Ntau hom tshuaj siv los kho cov txheej txheem inflammatory tshwm sim hauv tib neeg lub cev hauv cov ntaub ntawv mob thiab mob ntev. Qee qhov tsis yog-steroidal hauv qhov, lwm tus yog cuam tshuam ncaj qha rau cov tshuaj hormones.
tshuaj ua dab tsi?
Cov pab pawg kawg ntawm cov tshuaj uas kho mob tau zoo yog flucaticasone furoate. Qhov no trifluorinated compound yog tau synthetically. Los ntawm nws qhov xwm txheej, cov tshuaj no belongs rau cov tshuaj hormones ntawm pawg glucocorticosteroid. Cov tshuaj tivthaiv muaj cov tshuaj tiv thaiv zoo heev.
Muaj kev sib raug zoo siab rau glucocorticoid receptors, nws ua rau ntau hom hlwb, xws li macrophages, lymphocytes, eosinophils thiab lwm yam. Cov kab mob sib kis xws li chemokines thiab cytokines kuj raug cuam tshuam.
Nws nkag mus rau hauv lub cev li cas?
Qhov peculiarity ntawm cov tshuaj no yog tias flucaticasone furoate tsis tuaj yeem nqus tau los ntawm lub cev, vim nws tau metabolized los ntawm daim siab. Vim li no,Cov tshuaj yog tus yam ntxwv los ntawm lub cev tsis muaj zog.
Cov ntaub ntawv hauv qab no ntawm kev siv cov tshuaj no yog qhov txawv:
- Kev tswj hwm tus kheej. Nrog rau txoj kev kho tshuaj no, nws cov bioavailability nyob ntawm qhov ntau npaum li cas. Yog tias koj noj cov tshuaj ntawm 110 mcg ib hnub, ces nws cov ntsiab lus hauv tus neeg mob cov ntshav tsis tau kuaj pom. Nyob rau hauv cov ntaub ntawv ntawm kev noj cov tshuaj ntawm ib koob ntawm 880 mcg peb zaug nyob rau hauv 24 teev, nws bioavailability yog 0.5%;
- Yog tias koj noj flucaticasone furoate hauv daim ntawv ntawm kev nqus pa, ces nws qhov ntsuas bioavailability yuav yog 27.3%.
Cov tshuaj no tuaj yeem noj qhov ncauj thiab tso rau hauv.
Cov tshuaj no khi rau cov ntshav plasma protein ntawm tus nqi ntawm 99% lossis ntau dua. Ntxiv mus, nws reacts me ntsis nrog erythrocytes. Flucaticasone furoate yog qhov ua tau zoo metabolized hauv daim siab thiab tawg ua enzymatically rau cov khoom tsis zoo hu ua fluticasone. Cov tshuaj no tawm hauv cov hlab ntsha sai sai.
Yog hais tias cov tshuaj tau noj los ntawm qhov ncauj los yog tso rau hauv cov hlab ntsha, ces nws yuav luag tag nrho tawm ntawm cov hnyuv nrog cov kua tsib thiab ib qho tsis txaus ntseeg tau tawm los ntawm lub raum.
Kev qhia
Fluticasone furoate, cov lus qhia uas yuav tsum tau nrog lub pob nrog cov tshuaj, yog qhia rau cov kab mob hauv qab no:
- Txoj kab mob rhinitis txhua xyoo.
- Kab mob ntsws pulmonary, suav nrog mob ntev.
- Bronchial hawb pob - raws li kev txhawb nqakev kho mob ua ke.
Yog tias koj muaj cov tsos mob tshwm sim, uas tau piav qhia saum toj no, cov tshuaj raws li cov tshuaj nquag no tuaj yeem tiv taus lawv. Txawm li cas los xij, tsis txhob hnov qab txog qhov tseem ceeb ntawm fluticasone furoate tias nws yog tshuaj hormones. Tsuas yog koj tus kws kho mob thiaj li sau tau cov tshuaj no.
YContraindications
Cov khoom lag luam tshuaj no muaj ntau yam contraindications thiab txwv kev siv. Nws yuav tsum tsis txhob noj hauv cov xwm txheej hauv qab no:
- Ntau rhiab heev rau cov khoom xyaw tseem ceeb.
- Cov menyuam yaus hnub nyoog qis dua 18 xyoo (tsis muaj lus qhia tshwj xeeb rau kev kho mob).
txwv tsis pub noj cov tshuaj no tuaj yeem yog:
- siab tsis ua haujlwm.
- Pulmonary tuberculosis.
- Kab mob sib kis tsis kho kom zoo los yog mob ntev.
Hais txog txoj haujlwm ntawm seb fluticasone furoate tuaj yeem siv los ntawm cov poj niam cev xeeb tub thiab lactating, cov lus qhia rau kev siv qhia tias tsis muaj ntaub ntawv txaus txog qhov no. Cov tshuaj no tsuas yog siv thaum muaj kev pheej hmoo rau tus menyuam hauv plab lossis tus menyuam qis dua qhov kev xav tau rau leej niam.
Side effects
Cov lus qhia rau kev siv qhia tau hais tias muaj kev phiv ntau heev los ntawm kev noj cov tshuaj no, uas nyob ntawm seb hom kev siv. Nrog kev siv tshuaj intranasal, lawv tau qhia raws li hauv qab no:
- Kev cuam tshuam hauv kev ua pa: los ntshav los ntawm qhov ntswg, qhov pom ntawm qhov txhab ntawm nws cov mucous membrane.
- ua xua tshwm sim: ua pob khaus ntawm lub cev, angioedema, anaphylaxis, urticaria.
Yog tias fluticasone furoate, kev tshuaj xyuas uas feem ntau zoo, yog siv rau hauv daim ntawv ntawm inhalations raws li ib feem ntawm cov tshuaj ua ke, cov kev mob tshwm sim hauv qab no yuav tshwm sim:
- Cov kab mob sib kis: mob khaub thuas, mob ntsws, mob ntsws, thiab lwm yam tshwm sim zoo sib xws ntawm cov kab mob ua pa sab saud. Oropharyngeal candidiasis kuj tseem tuaj yeem tshwm sim.
- Kev cuam tshuam hauv kev ua haujlwm ntawm lub cev ua pa, uas tuaj yeem tshwm sim hauv daim ntawv mob oropharyngeal, nasopharyngitis, sinusitis, pharyngitis, hnoos, dysphonia thiab sinusitis.
- Kab mob ntawm cov kab mob sib txuas thiab musculoskeletal: pob txha, arthralgia, mob nraub qaum.
- Kuj kuj tuaj yeem ua rau mob plab, mob migraine, ua npaws, extrasystole, glaucoma, txo cov pob txha ntom ntom, hypothalamic-pituitary-adrenal hypothalamus, stunted loj hlob ntawm cov menyuam yaus thiab cov hluas, cataracts.
Yuav thov li cas thiab ntau npaum li cas?
Tshuaj tsuag "Fluticasone furoate" tuaj yeem noj intranasally ib hnub ib zaug. Tsis tas li, cov tshuaj no tuaj yeem siv rau kev nqus pa hauv kev npaj ua ke.
Cov tshuaj ntau npaum li cas yog nyob ntawm lub hnub nyoog ntawm tus neeg mob los ntawm 27.5 txog 55 mcg. Txhawm rau tswj hwm qhov concentration ntawm cov tshuaj nquag, 27.5 mcg ntawm cov tshuaj tau muab.
Cov neeg tsim khoom ntawm cov khoom lag luam tshuaj no ceeb toom tias thaum kho nrog tshuaj nws yogsiv ceev faj hauv kev ua cov dej num uas muaj kev pheej hmoo. Cov no suav nrog cov dej num uas xav tau kev saib xyuas tshwj xeeb thiab cov tshuaj tiv thaiv psychomotor ceev, xws li tsav tsheb lossis cov tshuab ua haujlwm.
Kev Sib Tham Tshuaj
Ceev faj yog qhia thaum siv fluticasone furoate nrog ketoconazole.
Nws kuj tsis pom zoo los koom nrog Ritonavir. Qhov no yog vim muaj kev pheej hmoo ntawm kev txhim kho kev ua haujlwm ntawm fluticasone furoate.
Ntau tshaj
Hauv kev tshawb nrhiav tshuaj ntau dhau, cov neeg mob tau txais 24 npaug ntawm cov tshuaj pom zoo rau ntau tshaj 3 hnub. Raws li qhov tshwm sim, tsis muaj qhov tshwm sim tsis zoo tshwm sim tau raug txheeb xyuas. Tab sis cov tuam txhab tshuaj ceeb toom tias cov nyhuv ntawm glucocorticosteroids tuaj yeem txhim kho. Hauv qhov xwm txheej no, yuav tsum muaj kev saib xyuas kev kho mob thiab kev kho mob tsim nyog raws li cov tsos mob.
Tshuaj
Muaj ntau ntau yam tshuaj nyob rau hauv khw muag tshuaj, lub ntsiab active ingredient ntawm uas yog fluticasone furoate: Avamys, Flutisan, Nazofan, Flutinex, Seroflo, Flohal thiab Flexonase. Cov tshuaj polar tshaj plaws los ntawm kab no yog thawj lub npe tshuaj. Avamis muaj fluticasone furoate ua cov khoom xyaw tseem ceeb thiab muaj raws li cov tshuaj tsuag yooj yim.
Avamys
Txoj kev kho no tau ua pov thawj nws tus kheej los ntawm sab zoo tshaj plaws hauv kev kho mobua xua rhinitis. Nrog rau tus kab mob no, tsis tsuas yog o ntawm lub qhov ntswg mucosa thiab ntau tawm los ntawm nws tshwm sim, tab sis kuj lub qhov muag tshwm sim nyob rau hauv daim ntawv ntawm lacrimation, khaus, liab thiab tsis xis nyob ntawm "xuab zeb". Cov tsos mob no txo qis qhov zoo ntawm tus neeg lub neej txhua hnub, cuam tshuam tsis zoo rau nws qhov kev ua tau zoo thiab ua rau cov nuj nqis tseem ceeb rau kev kho mob. Cov kws tshawb fawb tau pom tias qhov laj thawj tseem ceeb rau kev ua xua tshwm sim yog qhov excitation ntawm cov hlab ntsha parasympathetic, uas yog ua los ntawm cov neeg kho mob ntawm cov kab mob ntawm lub qhov ntswg qhov ntswg. Nrog rau tag nrho cov tsos mob ntawm kev tsis haum rhinitis, tshuaj "Avamys" ua haujlwm zoo heev. Fluticasone furoate, uas yog ib feem ntawm nws cov muaj pes tsawg leeg raws li lub ntsiab active ingredient, ua nyob rau hauv lub active sites ntawm analyzer receptors, uas yog vim li cas thaiv tib neeg lub cev cov tshuaj tiv thaiv rau allergens.
Yog li, tag nrho cov tsos mob tsis kaj siab thiab txawm tias mob hnyav ploj mus, thiab tus neeg mob lub neej zoo tuaj. Vim lub fact tias lub ntsiab tivthaiv muaj ib tug high degree ntawm affinity nrog receptors, lawv cov kev twb kev txuas ua heev muaj zog thiab ntev-ntev, uas ua rau kom cov nyhuv ntev ntawm cov tshuaj.
Tag nrho cov contraindications thiab kev phiv ntawm cov tshuaj no yog ncaj qha ntsig txog qhov tseeb tias cov khoom xyaw nquag ntawm Avamys yog fluticasone furoate, cov lus qhia uas tau muab los saum toj no. Nws ceeb toom tias cov tshuaj hormonal no yuav tsum tsis txhob noj yam tsis muaj kws kho mob tshuaj.
tshuaj sib xyaws
Kuj, rau kev kho mob rhinitis, COPD thiab bronchial hawb pob, kev npaj ua ke uas muaj fluticasone furoate, vilanterol thiab qee cov khoom siv pabcuam tau siv. Cov tshuaj nto moo tshaj plaws hauv peb lub tebchaws yog Relvar Ellipta.
Cov khoom lag luam tshuaj no muaj cov ntsiab lus hauv qab no ntawm cov khoom xyaw nquag hauv ib koob:
- Fluticasone furoate micronized, 100 mcg.
- Vilanterol triphenate micronized, 40 mcg.
Cov tshuaj no tuaj nyob rau hauv daim ntawv ntawm ib metered hmoov rau nqus tau pa. Nws muaj ib tug pronounced anti-inflammatory thiab bronchodilator nyhuv. "Relvar Ellippta" yog hais txog cov tshuaj uas muaj cov nyhuv bronchodilator, vim cov khoom xyaw nquag yog cov tshuaj hormones: xaiv beta-2-adrenergic agonist thiab ib lub zos glucocorticosteroid.
Cov lus qhia rau kev kho mob nrog cov tshuaj no yog:
- mob ntsws asthma, uas cov tshuaj siv rau kev kho mob.
- Kab mob ntsws obstructive pulmonary (COPD). Nrog rau qhov kev kuaj mob no, kev kho mob nrog tshuaj tuaj yeem txo qis exacerbations.
Cov tshuaj tau piav qhia yog npaj tshwj xeeb rau kev nqus pa, uas tau ua ib hnub ib hnub ntawm ib lub sijhawm (thaum yav tsaus ntuj lossis sawv ntxov). Cov neeg tsim khoom pom zoo kom yaug lub qhov ncauj nrog dej tom qab txheej txheem, tab sis tsis txhob nqos.
Cov neeg mob hawb pob yuav tsum tau noj tshuaj, txawm li cas los xijlub xub ntiag ntawm cov tsos mob ntawm tus kab mob. Yog tias thaum lub sijhawm ncua ntawm cov kev kho mob muaj qhov pom tseeb ntawm tus kab mob, ces tus kws kho mob feem ntau muab tshuaj beta 2 -agonists ntawm kev ua luv luv hauv daim ntawv ntawm inhalations. Qhov koob tshuaj tsuas yog xaiv los ntawm tus kws kho mob tuaj koom xwb.
Rau cov neeg laus thiab cov menyuam yaus hnub nyoog qis dua 12 xyoos, cov hauv qab no cov ntsiab lus ntawm cov khoom xyaw nquag (vilanterol trifenatate thiab flucatisone furotate, raws li) hauv ib qho kev nqus tau / 1 zaug hauv ib hnub tuaj yeem raug tshuaj:
- 22mcg + 92mcg;
- 22 mcg + 184 mcg.
Thawj koob tshuaj yog kws kho mob sau rau cov neeg mob uas xav tau qis lossis nruab nrab ntawm cov tshuaj nquag, nrog rau kev kho mob COPD hauv cov neeg laus. Nws yuav tsum tau muab sau tseg tias nws tsis yog siv rau kev kho mob ntawm pulmonary obstruction nyob rau hauv cov me nyuam. Tib koob tshuaj yog muab rau cov neeg uas muaj siab tshaj qhov nruab nrab lub siab ua haujlwm tsis zoo.
hom tshuaj thib ob yog muab rau cov neeg mob uas xav tau ntau dua ntawm cov khoom xyaw nquag hauv kev kho mob bronchial hawb pob, thaum qhov tsawg kawg nkaus tsis muaj qhov xav tau.
Cov neeg muaj hnub nyoog tshaj 65 xyoo, nrog rau cov neeg mob raum, tsis tas yuav kho tshuaj.
Yuav siv cov tshuaj no, muaj ib lub tshuab nqus tsev tshwj xeeb hauv pob, uas muaj cov nuances ntawm kev ua haujlwm thiab kev saib xyuas. Lawv tau piav qhia meej hauv cov lus qhia thiab ua ntej siv, koj yuav tsum ua tib zoo kawm cov lus piav qhia.
Ib qho kev phiv ntawm cov tshuaj tuaj yeem qhia tau hauv cov ntawv hauv qab no:
- Ntau heev: kab mob ua pa sab saud, mob khaub thuas, oropharyngeal candidiasis, mob ntsws; migraine; extrasystole; nasopharyngitis, sinusitis, rhinitis, dysphonia, hnoos; mob plab; pob txha, arthralgia, mob nraub qaum; ua npaws.
- Tsis tshua pom: hypersensitivity, tawm pob, Quincke's edema, urticaria, anaphylaxis; ntxhov siab vim; tshee; tachycardia.
Contraindications rau kev siv ntawm Relvar Ellipta yog:
- Kev tsis haum rau cov mis nyuj protein lossis ib yam tshuaj ntawm cov tshuaj.
- Cov menyuam yaus hnub nyoog qis dua 12.
Cov khoom lag luam tshuaj no yuav tsum tau siv nrog ceev faj rau cov neeg mob uas muaj kab mob plawv hnyav, pulmonary tuberculosis thiab kab mob sib kis.
Cov poj niam cev xeeb tub raug muab tshuaj no tsuas yog thaum qhov teeb meem ntawm nws cov txiaj ntsig rau leej niam txiav txim siab, ntau dua qhov kev pheej hmoo rau tus menyuam hauv plab. Thaum lactating, cov tshuaj no tau sau tseg nrog kev tsis kam pub niam mis thiab tshem tawm qhov kev pheej hmoo rau tus menyuam.
Kev siv ua ke ntawm cov tshuaj "Relvar Ellippta" nrog beta-blockers yuav tsum raug zam, tshwj tsis yog thaum muaj xwm txheej ceev. Koj yuav tsum tau ceev faj thaum sib txuas nrog Ketoconazole thiab Ritonavir.
Analogues
Yog tsis tuaj yeem siv fluticasone furoate los kho cov kab mob rhinitis, COPD, lossis mob hawb pob, cov tshuaj analogues ntawm cov tshuaj no yuav yog lwm txoj hauv kev.
Koj tus kws kho mob, raws litus yam ntxwv ntawm lub cev, sau cov tshuaj tsim nyog. Ntawm cov analogues ntawm cov tshuaj no tuaj yeem sau tseg:
- "Asmaneks";
- "Aurobin";
- Garazon;
- "Dexapos";
- Carizon;
- "Abistan";
- "Beklat" thiab lwm yam tshuaj uas muaj nyob hauv tib pab pawg kws tshuaj nrog flukatisone furotate.
Tsis txhob hnov qab tias cov tshuaj yuav tsum tau noj raws li kws kho mob tau sau tseg thiab tsuas yog tom qab ua tib zoo kawm cov lus qhia.
