Thioctic acid (lub ntsiab lus - lipoic lossis alpha-lipoic acid) yog cov tshuaj vitamin zoo li uas tau hais tawm cov khoom antioxidant. Nws yog ib lub teeb daj crystalline hmoov nrog ib tug iab saj. Thioctic acid yog synthesized nyob rau hauv tib neeg lub cev nyob rau hauv txaus kom muaj nuj nqis tsuas yog thaum hluas. Tom qab 30-40 xyoo, nws raug nquahu kom ntxiv nws cov khoom lag luam, raws li nws tau tsim los ntawm cov khoom me me rau xyoo.
keeb kwm keeb kwm
Thioctic acid tau pom thawj zaug hauv xyoo 1948, thaum tus kws kho kab mob bacteriologist Irwin Clude Gunsalus, thaum kawm cov kab mob aerobic, nrhiav pom qhov kev ncua ntawm lawv txoj kev loj hlob. Qhov no yog vim qhov tsis muaj qee yam, uas yog Ameslikas hu ua "pyruvate oxidant factor."
Tom qab ntawd, twb yog xyoo 1951, ib pawg kws tshawb fawb,coj los ntawm biochemist Lester Reed, tau txais alpha-lipoic acid (ALA) los ntawm nqaij nyug siab. Cov qauv tshuaj tau txiav txim siab tsuas yog hauv xyoo 1952.
Thawj qhov kev siv tshuaj tau hais hauv xyoo 1955, thiab cov lus hais no yog Colaruasso thiab Rausch. Nws tau raug pom tias cov kua qaub muaj txiaj ntsig zoo hauv kev kho mob ntawm daim siab, mob siab tsis nco qab thiab ua rau tus neeg mob noj qab haus huv zoo nrog qee hom kev qaug dab peg.
Tam sim no nyob rau hauv ib nrab ntawm lub xyoo pua nees nkaum, cov kws tshawb fawb tau tsim thiab ua tiav kev kawm thioctic acid thiab kev npaj raws li nws. Txij li thaum lub 60s lig, cov tshuaj tau siv dav rau kev kho mob ntawm cov neeg mob uas muaj cirrhosis ntawm daim siab thiab kab mob siab ntev.
Ntse
Hom tshuaj hepatoprotector no yooj yim nqus rau hauv cov hnyuv vim muaj cov kua tsib thiab hloov pauv sai sai los ntawm cov ntshav ua tsaug rau cov tshuaj xws li chylomicrons. Cov tshuaj accumulates nyob rau hauv daim siab, lub plawv, lub raum. Cov khoom tawg ntawm thioctic acid raug tso tawm los ntawm ob lub raum lossis cov hnyuv.
Qhov tshuaj ntawm tib neeg lub cev
Raws li cov lus qhia rau kev siv, thioctic acid muaj cov txiaj ntsig zoo hauv qab no rau lub cev:
- Neurotropic nyhuv - txhim kho axon kev loj hlob, txo qhov tsis zoo ntawm cov dawb radicals ntawm lub paj hlwb, normalizes cov piam thaj mus rau cov paj hlwb, txo cov kev pheej hmoo ntawm cov hlab ntsha puas tsuaj thaum muaj ntshav qab zib.
- Detoxification effect. Cov txiaj ntsig zoo ntawm lub zog metabolism,lipid thiab qabzib metabolism nrog kev kho dua ntawm Krebs lub voj voog.
- Ua kom cov piam thaj nce ntxiv thiab tshem cov piam thaj los ntawm cov hlwb. Accelerates lub hauv paus metabolism. Normalizes gluconeogenesis thiab ketogenesis.
- Inhibits tsim cov cholesterol plaques hauv cov hlab ntsha.
- Hepatoprotective action - slows down lub tsub zuj zuj ntawm lipids nyob rau hauv lub siab, tsub zuj zuj ntawm glycogen thiab txhim kho daim siab kev ua ub no, accelerating fermentation kev ua si.
- Cytoprotective effect - stabilization ntawm mitochondrial membranes, mob nyem, txo cov txheej txheem inflammatory, nce hauv kev ua haujlwm antioxidant.
- Immunotropic effect.
Cov lus qhia rau kev siv tshuaj
Raws li cov lus qhia, thioctic acid, tus nqi ntawm kev ywj pheej, tuaj yeem raug sau los ntawm kws kho mob ob qho tib si rau lub hom phiaj ntawm kev tiv thaiv thiab ua ib feem hauv kev kho mob ntawm cov kab mob hauv qab no:
- pob txuv;
- mob ntshav qab zib thiab cawv polyneuropathy;
- kev npam ntawm ntau lub hauv paus chiv keeb;
- atherosclerosis ntawm cov hlab ntsha;
- ntau yam kab mob siab, xws li kab mob siab ntev, kab mob Botkin, cirrhosis ntawm daim siab.
YPharmacokinetics
Thioctic acid thiab analogues tau nqus sai sai thaum noj qhov ncauj. Hauv 40-60 feeb, qhov siab tshaj plaws ntawm cov tshuaj tuaj yeem khaws cia hauv tib neeg lub cev. Lub bioavailability ntawm hepatoprotector yog 30%. Nrog rau kev tswj hwm txoj hlab ntshav ntawm 600 mg ntawm thioctic acid, cia li hauv 30 feeb tom ntej,Qhov siab tshaj plaws ntawm cov tshuaj hauv ntshav (txog 20 mcg hauv ib ml).
Tawm 80-90% ntawm cov tshuaj los ntawm lub raum, thiab ib nrab-lub neej yog los ntawm 20 mus rau 60 feeb. Los ntawm sab saw oxidation thiab conjugation, thioctic acid yog metabolized.
Kev sib sau thiab tso tawm daim ntawv
Hnub no, cov khw muag tshuaj muaj kev yuav tshuaj hauv cov ntawv tso tawm xws li:
- kev daws teeb meem rau kev npaj cov tshuaj rau infusion (muaj cov xim ntsuab thiab ib qho aroma);
- ntsiav tshuaj uas yog zaj duab xis-coated (puag, convex, xim - los ntawm lub teeb daj mus rau daj-ntsuab), cov ntsiav tshuaj muab tso rau hauv ib lub hlwv thiab hauv ib lub thawv.
Muaj 1 ml concentrated hmoov rau kev daws rau infusion:
- thioctic acid - mus txog 30 mg;
- excipients nyob rau hauv daim ntawv ntawm dej rau txhaj, propylene glycol thiab ethylenediamine.
Ib ntsiav tshuaj muaj:
- thioctic acid;
- microcrystalline cellulose, magnesium stearate, lactose monohydrate, croscarmellose sodium, povidone-K25, thiab colloidal silicon dioxide - excipients;
- plhaub muaj titanium dioxide, quinoline daj, hypromellose, hyprolose, macrogol-4000.
Cov khoom noj uas muaj lipoic acid
Thaum muaj qhov tsis muaj thioctic acid hauv lub cev lossis rau kev tiv thaivKoj tuaj yeem ntxiv koj cov zaub mov noj txhua hnub nrog cov zaub mov hauv qab no:
- rice;
- spinach;
- zaub cob pob;
- zaub qhwv dawb;
- yuav nyuj;
- nqaij (tshwj xeeb lub siab);
- muab offal xws li daim siab, siab, raum.
Nyob rau hauv me me, cov khoom muaj nyob rau hauv zaub ntsuab, poov xab, taum, zaub thiab txiv hmab txiv ntoo.
YContraindications
Cov kws kho mob tsis pom zoo siv thioctic acid yog tias kev tsis haum rau cov tshuaj tau kuaj pom yav dhau los lossis muaj kev tsis haum rau cov tshuaj nquag. Tsis tas li ntawd, kev siv tshuaj yuav tsum txwv thaum cev xeeb tub lossis lactation. Nrog ceev faj heev, thioctic acid yog siv rau cov menyuam yaus hnub nyoog qis dua 18 xyoo thiab rau cov neeg muaj hnub nyoog tshaj 75 xyoo. Cov tshuaj yog contraindicated rau cov neeg uas muaj lactase tsis txaus, lactose intolerance thiab qabzib-galactose malabsorption.
Kev siv thioctic acid yuav tsum txwv rau cov neeg mob uas muaj kab mob septic ntawm lub plab lossis duodenum. Qee zaum, siv tau hepatoprotector, tab sis tsuas yog raws li kws kho mob tau sau tseg.
Side effects
Kev siv cov thioctic acid tsis tu ncua tuaj yeem ua rau cov ntshav qab zib tsawg thiab ua xua xws li eczema thiab khaus khaus. Nrog rau kev noj ntau zaus, cov tsos mob dyspeptic yuav tshwm sim, xws li mob hauv cheeb tsam epigastric lossis kub siab.
ThaumKev tswj hwm ntawm thioctic acid hauv cov hlab ntsha, cov xwm txheej hauv qab no yuav tshwm sim raws li kev mob tshwm sim:
- mob taub hau.
- Nausea.
- Vim.
- Anaphylactic shock.
- Hypocoagulation.
- Txhawj xeeb.
- Apnea.
- Diplopia.
- Npaj intracranial siab.
Kev sib tham nrog lwm yam tshuaj
Ua ntej noj thioctic acid, thov nco ntsoov tias hepatoprotector tuaj yeem txhim kho cov nyhuv ntawm qhov ncauj hypoglycemic tshuaj thiab insulin. Nws kuj tseem tuaj yeem txo cov txiaj ntsig ntawm cisplatin.
Qhov tseem ceeb! Thioctic acid tsis sib haum nrog Ringer cov tshuaj thiab cov tshuaj dextrose. Nws tsis pom zoo kom siv cov tshuaj nrog cov tshuaj uas tuaj yeem cuam tshuam nrog cov tshuaj disulfide thiab SH pawg. Tsis txhob haus cawv ua ke nrog thioctic acid, uas tuaj yeem txo nws cov txiaj ntsig zoo rau lub cev.
Cov Cai thiab cov cai ntawm kev cia
Raws li cov lus qhia, thioctic acid yuav tsum tau muab cia rau hauv qhov qhuav, tawm ntawm qhov ncav cuag cov menyuam yaus thiab tawm ntawm lub hnub, ntawm qhov kub tsis tshaj 25 degrees. Khaws cov tshuaj tsis pom zoo rau hauv lub freezer. Lub txee lub neej ntawm cov tshuaj yog txog peb xyoos txij li hnub tsim khoom.
Tus nqi
Tus nqi ntawm cov ntsiav tshuaj thioctic acid hloov pauv nyob ntawm qhov ntau npaum li cas. Yog, rau 30 pcs. Thaum noj 300 mg, koj yuav tsum tau them 298 rubles. Yog tias qhov ntau npaum li cas (hauv mg) 600, tus nqi ntawm thioctic acid ib txwm yuav siab dua - hauv thaj tsam ntawm 650-700 rubles.
Cov tshuaj tsuas tuaj yeem yuav nrog tus kws kho mob sau ntawv.
Reviews
Cov kws kho mob los ntawm ntau hom tshuaj ntseeg tau tias thioctic acid yog universal neuroprotector thiab antioxidant. Raws li cov kws tshaj lij, cov tshuaj feem ntau yog muab rau cov neeg mob ntshav qab zib thiab polyneuropathy. Kev tshuaj xyuas ntawm thioctic acid feem ntau yog qhov zoo, txij li thaum nyob rau hauv cov txheej txheem ntawm kev kho mob, ntau tus poj niam poob phaus. Txawm li cas los xij, tsis muaj pov thawj tseeb txog qhov no rau hnub no. Tab sis ntau tus kws kho mob thiab kws kho mob sau tseg tias thioctic acid tseem muaj txiaj ntsig zoo tsis yog rau kev noj qab haus huv nkaus xwb, tab sis kuj rau cov neeg mob zoo li qub (txhim kho cov plaub hau, tawv nqaij, rau tes).
Analogues
Cov tshuaj hauv qab no raug suav tias zoo ib yam hauv cov tshuaj pharmacokinetics thiab muaj pes tsawg leeg nrog thioctic acid:
- Octolipen.
- "Thiogamma".
- Berlition.
- Neurolipon.
Ua tib zoo mloog! Thioctic acid thiab analogues yuav tsum tsuas yog tswj hwm los ntawm cov kws tshaj lij. Txwv tsis pub, thaum kho tus kheej, cov txheej txheem tsis zoo rov qab tuaj yeem pib hauv lub cev, ua rau cov kab mob tsis zoo.
KOJ
Thioctic acid, tus nqi uas pheej yig heev, yuav tsum siv tshuaj, uas yog:
- xav tau txhua hnub rau cov neeg laus raws li ntau qhov chaw yog 0.5-30 mg;
- menyuam yaus xav tau 13-25 mg ib hnub;
- txog 75mg pom zoo rau cov poj niam pub niam mis thiab cev xeeb tub.
Txoj kev siv tshuaj muaj zog
txhawm rau ua kom muaj txiaj ntsig zoo ntawm kev noj thioctic acid hauv kev kho mob ntshav qab zib, cov kws kho mob pom zoo kom mus kho lub cev. Xws li txoj kev muaj xws li kev kho mob magnetotherapy, kev kho mob qoj ib ce, acupuncture, so therapy, transcutaneous paj stimulation, balneotherapy. Lub hom phiaj tseem ceeb ntawm txoj kev kho mob no yog muab cov tshuaj analgesic thiab anti-inflammatory teebmeem. Ua tsaug rau physiotherapy, kev ua ntawm impulses raws cov hlab ntsha tau txhim kho zoo, nrog rau cov txheej txheem ntawm kev tsim kho cov paj hlwb tau nrawm dua, thiab cov ntshav ncig hauv perineural fibers txhim kho.
Siv hauv cosmetology
Raws li kev tshuaj xyuas ntawm ntau tus poj niam uas feem ntau ua cov txheej txheem tu tawv nqaij ntawm lub ntsej muag, alpha-lipoic acid tuaj yeem daws ntau yam teeb meem zoo nkauj, xws li hnub nyoog me ntsis, wrinkles thiab lwm yam tshwm sim uas nrog rau kev laus ntawm daim tawv nqaij. Kev ua haujlwm siab ntawm cov tshuaj yog nyob rau hauv qhov tseeb tias lipoic acid tuaj yeem yaj ob qho tib si hauv nruab nrab rog thiab hauv dej. Vim qhov no, cov cuab yeej muaj peev xwm txhim kho cov txiaj ntsig zoo ntawm cov vitamins ntawm daim tawv nqaij. Tsis tas li ntawd, thioctic acid accelerates metabolism ntawm qabzib nyob rau hauv lub hlwb ntawm lub epidermis, uas ua rau kom cov elasticity ntawm daim tawv nqaij.
Thiab hauv plab hnyuv
Cov tshuaj ua raws li coenzyme nyob rau hauv pyruvate dehydrogenase enzyme complex, thiab tseem koom nrog hauv oxidative.decarboxylation ntawm pyruvic acid. Tsis tas li ntawd, thioctic acid tuaj yeem tswj cov txheej txheem ntawm lub zog tsim hauv cov hlwb, thaum ua ib qho tseem ceeb hauv lipid thiab carbohydrate metabolism, cholesterol metabolism. Scope ntawm cov tshuaj nyob rau hauv gastroenterology: kab mob siab; kho kom zoo dua ntawm DNA hlwb vim oxidative "kev nyuaj siab"; txo cov kev puas tsuaj ntawm cov tshuaj lom; restoration ntawm glutathione reserves; tiv thaiv kev puas tsuaj mitochondrial.
Raws li kev tshawb fawb thiab tshuaj xyuas, thioctic acid muaj txiaj ntsig zoo heev. Thaum kho, nws tuaj yeem tswj tau lub sijhawm ntawm DNA tso tawm hauv lub cell, vim tias nws muaj peev xwm ua kom lub neej ntev ntawm cov hlwb.
Powerful lipophilic antioxidant - thioctic acid - yog ib feem tseem ceeb ntawm cov hlwb ntawm tib neeg lub cev uas tso tawm lub zog aerobically. Cov tshuaj no tau siv dav hauv cov tshuaj ib txwm siv los kho thiab tiv thaiv ntau yam kab mob.
