Arterial hypertension yog ib yam mob uas tshwm sim los ntawm kev nce ntshav siab tsis tu ncua, tus nqi ntawm ntau dua 140/90 mm Hg. Art. Xws li kev kuaj mob tau ua rau tus neeg mob, yog tias cov ntshav siab tau soj ntsuam nrog peb ntawm nws qhov kev ntsuas, uas tau ua nyob rau lub sijhawm sib txawv thiab tawm tsam qhov cuam tshuam ntawm qhov chaw nyob ntsiag to. Nyob rau tib lub sijhawm, nws yog ib qho tseem ceeb heev uas ua ntej xws li manipulations ib tug neeg tsis noj tej yam tshuaj uas nce los yog, conversely, qis dua.
Cov lus qhia dav dav txog tus kabmob
Leej twg feem ntau kuaj pom tias muaj ntshav siab? Raws li cov kws tshaj lij, tus kab mob no tau pom nyob hauv kwv yees li 30% ntawm cov neeg laus thiab cov hnub nyoog nruab nrab, txawm hais tias kev loj hlob ntawm cov kab mob no tsis suav nrog cov tub ntxhais hluas. Nws yuav tsum tau muab sau tseg tias qhov nruab nrab qhov tshwm sim ntawm cov poj niam thiab cov txiv neej muaj ib tug yuav luag sib npaug piv.
Ntawm txhua hom kev mob ntshav siab, mob me mus rau theem nrab suav txog li 80%.
Kev nyuaj siab, kho kab mob
HypertensionQhov no yog ib qho teeb meem loj heev rau kev kho mob thiab kev sib raug zoo. Qhov tsis muaj kev kho kom raug thiab raws sijhawm ntawm cov kab mob no tuaj yeem ua rau muaj kev cuam tshuam loj thiab txaus ntshai. Cov no suav nrog mob stroke thiab myocardial infarction, uas tuaj yeem ua rau muaj kev tsis taus thiab tuag.
Nws tsis tuaj yeem hais tias qhov mob hnyav lossis lub sijhawm ntev ntawm cov hlab ntshav siab ua rau muaj kev puas tsuaj loj rau cov hlab ntsha ntawm qee yam kabmob (piv txwv li, qhov muag, hlwb, lub raum thiab lub plawv) thiab cuam tshuam rau lawv cov ntshav.
Puas tau ntshav siab kho tau? Kev kho mob ntawm tus kab mob no yuav tsum yog tsom rau normalizing ntshav siab. Txawm li cas los xij, kev kho mob tsis xaus rau ntawd. Ua ke nrog kev noj tshuaj uas txo cov ntshav siab, yuav tsum tau kho txhua yam kab mob uas twb muaj lawm uas tau tsim nyob rau hauv lub cev sab hauv.
Cov kws tshaj lij hais tias tus kab mob hauv nqe lus nug feem ntau yog mob ntev. Nws tsis muaj txiaj ntsig rau kev cia siab kom rov zoo tag nrho hauv cov xwm txheej zoo li no, tab sis kev kho kom raug tuaj yeem tiv thaiv kev txhim kho ntawm cov kab mob pathology, nrog rau txo qis kev pheej hmoo ntawm cov teeb meem loj, suav nrog kev kub ntxhov siab.
Dab tsi yog cov tshuaj uas tau sau ntau tshaj plaws rau kev kub siab? Cov tshuaj nrov tshaj plaws rau tus kab mob no yog Telmisartan. Cov lus qhia rau kev siv, tshuaj xyuas txog cov tshuaj no, nws muaj pes tsawg leeg, cov kev mob tshwm sim, contraindications thiab lwm yam ntaub ntawv qhia hauv qab no.
Kev piav qhia ntawm cov tshuaj, ntim, muaj pes tsawg leeg thiab daim ntawv tso tawm
Cov tshuaj "Telmisartan" ua li cas? Kev tshuaj xyuas cov neeg mob tau tshaj tawm tias hauv cov khw muag tshuaj xws li cov tshuaj tuaj yeem pom nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj puag ncig thiab tiaj-cylindrical ntawm cov xim dawb lossis nrog cov xim daj daj, muaj kev pheej hmoo thiab chamfer.
Cov khoom xyaw nquag hauv cov tshuaj no yog telmisartan. Raws li rau excipients, cov ntsiav tshuaj muaj xws li:
- meglumine;
- lactose monohydrate (los yog mis nyuj qab zib);
- sodium hydroxide;
- croscarmellose sodium;
- Povidone K25;
- Ymagnesium stearate.
Raws li kev tshuaj xyuas, Telmisartan ntsiav tshuaj tau muag hauv cov khw muag tshuaj hauv cov cell contour, uas tau muab tso rau hauv cov ntawv ntim khoom.
Pharmacology
Telmisartan (40mg) yog dab tsi? Kev tshuaj xyuas ntawm cov kws tshaj lij hais tias qhov no yog cov tshuaj tiv thaiv kab mob siab uas yog ib qho antagonist ntawm AT1 receptors, uas yog, angiotensin II. Cov tshuaj nyob rau hauv nqe lus nug muaj ib tug siab affinity rau cov hais receptor subtype. Nws khi xaiv thiab ntev rau angiotensin II, tom qab ntawd cov tshuaj nquag txav nws los ntawm nws cov koom haum nrog AT1 receptors.
Lwm yam nta
Dab tsi lwm yam khoom muaj nyob hauv cov tshuaj "Telmisartan"? Kev tshuaj xyuas qhia tias cov khoom nquag ntawm cov cuab yeej no tsis cuam tshuam rau ACE thiab renin nyob rau hauv ib txoj kev, thiab tseem tsis thaiv cov channel uas yog lub luag haujlwm rau kev ua ions.
Cov tshuaj hais kom txo cov aldosterone hauv cov ntshav. Qhov koob tshuaj ntawm cov tshuaj, sib npaug li 80 mg, tshem tawm tag nrho cov ntshav siab, uas yog tshwm sim los ntawm angiotensin II.
Cov txiaj ntsig kho mob tom qab noj tshuaj yuav kav ntev li ib hnub, thiab tom qab ntawd maj mam txo qis. Nws kuj tseem yuav tsum tau muab sau tseg tias muaj txiaj ntsig tseem ceeb ntawm cov tshuaj tau hnov tsawg kawg ob hnub tom qab pib kho.
Raws li kev tshuaj xyuas, "Telmisartan" tuaj yeem txo qis systolic thiab diastolic siab. Txawm li cas los xij, cov tshuaj tsis cuam tshuam rau tus neeg lub plawv dhia hauv txhua txoj kev. Tsis tas li ntawd, thaum kho, tsis muaj kev cuam tshuam ntawm kev quav tshuaj thiab kev txuam nrog cov tshuaj nquag hauv lub cev.
Pharmacokinetic zog ntawm cov tshuaj
Cov tshuaj pharmacokinetic ntawm cov tshuaj "Telmisartan" yog dab tsi? Cov lus qhia thiab kev tshuaj xyuas ntawm cov kws tshaj lij tau tshaj tawm tias thaum cov tshuaj tau noj hauv qhov ncauj, nws cov khoom siv tau nrawm nrawm los ntawm txoj hnyuv. Nws bioavailability yog li 50%.
Thaum noj tshuaj ib txhij nrog zaub mov, qhov txo qis hauv AUC txawv ntawm 6-9% (ntawm koob tshuaj 40-160 mg, raws li).
Peb teev tom qab noj cov tshuaj, qhov concentration ntawm nws cov khoom nquag hauv cov ntshav plasma maj mam txo qis (tsis hais seb cov tshuaj puas tau noj nrog zaub mov lossis hauv plab khoob).
Kev sib txuas ntawm telmisartan nrog cov ntshav plasma yog li 99.5%. Cov tshuaj no yog metabolized los ntawm conjugation nrog glucuronic acid. Nyob rau hauv cov ntaub ntawv no, pharmacologically inactive metabolites yog tsim.
Ib nrab-lub neej ntawm cov tshuaj hauv nqe lus nug yog dhau 20 teev. Nws active tshuaj yog excreted unchanged los ntawm txoj hnyuv. Kev tshem tawm ntau dhau los ntawm lub raum system yog kwv yees li 1%.
Cov lus qhia rau kev sau tshuaj
Thaum twg cov tshuaj zoo li Telmisartan tau sau tseg? Kev tshuaj xyuas ntawm cov kws kho mob qhia tias cov tshuaj nyob rau hauv nqe lus nug yog nquag siv thaum lub sij hawm kev kho mob ntawm arterial hypertension. Nws tseem tuaj yeem raug sau tseg los tiv thaiv kev tuag ntawm tib neeg los ntawm pathologies ntawm cov hlab plawv, suav nrog tom qab lub plawv nres, mob stroke, kab mob peripheral vascular thiab sab laug ventricular hypertrophy.
txwv tsis pub sau tshuaj rau qhov ncauj
Thaum twg koj yuav tsum tsis txhob siv cov ntsiav tshuaj Telmisartan? Kev tshuaj xyuas ntawm cov kws kho mob tshwj xeeb, nrog rau cov lus qhia rau kev siv cov tshuaj no, qhia cov nram qab no contraindications rau lub sij hawm teem tseg:
- obstructive biliary tract disease;
- primary aldosteronism;
- mob siab ua tsis taus pa;
- raum tsis ua haujlwm hnyav;
- fructose intolerance rau cov neeg mob;
- tus neeg mob rhiab heev rau cov khoom tseem ceeb lossis lwm yam khoom ntawm cov tshuaj;
- lub sijhawm cev xeeb tub;
- hnub nyoog yau;
- lub sijhawm pub mis niam.
Cov lus qhia rau kev siv
Yuav siv tshuaj li cas"Telmisartan" (40 mg)? Kev tshuaj xyuas ntawm cov kws kho mob qhia tias yuav tsum tau noj cov ntsiav tshuaj hais ntawm qhov ncauj (qhov ncauj), tsis hais txog kev noj zaub mov.
Thaum kuaj mob ntshav siab, cov tshuaj hauv nqe lus nug feem ntau yog muab tshuaj ntawm 40 mg ib hnub ib zaug. Txawm li cas los xij, qee qhov xwm txheej, cov tshuaj tau qhia tuaj yeem raug txiav ib nrab (muab tias cov tshuaj muaj txiaj ntsig zoo ntawm 20 mg).
Yog tias qhov kev xav tau tsis ua tiav thaum noj 40 mg ntawm cov tshuaj, ces qhov koob tshuaj tau nce mus rau qhov siab tshaj plaws ntawm 80 mg. Nyob rau hauv rooj plaub no, daim ntawv thov ntawm tag nrho cov koob tshuaj yog nqa tawm ib zaug.
Thaum kho kho, nws yuav tsum nco ntsoov tias qhov kev kho mob siab tshaj plaws tsis tuaj yeem ua tiav tam sim ntawd, tab sis tom qab 1-2 lub hlis (yuav tsum tau noj cov ntsiav tshuaj tsis tu ncua).
txhawm rau txo cov ntshav siab, cov tshuaj "Telmisartan" (80 mg), kev tshuaj xyuas uas tau teev tseg hauv qab no, feem ntau tau sau nrog thiazide diuretics.
Tshuaj kho mob plawv
Kev ua tau zoo ntawm Telmisartan ntsiav tshuaj, siv los tiv thaiv kev tuag ntawm cov neeg mob uas muaj teeb meem plawv, raug pom ntawm koob tshuaj 80 mg ib hnub twg. Txawm hais tias qhov tshwm sim zoo sib xws tshwm sim ntawm cov koob tshuaj qis dua tam sim no tsis paub.
Nyob rau hauv rooj plaub ntawm cov kab mob ntawm daim siab thiab ob lub raum, nws yog ib qho tsim nyog yuav tau ua kom paub tseeb tias cov tshuaj uas tau hais tseg tsis ua rau muaj kev cuam tshuam los ntawm cov kab mob hauv nruab nrog cev. Yog li, nyob rau hauv cov xwm txheej zoo li no, nws raug nquahu kom pib kho nrog koob tshuaj 20 mg ib hnub. Nws tseem tsim nyogNco ntsoov tias rau cov neeg feem coob uas muaj lub siab ua haujlwm tsis zoo, ntau npaum li 40 mg ib hnub yog qhov txaus ntshai.
Side effects
Telmisartan 80 cov kev phiv dab tsi tuaj yeem ua rau? Kev tshuaj xyuas ntawm cov kws tshaj lij qhia tias qhov tshwm sim tsis zoo tawm tsam keeb kwm yav dhau los ntawm kev noj tus neeg sawv cev hauv nqe lus nug yog qhov tsawg kawg nkaus. Txawm li cas los xij, qee zaum, cov neeg mob tseem yws yws txog cov xwm txheej hauv qab no:
- Bradycardia, anemia, ua tsis taus pa, ntuav, ntshav siab creatinine, pw tsaug zog, raws plab, mob nraub qaum.
- Txoj kev nyuaj siab, ua tsis taus pa, vertigo, calf cramps, fainting, khaus ntawm daim tawv nqaij, ntshav siab poob qis, mob plab, tsis muaj zog.
- Dyspepsia, pob khaus, mob raum tsis ua haujlwm, hyperkalemia, mob hauv siab, lub raum tsis ua haujlwm, nce tawm hws.
- mob nqaij, ua pa thiab kab mob urinary (xws li cystitis, sinusitis lossis pharyngitis), tachycardia, sepsis, pom kev cuam tshuam, thrombocytopenia, qhov ncauj qhuav.
- Txo qis hauv qib hemoglobin, plab tsis xis nyob, tsis xis nyob, mob pob qij txha, poob ntshav siab nrog kev hloov pauv hauv lub cev, ua haujlwm tsis zoo ntawm daim siab, erythema, siab siab enzymes, eczematous pob, nce ntshav uric acid ntau ntau.
- Tendon mob, angioedema, tendonitis, lom pob khaus, nce eosinophils.
Tseem ceeb kom paub
Nrog kev saib xyuas tshwj xeeb, cov tshuaj "Telmisartan" raug sau rauLub siab ua haujlwm tsis zoo, aortic stenosis, gastric ulcer thiab duodenal ulcer (thaum lub sijhawm exacerbation), kab mob plawv, kab mob ntawm lub plab zom mov, mitral valve stenosis, plawv tsis ua haujlwm thiab hypertrophic obstructive cardiomyopathy.
Nyob rau hauv cov neeg uas txo BCC, nrog rau cov hyponatremia, cov tsos mob ntawm arterial hypotension yuav tshwm sim (xws li tom qab noj thawj ntsiav tshuaj ntawm cov tshuaj). Hauv qhov no, yuav tsum tau kho cov xwm txheej no ua ntej kho.
Nws yog txwv tsis pub siv telmisartan hauv cov neeg mob uas muaj thawj aldosteronism.
Kev siv cov tshuaj tuaj yeem ua ke nrog thiazide diuretics, vim tias kev sib xyaw ua ke no ua rau txo qis ntshav siab ntxiv.
tshuaj los ntawm ntshav siab "Telmisartan": tshuaj xyuas thiab analogues
Analogues ntawm cov tshuaj hauv nqe lus nug yog xws li:
- Micardis.
- Priter.
- Telmista.
- Teseo.
Ua ntej siv cov tshuaj no txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm rau txhawm
Telmisartan zoo npaum li cas? Kev tshuaj xyuas cov neeg mob ntawm cov tshuaj no yog qhov tsawg kawg nkaus. Ntawm cov ntawv ceeb toom uas muaj niaj hnub no, kwv yees li 80% yog qhov zoo. Cov neeg uas muaj ntshav siab tsis tu ncua thov hais tias noj cov tshuaj hais no tso cai rau koj kom sai thiab maj mamnormalize nws. Tsis tas li, cov neeg mob txaus siab rau qhov tseeb tias cov tshuaj no tsis tshua muaj tshwm sim.
