Qhov kev tshawb pom ntawm thawj cov tshuaj tua kab mob (hnub no paub rau txhua tus penicillin) nyob rau hauv nruab nrab ntawm lub xyoo pua nees nkaum yog ib qho kev ua tiav ntawm cov tshuaj. Thaum lub sij hawm Tsov Rog Thoob Ntiaj Teb Zaum Ob, cov tshuaj no tau cawm ntau txhiab tus neeg tiv thaiv Niam Txiv txoj sia.
Txij thaum ntawd los, kev lag luam biochemistry thiab kws tshuaj tau tsim kho sai thiab muab cov neeg siv khoom siv tshuaj tua kab mob tshiab thiab ntau dua. Ib qho ntawm feem ntau niaj hnub thiab dav siv nyob rau hauv ntau yam ntawm cov tshuaj yog Maximim, tshuaj xyuas uas tswj cov tshuaj no zoo heev, zoo heev rau ntau yam kab mob.
Kev sib sau thiab tso tawm daim ntawv
Cov khoom xyaw tseem ceeb ntawm cov tshuaj no yog cefepimadihydrochloride monohydrate. Daim ntawv tso tawm yog cov hmoov dawb-daj daj rau kev npaj cov tshuaj rau cov tshuaj intramuscular los yog cov tshuaj txhaj tshuaj. Hauv ntau npaum li cas, cov chaw tsim khoom muab cov neeg siv khoom nws cov khoom "Maxipim". Cov tshuaj tua kab mob muaj nyob rau hauv 500 mg thiab 1 g vials.
Ciav raukev taw qhia txog cov muaj pes tsawg leeg tuaj yeem khaws cia hauv chav sov thaum nruab hnub. Nyob rau hauv cov xwm txheej ntawm lub tub yees, lub txee lub neej ntawm cov tshuaj tiav nce mus rau 1 lub lis piam. Nyob rau hauv daim ntawv hmoov thiab nyob rau hauv ib lub vial kaw, cov tshuaj yuav khaws cia rau 3 xyoos. Cov xwm txheej tsim nyog - kub txog + 30 ° C thiab ib qho chaw tiv thaiv los ntawm lub teeb. Hloov cov xim ntawm cov tshuaj tsis cuam tshuam rau kev ua ntawm cov tshuaj.
Pharmacological influence
"Maxipim" cov lus qhia rau kev siv yog positioned raws li ib tug tshuaj tua kab mob uas muaj nyob rau hauv pab pawg neeg ntawm cephalosporins ntawm tiam 4th. Lub hauv paus ntsiab lus ntawm kev raug yog los rhuav tshem cov phab ntsa ntawm tes ntawm cov kab mob, hom kab mob. Cov tshuaj muaj ib tug dav spectrum ntawm lub hwj chim nyob rau hauv kev sib raug zoo rau ib tug xov tooj ntawm gram-positive thiab gram-tsis zoo kab mob, yam ntxwv los ntawm lawv cov tsis kam mus rau aminoglycosides thiab antibacterial neeg sawv cev ntawm lub thib 3 tiam ntawm pawg cephalosporin.
Maxipim yog tus cwj pwm los ntawm kev ua haujlwm ntawm beta-lactamases thiab kev ua haujlwm tawm tsam ntau ntawm gram-positive thiab gram-negative aerobes (cov ncauj lus kom ntxaws yog nyob rau hauv cov lus qhia siv). Tab sis cov tshuaj tsis muaj zog tiv thaiv methicillin-resistant staphylococci, penicillin-resistant pneumococci.
Tom qab kev tswj hwm, cov tshuaj tua kab mob "Maxipim" (qhia rau kev siv suav nrog cov ntaub ntawv zoo li no) tau nqus tag nrho. Kev kho mob tseem ceeb ntawm cov khoom tseem ceeb muaj nyob rau hauv cov zis, kua tsib, bronchial secretions, nyob rau hauv lub caj pas prostate thiab peritoneal kua.
Lub sijhawmtshem tawm ib nrab-lub neej yog kwv yees li ob teev. Rau kev sib piv, peb tuaj yeem hais tias, piv txwv li, hauv cov neeg mob laus uas tau txais 2 g ntawm cov tshuaj txhaj rau 9 hnub nrog lub sijhawm ncua ntawm cov txheej txheem tsawg kawg 8 teev, tsis pom muaj ntau ntawm cefepime hauv lub cev. Qhov ntim loj tshaj plaws yog tawm hauv cov zis (txog 85% ntawm thawj koob tshuaj tau txais los ntawm tus neeg mob hauv daim ntawv ntawm cefepime tsis hloov pauv).
Cov lus qhia rau kev siv
Tus neeg sawv cev tshuaj tua kab mob "Maxipim" cov lus qhia rau kev siv pom zoo muab tshuaj rau ntau hom kab mob ntawm cov kab mob sib kis thiab mob. Cov txiaj ntsig zoo yuav tau txais hauv kev kho mob ntawm cov kab mob hauv lub ntsws (xws li mob ntsws thiab mob ntsws) thiab cov kab mob tso zis (ob qho tib si tsis yooj yim thiab nyuaj, suav nrog pyelonephritis). Kev ua tau zoo yog pom nyob rau hauv kev kho mob ntawm ntau yam kab mob hauv plab hnyuv (tsis suav nrog kab mob biliary tract thiab peritonitis).
Kuj "Maxipim" yog siv dav los ntawm cov neeg ua haujlwm noj qab haus huv rau kev kho mob ntawm cov kab mob gynecological, kis kab mob ntawm daim tawv nqaij thiab cov nqaij mos, septicemia (sepsis). Hauv kev kho mob ntawm cov neeg mob uas muaj febrile neutropenia, "Maxipim" cov lus qhia pom zoo kom siv raws li kev kho mob empirical.
Lwm thaj tsam ntawm kev siv tshuaj yeeb yog kab mob meningitis hauv menyuam yaus. Ntawm no, cov tshuaj tua kab mob no kuj ua pov thawj tias zoo heev.
Rau lub hom phiaj prophylactic, cov tshuaj yog siv los tiv thaiv kab mob hauv plabkev cuam tshuam kev phais.
Feem ntau, peb tuaj yeem hais tias "Maxipim" tuaj yeem siv rau txhua yam kab mob sib kis, kev loj hlob uas yog provoked los ntawm cov kab mob thiab cov kab mob nkag mus rau nws. Kev ntsuam xyuas yuav tsum tau ua los txheeb xyuas cov kab mob ua rau kab mob thiab txiav txim siab nws (lossis lawv) rhiab heev rau cov tshuaj tua kab mob no. Txawm li cas los xij, "Maxipim" cuam tshuam rau ntau yam kab mob thiab hom kab mob uas nws tuaj yeem raug coj los ua monotherapy txawm tias ua ntej cov kab mob raug txheeb xyuas. Yog tias muaj kev pheej hmoo ntawm kev tsim cov kab mob sib xyaw (aerobic-anaerobic), ua ntej kuaj xyuas cov kab mob pathogenic, kev kho mob nrog Maximim tuaj yeem pib ua ke nrog cov tshuaj uas cuam tshuam rau anaerobes.
Txoj kev ntawm daim ntawv thov thiab koob tshuaj
Cov koob tshuaj thiab hom kev tswj hwm (hauv / hauv lossis / m) yog txiav txim siab nyob ntawm qhov rhiab heev ntawm cov kab mob, qhov hnyav ntawm cov kab mob thiab cov xwm txheej ntawm tus neeg mob lub raum. Tsis tas li ntawd, txoj kev txhaj tshuaj yog feem ntau nyiam nyob rau hauv cov xwm txheej uas tus kab mob hnyav heev thiab ua rau muaj kev hem thawj rau tus neeg mob lub neej.
Cov neeg lub raum noj qab nyob zoo thiab lub cev hnyav dua 40 kg tau txhaj txhua 12 teev ntawm cov tshuaj uas kws kho mob tau sau tseg. Cov kab mob ntawm cov zis ntawm qhov mob me me thiab nruab nrab, lwm yam kab mob uas tshwm sim nrog tib lub zog, raug kho nrog ntau npaum li cas ntawm 0.5-1 g muab intramuscularly lossis intravenously (raws li kws kho mob txiav txim siab). Txhawm rau tiv thaiv kev kis kab mob hnyav, nws raug coj los txhaj 2 g ntawm cov tshuaj tso rau hauv txoj hlab ntshav (ib zaus - 12 teev). Rau qhov mob hnyav heev thiab muaj kev phom sij rau lub neej, qhov tsim nyogqhov koob tshuaj kuj yog 2 g, tab sis qhov zaus yog txhua 8 teev.
Cov tshuaj tua kab mob "Maxipim" yog siv rau tus mob khaub thuas nkaus xwb thaum muaj kab mob kis kab mob kuj tseem txuas nrog thaum kis tus kab mob.
Nyob rau hauv cov txheej txheem ntawm kev phais (1 teev ua ntej pib), rau kev tiv thaiv, 2 g ntawm "Maxipim" yog muab tso rau hauv ib nrab ib teev, tom qab ntawd 500 mg ntawm metronidazole ntxiv infused. Tsis txhob muab ob qho tshuaj tib lub sijhawm.
Qhov nruab nrab ntawm cov tshuaj rau cov neeg mob qis dua 40 kg lub cev qhov hnyav hauv kev kho mob ntawm cov kab mob urinary (qhov nyuaj thiab tsis nyuaj), cov ntaub so ntswg thiab cov tawv nqaij (tsis nyuaj), mob ntsws thiab kev kho mob ntawm neutropenic fever yog 50 mg ib kilogram ntawm lub cev hnyav. Kev txhaj tshuaj yog ua thaum lub sijhawm 12 teev. Rau cov kab mob meningitis thiab neutropenic fever, tib yam 50mg / kg raug pom zoo nyob rau 8-teev lub sij hawm ntawm kev kho mob.
Rau cov neeg mob uas muaj lub raum tsis ua haujlwm, yuav tsum tau kho cov tshuaj kho mob. Cov tshuaj tua kab mob "Maxipim" piav qhia ntawm cov tshuaj (qhov ntau npaum li cas nyob ntawm hom kab mob thiab qhov hnyav ntawm tus kab mob yuav raug xaiv los ntawm tus kws kho mob uas tuaj koom) pom zoo tias thawj tus nqi ntawm cov tshuaj yuav tsum tau noj tib yam li cov neeg muaj lub raum noj qab haus huv, thiab kev saib xyuas ntau npaum li cas yuav tsum raug xaiv nyob ntawm qhov tseem ceeb ntawm creatine clearance.
Cov neeg mob uas noj "Maxipim" thiab ua rau hemodialysis raug pom zoo kom rov muab tshuaj tshiab thaum kawg ntawm cov txheej txheemtshuaj tua kab mob sib npaug li qub. Qhov no yog qhov tsim nyog, vim tias hauv 3 teev ntawm hemodialysis, txog li 68% ntawm tag nrho cov tshuaj "Maxipim" yuav raug tshem tawm ntawm lub cev (cov lus qhia muaj cov ntaub ntawv no).
Contraindications rau noj Mexipim
Txawm tias muaj ntau yam teebmeem ntawm cov tshuaj tua kab mob no, nws tsis muaj cov npe loj ntawm contraindications. "Maxipim" cov lus qhia rau kev siv txwv tsis pub cov neeg uas muaj ib tug neeg hypersensitivity los ntawm kev noj cefepime thiab L-arginine. Nws tseem tsis tuaj yeem muab tshuaj rau cov neeg mob uas muaj qhov tsis txaus ntseeg tam sim rau penicillins, lwm yam tshuaj beta-lactam, cephalosporin-hom tshuaj tua kab mob.
Cov poj niam cev xeeb tub thiab cov niam laus, cov neeg mob los ntawm cov kab mob ntawm lub plab zom mov, tshwj xeeb tshaj yog cov kab mob xws li mob plab lossis kab mob tshuaj tua kab mob, cov kab mob hauv cheeb tsam yuav tsum tau saib xyuas lawv txoj kev noj qab haus huv thaum lub sijhawm kho nrog Maximim.
Txog qhov cuam tshuam rau kev ua haujlwm ntawm kev ua me nyuam, nws yuav tsum tau hais tias hauv kev sim tshuaj rau tsiaj, tsis muaj qhov tsis zoo rau lub cev ntawm leej niam thiab tus menyuam hauv plab. Txawm li cas los xij, cov kev tshawb fawb tswj tau zoo ntawm cov nyhuv ntawm lub cev ntawm tus poj niam tsis tau ua. Yog li ntawd, nws tso cai rau cov poj niam cev xeeb tub noj "Maxipim" tsuas yog nyob rau hauv kev saib xyuas ntawm kws kho mob. Hauv cov poj niam cov kua mis, cov tshuaj tau tawm hauv qhov tsawg heev, tab sis nws tsis tsim nyog rau kev pheej hmoo. Thaum lactation, cov tshuaj yuav tsum tau noj nrogceev faj.
Ntxiv rau, cov lus qhia pom zoo kom siv cov tshuaj tua kab mob "Maxipim" nrog kev ceev faj zoo rau cov neeg uas raug kev txom nyem los ntawm mob raum tsis ua haujlwm. Kev tshawb fawb tau pom tias nyob rau hauv cov neeg mob uas lub raum tsis ua hauj lwm, ib nrab-lub neej ntawm cov tshuaj los ntawm lub cev nce. Tib lub sijhawm, cov neeg uas muaj lub siab ua haujlwm tsis zoo lossis cystic fibrosis tsis muaj kev hloov pauv tshuaj cuam tshuam nrog kev nqus thiab tshem tawm ntawm cefepime los ntawm lub cev.
Kev mob tshwm sim, overdose
Feem ntau, peb tuaj yeem hais tias "Maxipim" tau txais txiaj ntsig zoo los ntawm cov neeg mob, thiab qhov tshwm sim ntawm cov kev mob tshwm sim tsis siab. Ntawm tag nrho cov xwm txheej, feem ntau nws yog hais txog kev ua haujlwm ntawm txoj hnyuv (dyspepsia, raws plab, cem quav, xeev siab, ntuav) thiab rhiab heev (pob liab, khaus, kub taub hau).
Ntxiv rau, cov ntaub ntawv muaj txog cov tshuaj xws li tshuaj tua kab mob "Maxipim" - cov lus piav qhia ntawm cov tshuaj, cov lus qhia rau kev siv - qhia txog qhov muaj peev xwm ntawm cov tshuaj tiv thaiv kab mob plawv hauv daim ntawv ntawm tachycardia (lub plawv dhia ceev.) thiab mob hauv siab. Cov kab mob ua pa tuaj yeem tshaj tawm lawv tus kheej nrog mob caj pas, ua tsis taus pa thiab hnoos. Qhov feem ntau yuav tshwm sim los ntawm ib sab ntawm lub hauv paus paj hlwb yuav insomnia, mob taub hau, kiv taub hau, ntxhov siab vim, tsis meej pem, paresthesia yog ua tau. Ntawm lwm qhov tshwm sim, peb tuaj yeem tham txog asthenia, vaginitis, tawm hws, mob nraub qaum, peripheral edema. Tsis tas li ntawd, raws li kev mob tshwm sim, cov kws kho mob tham txogmuaj peev xwm hloov nyob rau hauv lub chaw kuaj tsis.
Raws li ntau tshaj qhov tso cai ntawm cov tshuaj tua kab mob "Maxipim", cov lus qhia rau kev siv daim ntawv qhia txog kev ua tau zoo ntawm hemodialysis nyob rau hauv xws li mob.
Kuv yuav tsum xyuam xim rau dab tsi?
Ntau qhov xwm txheej txawv txawv tuaj yeem tshwm sim thaum lub sijhawm tshuaj tua kab mob "Maxipim" raug tshuaj. Yuav siv li cas rau hauv cov xwm txheej zoo li no? Yog tias tawm tsam keeb kwm yav dhau los ntawm "Maxipim" pseudomembranous colitis nrog rau qhov mob raws plab ntev tshwm sim, nws feem ntau raug tso tseg thiab siv tshuaj vancomycin lossis metronidazole.
Yog tias tus neeg mob raug kev txom nyem los ntawm kev sib xyaw ua ke ntawm lub siab thiab lub raum tsis txaus, cov neeg ua haujlwm kho mob yuav tsum tau saib xyuas cov tshuaj hauv cov ntshav plasma tas li thiab, nyob ntawm qhov ntsuas, kho qhov ntau npaum li cas.
Yog tias cov tshuaj tua kab mob tau siv rau lub sijhawm ntev, nws yog ib qho tseem ceeb uas yuav tsum tau ua tib zoo saib xyuas cov ntshav peripheral thiab cov cim ua haujlwm ntawm lub raum thiab lub siab.
Yog tias tus neeg mob los ntawm qhov chaw tiv thaiv kab mob hauv thaj chaw muaj kev sib kis kab mob meningeal (kev sib kis ntawm cov kab mob hauv qhov tsom thiab thoob plaws hauv lub cev), muaj kev xav tias muaj kab mob meningitis lossis kev kuaj mob tau tsim, kho nrog Maximim yuav tsum tau muab tso tseg.”thiab muab tshuaj tua kab mob lwm yam uas muaj pov thawj zoo rau qhov kev kuaj mob no.
Muaj peev xwm kuaj pom qhov zoo rau Coombs kuaj, qhov tsis tseeb qhov zoo - kom muaj cov piam thaj hauv cov zis.
"Maxim"rau mob khaub thuas thiab mob khaub thuas (piv txwv li kev kis kab mob) yuav tsis ua haujlwm.
Kev sib tham nrog lwm yam tshuaj
Yog tias tus neeg mob tau txais "Maxipim", kev siv lwm yam tshuaj sib npaug yuav tsum nyob rau hauv kev saib xyuas ntawm tus kws kho mob. Cov tshuaj tua kab mob no tsis yog tshuaj siv tau nrog lwm cov tshuaj tua kab mob thiab heparin.
Tubular secretion ntawm cefepime yuav txo qis thaum ua ke nrog cov tshuaj diuretics, aminoglycosides thiab polymyxin B. Cov tib tandem ntawm cov tshuaj yuav ua rau kom cov concentration ntawm "Maxipim" nyob rau hauv cov ntshav cov ntshav, nce nephrotoxicity mus rau txoj kev loj hlob ntawm nephronecrosis. Tsis tas li ntawd, ib nrab lub neej yuav nce.
Kev sib xyaw "Maxiprim" nrog NSAIDs (cov tshuaj tsis yog tshuaj steroidal anti-inflammatory) yuav ua rau qeeb ntawm kev tso tawm ntawm cephalosporins los ntawm lub cev thiab tuaj yeem ua rau los ntshav.
Siv ua ke nrog lwm cov tshuaj tua kab mob bactericidal (aminoglycosides) yuav ua rau muaj kev sib koom ua ke, nrog cov kab mob bacteriostatic - antagonism.
Analogues
tshuaj Analogue raug xaiv raws li lub npe thoob ntiaj teb tsis yog tswv cuab (INN), lub npe ntawm cov khoom xyaw tseem ceeb (rau "Maxipim" qhov no yog cefepime). Cov analogues nrov tshaj plaws ntawm cov tshuaj tua kab mob "Maxipim" tshuaj xyuas ntawm cov kws tshaj lij hu cov tshuaj xws li "Cefepim-Alpa", "Cefepim", "Movizar", "Maxicef", "Cefepim Sterile"
Nov tsis yog ib daim ntawv teev tag nrho, tab sis rau lub npe "Cefepim",ces ntawm no, ntxiv rau cov saum toj no, kuj muaj "Cefepim-Vial", "Cefepim-Agio", "Cefepim-Jodas", "Cefepim-Alchem", "Cefepim Hydrochloride".
Kuj, rau ntau hom kab mob, cov neeg ua haujlwm noj qab haus huv tau sau npe Ladef, Efipim, Kefsepim, Cefomax, Tsepim.
Raws li cov tshuaj nquag, lawv yuav tsis zoo ib yam li cov tshuaj muaj ntawv tso cai.
Kev xav ntawm cov neeg mob thiab cov neeg ua haujlwm noj qab haus huv
Txij li cov tshuaj muaj ntau yam kev siv hauv ntau yam kab mob microbial, muaj ob qho kev xav zoo thiab tsis zoo txog Maximim. Cov neeg feem coob uas tau noj tshuaj tua kab mob tau txaus siab rau qhov tshwm sim. Kev txhim kho nyob rau hauv lub xeev ntawm kev noj qab haus huv, txawm nyob rau hauv cov ntaub ntawv loj ntawm cov kab mob, tshwm sim 2-3 hnub tom qab pib ntawm kev kho mob. Raws li cov neeg ua haujlwm noj qab haus huv, cov tshuaj kuj tau ua pov thawj nws tus kheej hauv ntau qhov chaw kho mob. Thiab tus nqi ntawm cov tshuaj tsis yog siab heev (muaj cov tshuaj pheej yig dua, tab sis tib lub sijhawm kuj tseem kim dua Maximim).
Txawm li cas los xij, tsis muaj cov lus pom zoo txog cov tshuaj no. Feem ntau cov neeg mob uas muaj kev phiv thaum lub sij hawm kho mob reacts tsis zoo. Tsis tas li ntawd, ib qho kev xav tsis zoo tau nthuav tawm los ntawm ib pawg neeg sib cais uas tau siv tshuaj tua kab mob "Maxipim" rau khaub thuas. Txawm hais tias nyob rau hauv rooj plaub no qhov tshwm sim yog, yog li hais, xav tau. Txhua tus mob khaub thuas muaj kab mob kis, thiab "Maxipim" yog cov tshuaj tua kab mob, lub hauv paus ntsiab lus ntawm kev ua haujlwm yog ua raws li kev puas tsuaj ntawm cellular.cov kab mob membrane.
Koj tuaj yeem yuav tshuaj tsuas yog nrog daim ntawv xaj los ntawm koj tus kws kho mob. Thiab yog li ntawd: tus kws kho mob uas muaj kev paub tshwj xeeb thiab kev paub dhau los yuav yog li xaiv cov tshuaj tua kab mob thiab suav cov koob tshuaj tsawg kawg nkaus, kom txhua qhov kev pheej hmoo ntawm cov kev mob tshwm sim yuav raug txo kom tsawg, thiab cov txiaj ntsig zoo ntawm lub cev yuav siab tshaj plaws.
