Tam sim no, muaj ntau ntau yam kev kho mob ntshav siab thiab angina tawm tsam. Ib tug ntawm lawv yog xws li "Farmadipin" (tej) tshuaj. Los ntawm dab tsi cov tshuaj no, peb yuav txiav txim siab ntxiv nyob rau hauv kom meej ntxiv.
Composition
Cov khoom xyaw nquag hauv qhov no yog nifedipine (nifedipine). Hauv 1 ml ntawm cov tshuaj no, nws yog nyob rau hauv ib qho nyiaj. Namely, thaum rov xam rau 100% qhuav hom tshuaj - 20 mg. Qhov no ua rau peb caug tee.
"Farmadipine" (tee), cov lus qhia rau kev siv uas yuav tau tham hauv qab no, muaj xws li excipients li polyethylene glycol 400 thiab ethanol 96%.
tshuaj muaj txiaj ntsig
Cov tshuaj no muaj cov tshuaj pharmacodynamics tshwj xeeb. Raws li tau hais los saum no, "Farmadipine" (tee) muaj cov tshuaj nifedipine, uas muaj cov nyhuv hypotensive thiab antianginal. Nws pab thaiv kev nkag ntawm calcium ions rau hauv cardiomyocytes thiab rau hauv qee cov leeg nqaij leeg ntawm peripheral thiab coronary hlab ntsha los ntawm voltage-dependent qeeb sib xws.cov channel hauv cell membranes. Qhov no yog ib qho khoom tseem ceeb. Nifedipine kuj ua rau cov leeg nqaij du, ua kom cov hlab ntsha peripheral thiab coronary, thiab tshem tawm spasms. Nyob rau tib lub sijhawm, ntshav siab, peripheral vascular tsis kam, tom qab lub plawv thiab oxygen thov ntawm myocardium txo. Tsis tas li ntawd, thaum noj cov tshuaj no, qee qhov kev tshwm sim tseem pom. Namely, muaj qhov txo qis hauv myocardial contractility thiab lub plawv ua haujlwm, nrog rau kev txo qis hauv platelet aggregation.
YPharmacokinetics
Hauv qhov no, "Farmadipin" (tee), cov lus qhia rau kev siv uas tau tham hauv qhov kev tshuaj xyuas no, nws muaj nws tus yam ntxwv. Thaum noj nyob rau hauv, nws yog zoo absorbed nyob rau hauv lub digestive ib ntsuj av. Nws bioavailability yog li 40-60 feem pua. Kev loj hlob sai tshwj xeeb ntawm cov nyhuv (tom qab 5-10 feeb) tau pom thaum tswj hwm sublingual. Qhov no yog ib qho tseem ceeb kom paub. Feem ntau cov txiaj ntsig zoo tshaj plaws tshwm sim tom qab 30-40 feeb. Kev siv cov pluas noj tsis tshwj xeeb rau tus nqi ntawm kev nqus ntawm tus neeg sawv cev no. Qhov tshwm sim ntawm cov nyhuv hemodynamic yuav tshwm sim rau 4-6 teev, tib lub sijhawm, txog li 90 feem pua ntawm nifedipine khi rau cov ntshav plasma protein. Cov tshuaj xws li "Farmadipin" (tee) yog metabolized hauv daim siab. Lub xub ntiag ntawm tag nrho cov kev tshem tawm ntawm nifedipine thaj tsam ntawm 0.4 txog 0.6 l / kg / h. Nws yog tawm los ntawm lub cev feem ntau nyob rau hauv daim ntawv ntawm inactive metabolites. Kev tshem tawm ib nrab-lub neej tuaj yeem yog los ntawm 2 mus rau 4 teev. Hauv cov neeg laus thiab cov neeg mob nrogCirrhosis ntawm daim siab, cov txheej txheem ntawm cov metabolism hauv nifedipine ua rau qeeb qeeb. Yog li ntawd, lawv muaj qhov ntsuas ntawm ib nrab-lub neej ntawm tus neeg sawv cev no tuaj yeem nce li ntawm 2 zaug. Hauv qhov no, nws yuav tsum tau txo qhov koob tshuaj thiab nce lub sijhawm ntawm kev noj cov tshuaj qhia. Nifedipine tsis khaws cia hauv lub cev. Nws tseem tuaj yeem nkag mus rau qhov chaw placental thiab ntshav-hlwb hauv lub hlwb hauv qhov me me. Txawm li cas los xij, nws tau tawm hauv cov kua mis.
Cov lus qhia rau kev siv
Teem "Farmadipin" (poob) hauv cov xwm txheej hauv qab no:
- Thaum qhov tseem ceeb thiab cov tsos mob ntshav siab tshwm sim.
- Kev kho thiab tiv thaiv kev mob angina.
- Nrog hypertrophic cardiomyopathy.
- Rau Raynaud's disease.
Daim ntawv thov
Noj "Farmadipin" (tee) sublingually. Nrog rau kev nce siab hauv cov ntshav siab (piv txwv li, 180/100–190/110 mm Hg), thawj koob tshuaj no rau cov neeg laus feem ntau yog li 3-5 tee (2–3.35 mg). Cov neeg mob laus kuj tau muab tshuaj rau qee yam. Namely - tsis ntau tshaj 3 tee (li 2 mg). Tsis tas li ntawd, tus nqi qhia tau muab tso rau hauv ib qho me me ntawm cracker lossis qab zib. Tus neeg mob yuav tsum khaws cia rau hauv lub qhov ncauj kom ntev li ntev tau. Nrog rau qhov tshwm sim tsis txaus, qhov ntau npaum ntawm cov tshuaj no tau nce zuj zus mus txog thaum kev kho mob ua tau zoo. Hauv qhov no, txhua yam nyob ntawm tus kheej mus kom ze. Nrog rau tom ntej manifestations ntawm nce ntshav siabkoj yuav tsum tsom ntsoov rau cov koob tshuaj. Kuj tseem muaj lwm qhov kev ntsuas tshwj xeeb. Nws nyob hauv qhov tseeb tias yog tias ntshav siab tau nce mus rau 190/100-220/110 mm Hg. Art., ces noj tee ntawm cov tshuaj no maj mam nce mus rau 10-15 (6, 7-10 mg). Nyob rau hauv cov ntaub ntawv no, kev hloov ntawm lub siab nyob rau hauv ib tug tshwj xeeb tus neeg mob yuav tsum tau muab coj mus rau hauv tus account. Qhov no tseem ceeb kom paub.
Koj kuj yuav tsum xav txog qhov muaj qhov tsis txaus siab ntawm qee tus neeg mob rau cov tshuaj xws li "Farmadipin" (tee), tshuaj xyuas qhov zoo. Hauv cov xwm txheej zoo li no, qhov ntau npaum li cas yog xaiv tus kheej. Pib nrog 3 tee thiab mam li maj mam nce los ntawm 2-3 tee (1.34-2 mg) kom txog rau thaum cov kev kho mob xav tau tiav.
Nws yuav tsum nco ntsoov tias yog tias thawj koob tshuaj no dhau lawm, qhov txo qis hauv cov ntshav yuav tshwm sim!
Side effect
Thaum siv cov tshuaj xws li "Farmadipin" (tej los ntawm lub siab), tej zaum yuav tshwm sim ntawm xeev siab, tachycardia, arterial hypotension, "tides" rau lub ntsej muag ntawm cov ntshav. Qee zaum, kev tsis haum tshuaj yuav tshwm sim nyob rau hauv daim ntawv ntawm o ntawm ob txhais ceg, pob khaus ntawm daim tawv nqaij. Cov tsos mob ntawm qaug zog, kiv taub hau, mob taub hau kuj tshwm sim.
YContraindications
Kev noj tshuaj xws li "Farmadipin" (tee) yog txwv tsis pub nyob rau hauv lub xub ntiag ntawm hypersensitivity rau nws cov Cheebtsam, cardiogenic poob siab, hnyav aortic thiabmitral stenosis, hypotension, tachycardia, nrog rau thaum cev xeeb tub thiab lactation.
Ntau tshaj
Hauv qhov no, qee qhov tsos mob tsis zoo yuav tshwm sim. Namely, kev noj tshuaj ntau dhau ntawm cov tshuaj xws li "Farmadipin" (tee), tuaj yeem ua ke los ntawm qhov tshwm sim ntawm lub plawv tsis ua haujlwm, poob siab, metabolic acidosis thiab qaug dab peg, txo qis hauv ntshav siab. Thaum cov tsos mob tshwm sim, nws yog ib qho tsim nyog yuav tsum tau siv qee yam kev pab cuam sai. Lawv muaj xws li gastric lavage, activated charcoal, tswj calcium chloride thiab sympathomimetics, symptomatic therapy.
Txoj kev siv
"Farmadipin" (kev poob siab) lossis nws qhov hloov pauv yuav tsum tau siv tsuas yog ua tib zoo saib xyuas cov neeg mob laus thiab cov neeg mob uas muaj:
- Tsis ruaj tsis khov angina.
- mob plawv tsis ua hauj lwm.
Y- Hypertrophic cardiomyopathy.
- Mob aortic stenosis.
- Pulmonary hypertension.
- Mob cerebrovascular raug mob.
- Mob ntshav qab zib mellitus.
- Kev ua txhaum ntawm kev ua haujlwm ntawm lub raum thiab lub siab.
Qhov ntau npaum ntawm lwm cov tshuaj uas siv nrog nifedipine yuav tsum tau teem rau ntawm tus kheej. Cardiac glycosides kuj tseem siv tau thaum noj tshuaj xws li "Farmadipin" (tee), cov analogues uas tau qhia hauv qab no hauv cov ntawv no.
Thaum noj nifedipine nrog rau kev txhaj tshuaj ib txhij ntawm magnesium sulfate, cov poj niam cev xeeb tub yuav tsum ua tib zoo saib xyuas ntshav siab. Qhov no yuav tsum tau ua vim tias muaj peev xwm txo qis ntshav siab, uas tuaj yeem ua mob rau leej niam thiab tus menyuam hauv plab.
Cov neeg mob uas lub siab ua haujlwm tsis zoo yuav tsum tau ua tib zoo saib xyuas. Hauv qhov xwm txheej hnyav, koob tshuaj yuav tsum raug txo.
Nifedipine yog metabolized los ntawm cytochrome P450 3A4 system. Yog li ntawd, cov tshuaj uas inhibit los yog induce cheeb tsam ntawm enzymes no tej zaum yuav hloov cov nyhuv ntawm "pib passage" los yog clearance ntawm cov tshuaj no. Nrog rau kev siv nifedipine nrog cov tshuaj ntawm hom no, ntshav siab yuav tsum tau saib xyuas. Yog tias tsim nyog, koj yuav tsum mus rau qhov txo qis ntawm cov tshuaj xws li "Farmadipin" (tee).
Sib cais hauv vitro thwmsim qhia txog kev sib raug zoo ntawm kev siv calcium antagonists, qhov no nifedipine, thiab biochemical thim rov qab cov spermatozoa uas cuam tshuam rau qhov tsis zoo ntawm lub peev xwm los ua fertilization.
Thaum noj "Farmadipin" (tee), koj yuav tsum tsis txhob ua haujlwm ntawm hom kev phom sij uas yuav tsum tau ua kom ntau ntxiv. Namely, tib lub sijhawm, koj yuav tsum tsis txhob tsav tsheb, ua haujlwm nrog lwm cov txheej txheem, thiab lwm yam.
Kev sib tham
"Farmadipine" (tee) muaj cov nyhuv hypotensive. Cov cuab yeej no txhawb nqa cov tshuaj ntxiv los ntawm qebblockers. Ntawd yog, "Farmadipin" (tee) tsub kom cov nyhuv ntawm β-adrenergic receptors, diuretics, nitrates, lwm yam tshuaj antihypertensive, tshuaj thiab dej haus uas muaj cawv, tricyclic antidepressants. Qee zaum, nifedipine pab txo qis cov concentration ntawm quinidine hauv cov ntshav plasma. Tab sis lub abolition ntawm nws ho nce nws. Yog li, thaum siv kev sib xyaw ua ke, nws raug nquahu kom saib xyuas qib ntawm quinidine concentration hauv cov ntshav plasma.
"Diltiazem" txo cov kev tshem tawm ntawm cov tshuaj xws li "Farmadipine" (tee). "Fentanyl" ho txhim kho qhov tshwm sim ntawm hypotensive nyhuv. Yog li ntawd, ua ntej kev qhia txog cov tshuaj no (tsawg dua 36 teev), koj yuav tsum tsis txhob noj "Farmadipine". Kev siv ua ke ntawm β-blockers nrog nifedipine tuaj yeem ua rau muaj kev loj hlob ntawm hypotension. "Farmadipine" (tee) pab kom cov concentration ntawm theophylline, carbamazepine thiab digoxin hauv cov ntshav. "Rifampicin" ua rau kom tsis muaj zog ntawm kev kho mob ntawm nifedipine, thaum ua kom nws cov metabolism. "Cimetidine" pab ua kom cov concentration ntawm "Farmadipine" hauv cov ntshav plasma.
Cov Cai thiab cov cai ntawm kev cia
Hauv qhov no, muaj qee yam qauv. Khaws "Farmadipin" (tee) ntawm chav tsev kub hauv qhov chaw qhuav. Cov tshuaj yuav tsum tau tiv thaiv los ntawm lub teeb thiab tawm ntawm cov me nyuam ncav cuag. Cov tshuaj no muaj lub neej txee ntev txog 1 xyoos.6 hli. Tom qab lub raj mis qhib - 28 hnub.
Vajtswv
"Farmadipin" (tee) yog muag tshwj xeeb los ntawm cov tshuaj.
Packaging
YNyob rau hauv vials ntawm 25 ml lossis 5 ml. Lawv suav nrog hauv pob.
"Farmadipin" (tee): analogues hauv Russia
Muaj ntau yam hloov pauv rau cov tshuaj no. Cov tseem ceeb yog:
- "Kordipin".
- "Nifedipine".
- "Adalat".
- "Cordaflex".
- "Corinfar Uno".
- "Kordaflex RD".
- "Phenigidine".
- "Osmo-adalat".
- "Kordipin retard".
- "Kordipin xl".
Zoo kawg
Tam sim no koj paub tias cov tshuaj zoo li "Farmadipin" (tee) yog dab tsi, nws pab dab tsi thiab nws muaj dab tsi. Txawm li cas los xij, ua ntej noj cov tshuaj no, koj yuav tsum nrhiav kev qhia ntawm tus kws kho mob uas tsim nyog.
