tshuaj "Indapamide" yog dab tsi? Analogues ntawm cov tshuaj no, nws cov lus qhia, kev phiv thiab indications rau kev siv yuav tsum tau nthuav tawm hauv qab no. Tsis tas li ntawd, los ntawm kab lus no koj yuav kawm txog seb cov tshuaj no puas muaj contraindications, yuav ua li cas thaum noj ntau dhau, nws yuav tsum tau noj li cas, seb nws puas tuaj yeem ua ke nrog lwm cov tshuaj, thiab cov kws tshaj lij xav li cas txog nws.
Cov khoom siv tshuaj thiab nws daim ntawv tso tawm
Cov tshuaj no muag hauv daim ntawv twg? Hauv lub tsev muag tshuaj, nws tsuas tuaj yeem pom nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj biconvex, npog nrog lub plhaub dawb zaj duab xis.
Cov tshuaj "Indapamide" puas muaj dab tsi? Analogues ntawm cov tshuaj no (feem ntau ntawm lawv) thiab cov tshuaj nws tus kheej muaj xws li ib tug active ingredient li indapamide. Raws li rau excipients, cov ntsiav tshuaj muaj cov nram qab no cov ntsiab lus: lactose monohydrate, crospovidone, povidone K-30, magnesium. Stearate, talc thiab sodium lauryl sulfate.
Pharmacological kev txiav txim ntawm cov tshuaj
Dab tsi yog cov khoom ntawm cov tshuaj "Indapamide", tus nqi uas tau nthuav tawm nyob rau hauv kawg ntawm tsab xov xwm? Cov tshuaj no belongs rau cov tshuaj antihypertensive. Hauv lwm lo lus, nws yog diuretic thiab vasodilator.
Hais txog nws cov khoom siv tshuaj, cov tshuaj yog ze rau thiazide diuretics thiab raug coj mus ua txhaum ntawm reabsorption ntawm sodium ntsev, uas nyob rau hauv cortical ntu ntawm lub voj ntawm Henle. Nws muaj peev xwm ua kom cov tshuaj chlorine, magnesium, sodium thiab potassium ions nrog rau cov zis.
Vim li cas cov tshuaj "Indapamide" tau sau tseg? Analogues ntawm cov tshuaj no thiab cov tshuaj hais nws tus kheej muaj peev xwm los thaiv "slow down" calcium channels nyob rau hauv ib tug xaiv, ua kom lub elasticity ntawm phab ntsa ntawm cov hlab ntsha thiab txo tag nrho cov vascular kuj (peripheral).
Kev noj cov tshuaj no txo cov ntshav siab ntawm lub plawv, lossis nws lub ventricle sab laug. Nws tsis cuam tshuam rau cov lipids hauv cov ntshav, nrog rau cov metabolism hauv carbohydrate, nrog rau cov neeg muaj kab mob xws li ntshav qab zib.
Cov tshuaj hais txog txo qhov rhiab ntawm phab ntsa vascular mus rau angiotensin II thiab norepinephrine, txo qhov tsim cov pa oxygen ruaj khov thiab dawb radicals, txhawb cov synthesis ntawm prostaglandin E2.
Tom qab siv cov tshuaj, cov nyhuv hypotensive tsim los ntawm qhov kawg ntawm 1 lub lim tiam ntawm kev kho. Tib lub sijhawm, nws kav li 25 teev (tom qab noj ib ntsiav tshuaj)
YPharmacokineticstshuaj kho mob
tshuaj "Indapamide" absorbed nyob qhov twg? Cov lus qhia, kev tshuaj xyuas ntawm cov kws tshaj lij hais tias tom qab noj cov tshuaj sab hauv, nws yuav luag tag nrho thiab tam sim ntawd nqus los ntawm txoj hnyuv. Raws li kws tshuaj, nws bioavailability yog 93%. Ib txhij noj zaub mov me ntsis qeeb tus nqi ntawm kev nqus, txawm hais tias nws tsis cuam tshuam rau qhov ntim ntawm cov khoom nquag nqus.
Qhov siab tshaj plaws ntawm cov khoom xyaw nquag hauv cov ntshav ntshav tau mus txog kwv yees li 2 teev tom qab noj ib ntsiav tshuaj. Ib nrab-lub neej ntawm cov tshuaj yog 14-25 teev. Kev sib txuas lus nrog cov ntshav protein - txog 79%.
Cov tshuaj no kis tau zoo los ntawm cov kab mob histohematic (xws li placental). Nws kuj kis mus rau hauv cov kua mis.
Metabolism ntawm cov tshuaj yog nqa tawm hauv daim siab. Nws yog tawm los ntawm ob lub raum (raws li metabolites) nyob rau hauv tus nqi ntawm 60-80% thiab 20% ntawm cov hnyuv.
Cov lus qhia rau kev siv tshuaj
Yuav ua li cas cov tshuaj "Indapamide" tau muab rau cov neeg mob? Cov lus qhia rau kev siv cov tshuaj no tsuas yog ib qho mob ntawm tus neeg mob. Qhov no yog ntshav siab. Tsis tas li ntawd, cov tshuaj tuaj yeem muab tshuaj rau sodium thiab dej tuav hauv lub cev. Raws li txoj cai, tus mob no feem ntau pom nyob rau hauv lub plawv tsis ua hauj lwm.
Contraindications rau kev siv tshuaj
Tam sim no koj paub tias cov tshuaj "Indapamide" yog dab tsi (cov lus qhia rau kev sivntawm cov cuab yeej no tau nthuav tawm me ntsis siab dua). Txawm li cas los xij, nws yuav tsum tau muab sau tseg tias cov tshuaj no muaj contraindications. Cov no suav nrog cov hauv qab no:
- tus neeg mob lactose intolerant;
- lub sijhawm cev xeeb tub;
- galactosemia;
- hypokalemia;
- galactose lossis qabzib malabsorption syndrome;
- lactation;
- siv tib lub sijhawm ntawm cov tshuaj uas tuaj yeem ncua sijhawm QT;
- mob raum tsis ua haujlwm (los yog theem ntawm anuria);
- hnub nyoog ntawm tus neeg muaj hnub nyoog qis dua 18 xyoo (kev nyab xeeb thiab kev ua haujlwm ntawm cov tshuaj hauv kev kho menyuam yaus tsis tau tsim);
- hais lus siab, suav nrog encephalopathy, tsis txaus;
- hypersensitivity rau cov tshuaj thiab lwm yam sulfonamide derivatives.
ceev faj siv tshuaj
Ntau tus neeg xav tsis thoob: Kuv puas xav tau daim ntawv xaj yuav Indapamide? Qhov tseeb, ua ntej siv cov tshuaj, nws raug nquahu kom sab laj nrog kws kho mob - tsuas yog tus kws kho mob tshwj xeeb, tom qab kuaj xyuas thiab ua raws li cov txiaj ntsig ntawm kev sim, yuav muaj peev xwm tsim kom muaj peev xwm kho tau. Raws li peb cov ntaub ntawv, peb tau sau tseg tias cov tshuaj hauv nqe lus nug tau sau tseg nrog ceev faj rau cov neeg mob ntshav qab zib mellitus, gout, nrog rau cov neeg mob uas tsis haum rau sulfonamide derivatives.
Ntawm lwm yam, cov tshuaj yuav tsum tau noj nrog ceev faj hauv kev ua txhaum ntawm daim siab, ob lub raum thiab dej-electrolyte imbalance.
Thaum lub sijhawm kho, tus kws kho mob yuav tsum saib xyuas cov qibelectrolytes nyob rau hauv tus neeg mob cov ntshav (potassium, sodium, calcium).
Tshuaj "Indapamide": cov lus qhia rau kev siv, kws tshuaj xyuas
Raws li cov lus qhia txuas mus, cov tshuaj no yuav tsum tau noj hauv qhov ncauj, tsis hais txog kev noj zaub mov. Cov ntsiav tshuaj yuav tsum tau muab ntxuav kom txaus nrog dej huv.
Y Yuav ua li cas noj "Indapamide"? Raws li cov kws tshaj lij, cov tshuaj no zoo dua absorbed los ntawm lub plab zom mov tsuas yog thaum sawv ntxov ntxov. Yog li ntawd, nws raug pom zoo kom coj nws tshwj xeeb rau lub sijhawm ntawm hnub no.
Cov koob tshuaj yuav tsum yog 2.5 mg (piv txwv li 1 ntsiav tshuaj) ib hnub. Yog tias tom qab 4-8 lub lis piam ntawm kev kho cov kev xav tau tsis tau ua tiav, ces qhov ntim ntawm cov tshuaj yuav tsum tsis txhob nce ntxiv (txawm tias cov kws kho mob feem ntau ua li ntawd). Qhov tseeb no yog vim qhov tseeb tias nrog ntau npaum li cas, qhov kev pheej hmoo ntawm kev mob tshwm sim nce. Hloov chaw, kev kho tshuaj yuav tsum suav nrog lwm cov tshuaj tiv thaiv kab mob siab uas tsis yog diuretic.
Yuav ua li cas noj "Indapamide" hauv qhov no? Nrog rau kev teem sijhawm ib txhij ntawm ob cov tshuaj, qhov koob tshuaj ntawm cov tshuaj peb tab tom txiav txim siab tseem zoo ib yam, uas yog, 2.5 mg ib hnub (thaum sawv ntxov).
Cov neeg mob ntau dhau: cov tsos mob, kev kho mob
Yuav ua li cas yog tias koj noj ntau cov tshuaj "Indapamide"? Kev tshuaj xyuas ntawm cov kws kho mob hais tias nyob rau hauv cov xwm txheej zoo li no tus neeg mob muaj kev xeev siab, tsis muaj zog thiab ntuav. Tsis tas li ntawd, tus neeg mob qhov dej-electrolyte tshuav nyiaj li cas thiab kev ua haujlwm ntawm lub plab zom mov raug cuam tshuam. Qee zaum, tus neeg mob muaj qhov txo qis heevntshav siab thiab ua pa nyuaj. Hepatic coma yog ua tau rau cov neeg mob cirrhosis ntawm daim siab.
Yuav kho li cas? Nyob rau hauv cov ntaub ntawv ntawm overdose, tus neeg mob yuav tsum ntxuav lub plab, kho cov dej thiab electrolyte tshuav nyiaj li cas, thiab siv cov tsos mob kho.
Kev mob tshwm sim tom qab noj tshuaj
Puas muaj qhov tsis zoo tshwm sim tom qab noj tshuaj "Indapamide"? Cov tshuaj no muaj kev phiv. Cia peb teev lawv tam sim no.
- digestive system: gastralgia, xeev siab, mob plab, ntuav, anorexia, cem quav, qhov ncauj qhuav, pancreatitis, raws plab, kab mob siab.
- Ua pa kab mob: sinusitis, hnoos, rhinitis thiab pharyngitis.
- Nervous system: insomnia, asthenia, nqaij spasms, nervousness, general tsis muaj zog, ntxhov siab vim, mob taub hau, nkees, vertigo, kiv taub hau, kev nyuaj siab, tsaug zog, chim siab, malaise thiab nro.
- Urinary system: nocturia, nquag kis kab mob thiab polyuria.
- Lub plawv thiab cov hlab ntsha: arrhythmia, orthostatic hypotension, palpitations thiab ECG hloov pauv (piv txwv li hypokalemia).
- Ua xua: khaus khaus, pob khaus, hemorrhagic vasculitis thiab khaus.
- Hematopoietic system: thrombocytopenia, hemolytic anemia, leukopenia, pob txha pob txha aplasia thiab agranulocytosis.
- kuaj ntsuas: glycosuria, hyperuricemia, nce ntshav urea nitrogen, hyperglycemia, hypercreatininemia, hypokalemia, hypercalcemia, hyponatremia thiabhypochloremia.
- Lwm yam: exacerbation ntawm systemic lupus erythematosus.
Kev sib tham nrog lwm cov tshuaj
Cov tshuaj "Indapamide", uas nws qhov kev txiav txim yog txhawm rau txo qis, tsis pom zoo kom noj ua ke nrog lub plawv glycosides, vim tias qhov tshwm sim ntawm digitalis intoxication nce. Yog tias cov tshuaj no tau siv nrog cov tshuaj calcium thiab metformin, tus neeg mob tuaj yeem tsim hypercalcemia thiab ua rau lactic acidosis zuj zus.
Kev tswj hwm ib txhij ntawm cov tshuaj nrog corticosteroids, NSAIDs, sympathomimetics thiab tetracosactide txo qis cov nyhuv hypotensive ntawm yav dhau los. Raws li rau Baclofen, ntawm qhov tsis sib xws, nws hnyav nrog nws.
Kev sib xyaw tshuaj nrog cov tshuaj potassium-sparing diuretics yog siv tau rau cov neeg mob tsawg. Txawm li cas los xij, qhov muaj peev xwm ntawm kev tsim hyper- lossis hypokalemia tsis suav nrog, tshwj xeeb tshaj yog rau cov neeg mob lub raum tsis txaus thiab ntshav qab zib mellitus.
ACE inhibitors tuaj yeem ua rau muaj kev pheej hmoo ntawm arterial hypotension thiab mob raum tsis ua haujlwm.
Lub raum ua haujlwm yuav ua tsis taus thaum siv tshuaj ntau iodine ib txhij.
Neuroleptics thiab imipramine antidepressants ua rau cov nyhuv hypotensive thiab ua rau muaj kev pheej hmoo ntawm orthostatic hypotension.
cov lus qhia tshwj xeeb rau kev siv tshuaj "Indapamide"
Yuav ua li cas tus neeg mob yuav tsum tau saib xyuas cov ntshav tom qab kev teem sijhawm ntawm cov tshuaj "Indapamide"? Kev tshuaj xyuas cov kws kho mob hais tiasCov tshuaj no tuaj yeem hloov pauv tus nqi ntawm creatinine thiab potassium ions hauv cov neeg mob uas noj cov tshuaj laxatives, plawv glycosides, thiab hauv cov neeg muaj hnub nyoog tshaj 60 xyoo.
Thaum siv cov tshuaj no, cov kws kho mob tshwj xeeb tau qhia kom tswj xyuas cov concentration ntawm sodium, potassium thiab magnesium ions hauv cov ntshav plasma, vim tias cov neeg mob tuaj yeem tsim cov electrolyte cuam tshuam. Nws tseem yuav tsum tau saib xyuas pH, qhov concentration ntawm uric acid, qabzib thiab cov nitrogen seem.
Cov neeg mob uas muaj lub siab mob siab (nrog rau qhov mob hnyav lossis mob ascites), nrog rau cov neeg mob plawv thiab mob plawv, yuav tsum tau saib xyuas tshwj xeeb.
Muaj kev pheej hmoo siab yog cov neeg mob uas txuas ntxiv QT lub sijhawm ntawm ECG (tej zaum yuav yog los yog tsim tawm tsam keeb kwm ntawm txhua yam kab mob).
Thawj qhov kev ntsuas ntawm qhov concentration ntawm cov poov tshuaj ions hauv tus neeg mob cov ntshav tau pom zoo thaum thawj lub lim tiam ntawm kev kho mob.
Kev saib xyuas tshwj xeeb yog pom zoo rau cov neeg mob ntshav qab zib. Tshwj xeeb, nws yog ib qho tsim nyog los saib xyuas cov piam thaj hauv cov ntshav, tshwj xeeb tshaj yog tias tus neeg raug kuaj pom tias muaj hypokalemia.
Cov neeg mob noj cov tshuaj no yuav tsum them nyiaj rau qhov poob dej los ntawm kev haus dej ntau hauv ib hnub. Ntxiv mus, thaum pib ntawm kev kho mob, lawv yuav tsum tau tswj kev ua haujlwm ntawm lub raum.
Nws tsis tuaj yeem tsis hais tias cov tshuaj "Indapamide", cov analogues uas yuav tau nthuav tawm hauv qab no, tuaj yeem ua rau muaj txiaj ntsig zoo thaum tswj doping.
Rau cov neeg mob nroghyponatremia thiab arterial hypertension 3 hnub ua ntej pib siv cov tshuaj angiotensin-hloov enzyme inhibitors, diuretics yuav tsum tau txiav. Kev kho mob tuaj yeem rov pib dua me ntsis tom qab.
Thaum muab tshuaj Indapamide, cov kws kho mob tshwj xeeb yuav tsum ua tib zoo xav tias sulfonamide derivatives tuaj yeem ua rau tus kab mob ua rau mob hnyav ntxiv xws li lupus erythematosus.
Tam sim no, kev nyab xeeb thiab kev ua tau zoo ntawm cov tshuaj hauv kev kho cov menyuam yaus thiab cov tub ntxhais hluas tseem tsis tau tsim.
Nyob rau qee kis, tus neeg mob tuaj yeem tshwm sim, uas cuam tshuam nrog kev hloov ntshav siab. Raws li txoj cai, qhov no tshwm sim thaum pib ntawm kev kho mob, nrog rau thaum siv lwm yam tshuaj tiv thaiv hypertensive. Raws li qhov tshwm sim, lub peev xwm tsav lub tshuab thiab ua haujlwm nrog lwm cov txheej txheem yuav txo qis, uas yuav tsum tau ua kom muaj zog ntxiv.
Kev tshuaj xyuas ntawm cov kws tshaj lij thiab cov neeg mob txog tshuaj
Tam sim no koj paub tias Indapamide yog dab tsi. Kev tshuaj xyuas, tus nqi ntawm cov tshuaj no yuav nthuav tawm tam sim no.
Cov kws tshaj lij hais tias cov tshuaj no ua haujlwm zoo. Nws zoo txo cov ntshav siab thiab kuj ua raws li diuretic.
Kev tshuaj xyuas txog cov tshuaj "Indapamide" qhia tias tom qab nws siv, sab laug ventricular hypertrophy txo qis, thiab nws cov nyhuv hypotensive tau tshwm sim txawm tias nyob rau hauv cov neeg mob uas muaj hemodialysis.
Hais txog cov lus tsis zoo hauvqhov chaw nyob ntawm qhov hais daws, ces feem ntau lawv yog txuam nrog rau qhov tshwm sim ntawm ib tug loj tus naj npawb ntawm kev phiv tshuaj. Txawm li cas los xij, nws yuav tsum raug sau tseg tias cov txiaj ntsig zoo li no tsuas yog pom nyob rau hauv cov neeg siv ntau tshaj li cov tshuaj tau sau tseg lossis tau noj, txawm tias muaj cov contraindications uas twb muaj lawm.
Nqe thiab analogues ntawm cov tshuaj
Tus nqi Indapamide pes tsawg? Tus nqi ntawm cov tshuaj no yuav txawv (nyob ntawm cov chaw tsim khoom thiab cov cim ntawm lub khw muag tshuaj). Txawm li cas los xij, qhov nruab nrab, qhov kev kho no tuaj yeem yuav tau rau 95-100 Lavxias teb sab rubles (rau 30 ntsiav tshuaj).
Tab sis yuav ua li cas yog tus neeg mob nrhiav tsis tau cov tshuaj "Indapamide"? Analogues, tus nqi ntawm uas kuj tsis yog siab heev, yog muag nyob rau hauv yuav luag txhua lub tsev muag tshuaj. Cov tshuaj muaj xws li: Indapamide retard, Akripamide, Indapamide-Teva, SR-Indamed, Acripamide retard, Ravel SR, Akuter-Sanovel, Retapres, Arindap”, “Lorvas”, “Arifon”, “Pamid”, “Arifon retard” "Tenzar", "Ipres Long", "Vero-Indapamid", "Indipam", "Indap", "Indiur", "Indapamid-Verte", "Ionic", "Indapamide retard-Teva", "Indapress", " Indapamide Sandoz", "Ionic retard", "Indapamide-OBL", "Indapamide Shtada" thiab lwm yam.
Nws yog txwv tsis pub noj cov nyiaj no ntawm koj tus kheej txiav txim siab thiab hloov lawv nrog cov tshuaj Indapamide. Tsuas yog kws kho mob yuav tsum tau sau ntawv rau lawv, thiab tsuas yog tom qab kuaj mob. Tsis tas li, ua ntej noj cov tshuaj no, koj yuav tsum nyeem cov lus qhia txuas ntxiv.
Tshuaj kho mob thiab hnub tas sij hawm
Khoomcov tshuaj yog tsim nyog nyob rau hauv ib qho chaw qhuav thiab tsaus, uas yog nkag tsis tau rau cov me nyuam me. Qhov ntsuas kub ntawm cov tshuaj yuav tsum tsis pub tshaj 25 degrees. Nws lub neej txee yog 3 xyoos. Tom qab lub sijhawm teev tseg, kev noj tshuaj yog txwv nruj.
