Tshuaj "Anastrozole TL" muaj cov khoom nquag ntawm tib lub npe thiab cov khoom pabcuam uas tsim lub plhaub thiab txhim kho kev nqus ntawm cov khoom tseem ceeb. Cov tshuaj no muaj cov nyhuv antitumor thiab tau sau rau mob qog noj ntshav.
Qhov tseeb analogue ntawm cov tshuaj no yog cov tshuaj "Anastrozole". Qhov sib txawv ntawm "Anastrozole" thiab "Anastrozole TL" yog qhov tom kawg yog txhim kho los ntawm qee cov khoom uas ua rau nws yooj yim rau nqus thiab du tawm cov kev mob tshwm sim. Txwv tsis pub, cov tshuaj no zoo ib yam nkaus.
Cov chaw tsim khoom ntawm "Anastrozole TL" yog lub tuam txhab Lavxias kws tshuaj LLC Technology of Medicines.
Ntseeg ntawm cov tshuaj
Ib qho tshwj xeeb ntawm kev siv tshuaj "Anastrozole TL" yog nws cov nyhuv xaiv, nyob rau hauv uas nws tsis cuam tshuam rau kev tso tawm ntawm lwm cov tshuaj hormones, suppressing nkaus xwb.kev tsim cov tshuaj estrogen. Qhov no txo qis kev ntxhov siab ntawm lub cev thiab tshem tawm qhov xav tau los qhia corticosteroids rau hauv chav kho mob kom them nyiaj rau qhov tsis zoo ntawm cov tshuaj. Nws yog sai absorbed rau hauv cov ntaub so ntswg los ntawm lub digestive ib ntsuj av (tsawg tshaj li ob teev) tsis hais lub sij hawm ntawm noj mov. Yog tias cov tshuaj tau noj nrog zaub mov, qhov no tsuas yog cuam tshuam me ntsis rau cov txheej txheem ntawm nws qhov nqus. Cov tshuaj nquag tsis sib sau hauv lub cev thiab tsis nyiam sib sau. Cov tshuaj txo cov concentration ntawm estradiol hauv cov ntshav los ntawm 80%.
Scope of application
Lub Scope ntawm "Anastrozole TL" yog qhov nqaim heev. Nws raug sau tseg tshwj xeeb rau kev mob qog noj ntshav mis, nrog rau kev laus, yog tias muaj kev sib txuas ntawm qib estrogen thiab kev loj hlob ntawm kev loj hlob ntawm neoplasms.
YContraindications
Raws li cov lus qhia rau "Anastrozole TL", kev kho mob nrog tshuaj kho mob qog noj ntshav muaj qee qhov contraindications:
- hnub nyoog yug me nyuam, lactation, cev xeeb tub;
- raum, siab tsis ua hauj lwm;
- muaj lwm yam pathologies uas ua rau tsis ntseeg txog qhov ua tau zoo ntawm kev kho mob yav tom ntej.
kev tawm tsam tsis zoo
Tom qab hloov hom kev kho hormonal tiv thaiv keeb kwm yav dhau los ntawm kev ntxhov siab hnyav, cov kev mob tshwm sim tuaj yeem tshwm sim uas txawv ntawm lawv qhov kev siv zog thiab hnyav rau kev noj qab haus huv. Raws li kev tshuaj xyuas ntawm "Anastrozole TL", feem ntau pom hauv cov neeg mob:
- paj hlwb: kiv taub hau, lethargylos yog, ntawm qhov tsis sib xws, kev zoo siab heev, mob taub hau, tsaug zog, neurosis, insomnia;
- digestive disorders: raws plab, cem quav, xeev siab, tsis qab los, qhov ncauj qhuav;
- cuam tshuam ntawm kev sib koom tes, kev tsis zoo ntawm cov kev cuam tshuam ntawm lub paj hlwb rau kev cuam tshuam ntawm lwm yam;
- dermatological tshwm sim: tawv pob khaus, khaus khaus, kub hnyiab, tawm hws ntau dhau.
Lwm yam tsis zoo tshwm sim
Kuj feem ntau muaj qhov tshwm sim tsis zoo xws li qhov muag plooj ib nrab, mob nraub qaum thiab hauv siab, los ntshav hauv tsev menyuam. Feem ntau, cov tsos mob no yog cov yam ntxwv ntawm lub sijhawm pib ntawm cov tshuaj. Tsis tas li ntawd, tom qab qee lub sijhawm, thaum lub cev tau siv rau qhov hloov pauv hormonal keeb kwm yav dhau los, cov kev mob tshwm sim dhau los ua qhov tsis tseem ceeb thiab tsis pom. Qhov no tau lees paub los ntawm cov lus qhia siv rau Anastrozole TL.
Analogues
Cov npe ntawm cov tshuaj analogues no suav nrog:
- "Egistrazol" yog ib qho muaj zog thiab xaiv ntau yam uas tsis yog-steroidal aromatase inhibitor, ib qho enzyme uas hloov testosterone thiab androstenedione hauv cov ntaub so ntswg rau hauv estradiol thiab estrone hauv cov poj niam. Kev txo qis hauv cov concentration ntawm estradiol ncig hauv cov ntshav hauv cov neeg mob uas muaj cov qog oncological ntawm lub caj pas mammary muaj qhov tsim nyog kho mob. Lub ntsiab tseem ceeb ntawm cov tshuaj no yog anastrozole. Nws tsis muaj androgenic, progestogenic thiab estrogenic kev ua, thiab nyob rau hauv txhua hnub noj nws tsis muaj kev cuam tshuam rau zus tau tej cov cortisol thiab aldosterone. Thaum siv anastrozole, kev hloov kho nrog corticosteroids tsis tas yuav tsum tau. Cov tshuaj no yog qhia rau kev kho mob ntawm cov tshuaj hormones-receptor-zoo mob cancer mis nyob rau hauv cov poj niam postmenopausal. Tsis tas li, cov tshuaj tuaj yeem raug sau rau hauv kev kho mob metastatic lossis mob qog noj ntshav hauv zos, nrog rau qhov tsis paub lossis zoo hormonal, thiab hauv kev mob qog noj ntshav tom qab kev kho mob yav dhau los nrog tamoxifen. Tsim tawm hauv cov ntsiav tshuaj.
- "Anastera" - tshuaj tua kab mob. Nws yog ib hom tshuaj uas tsis yog-steroidal uas inhibits zus tau tej cov aromatase. Hauv cov poj niam postmenopausal, estradiol yog tsim los ntawm estrone, uas yog synthesized nyob rau hauv peripheral ntaub so ntswg los ntawm androstenedione (nrog kev koom tes ntawm aromatase). Txo cov theem ntawm estradiol muaj kev kho mob siab rau cov poj niam uas mob qog noj ntshav. Nws tuaj yeem muab tshuaj tshwj xeeb rau cov poj niam uas nyob hauv lub sijhawm postmenopausal. Cov tshuaj no yog contraindicated nyob rau hauv premenopausal lub sij hawm, nrog rau mob raum tsis ua hauj lwm, mob siab thiab mob siab tsis ua hauj lwm, thaum cev xeeb tub, lactation, hypersensitivity. Cov tshuaj no muaj nyob rau hauv daim ntawv ntsiav tshuaj.
- Selana yog ib yam tshuaj uas muaj cov nyhuv inhibitory ntawm ib qho enzyme uas txhawb kev hloov pauv ntawm androstenedione rau estrone hauv cov poj niam postmenopausal. Lub ntsiab tseem ceeb tam sim no nyob rau hauv cov tshuaj muaj ib tug siab antitumor ua hauj lwm tiv thaiv estrogen-dependent neoplasms ntawm mammary.qog. Nws muaj tib daim ntawv qhia, contraindications thiab tsis zoo tshwm sim raws li "Anastrozole TL" thiab cov saum toj no analogues ntawm cov tshuaj no.
- "Abitaxel" yog ib qho kev kho uas tsis yog cov qauv analogue ntawm cov tshuaj hauv nqe lus nug, tab sis muaj cov txiaj ntsig zoo tib yam. Nws yog ib qho tshuaj antitumor, inhibitor ntawm mitosis. Paclitaxel, tam sim no nyob rau hauv cov muaj pes tsawg leeg, khi rau microtubule beta-tubulin, uas cuam tshuam lub depolymerization ntawm cov protein no thiab pab txo qis qhov tseeb dynamic reorganization ntawm microtubules. Qhov no ua lub luag haujlwm txiav txim siab thaum lub sijhawm interphase, yam tsis muaj cellular functions nyob rau theem mitosis yog tsis yooj yim sua. Tsis tas li ntawd, cov tshuaj nquag no ua rau tsim cov kab mob microtubule txawv txav thaum lub sij hawm tag nrho lub voj voog ntawm tes thiab cov tsos ntawm ob peb centrioles thaum lub sij hawm mitosis. Cov tshuaj no yog muab rau cov kab mob oncological ntawm lub mis, zes qe menyuam, ntsws, txoj hlab pas, zais zis, thiab lwm yam. Nws yog contraindicated nyob rau hauv kev loj hlob ntawm neutropenia, thaum cev xeeb tub thiab siab rhiab heev rau lub active caij. Cov tshuaj yog tsim nyob rau hauv daim ntawv ntawm ib tug concentrate rau kev npaj ntawm ib tug infusion tov.
- "Bilem" - ib qho tshuaj tiv thaiv kab mob antiestrogen. Competitively suppresses estrogen receptors nyob rau hauv cov qog thiab lub hom phiaj ntawm lub cev. Yog li ntawd, ib qho nyuaj tshwm sim uas, tom qab hloov mus rau lub cell nuclei, tiv thaiv cell hypertrophy, uas nyob ntawm kev tswj cov tshuaj estrogen. Cov tshuaj muajantigonadotropic cov cuab yeej, inhibits lub synthesis ntawm Pg nyob rau hauv cov ntaub so ntswg, inhibits kev loj hlob ntawm malignant txheej txheem, uas yog stimulated los ntawm estrogen. Lub peev xwm los thaiv cov tshuaj hormones no yuav nyob mus ob peb lub lis piam tom qab ib koob tshuaj. Tsis tas li ntawd, cov tshuaj tuaj yeem ua rau ovulation hauv cov poj niam los ntawm kev txhawb nqa GRF los ntawm hypothalamus. Hauv cov txiv neej nrog oligospermia, nws nce qhov concentration ntawm FSH thiab LH, nrog rau cov tshuaj estrogen thiab testosterone hauv cov ntshav. Cov khoom tseem ceeb thiab qee yam ntawm nws cov metabolites yog inhibitors ntawm oxidase kev ua haujlwm ntawm cytochrome P450 system hauv daim siab, tab sis qhov tseem ceeb ntawm cov tshuaj no tsis tau txiav txim siab. Cov tshuaj no yog qhia rau mob qog noj ntshav, raum oncology, melanoma thiab cov nqaij mos sarcoma, malignant zes qe menyuam hlav, endometrial cancer, prostate cancer, thiab lwm yam. Cov tshuaj yog contraindicated rau hypersensitivity, cev xeeb tub, lactation, mob qhov muag, hyperlipidemia, thrombophlebitis, leukopenia, hypercalcemia., kab mob thromboembolic.
Drug interaction
Qhov ntau npaum li cas "Anastrozole TL" ua rau muaj kev hem thawj rau lub neej tsis tau tsim. Nyob rau hauv rooj plaub ntawm kev quav tshuaj lom, cov tsos mob kho tau ua thiab kev ntsuas tau coj mus rau tus neeg mob resuscitate.
Kev npaj kho mob "Anastrozole TL" tsis tau sau nrog lwm cov tshuaj tiv thaiv kab mob, nrog rau cov tshuaj uas muaj tshuaj estrogen vim lawv qhov kev sib hloov pauv thaum noj ua ke.
Kev sim tshuaj tau pom tias thaum twgThaum siv cov tshuaj no nrog cov tshuaj xws li antipyrine thiab cimetidine, kev sib cuam tshuam ntawm cov tshuaj vim yog induction ntawm microsomal daim siab enzymes tsis zoo li.
Special Recommendations
Cov tshuaj "Anastrozole TL" tsis tuaj yeem muab tshuaj raws li kev kho ib leeg. Nws qhov kev txais tos yuav tsum tau kuaj ua ntej nrog kev kawm txog tus neeg mob keeb kwm. Ib qho kev txwv nruj rau kev kho mob yog qhov tsis txaus ntseeg ntawm cev xeeb tub. Nws tseem yog qhov yuav tsum tau ua cov kev kuaj sim uas paub meej tias lub xeev ntawm cov poj niam cev xeeb tub. Kev loj hlob los ntshav los ntawm qhov chaw mos thaum kho yog vim li cas mus ntsib kws kho mob.
Lwm kev sib cuam tshuam
Nws kuj tau raug pov thawj tias cov khoom kho mob txo qhov ceev ntawm cov ntaub so ntswg ntawm cov leeg musculoskeletal. Nws yuav tsum nco ntsoov tias qhov ua tau zoo ntawm kev kho nrog cov tshuaj yog txo qis nrog kev tswj hwm ntawm cov tshuaj uas muaj estrogens. Kev tshuaj xyuas ntawm cov kws kho mob txog "Anastrozole TL" hauv qhov no muaj.
Nws tsis tuaj yeem siv tshuaj ua ke nrog tamoxifen. Tsis tas li ntawd, nws tsis raug nquahu kom siv Anastrozole hauv kev txhim kho cov qog qog nqaij hlav uas tsis yog tshuaj estrogen-dependent, vim tias cov kev kho no yuav tsis muaj txiaj ntsig.
Reviews
Tus kws tshuaj no yog qhov tshwj xeeb thiab tsis siv ntau zaus. Tsuas yog tus kws tshaj lij tsim nyog yuav tsum xaiv nws.
Muaj ntau qhov kev tshuaj xyuas ntawm cov neeg mob txog "Anastrozole TL"cov ntaub ntawv zoo txog nws cov txiaj ntsig. Cov poj niam nyob rau lub sijhawm postmenopausal uas tau muab tshuaj tau sau tseg tias nws cov txiaj ntsig zoo, thaum qhov kev loj hlob ntawm cov qog nqaij hlav hauv lub caj pas mammary sai sai. Qhov no tau lees paub los ntawm kev kuaj ntshav suav thiab cov txheej txheem ntsuas kev ntsuas (piv txwv li, ultrasound).
Qhov tsuas yog qhov tsis zoo ntawm kev kho cov tshuaj no, raws li cov neeg mob, yog ntau qhov kev phiv tshwm sim tom qab noj thawj ntsiav tshuaj.
Expert comments
Kev tshuaj xyuas ntawm cov kws kho mob txog "Anastrozole TL" ceeb toom tawm tsam kev tswj hwm tus kheej ntawm cov tshuaj no, vim tias, raws li cov kws tshaj lij, qhov no tuaj yeem ua rau muaj kev phom sij rau kev noj qab haus huv. Feem ntau, cov kws kho mob xav tias cov tshuaj no ua tau zoo heev thiab nrov tshaj plaws ntawm cov analogues.
Tam sim no nws tau pom meej rau ntau npaum li cas Anastrozole txawv ntawm Anastrozole TL.
