Lipase yog dej-soluble enzyme synthesized los ntawm tib neeg lub cev. Nws catalyzes cov hydrolysis ntawm insoluble esters thiab tseem pab nruab nrab rog kom zom, yaj thiab fractionated.
Lub luag haujlwm tseem ceeb
Cov enzyme lipase, ua ke nrog cov kua tsib, pab hauv kev zom cov rog thiab cov roj fatty acids. Nws koom nrog hauv kev ua cov rog-soluble vitamins A, E, D, K thiab hloov lawv mus rau hauv tshav kub thiab lub zog.
Lipase hauv cov ntshav lov triglycerides (lipids). Qhov no xa cov fatty acids ncaj qha mus rau lub cev nqaij daim tawv.
Lub cev twg tsim lipase
Hauv tib neeg lub cev, cov enzyme lipase yog tsim:
- hauv lub txiav;
- hauv siab;
- hauv ntsws;
- nyob rau hauv txoj hnyuv.
Tsis tas li ntawd, cov enzyme yog tsim nyob rau hauv cov me nyuam mos nyob rau hauv lub qhov ncauj kab noj hniav vim cov qog tshwj xeeb. Hauv cov menyuam mos, lingual lipase yog synthesized, uas ua rau cov mis nyuj rog.
Txhua lub hauv nruab nrog cev muab cov enzyme tshwj xeeb uas rhuav tshem cov rog rog.
Lub hom phiaj ntawm lipase hauv tib neeg lub cev
YogLub luag haujlwm tseem ceeb ntawm txhua hom lipase yog kev ua cov rog, lawv qhov sib cais thiab kev faib ua feem. Tsis tas li ntawd, cov tshuaj no tau koom nrog hauv kev sib pauv ntawm lub zog, txhawb kev nqus ntawm polyunsaturated fatty acids, qee cov vitamins.
Qhov tseem ceeb tshaj plaws enzyme yog tsim los ntawm pancreas. Pancreatic lipase yog ib qho enzyme uas lipid absorbed tag nrho thiab tag nrho. Nws nkag mus rau hauv lub plab zom mov, qhov twg, nyob rau hauv tus ntawm colipase, uas kuj yog ib tug pancreatic enzymes, nws combines cov kua tsib acids thiab hloov mus rau hauv ib tug active daim ntawv. Pancreatic lipase ua lub luag haujlwm tseem ceeb - nws rhuav tshem triglycerides (cov rog nruab nrab) ua ob yam: glycerol thiab ntau dua fatty acids.
Qhov txawv ntawm ntau hom lipase
Raws li tau sau tseg saum toj no, ntau hom lipase cuam tshuam nrog qee hom rog.
Lepatic lipase ua haujlwm nrog cov lipoproteins tsawg. Nws yog nws uas ua tus tswj hwm ntawm plasma lipids.
Gastric lipase nquag zom cov roj tributyrin. Lingual koom nrog hauv kev rhuav tshem cov rog uas muaj nyob hauv cov kua mis.
Norm and deviation
Los ntawm qib ntawm lipase ntau npaum li cas hauv cov ntshav, ib tus tuaj yeem txiav txim siab txog lub xeev ntawm tib neeg lub cev. Deviations nyob rau hauv cov kev taw qhia ntawm nce los yog txo cia cov kws kho mob txiav txim seb cov kab mob txuam nrog lub plab hnyuv ib ntsuj av. Yog li ntawd, thaum yws txog cov kab mob, cov kws kho mob tau sau ib qho kev ntsuam xyuas dav dav. Lipase - nws yog dab tsi: kev cai lossis kev sib txawv? Muaj qee yam kev qhia dav dav.
- Hauv cov neeg laus, tsis hais poj niam los txiv neej, uas muaj hnub nyoog 17 xyoo, qhov ntsuas lipase ib 1 milliliter ntawm cov ntshav yuav tsum yog los ntawm 0 txog 190 units.
- Rau cov menyuam yaus thiab cov tub ntxhais hluas, qhov ntsuas no qis dua me ntsis thiab yuav tsum nquag poob hauv thaj tsam ntawm 0 txog 130 units.
- Yog tias qib ntawm pancreatic lipase raug kuaj, ces tus qauv yuav yog 13-60 units ntawm enzyme ib 1 ml ntawm cov ntshav. Txhua yam saum toj no qhia tau tias muaj kev ua haujlwm tsis zoo hauv lub cev.
Yog tias qhov ntsuas tau dhau qhov ntsuas
Yog tias lipase nce siab, nws puas tsim nyog ua lub tswb? Yog, qhov tseeb no yuav tsum tau ua tib zoo mloog. Thiab tsuas yog ib tus kws kho mob nrog kev pab ntawm cov kev sim thiab cov txheej txheem kuaj ntxiv tuaj yeem ua qhov kev kuaj mob kom raug. Tom qab tag nrho, lipase yog ib qho enzyme koom nrog ntau cov txheej txheem metabolic, thiab tsuas yog tus kws tshaj lij tuaj yeem txiav txim siab seb lub cev twg raug kev txom nyem.
Lipase nce siab hauv cov kab mob no:
- YPancreatitis. Cov enzyme no tau dhau los ua cov kab mob hnyav dua, nrog rau thaum lub sijhawm ua haujlwm hnyav.
- biliary colic.
- Kev raug mob rau tus txiav yog feem ntau nrog los ntawm qhov nce siab hauv cov enzyme no.
- Neoplasms hauv pancreas.
- Cov kab mob ntev ntawm lub gallbladder pab txhawb ntau cov lipase ntau lawm.
- Kev muaj cyst hauv lub txiav.
- Kev cuam tshuam ntawm cov kab mob pancreatic los ntawm pob zeb lossis caws pliav.
- YIntrahepatic cholestasis.
- mob plab hnyuv plab.
- Peritonitis.
- Heart attackplab.
- Perforated plab ulcer.
- Perforation of internal organs.
- Mumps.
Raws li koj tuaj yeem pom, cov npe ntawm cov kab mob uas qib lipase hauv cov ntshav nce siab heev. Ntxiv rau nws ntau yam kab mob metabolic hauv lub cev uas nrog ntshav qab zib mellitus, gout lossis rog rog, nrog rau mob siab rau lub siab lossis kev siv tshuaj tsis raug ntev, thiab cov npe yuav ua ob npaug. Nws yog ib qho tsim nyog nco ntsoov tias lipase yog ib qho enzyme uas nquag koom nrog hauv cov txheej txheem metabolic, yog li txhua txoj haujlwm tseem tuaj yeem ua rau nws nce ntau hauv lub cev.
Yog li ntawd, koj yuav tsum tsis txhob kuaj xyuas koj tus kheej, tsuas yog los ntawm kev sim thiab nyeem phau ntawv kho mob xwb. Tsuas yog tus kws kho mob tshwj xeeb, tso siab rau cov txheej txheem ntawm lwm cov kev tshawb fawb, tuaj yeem txheeb xyuas qhov ua rau ntawm pathology thiab tsim cov lus pom zoo rau kev kho mob.
tseem ceeb nuances
Qee zaum lipase pib ua kom hnyav tom qab raug mob. Nrog kev puas tsuaj ntawm cov pob txha tubular, qhov nce ntawm cov enzyme no hauv cov ntshav tau pom. Thiab cov kws kho mob paub qhov no zoo thiab.
qib Lipase tseem ceeb heev kom txiav txim siab kom raug thaum txiav txiav. Yog tias cov ntshav ntawm amylase (ib qho enzyme uas ua rau cov hmoov txhuv nplej siab) siab dhau, ces tus kws kho mob tuaj yeem kuaj xyuas cov kab mob pancreas nrog kev ntseeg siab.
Thaum nws muaj peev xwm tshem tawm qhov mob ntawm lub cev muaj kab mob, ob qho tib si ntawm cov ntsuas no rov qab mus rau qhov qub. Muaj tseeb, amylase tau rov qab ntau duasai dua. Tab sis lipase tuaj yeem siab dua li qub rau lub sijhawm ntev.
Hauv qhov no, tus nqi ntawm cov enzyme tsis nce tam sim ntawd. Yog tias mob pancreatitis tau pib, tom qab thawj hnub, cov ntsuas lipase tseem nyob hauv qhov kev lees paub. Tsawg heev lawv sawv tam sim ntawd. Feem ntau, raws li kev txheeb xyuas, tus kab mob tsuas yog txiav txim rau hnub thib peb.
Tom qab qhov pib ntawm cov txheej txheem inflammatory, qib siab ntawm lipase tau pom los ntawm peb mus rau xya hnub. Thiab tsuas yog tom qab ntawd cov ntsuas maj mam poob.
Kev saib xyuas tshwj xeeb yuav tsum tau them yog tias qib ntawm lipase ntau dua 10 lossis ntau dua. Cov kws kho mob txiav txim siab cov ntsuas no tsis zoo heev. Hauv qhov no, yuav tsum tau kho tam sim.
Txo cov lipase hauv cov ntshav
qib siab lipase qhia txog kev ua haujlwm tsis zoo hauv lub cev. Tab sis nws cov ntsiab lus qis kuj qhia qee yam kab mob loj.
Qib qis ntawm cov enzyme no pom:
- Yog tias muaj cov kab mob qog nqaij hlav hauv lub cev, thiab tsis yog hauv plab hnyuv xwb.
- Yog tias qhov ua haujlwm ntawm pancreas txo qis.
- Rau cystic fibrosis (los yog lwm yam cystic fibrosis). Qhov no yog ib hom kab mob loj heev nrog kev rov ua dua tshiab, xav tau kev kho mob ntev. Nws tshwm sim vim muaj kab mob pathological ntawm cov qog qog nqaij hlav sab nraud.
- Tom qab kev phais, thaum txiav txiav tawm.
- Vim kev noj zaub mov tsis txaus, thaum noj zaub mov muaj cov khoom noj muaj roj ntau.
Tseem kws kho mobNco ntsoov tias yog tias qib ntawm lipase txo qis rau lub sijhawm ntev, qhov no yuav qhia tau tias tus mob pancreatitis tau dhau mus ntev.
Yog tias koj muaj teeb meem nrog cov metabolism, nrog rau lub plab zom mov, nws tsuas yog tsim nyog los saib xyuas qib lipase hauv cov ntshav. Qhov no yog qhov taw qhia tseem ceeb uas yuav tso cai rau kuaj pom tus kab mob raws sijhawm thiab pib kho raws sijhawm.
