Cov roj plasma siab pab txhawb kev txhim kho atherosclerosis thiab kab mob plawv.
Rau lipid-txo kev kho mob, tshwj xeeb txhais tau tias yog siv, ib qho ntawm cov tshuaj "Atocor". Cov lus qhia rau cov tshuaj no piav qhia txog nws lub luag haujlwm hypocholesterolemic thiab hypotriglyceridemic hauv kev txo qis cov roj cholesterol thiab lwm cov rog hauv tib neeg lub cev.
yam ntxwv dav dav
Cov tshuaj muaj nyob rau hauv inhibitors ntawm 3-methylglutaryl-3-hydroxy-coenzyme A reductase. Tsim los ntawm Indian tuam txhab "Doctor Reddy's Laboratories".
Atokor tuaj yeem muaj ntau npaum li cas ntawm 0.020 thiab 0.010 g.
Ib daim foos
Cov khoom lag luam yog tsim hauv cov ntsiav tshuaj daim ntawv nrog cov xim dawb txheej. Cov ntsiav tshuaj yog extruded nyob rau hauv cov duab ntawm daim duab peb sab nrog biconvex nto, ntawm ib tug ntawm cov ntawv "A" yog siv, thiab nyob rau lwm yam muaj ib tug koob npe ntawm "10" los yog "20".
Composition
Cov khoom xyaw nquag ntawm cov tshuaj yog atorvastatin, uas yog sawv cev los ntawm micronized calcium.trihydrate. Nyob rau hauv cov tshuaj "Atocor" ntau npaum thiab muaj pes tsawg leeg ntawm lub active ingredient muaj ib tug me ntsis txawv. Txhua 0.01084 lossis 0.02168 g ntawm atorvastatin calcium trihydrate yog sib npaug rau 0.01 lossis 0.02 g ntawm atorvastatin ntshiab.
Mis qab zib, calcium carbonate, croscarmellose sodium, polysorbate 80, hydroxypropyl cellulose, lactose DT, magnesium stearate tsim cov ntsiav tshuaj qauv.
Lub plhaub zaj duab xis yog tsim los ntawm hypromellose 15 cps, propylene glycol, purified talc, titanium dioxide.
Cov muaj pes tsawg leeg yog tib yam rau ob qho tshuaj ntawm Atokor, thiab lawv muaj cov lus qhia ntau.
ntsiav tshuaj ntawm 0.01 lossis 0.02 g muaj nyob rau hauv pob ntawm 10 hauv ib lub hlwv ntim rau hauv ib lub thawv ntawv.
Mechanism of action
Cov lus qhia rau kev siv tshuaj xa mus rau kev xaiv, kev sib tw inhibitors ntawm 3-methylglutaryl-3-hydroxy-coenzyme A reductase. Nws yog ib qho tseem ceeb enzymatic compound rau kev hloov ntawm 3-hydroxy-3-methylglutaryl coenzyme A rau mevalonic acid, uas yog cov precursor rau styrenes thiab cholesterol.
Yog tias cov neeg mob muaj homozygous, heterozygous tsev neeg thiab tsis yog tsev neeg hypercholesterolemia, nrog rau kev sib xyaw dyslipidemia, tom qab ntawd noj Atocor pab txo qis cov roj (cholesterol) tag nrho, cov roj (cholesterol) hauv cov lipoproteins tsawg thiab tsawg ntom ntom, triglycerides thiab apolipoprotein. B.
Tshuaj "Atokor" cov lus piav qhia ntawm cov tshuaj qhia txog lub peev xwm ntawm cov ntsiav tshuaj kom tsis ruaj khov nce qib ntawm cov txiaj ntsig sterol hauvCov lipoproteins ntau ntom ntom.
Hauv daim siab hlwb, triglyceride thiab cov roj cholesterol molecules dhau los ua ib feem ntawm cov lipoprotein tshuaj, uas muaj qhov ntom ntom. Lawv nkag mus rau lub plasma, uas lawv nkag mus rau hauv cov ntaub so ntswg peripheral. Lawv tsim cov lipoprotein tebchaw nrog tsawg saturation, uas tuaj yeem ua rau muaj kev cuam tshuam los ntawm kev sib cuam tshuam nrog kev sib raug zoo receptor formations. Tag nrho cov tshuaj no tuaj yeem txhim kho txoj kev loj hlob ntawm atherosclerosis.
Qhov kev txiav txim ntawm atorvastatin yog tus cwj pwm los ntawm kev hais tawm thiab tsis tu ncua hauv kev ua haujlwm ntawm LDL-receptor complexes, txo qis hauv cov ntsiab lus ntawm cov roj (cholesterol) phem nrog nce cov roj cholesterolemia ntawm homozygous hereditary hom.
Txhais tau tias "Atocor" cov lus qhia qhia nws lub peev xwm los txo cov roj cholesterol thiab lipoprotein hauv plasma los ntawm inhibiting HMG-CoA reductase enzyme. Nws slows tus tsim ntawm cov cholesterol nyob rau hauv daim siab hlwb, ua rau kom tus naj npawb ntawm receptor formations ntawm lipoproteins nrog tsawg saturation nyob rau hauv cell membranes. Qhov no pab txhawb kev nce thiab catabolism ntawm cov roj cholesterol molecules los ntawm cov lipoproteins tsawg concentration.
Yuav siv li cas
Tshuaj "Atocor" cov lus qhia rau kev siv cov ntsiav tshuaj qhia kev noj nrog cov cim tseem ceeb ntawm kev nce cov roj cholesterolemia ntawm hom heterozygous, nce hauv zos thiab tsis nyob hauv zos nce hauv cov roj cholesterol concentration, sib xyaw heterolipidemia, nce cov ntshav plasma triglyceride molecules.
Lawv tau sau nrog kev noj hausCov tshuaj noj kom txo qis cov roj (cholesterol) siab hauv cov lipoproteins saturation tsawg, apolipoprotein B thiab triglyceride compounds.
Cov tshuaj txo cov ntshav plasma LDL cov roj cholesterol ntau hauv cov tsev neeg homozygous nce cov roj cholesterolemia thaum noj zaub mov noj thiab lwm txoj hauv kev tsis siv tshuaj tsis zoo.
Yuav ua li cas
Tshuaj "Atokor" cov lus qhia rau kev siv pom zoo haus tsuas yog tom qab sau cov txheej txheem hypocholesterolemic noj rau tus neeg mob, uas yuav tsum tau siv thaum kho. Kev noj tshuaj yog teem rau txhua tus neeg mob sib cais, uas yog xam los ntawm thawj theem ntawm cov roj (cholesterol) hauv cov lipoproteins tsawg saturation. Nws yog ib qho tseem ceeb uas yuav tsum tau coj mus rau hauv tus account lub hom phiaj, qhov ua tau zoo ntawm kev kho mob nrog Atocor, qhia.
Feem ntau, thawj koob tshuaj yog 0.010 g ib koob tshuaj ib hnub. Kev siv cov ntsiav tshuaj tsis yog nyob ntawm lub sijhawm ntawm hnub thiab kev noj zaub mov.
Cov tshuaj noj txhua hnub ntawm 0.010 txog 0.080 g yog xaiv los ntawm cov ntsuas thawj zaug ntawm cov roj (cholesterol) phem, lub hom phiaj ua ntej thiab kev ua haujlwm ntawm tus kheej. Thaum thawj theem ntawm kev siv thiab nrog kev nce hauv cov concentration ntawm cov tshuaj, qib ntawm plasma rog yuav tsum tau kuaj xyuas tom qab ib nrab ib hlis, thiab yog tias tsim nyog, kho cov koob tshuaj.
Primary hypercholesterolemia thiab ua ke hyperlipidemia yog kho nrog ib hnub noj ntawm 0.010 g.
Kev kho mob tshwm sim tom qab 14 hnub, thiab qhov ua tau zoo tshaj plaws yog ua tau tom qab ib qhohli. Kev siv mus sij hawm ntev tso cai rau koj los tswj cov kev kho mob.
Tshuaj "Atokor" cov lus qhia hauv Lavxias muaj cov ntaub ntawv hais txog kev kho mob hypercholesterolemia los ntawm homozygous tsev neeg. Feem ntau, kev noj tshuaj txhua hnub ntawm 0.080 g. Nrog rau kev siv no, cov roj cholesterol hauv LDL txo qis rau 40%.
Txoj kev kho mob
Ntawm Atokor ntsiav tshuaj, cov lus qhia rau kev siv tau pom zoo tias ua ntej koj pib siv cov tshuaj, koj yuav tsum nrhiav qhov ua rau qhov nce qib ntawm cov roj cholesterol. Cov xwm txheej no suav nrog kev kho tsis zoo rau ntshav qab zib mellitus, hypothyroidism, txheej txheem nephrotic, hloov pauv dysproteinemic, kab mob siab. Qhov no tuaj yeem suav nrog kev kho mob nrog lwm yam tshuaj thiab kev haus dej cawv. Tsuas yog tom qab tshem tawm cov laj thawj saum toj no, koj tuaj yeem pib siv Atocor ntsiav tshuaj.
Txawm tias ua ntej kho, qhov lipid tshuav ntawm tag nrho cov roj (cholesterol), LDL cholesterol, HDL cholesterol thiab triglycerides yog txiav txim siab.
Tsis muaj ntaub ntawv qhia txog kev siv tshuaj hauv kev xyaum menyuam yaus, yog li cov tshuaj no tsis raug tshuaj rau menyuam yaus.
Nyob rau hauv kev kho cov neeg laus laus dua 60 xyoo, muaj kev nce qib hauv cov ntshav plasma ntawm cov khoom xyaw nquag ntawm cov tshuaj mus txog 40%.
Yog tias lub raum tsis ua haujlwm, tsis tas yuav tsum hloov koob tshuaj, vim tias tus mob no tsis cuam tshuam rau qib atorvastatin hauv cov hlab ntshav thiab txo qis cov roj cholesterol.
Muaj pov thawj tias siv tshuajntawm chav kawm no ua rau kev loj hlob ntawm rhabdomyolysis myopathy thiab lub raum tsis txaus ua haujlwm hauv daim ntawv mob hnyav. Nrog cov kab mob zoo li no, cov tshuaj yuav tsum tau tso tseg ib ntus.
tshuaj raws li Atorvastatin yuav tsum tau ceev faj rau cov neeg siv cawv lossis muaj keeb kwm mob siab.
Nyob rau hauv qhov kev txiav txim ntawm inhibitors ntawm HMG-CoA reductase enzyme, kev hloov pauv hauv biochemical tsis ntawm lub siab tuaj yeem ua tau. Txog rau cov kev cuam tshuam raws sijhawm, nws yog qhov tsim nyog los ntsuas lub siab ua ntej kev kho ua ntej kev kho mob, thiab tom qab ntawd rov kuaj 3 hlis tom qab noj tshuaj.
Tshuaj "Atocor" cov lus qhia hauv Lavxias suav nrog cov ntaub ntawv hais txog kev nce qib hauv cov ntshav plasma ntawm cov khoom xyaw nquag hauv cov neeg mob siab uas raug kev quav dej caw. Kev tsis kam ua ib ntus lossis ua tiav ntawm kev kho mob rov qab ua haujlwm transaminase ntawm daim siab rau nws qhov kev txwv qub. Ntau tus neeg mob tsis tau tso tseg kev siv tshuaj hauv koob tshuaj me me, thiab tsis muaj qhov tshwm sim tsis zoo.
Kev kho yuav ua rau kiv taub hau, tsaug zog tuaj yeem tsim, yog li cov neeg mob raug txwv tsis pub tsav tsheb lossis lwm yam khoom siv nyuaj thaum noj cov ntsiav tshuaj.
leej twg yuav tsum tsis txhob siv
Contraindications rau cov tshuaj "Atokor" suav nrog hypersensitivity rau txhua yam khoom xyaw ntawm cov tshuaj.
Nws tsis raug coj los rau hauv cov kab mob siab heev thiab nrog kev ua kom siab ntawm transaminase serum enzymes, thaumlawv cov dej num yog 3 zaug siab dua tus nqi ntawm cov kev txwv sab sauv ntawm ib txwm ntsuas.
Cov tshuaj no tsis yog tshuaj rau cov poj niam uas muaj hnub nyoog me nyuam uas tsis siv cov tshuaj tiv thaiv zoo. Contraindication yog lub xeev ntawm kev xeeb tub thiab pub niam mis.
Cov tshuaj tsis kho cov menyuam yaus thiab cov tub ntxhais hluas hnub nyoog qis dua 18 xyoo.
Vim muaj cov kua mis qab zib nyob rau hauv cov tshuaj Atokor cov lus qhia rau kev siv txwv tsis pub lawv siv nyob rau hauv cov ntaub ntawv ntawm hereditary intolerance rau galactose molecules, uas tsis muaj lactase thiab malabsorption ntawm galactose-glucose.
Analogues
Muaj ntau cov tshuaj raws li atorvastatin. Lub luag haujlwm hypocholesterolemic yog muab rau kev npaj "Atocor" cov lus qhia rau kev siv. Analogues kuj tseem tuaj yeem txo qis cov roj (cholesterol) phem hauv tib neeg cov ntshav.
Ib qho ntawm cov tshuaj no yog cov tshuaj Slovenian "Atoris", cov chaw tsim khoom ntawm cov tuam txhab sib koom ua ke "Krka, Novo mesto". Muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj uas muaj active ingredient ntawm 0.010 g, 0.020 g, 0.040 g.
Cov tshuaj yog npaj los tshem tawm cov mob hyperlipidemic, uas yuav tsum tau txo qis tag nrho cov roj (cholesterol), cov roj (cholesterol) hauv lipoprotein cov ntsiab lus nrog cov saturation tsawg, tus naj npawb ntawm apolipoprotein thiab triglyceride molecules hauv cov hlab ntsha.
Cov tshuaj yog siv los kho cov neeg mob hypercholesterolemia ntawm polygenic, heterozygous homozygous tsev neeg hom.
Nrog kev pabCov tshuaj "Atoris" nce qhov concentration ntawm cov roj cholesterol hauv lipoproteins nrog siab saturation.
Lwm Slovenian analogue yog cov tshuaj Tulip, uas yog tsim los ntawm Lek Pharmaceutical Company. Zaj duab xis-coated ntsiav tshuaj muaj nyob rau hauv peb lub zog: 0.01g, 0.02g thiab 0.04g txhua.
Cov tshuaj tau sau tseg kom tshem tawm thawj hom hypercholesterolemic thiab ua ke hyperlipidemic xeev, rau kev kho cov roj cholesterol siab heterozygous thiab homozygous tsev neeg hom.
Ib qho tshuaj zoo sib xws yog cov tshuaj Indian "Astin", uas yog tsim los ntawm lub tuam txhab "Micro Labs Limited". Muaj nyob rau hauv ob koob tshuaj: 0.010 g thiab 0.020 g ntawm atorvastatin.
Cov tshuaj tau sau rau cov ntsiab lus lipid siab, thaum tsis muaj txiaj ntsig zoo los ntawm kev noj zaub mov noj thiab lwm yam dej num.
Indian ntau lawm yog cov tshuaj "Storvas" raws li calcium ntsev ntawm atorvastatin. Ua los ntawm Ranbaxy Laboratories Limited nyob rau hauv daim ntawv ntawm ib ntsiav tshuaj coated nyob rau hauv ob ntau npaum: 0.010 g thiab 0.020 g txhua.
Cov tshuaj "Storvas" txo cov ntsiab lus ntawm tag nrho cov roj cholesterol, cov roj cholesterol molecules hauv LDL, qhov concentration ntawm apolipoprotein thiab triglyceride compounds hauv thawj, heterozygous tsev neeg thiab tsis yog tsev neeg hypercholesterolemic xeev, nrog rau cov kab mob sib xyaw hyperlipidemic..
Cov tshuaj txo qhov muaj peev xwm tsim lub plawv nres ntawm cov leeg myocardial, strokes thiab hloov pauv hauv lub hlwbkev ncig. Cov ntsiav tshuaj ua kom qeeb ntawm kev loj hlob ntawm coronary atherosclerosis.
Asmeskas analogue yog cov tshuaj "Liprimar", uas yog tsim los ntawm lub tuam txhab "Pfizer". Muaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj coated nyob rau hauv peb qhov ntau npaum li cas: 0.010 g, 0.020 g, 0.040 g txhua.
Reviews
Tshuaj "Atokor" cov lus qhia rau kev siv cov yam ntxwv ua ib lub cuab yeej nrog kev ua haujlwm siab. Ntau tus neeg mob raug kev txom nyem los ntawm qib siab plasma ntawm cov roj (cholesterol) phem zoo dua tom qab siv sijhawm. Cov txiaj ntsig ntawm tag nrho cov roj cholesterol, nrog rau LDL, raug txo qis mus rau qhov qub, uas txo qis qhov tshwm sim ntawm kev txhim kho atherosclerotic thiab ischemic mob.
Cov tshuaj no tau txais txiaj ntsig zoo, tab sis hauv qee cov neeg mob nws tuaj yeem ua rau quav quav, plab plab, mob plab, xeev siab, thiab plab zom mov. Muaj mob taub hau, pw tsaug zog cuam tshuam. Cov kab mob convulsive, asthenic thiab myalgic tuaj yeem tshwm sim.
Qee zaus, cov kev mob tshwm sim tshwm sim los ntawm myositis, myopathy, paresthesia, peripheral neuropathy, pancreatitis, kab mob siab, cholestatic jaundice.
Cov tshuaj yuav ua rau mob anorexia, ntuav, hepatotoxicity, alopecia, pruritic pob, impotence, cataracts, hyper- lossis hypoglycemia.
