Pancreatic qog marker: hom thiab cov qauv

Cov txheej txheem:

Pancreatic qog marker: hom thiab cov qauv
Pancreatic qog marker: hom thiab cov qauv

Video: Pancreatic qog marker: hom thiab cov qauv

Video: Pancreatic qog marker: hom thiab cov qauv
Video: Tshuaj theem vim li cas thiaj tau nqi ?/ Siv kho mob dab tsi?/paris polyphylla use for? 2024, Kaum ib hlis
Anonim

Yog tias muaj qhov tsis txaus ntseeg ntawm kev tsim cov qog nqaij hlav qog nqaij hlav, tus kws kho mob tshwj xeeb yuav tsum tau tshuaj xyuas cov ntshav uas txiav txim siab txog qhov tshwm sim ntawm tus txiav txiav. Txoj kev tshawb no yog ib qho ntawm thawj zaug siv rau kev tshawb pom ntxov ntawm cov txheej txheem oncological. Ob peb hom tshuaj uas tsim los ntawm cov qog raug teeb tsa, thiab lawv tau teeb tsa los ntawm cov kev tshawb fawb tshwj xeeb hauv chav kuaj.

qog marker rau pancreatic cancer
qog marker rau pancreatic cancer

Indications rau kev tshawb fawb

Muaj ntau ntau yam kab mob uas yuav tsum tau kuaj xyuas tus kab mob qog nqaij hlav rau kev kuaj mob raws sij hawm ntawm cov txheej txheem pathological:

  • mob pancreatitis;
  • cystic formations thiab lwm yam qog nqaij hlav qog nqaij hlav, tshwj xeeb tshaj yog cov uas nce qhov loj thaum ua tiav ultrasound;
  • kev kho mobdaim duab, uas yog ib txwm rau oncology ntawm lub caj pas;
  • pseudotumorous pancreatitis;
  • saib xyuas qhov ua tau zoo ntawm kev ua haujlwm (yuav ua li cas tshem tawm tag nrho cov tsim) thiab kev kho kom zoo (kev kho mob, hluav taws xob) rau mob qog noj ntshav pancreatic;
  • txhawm rau tsim cov kab mob metastatic ntawm lwm cov kabmob, yog tias tsis muaj cov tsos mob ntawm metastases;
  • tos kwv yees kab mob qog noj ntshav.

Txoj cai npaj rau kev kawm

Txhawm rau npaj rau kev kuaj mob qog nqaij hlav pancreatic, koj yuav tsum ua raws qee cov lus pom zoo:

  • Tsis txhob haus lossis noj lwm yam uas tsis yog cov dej huv uas tsis muaj carbonated rau kaum teev ua ntej kev kuaj: cov protein nkag mus rau hauv cov ntshav tom qab noj mov tuaj yeem ua rau qhov kev kuaj pom tsis tseeb.
  • Tsis txhob haus cawv tsawg kawg ob hnub ua ntej kev xeem.
  • Tsis pub tsawg tshaj li ib hnub ua ntej kev kuaj mob, koj yuav tsum tso cov khoom qab zib, kib, qab ntsev, cov zaub mov muaj roj thiab lwm yam khoom noj uas txhim kho cov kua txiv kua txiv pancreatic, nrog rau lub plab hnyuv thiab lwm yam kab mob hauv plab.
  • qog cov cim rau lub txiav
    qog cov cim rau lub txiav

Rau ob lub lis piam ua ntej kev tshuaj ntsuam xyuas cov kab mob pancreatic, tsis txhob noj cov tshuaj hauv txhua hom kev tso tawm (cov tshuaj pleev, tshuaj pleev, tshuaj, ntsiav tshuaj, thiab lwm yam), suav nrog lwm cov tshuaj npaj (infusions thiab tshuaj ntsuab tshuaj yej). Yog tias tus neeg mob noj cov tshuaj uas tsim nyog rau lub neej, piv txwv li,anticonvulsants rau qaug dab peg, ntshav-thinning, tshuaj antihypertensive, ces lawv tsis tuaj yeem muab tso tseg. Txawm li cas los xij, nws yog ib qho tseem ceeb kom qhia rau koj tus kws kho mob txog lawv txoj kev siv ua ntej kev kawm txog cov kab mob qog nqaij hlav pancreatic.

Kev ua haujlwm lub cev thiab ntau yam kis las yuav tsum tsis txhob ua tsawg kawg ib hnub ua ntej kev tshuaj xyuas. Nws tseem yog qhov tsim nyog kom tsis txhob muaj kev ntxhov siab neuro-kev xav.

Nws yog txwv tsis pub haus luam yeeb ua ntej txoj kev kawm tsawg kawg ib hnub, vim yog kev haus luam yeeb, qhov tso tawm ntawm lub plab zuj zus, kev sib xyaw ntawm cov kua txiv kua txiv pancreatic thiab cov kua tsib synthesis reflexively nce, uas yuav cuam tshuam rau cov txiaj ntsig ntawm kev tshawb fawb..

txheej txheem dhau qhov kev tshuaj ntsuam

Txhawm rau kuaj cov qog qog nqaij hlav qog noj ntshav, tus neeg yuav tsum pub ntshav venous. Nws yog qhov zoo dua los noj cov khoom ntawm lub plab khoob thaum sawv ntxov. Ntshav (tsib milliliters) yog muab los ntawm tus neeg mob los ntawm cov hlab ntsha cubital. Txhawm rau ua kom cov txiaj ntsig tau paub ntau ntxiv, nws yuav tsum tau npaj kom raug rau qhov kev kawm zoo li no.

pancreatic qog markers normal
pancreatic qog markers normal

Tus kws tshaj lij hauv kev kuaj mob tom qab pub ntshav ua ntau yam kev tshawb fawb (ELISA txoj kev) thiab sau cov lus xaus. Qhov tshwm sim yuav npaj tau nyob rau hauv ib hnub lossis ntxov dua yog tias tsim nyog. Cov txiaj ntsig tau txhais tsuas yog los ntawm tus kws kho mob oncologist, uas paub txog tus neeg mob keeb kwm kev kho mob, nws cov kab mob sib kis, uas cov qog nqaij hlav ntau ntxiv.

Thaum kuaj pom lawv cov ntsiab lus siab hauv yuav luag txhua qhov xwm txheej, nws yuav tsim nyog los ua kev tshawb fawb ntxiv. Kev tswj xyuas yuav tsum tau uanyob rau tib lub tsev kho mob thiab kuaj mob uas yog thawj qhov chaw, txij li qhov ntsuas ntawm cov chaw soj ntsuam sib txawv feem ntau sib txawv.

hom cim thiab qhov zaus ntawm txoj kev kawm yog teem rau tus kheej los ntawm tus kws kho mob.

Tus qauv rau tus kab mob pancreatic yog dab tsi?

Norm thiab deviations hauv cov txiaj ntsig ntawm kev kawm

Ntau qhov ntau dhau ntawm cov txiaj ntsig ib txwm muaj thaum txiav txim siab cov ntsiab lus ntawm cov tshuaj, uas yog, cov cim ntawm hom qog nqaij hlav, yuav luag ib txwm qhia tias muaj cov qog no hauv lub cev. Qhov qhab nia siab dua, qhov feem ntau yuav muaj mob qog noj ntshav. Lub xub ntiag ntawm metastases thiab qhov luaj li cas ntawm neoplasm kuj raug txiav txim los ntawm ntau npaum li cas cov ntsiab lus ntawm oncomarkers yog tshaj tus txheeb ze rau tus qauv.

Cov txiaj ntsig zoo ntawm cov cim qog, uas tau txiav txim siab yog tias xav tias mob qog noj ntshav pancreatic:

ntshav rau pancreatic qog markers
ntshav rau pancreatic qog markers

CA19-9 - tsis tshaj 40 IU/ml;

M2-RK - tsis ntau tshaj 15 units / ml;

CA50 - tsis tshaj 23 units / ml;

CA72-4 - tsis ntau tshaj 6.9 IU/ml;

CA125 - 22-30 IU/ml;

CA242 - tsis ntau tshaj 30 IU/ml;

AFP - tsis ntau tshaj 10 IU/ml.

Cov qauv ntawm cov cim qog nqaij hlav feem ntau tshaj nyob rau hauv rooj plaub ntawm pancreatic neoplasm.

Thaum cov txiaj ntsig tau txawv ntawm qhov txiaj ntsig ib txwm muaj, yuav tsum muaj kev tshuaj xyuas ntxiv ntawm tus neeg: CT, ultrasound ntawm lub plab kab noj hniav tau raug sau tseg, tom qab ntawd ib qho kev kuaj ntshav tau ua thaum kuaj pom cov qog zoo li hauv lub cev. kab mob pancreas.

qog cov cim ntawm pancreatic neoplasms

Rau mob qog noj ntshav pancreaticqog markers yog cov khoom secreted los ntawm cov qog no rau hauv cov ntshav. Raws li cov qauv tshuaj, cov no yog cov protein-carbohydrate compounds (glycoproteins). Txhawm rau kuaj mob qog nqaij hlav, saib cov cim thawj thiab theem nrab hauv txoj kev tshawb no.

Tus kab mob qog nqaij hlav pancreatic twg yog cov lus qhia tshaj plaws, nthuav rau ntau tus.

Cov cim qog nqaij hlav yog qhov qub hauv pancreatic neoplasms
Cov cim qog nqaij hlav yog qhov qub hauv pancreatic neoplasms

Cov cim tseem ceeb

Ntawm cov neeg mob tseem ceeb ntawm cov kab mob oncological ntawm lub caj pas, uas tau kuaj pom yam tsis tau poob yog tias muaj kev xav tias mob qog noj ntshav, yog glycoproteins CA19-9 thiab CA50. Nws yog qhov zoo rau kev tshawb xyuas qhov tseem ceeb ntawm ob lub tebchaw no, vim tias qhov kev txiav txim siab ntawm ib qho qog nqaij hlav tsis zoo.

Yog tias ob qhov ntsuas tau nce ib zaug, qhov kev kuaj mob poob siab yuav luag 100% lees paub.

CA50

Kev kuaj pom ntawm sialoglycoprotein no yog qhov kev ntsuam xyuas tshaj plaws rau tus kab mob pancreatic: yog tias CA50 nce siab, muaj qhov tshwm sim ntau ntawm cov txheej txheem oncological hauv txiav txiav, vim nws yog cov kab mob hauv nruab nrog cev.

Qhov tsis zoo ntawm txoj kev tshawb fawb no yog nws tus nqi siab, piv nrog rau kev tsim cov qog nqaij hlav tseem ceeb - CA19-9 - pancreas.

CA19-9

Lub synthesis ntawm no glycoprotein yog nqa tawm los ntawm cov hlwb ntawm lub epithelium ntawm lub gallbladder, cov hnyuv, pancreas, bronchi thiab lwm qhov chaw ntawm lub gastrointestinal ib ntsuj av, thiab yog li ntawd nws nce qhia oncology ntawm yuav luag txhua yam digestive kabmob.

Thaum tus neeg mob tau kuaj pom tias mob cirrhosisdaim siab, cholecystitis, pancreatitis, kab mob siab, cholelithiasis, kab mob sib txuas cov ntaub so ntswg pathologies, nws yuav muaj me ntsis siab C19-9, tab sis tsis ntau piv rau cov qauv.

pancreatic qog marker test
pancreatic qog marker test

Kev kuaj ntshav rau tus kab mob qog nqaij hlav pancreatic yog ib qho ntawm cov ntaub ntawv tshaj plaws hauv kev kuaj mob qog noj ntshav: CA19-9 tau nce ntau hauv 80% ntawm cov xwm txheej uas muaj tus kabmob no. Nws tseem yog ib qho tsim nyog los txiav txim siab rau qhov kev xaiv ntawm kev kho mob tactics: yog tias cov ntsiab lus ntawm qhov sib xyaw no ntau dua 1000 IU / ml, kev phais tsis tas yuav tsum tau ua vim qhov muaj feem ntau ntawm cov metastases. Hauv qhov no, xaiv lwm txoj kev kho mob.

Txhawm rau saib xyuas qhov ua tau zoo ntawm kev kho mob lossis tsim kev rov ua haujlwm dua, kev tshuaj ntsuam dynamic ntawm cov qog qog no ua tiav.

Nyob rau hauv qee cov neeg mob, muaj insensitivity rau CA19-9, los yog cov khoom no tsis yog synthesized nyob rau hauv lub cev tag nrho, txawm muaj malignant o. Kev tshuaj xyuas hauv cov xwm txheej zoo li no yuav yog qhov tsis tseeb-tsis zoo, thiab koj tsis tuaj yeem tso siab rau nws: koj yuav tsum tau sim rau lwm cov qog nqaij hlav.

Cov cim ntxiv

Cov kab mob pancreatic ntau yam no suav nrog cov tshuaj uas tau txiav txim siab hauv tus neeg mob cov ntshav nrog rau cov qog nqaij hlav qog nqaij hlav.

CA72-4. Nws yog ib qho carcinomaembryonic antigen uas nce hauv 80% hauv kev mob qog noj ntshav pancreatic. Nws kuj pom muaj thaum cev xeeb tub, pancreatitis, benign formations. Ib qib siab ntawm cov khoom no qhia tias muaj cov metastases hauv cov qog ntshav.

AFP, los yogalpha-fetoprotein feem ntau yog synthesized nyob rau hauv utero los ntawm lub yolk sac nyob rau hauv lub tsim embryo. Nyob rau hauv lub cev ntawm cov neeg laus, nws ntau lawm yog nqa tawm los ntawm daim siab hlwb. Kev nce hauv cov ntsiab lus ntawm cov tshuaj no qhia tau hais tias daim siab carcinoma lossis mob qog noj ntshav pancreatic. Kev kuaj AFP yuav tsum raug coj mus rau ib txhij nrog lwm cov tshuaj tiv thaiv.

M2-RK

Tumor pyruvate kinase M2 qhia txog kev hloov pauv hauv cov metabolism. Qhov no tshwm sim vim qhov tshwm sim ntawm cov qog malignant.

dab tsi yog pancreatic qog markers
dab tsi yog pancreatic qog markers

CA242

Kev tsim cov khoom sib xyaw no tshwm sim los ntawm cov mucous ntawm cov hnyuv thiab cov excretory pancreatic ducts. Cov ntsiab lus siab ntawm CA242 qhia tias mob qog noj ntshav ntawm cov hnyuv loj thiab me, mob pancreatitis, pancreatic oncology, gastric ulcer. Tus neeg sau npe no tsuas yog txiav txim siab ua ke nrog cov tseem ceeb.

CA125

Cov tshuaj no yog tsim los ntawm cov epithelium ntawm cov kab mob ua pa, plab zom mov hauv fetus. CA125 nyob rau hauv cov neeg laus kab mob yog secreted los ntawm cov ntaub so ntswg ntawm lub pa system. Nws cov ntsiab lus nce hauv kev mob qog noj ntshav pancreas, plab, siab, cev xeeb tub, pancreatitis, degenerative thiab inflammatory daim siab pathologies.

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