Cov tshuaj Antianginal yog cov tshuaj uas ua rau cov ntshav ntws mus rau lub plawv thiab txo nws qhov kev thov oxygen. Cov tshuaj no feem ntau siv los nres lossis tiv thaiv kev mob angina.
Angina pectoris yog kab mob uas tshwm sim los ntawm qhov mob lossis tsis xis nyob hauv siab. Raws li txoj cai, qhov mob nyob rau hauv xws li ib tug kab mob manifests nws tus kheej dheev nrog kev nyuaj siab los yog lub cev exertion, raws li zoo raws li tom qab noj mov. Feem ntau nws muab rau lub caj dab, sab laug xub pwg, nruab nrab ntawm lub xub pwg hniav, lub puab tsaig sab laug thiab sab laug subscapular cheeb tsam. Xws li qhov tsis xis nyob yuav ploj mus tom qab ¼ teev. Tsis tas li ntawd, qhov mob ploj tom qab kev ua haujlwm ntawm lub cev lossis tom qab noj tshuaj antianginal. Raws li yav tas los, cov tshuaj "Kordinik" feem ntau siv. Cov lus qhia rau kev siv, kev piav qhia ntawm cov tshuaj thiab nws cov khoom muaj nyob hauv qab no.
Kev piav qhia ntawm cov khoom siv tshuaj, nws daim ntawv, muaj pes tsawg leeg thiab ntim khoom
Daim ntawv twg yog qhov muaj nyob hauv cov tshuaj "Kordinik"? Cov lus qhia rau kev siv qhia tias cov tshuaj no tuaj yeem yuav hauv daim ntawv ntawm cov ntsiav tshuaj. Lawv yogmuaj lub tiaj-cylindrical zoo, muaj xim dawb lossis tsis muaj zog greyish-daj.
Cov tshuaj muaj pes tsawg leeg hauv nqe lus nug suav nrog nicorandil. Qos yaj ywm starch, calcium stearate thiab microcrystalline cellulose yog siv los ua cov khoom pab.
Cov tshuaj "Kordinik" yog muag, cov lus qhia rau kev siv uas tau ntim rau hauv ib lub pob ntawm cardboard, nws los nyob rau hauv contour hlwb.
Tshuaj kho mob ntawm tshuaj
Dab tsi yog qhov zoo tshaj ntawm cov tshuaj "Kordinik" (cov ntsiav tshuaj)? Cov lus qhia rau kev siv qhia tias nicorandil muaj cov nyhuv antianginal. Nws yog raws li kev sib xyaw ua ke ntawm cov khoom zoo li nitrate nrog rau lub peev xwm qhib cov poov tshuaj raws. Vim yog cov cuab yeej tom qab, cov tshuaj no ua rau hyperpolarization ntawm cell membrane.
Cov txiaj ntsig zoo li nitrate ntawm cov tshuaj no yog txhawm rau nce cov ntsiab lus ntawm cyclic guanyl monophosphate hauv cov hlwb. Xws li cov tshuaj pharmacological pab txhawb kom cov leeg du, nrog rau kev tiv thaiv myocardial thaum ischemia.
Raws li rau cov teebmeem hemodynamic, lawv tau qhia nyob rau hauv qhov sib npaug ntawm kev txo qis tom qab- thiab preload. Noj mus rau hauv tus account vasodilation (xaiv) ntawm cov hlab ntsha coronary, lub load ntawm ischemic myocardium yog qhov tsawg.
Nicorandil tsis cuam tshuam rau myocardial contractility. Tsis tas li ntawd, cov tshuaj no tsis hloov lub plawv dhia. Txawm li cas los xij, nws txo qis cov ntshav siab, thiab tseem muaj txiaj ntsig zoo rau cov hlab hlwb hauv cov neeg mob stroke.
Dab tsi ntxivCov khoom muaj nyob rau hauv kev npaj "Kordinik"? Cov lus qhia rau kev siv (analogs ntawm cov tshuaj muaj npe hauv qab no) hais tias nicorandil tsis muaj kev cuam tshuam rau cov piam thaj metabolism thiab lipid metabolism. Nws nres qhov kev tawm tsam ntawm angina pectoris, thiab tseem txo qhov mob li ntawm xya feeb tom qab noj nws hauv qab tus nplaig. Kev tshem tawm tag nrho ntawm qhov tsis xis nyob yog pom tom qab ¼ teev.
Kinetics ntawm cov khoom
tshuaj "Kordinik" nqus los ntawm qhov twg? Cov lus qhia rau kev siv qhia tau hais tias qhov nqus ntawm cov tshuaj nyob rau hauv nqe lus nug los ntawm txoj hnyuv. Nws ncav cuag nws qhov siab tshaj plaws plasma concentration tom qab 35-60 feeb.
Nicorandil khi tsuas yog me ntsis rau plasma proteins. Nws cov feem dawb hauv cov ntshav yog 75%.
Cov tshuaj no tsis yog metabolized los ntawm daim siab. Nws raug tso tawm los ntawm ob lub raum hauv 50 feeb.
Indications rau nkag
Cordic ntsiav tshuaj yuav tsum siv thaum twg? Cov lus qhia hais tias cov cuab yeej no ua tau zoo thaum:
- tiv thaiv angina tawm tsam (ruaj khov) ua ke nrog lwm cov tshuaj tiv thaiv kab mob;
- nres angina tawm tsam;
- monotherapy rau intolerance rau BMCC thiab beta-blockers.
Contraindications rau noj
Thaum twg yuav tsum tsis txhob muab cov tshuaj Cordinic? Cov lus qhia rau kev siv (lub ntsiab lus ntawm cov tshuaj tau hais hauv qab no) hais txog cov contraindications xws li:
- collapse, cardiogenic shock;
- AV-thaiv ntawm qhov thib peb thiab thib ob degree;
- mob myocardial infarction, thiab tseem nyob hauv 90 hnub tom qab nws;
- tsis ruaj tsis khov angina;
- mob plawv tsis ua hauj lwm (NYHA functional class 3 or 4);
- arterial hypotension;
- lub sijhawm cev xeeb tub;
- qhia bradycardia;
- lactation;
- sab laug ventricular tsis ua haujlwm nrog txo qhov siab;
- hnub nyoog yau;
- kev siv sib txuas ntawm phosphodiesterase-5 inhibitors (xws li Sildenafil, Vardenafil lossis Tadalafil);
- drug hypersensitivity.
Nrog ceev faj, cov ntsiav tshuaj no tau muab tshuaj rau lub plawv dhia tsis zoo, Prinzmetal's angina, thawj-degree AV block, arterial hypotension, impaired siab thiab raum ua haujlwm, hypovolemia, pulmonary edema, hyperkalemia, lub kaum sab kaw glaucoma thiab anemia.
Kev Npaj "Kordinik": txheej txheem ntawm daim ntawv thov thiab koob tshuaj
Cordinic ntsiav tshuaj yuav tsum tau noj hauv qhov ncauj, tsis hais noj mov.
Cov tshuaj no yog xaiv ib tus zuj zus. Raws li txoj cai, nws nyob ntawm lub sijhawm thiab qhov hnyav ntawm tus kabmob.
Txhawm rau tiv thaiv tus mob angina pectoris, cov tshuaj yuav tsum tau noj thaum thawj cov tsos mob ntawm tus kab mob. Nyob rau hauv cov ntaub ntawv no, nws yog sau nyob rau hauv ib koob ntawm 20 mg. Lub ntsiav tshuaj muab tso rau hauv qab tus nplaig thiab tuav kom txog thaum nws yaj.
Kev tiv thaiv ntawm angina tawm tsamruaj khov (xws li kev kho mob mus ntev), cov tshuaj feem ntau yog muab rau ntawm ib koob ntawm 10-20 mg peb zaug ib hnub.
Qhov siab tshaj plaws ntawm cov tshuaj no ib hnub twg yog 80 mg. Rau kev mob taub hau, koob tshuaj pib yuav raug txo.
Side effects
Koj yuav tsum paub dab tsi ua ntej noj cov tshuaj Cordinic? Cov lus qhia rau kev siv hais tias qhov kev kho no yuav ua rau muaj qhov tsis txaus siab xws li:
- qaug zog, palpitations, mob taub hau, txo ntshav siab, kiv taub hau;
- tachycardia, tinnitus, ntws tawm ntawm daim tawv nqaij, insomnia;
- tshuaj tsis haum, peripheral edema, xeev siab;
- xav tias plab plab, ntuav, nce kev ua haujlwm ntawm "siab" transaminases, tsis xis nyob hauv plab, stomatitis.
Pill overdose
Thaum noj cov ntsiav tshuaj ntau, tus neeg mob muaj cov tsos mob xws li tachycardia thiab txo qis hauv cov ntshav siab. Hauv qhov no, tus neeg raug tsim txom raug ntxuav nrog lub plab thiab muab activated charcoal. Lawv kuj txhawb cov hlab plawv.
Sib tham nrog lwm yam cuab yeej
Cov nyhuv antianginal ntawm cov tshuaj hauv nqe lus nug yog txhim kho thaum noj tshuaj tua kab mob, vasodilators, phosphodiesterase-5 inhibitors, antihypertensives thiab tricyclic antidepressants. Tib yam siv rau diuretics, MAO inhibitors, beta-blockers thiab ethanol.
Specialcov lus pom zoo
Cov tshuaj yuav tsum tau txiav kom maj mam. Thaum kho, nws yuav tsum tau saib xyuas ECG thiab ntshav siab, nrog rau cov ntsiab lus ntawm sodium thiab potassium ions hauv cov ntshav. Tsis tas li ntawd, thaum noj cov tshuaj no, nws muaj peev xwm ua kom lub plawv dhia tsis zoo.
Analogues thiab synonyms ntawm cov tshuaj, nws tus nqi
Tam sim no koj paub tias cov tshuaj "Kordinik" ua haujlwm li cas. Cov lus qhia rau kev siv, cov duab thiab cov khoom ntawm cov tshuaj no tau nthuav tawm saum toj no.
Cov tshuaj hauv nqe lus nug nqi pes tsawg? Raws li txoj cai, tus nqi ntawm cov tshuaj no rau 60 ntsiav tshuaj (10 mg) yog 450 rubles. Txawm hais tias nyob rau qee thaj tsam ntawm peb lub teb chaws tus lej no tuaj yeem nce ntxiv lossis, hloov pauv, txo qis.
Yog xav tau ceev, cov tshuaj no tuaj yeem hloov tau los ntawm cov tshuaj xws li "Dilasid", "Corvamin", "Carbocromen", "Corvaton", "Sydnopharm", "Oxycardin", "Reasanz" thiab lwm yam.
Raws li cov ntsiab lus, tsuas yog Coronel raug xa mus rau lawv.
tshuaj tshuaj xyuas
Muaj ntau qhov kev tshuaj xyuas zoo txog cov tshuaj "Kordinik". Cov neeg siv khoom thov hais tias tus neeg sawv cev antianginal zoo li no tau ua tiav nrog txoj haujlwm. Noj cov tshuaj hauv nqe lus nug zoo nres angina tawm tsam, thiab tseem tshem tawm qhov mob thiab tsis xis nyob tom qab lub sternum.
Ntxiv rau, qhov zoo ntawm cov tshuaj no suav nrog nws qhov muaj thiab muaj peev xwm los hloov cov tshuaj analogues, thiab qhov tsis zoo yog tus nqi siab thiab muaj ntau yam tsis zoo.
