Migraine yog ib yam kab mob uas tuaj yeem txo qis kev ua haujlwm ntawm ntau tus neeg mob. Tus kab mob no cuam tshuam txog li 6% ntawm cov txiv neej thiab 18% ntawm cov poj niam. Cov naj npawb no loj heev. Nyob rau tib lub sijhawm, 60% ntawm cov neeg uas raug kev txom nyem los ntawm tus kab mob no nws tus kheej noj ntau yam tshuaj tua kab mob kom tshem tawm qhov mob. Raws li txoj cai, kev ua li no tsuas yog ua rau tus kab mob hnyav dua.
hais tsis yog rau tshuaj loog
Ntau tus neeg uas raug mob migraines tsis paub yuav ua li cas thiaj txwv tau qhov kev tawm tsam thiab noj tshuaj tua kab mob lig. Tsis tshua muaj txiaj ntsig los ntawm kev kho zoo li no. Los yog nws tsis tuaj. Qhov no ua rau qhov tseeb tias tus neeg mob pib maj mam nce cov tshuaj noj. Yog li ntawd, cov kev ua no tsuas yog ua rau muaj kev pheej hmoo ntawm lub raum puas, kev loj hlob ntawm gastritis. Qee zaum, kev noj tshuaj analgesics tuaj yeem ua rau muaj teeb meem loj dua - qhov tshwm sim ntawm kev mob taub hau.
Yog vim li cas yog tias koj muaj cov tsos mob ntawm migraine, koj yuav tsum sab laj nrog kws kho mob tshwj xeeb. Kev kho tus kheej hauv qhov no tsuas yog tuaj yeem ua tauua rau tus neeg mob hnyav dua. Thaum kawg ntawm lub xyoo pua 19th, ib pab pawg tshiab ntawm cov tshuaj tiv thaiv kab mob migraine tau tsim - xaiv agonists ntawm 5 HT 18 / D receptors. Cov tshuaj zoo sib xws yog cov derivatives ntawm 5-hydroxytritamine. Lawv lub npe luv yog triptanites. Cov tshuaj migraine ntawm cov tiam no muaj txiaj ntsig zoo dua li cov tshuaj ua kom zoo. Tsis tas li ntawd, cov nyiaj no tau nkag mus rau txhua pawg ntawm cov neeg mob.
Yuav ua li cas tshuaj ua haujlwm
Triptans yog txoj kev niaj hnub tshaj plaws rau kev kho mob xws li mob tsis zoo li migraine. Nws ntseeg tau tias tag nrho cov tshuaj no ua tib yam nkaus. Txawm li cas los xij, tsuas yog ob peb ntawm cov neeg coob coob ntawm triptans pab ib tus neeg mob. Yog li ntawd, qhov kev xaiv zaum kawg ntawm cov tshuaj no tsuas yog nrog tus neeg mob. Txhawm rau txiav txim siab qhov ua tau zoo ntawm ib qho triptan tshwj xeeb, nws yog ib qho tsim nyog los ntsuas cov tshuaj thaum lub sij hawm mob migraine. Yuav tsum muaj tsawg kawg yog peb ntawm lawv. Yog tias cov tshuaj pab tau, ces nws tuaj yeem siv tau yav tom ntej. Tau kawg, tus nqi ntawm triptan kuj tseem cuam tshuam rau kev xaiv. Tom qab tag nrho, cov tshuaj no kim heev. Tsis tas li ntawd, txhua yam tshuaj muaj qee yam tshuaj ua kom mob. Tsis tas li ntawd, nws tsim nyog paub tias hom triptans muaj nyob rau migraine, cov yam ntxwv ntawm qhov kev txiav txim, yuav ua li cas coj lawv thiab contraindications.
Ua ntej tshaj, cov tshuaj no cuam tshuam rau cov receptors ntawm phab ntsa ntawm cov hlab ntsha. Yog li ntawd, qhov no ua rau kom cov hlab ntsha ntawm lub paj hlwb nqaim, thiab tseem yuav pab txo qhov mob taub hau.
Cov tshuaj no muaj kev xaiv zoo. Tias yog vim li cas triptans muaj kev cuam tshuam rau cov hlab ntsha ntawm dura mater ntawm lub hlwb. Qhov no yog ib qho ntawm lawv cov yam ntxwv. Txawm li cas los xij, lawv tsis cuam tshuam rau peripheral thiab coronary hlab ntsha. Nws yog ib qho tsim nyog sau cia tias triptans yog cov tshuaj migraine uas thaiv qhov tshwm sim ntawm qhov mob tshwm sim ntawm theem ntawm receptors nyob rau hauv tus txha caj qaum ntawm lub paj hlwb trigeminal. Qhov no yuav txo tau qhov mob rhiab heev.
Ntxiv rau, cov tshuaj no tuaj yeem txo qhov zaus ntawm tus kab mob rov qab, nrog rau kev tshem tawm cov tsos mob zoo dua, xws li suab thiab photophobia, ntuav thiab xeev siab.
Kev taw qhia ntawm kev ua ntawm triptans
Yuav kom nkag siab tias cov tshuaj no ua haujlwm li cas, nws tsim nyog hais txog qhov tseem ceeb:
- Txo cov hlab ntsha nyob hauv lub hlwb.
- Anti-inflammatory effect: txo qhov o uas nias ntawm cov hlab ntsha xaus.
- Inhibition ntawm lub paj hlwb trigeminal thiab txo nws qhov mob rhiab heev.
Raws li koj tuaj yeem pom, migraine triptans yog cov tshuaj zoo tshaj plaws uas tuaj yeem tiv thaiv kev mob migraine. Qhov tseem ceeb yog xaiv cov tshuaj zoo
Qhov zoo thiab qhov tsis zoo ntawm triptans
Ntawm qhov zoo ntawm cov tshuaj no, nws tsim nyog hais txog kev tshem tawm qhov mob thiab cov tsos mob cuam tshuam, kev ua haujlwm nrawm. Tsis tas li ntawd, triptans tuaj yeem siv los kho tus kab mob hauv ntau pawg hnub nyoog.
Tau kawg, txhua yam tshuaj muaj nws qhov tsis zoo. Triptans yog qhov zoo rau migraine thiab mob taub hau. Txawm li cas los xij, qhov spectrum ntawm kev ua ntawm cov tshuaj no tseem tsis tau nkag siab tag nrho. Tsis tas li ntawd, tsis yog txhua tus muaj peev xwm noj triptans rau lawv cov laj thawj kev noj qab haus huv. Nws yog txwv tsis pub siv cov tshuaj no rau cov neeg uas muaj kab mob plawv. Cov neeg uas muaj ntshav txhaws thiab mob ntshav siab kuj poob rau hauv pawg no.
Cov tshuaj Migraine - triptans - tau muab faib ua ob peb pawg. Qhov no yog thawj thiab thib ob tiam. Txhua yam tshuaj muaj nws qhov zoo thiab qhov tsis zoo. Yog li, Sumatriptan belongs rau thawj tiam. Qhov no yog thawj zaug tshuaj. Nws yog yuav luag tag kev kawm thiab yog ib hom qauv hauv kev kho mob migraine. 60 txhiab tus neeg tau koom nrog hauv kev sim tshuaj. Cov tshuaj tau pom thawj zaug los ntawm GlaxoSmithKline hauv xyoo 1989.
Yeej, "Sumatriptan" yog muag nyob rau hauv daim ntawv ntawm cov pa coated ntsiav tshuaj thiab tshuaj tsuag. Txhua tus ua haujlwm ib yam nkaus. Qhov siab tshaj plaws tom qab noj cov ntsiav tshuaj tshwm sim tom qab ob thiab ib nrab teev, thiab tshuaj tsuag tom qab 90 feeb.
Second Generation
Triptans - tshuaj migraine uas yog pawg neeg no - muaj ntau heev. Tsis tas li ntawd, lawv tsis to taub zoo. Lawv raug tso tawm nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Qhov zoo tshaj plaws yog:
- "Natriptan" - cov nyhuv tau pom lawm ib teev tom qab noj. Kev hnov mob raug txo. Qhov kev txiav txim siab tshaj plaws losob peb teev tom qab.
- "Frovatripan" - cov tshuaj no tsis muaj zog me ntsis, tab sis thaum nws noj, cov kev mob tshwm sim tsis zoo tshwm sim tsawg dua.
- "Zolmitriptan" - ua 15 feeb tom qab noj. Cov nyhuv siab tshaj plaws yog ua tiav hauv ib teev. Cov tshuaj no ua haujlwm zoo ntawm qhov kawg ntawm kev tawm tsam.
- "Rizatriptan" - zoo ib yam li cov tshuaj ntawm thawj tiam, tab sis muaj kev cuam tshuam ntau dua.
- "Almotriptan" - cov tshuaj no yog ob peb zaug zoo dua li "Sumatriptan". Cov txiaj ntsig siab tshaj plaws tau mus txog tom qab 1.5 teev.
- "Relpax" - cov tshuaj no yog qhov kev tsim kho ntau dua los ntawm kev cuam tshuam cov hlab ntsha ntawm lub hlwb. Txawm hais tias cov yam ntxwv zoo ib yam li Sumatriptan.
tshuaj mob taub hau (triptans): nqe thiab lus pom zoo rau kev noj
Yuav kom paub meej tias cov tshuaj twg muaj nyob, ntawm no yog lub rooj:
| Lub npe lag luam | Gene thoob ntiaj teb lub npe | Khoom noj hauv milligrams | Ntau tshaj txhua hnub noj hauv milligrams | Tus nqi tshuaj nruab nrab |
| Sumamigren | Sumatriptan ntsiav tshuaj | 50 lossis 100 | Tsis ntau tshaj 300 | ntawm 170 rau 387 rubles |
| "Amigrenin" | Sumatriptan ntsiav tshuaj | 50 lossis 100 | Tsis ntau tshaj 300 | Ntawm 132 txog 288 rubles |
| Imigran | Sumatriptan tsuag | 20 | 40 | ntawm 449 rau 1010 rubles |
| Sumatriptan | Sumatriptan ntsiav tshuaj | 50 lossis 100 | Tsis ntau tshaj 300 | Ntawm 88 txog 170 rubles |
| Zomig | Zolmitriptan ntsiav tshuaj | 2,5 | Tsis ntau tshaj 10 | Ntawm 593 rau 1170 rubles |
| "Replaks" | Eletriptan ntsiav tshuaj | 40 | Tsis ntau tshaj 80 | Ntawm 338 txog 636 rubles |
Reception nta
Yog li, txoj hauv kev zoo tshaj los noj triptans rau migraine thiab mob taub hau yog dab tsi? Cov lus qhia nyob rau hauv cov ntaub ntawv no yuav pab txiav txim siab npaum li cas thiab lub sij hawm ntawm kev tswj. Qhov tseem ceeb tshaj plaws yog kom nco ntsoov tias yog mob tshwm sim, uas maj mam nce thiab tsis muaj tus cwj pwm migraine, nws tsis muaj kev nkag siab zoo rau kev noj tshuaj ntawm hom no. Hauv qhov no, yuav tsum tau noj tshuaj tsis tshwj xeeb. Nws tseem ceeb heev. Feem ntau, triptans yuav tsum tau noj tom qab lub aura tas lawm, lossis tsis pub dhau ob teev tom qab qhov pib tsis xis nyob. Tsis tas li ntawd, yog tias mob migraine tshwm sim, triptan tuaj yeem siv nrog lwm cov tshuaj, xws li metoclopramide lossis domperidone.
Raws li cov tshuaj tsuag, lawv yuav tsum siv thaum twgncaj ncees pronounced bouts ntawm xeev siab thiab, ntawm chav kawm, ntuav. Txhawm rau tshem tawm cov xwm txheej ntawm migraine, koj tuaj yeem noj "Imigran". Triptanites tuaj yeem muab tsis tau tsuas yog thaum lub sij hawm kev loj hlob ntawm tus kab mob, tab sis kuj nyob rau hauv lub sij hawm ntawm kev tawm tsam rau kev tiv thaiv. Qhov no tso cai thaum:
- Tus neeg mob lub neej zoo tau poob qis heev.
- NSAIDs nyuaj heev.
- Migraine tawm tsam tshwm sim ntau dua ob zaug txhua 30 hnub.
Yuav ua li cas thiaj mob taub hau
Txhawm rau tshem tawm qhov mob migraine, koj yuav tsum xub sim noj 1000 milligrams ntawm acetylsalicylic acid, dej qab zib uas muaj caffeine, lossis 10 milligrams ntawm Motilium. Yog tias tom qab 45 feeb qhov mob taub hau tsis tau ploj mus, koj tuaj yeem siv triptan.
Nws tsim nyog sau cia tias nyob rau hauv cov xwm txheej uas tsis yog qhov tshwj xeeb analgesic tsis tau muab qhov xav tau rau peb qhov kev tawm tsam, koj tuaj yeem siv tshuaj kho mob migraine tam sim ntawd. Yog tias muaj aura, koj yuav tsum siv cov tshuaj aspirin tsuas yog tom qab nws pib, thiab tom qab pib mob - tshuaj rau migraine (triptans).
Yuav ua li cas yog qhov mob rov qab?
Kwv yees li 50% ntawm cov neeg mob tau mob taub hau rov qab li ob peb hnub. Cov kws tshaj lij pom zoo hauv qhov xwm txheej zoo li no kom noj tshuaj ntxiv rau migraine - triptans. Hauv qhov no, nws tsim nyog nco ntsoov qhov siab tshaj plaws niaj hnub tshuaj ntawm cov tshuaj. Noj cov tshuaj tsis pub dhau ob teev tom qab thawj ntsiav tshuaj. Yog ua tau mob taub hauzam, tus neeg mob tuaj yeem hloov lub triptan nrog ib qho tshuaj tsis haum tshuaj.
Nws tsim nyog sau cia tias qhov rov qab los ntawm qhov tsis xis nyob feem ntau pom hauv cov neeg mob uas muaj kev tawm tsam ntev txaus uas tuaj yeem kav ntev dua 24 teev yam tsis muaj tshuaj kho mob. Txawm tias tawm tsam keeb kwm ntawm kev noj ib qho triptan, qhov zaus ntawm cov xwm txheej no tseem yuav luag zoo ib yam. Txawm li cas los xij, cov kws tshaj lij ntseeg tias kev siv "Eletriptan" thiab "Naratriptan" yuav pab txo qis kev tawm tsam tshiab.
Yog tsis muaj qhov tshwm sim
Muaj cov xwm txheej thaum cov tshuaj migraine (triptans) thiab cov tshuaj tsis haum tshuaj tsis muab cov txiaj ntsig xav tau thiab tsis tshem tawm qhov mob. Nyob rau hauv cov ntaub ntawv no, tus kws kho mob yuav sau ntawv complex txoj kev kho, uas muaj xws li noj tshuaj anticonvulsant, nrog rau B-blockers. Cov tshuaj no suav nrog Nadolol, Acebutalol, Penbutolol, Labetanol, Betaxolol thiab lwm yam.
Cov teebmeem ntawm triptans
Cov tshuaj no tuaj yeem noj tau 10 hnub hauv ib hlis xwb. Txwv tsis pub, tej zaum yuav muaj teeb meem. Kev siv ntau zaus ntawm triptans tuaj yeem ua rau muaj mob taub hau uas tshwm sim thaum noj tshuaj. Ntxiv rau, cov tshuaj ntawm qhov kev txiav txim no muaj kev phiv, suav nrog:
- Xav txog qhov sov thiab qhov tawv nqaij ntawm ko taw, tsaug zog, asthenia, kiv taub hau, tsis hnov tsw.
- mob plab lossis tus po, ischemic colitis, hemorrhagic raws plab, qhov ncauj qhuav, mob hauv cheeb tsamplab thiab xeev siab.
- Myalgia thiab leeg tsis muaj zog.
- mob plawv, myocardial infarction, angina, tachycardia, palpitations.
- polyuria thiab tso zis ntau zaus.
- Anaphylactic shock, angioedema, urticaria.
Txawm hais tias tag nrho cov no, migraine triptans yog ib qho kev kho sai sai. Yog tias koj noj cov tshuaj nruj me ntsis raws li cov lus qhia, ces yuav tsis muaj teeb meem. Lub tsuas drawback ntawm cov tshuaj no yog tus nqi. Tsis yog txhua tus muaj peev xwm yuav tau cov tshuaj no.
