshuaj thiab qhov ua rau muaj kev phom sij rau leej niam thiab tus menyuam hauv plab. Thaum muab tshuaj kho thaum pub niam mis, qhov kawg yuav tsum tau muab tso tseg.
Daim ntawv thov nta
Cov tshuaj thiab nws cov analogues yuav tsum tau siv nrog ceev faj rau cov neeg mob khaub thuas, nrog rau cov neeg mob uas muaj xanthine oxidase deficiency.
Side effects
Pab pawg tseem ceeb ntawm cov kev mob tshwm sim yog cuam tshuam nrog inhibition ntawm kev ua haujlwm ntawm cov pob txha pob txha lub luag haujlwm rau kev tsim cov qe ntshav. Thaum siv cov tshuaj analogues uas muaj azathioprine, muaj qhov nce ntawm cov cell hauv cov ntshav, txo cov leukocytes, platelets, anemia.
Rau ib feem ntawm txoj hnyuv, cov kev mob tshwm sim feem ntau yog: txo qis qab los noj mov, quav quav, ua tsis tauskev ua haujlwm ntawm lub siab, ulcerative lesions ntawm txoj hnyuv. Kev puas tsuaj rau hepatocytes nrog kev nce ntxiv hauv cov ntsiab lus ntawm bilirubin thiab lwm yam kev kuaj mob siab. Cov neeg mob uas tau txais kev hloov pauv hauv nruab nrog cev thiab cov ntaub so ntswg tuaj yeem tsim kab mob pancreatitis, ulcerative lesions ntawm lub plab, hnyuv, thiab kev loj hlob ntawm cov kab mob siab.
Kev tsis haum tshuaj tshwm sim tsis tshua muaj thaum cov tshuaj "Azathioprine" raug tswj hwm, analogues raws li nws (piv txwv li, "Imuran"). Cov kev tshwm sim tsis tau nthuav tawm, feem ntau yog los ntawm daim tawv nqaij ua pob lossis ua npaws.
Nrog rau lwm cov kev mob tshwm sim, nws yog ib qho tsim nyog yuav tsum nco ntsoov txog kev txhim kho cov txheej txheem sib kis thib ob hauv lub cev, pom cov leeg nqaij thiab mob pob qij txha, thiab mob raum tsis ua haujlwm. Hauv qee kis mob hnyav, cov tshuaj "Azathioprine", analogues nrog tib yam tshuaj nquag tuaj yeem ua rau hemolytic anemia, muab cov tsos mob ntawm lub hauv nruab nrab lub paj hlwb. Azathioprine ua ib qho tshuaj nquag, uas yog ib feem ntawm cov tshuaj ntawm tib lub npe thiab nws cov analogues, muaj cov txiaj ntsig zoo ntawm tus menyuam hauv plab (teratogenic thiab mutagenic teebmeem), thiab tseem muaj peev xwm ua rau muaj qhov tshwm sim ntawm cov qog nqaij hlav nrog lawv cov kev mob qog noj ntshav. Yog li, nws yog ib qho tsim nyog yuav tsum tau kawm thaum sau tshuaj "Azathioprine" (cov ntsiav tshuaj) tshuaj xyuas, piav qhia, analogues ntawm cov tshuaj thiab xaiv cov tswv yim zoo. Saib ua ntej, peb nco ntsoov tias azathioprine ua cov tshuaj nquag muaj txiaj ntsig zoo ntawm chav kawmkab mob raws li qhia. Tsis yog cov kws kho mob uas tuaj koom tham txog qhov no, tab sis kuj yog cov neeg mob lawv tus kheej.
"Azathioprine" - cov lus sib dhos, cov lus sib dhos
Azathioprine yog ib yam khoom tshwj xeeb nrog cov tshuaj tiv thaiv kab mob. Hauv kev pom ntawm qhov no, kev npaj muaj azathioprine tsis yog dav dav sawv cev ntawm cov khw muag tshuaj. Analogues ntawm "Azathioprine" tuaj yeem sawv cev los ntawm cov tshuaj xws li "Imuran".
Cov tshuaj no muaj nyob rau hauv daim ntawv ntsiav tshuaj nrog tib cov ntsiab lus ntawm azathioprine. Qhov tsuas caveat yog tus nqi ntawm Imuran, uas yuav ua tau 4-5 npaug tshaj tus nqi ntawm Lavxias teb sab-ua Azathioprine.
tshuaj lom thiab tshuaj ntau dhau
Kev noj ntau dhau ntawm cov tshuaj "Azathioprine" thiab nws cov analogue "Imuran" yog tshwm sim los ntawm kev ua txhaum ntawm txoj hnyuv, inhibition ntawm cov pob txha ua haujlwm, nrog rau kev nce hauv kev kuaj mob siab. Kev kho cov tshuaj lom nrog ob qho tib si tshuaj nws tus kheej thiab nws cov analogues yog cov tsos mob, tsom rau kev tshem tawm sai ntawm cov tshuaj los ntawm lub cev. Tsis muaj tshuaj tiv thaiv tshwj xeeb. Dialysis txoj kev detoxification yog ib feem siv tau, vim hais tias cov active tshuaj nrog lawv pab yog tsis tshem tawm tag nrho ntawm lub cev.
Cov lus qhia tshwj xeeb
Cov tshuaj thiab nws cov analogues tsis pom zoo rau kev siv mus ntev. Thaum pib ntawm kev kho mob, kev saib xyuas tas li ntawm cov cellular muaj pes tsawg leeg ntawm cov ntshav peripheral yog qhov tsim nyog, nrog rau kev saib xyuas lub siab enzymes.
Nyob rau yav tom ntej, kev saib xyuas txhua hnub raug tso tseg, ua kev soj ntsuam xyuas ib zaug lossis ob zaug hauv ib hlis.
Zoo kawg
Cov khoom siv tshuaj no thiab nws cov analogues tsuas yog muab los ntawm tus kws tshaj lij kev paub dhau los. Ua ntej koj pib noj cov tshuaj, koj yuav tsum tau kuaj xyuas kom tiav thiab, tejzaum nws, ua kev kho mob. Cov ntaub ntawv ntxiv yog muab thaum muab tshuaj "Azathioprine" cov lus qhia rau kev siv. Tus nqi, analogues ntawm cov tshuaj no kuj feem ntau txhawj xeeb cov neeg mob. Yog li, qhov tsawg kawg nkaus tus nqi ntawm 50 ntsiav tshuaj yog nyob rau hauv cheeb tsam ntawm 250-300 rubles, thiab cov analogues tau hais los saum toj no. Ua ntej koj pib noj nws, koj yuav tsum ntsuas qhov zoo thiab qhov tsis zoo thiab pib kho.
