Hydroxyzine yog ib qho derivative ntawm diphenylmethane. Cov lus qhia rau kev siv hais tias cov khoom yog sawv cev los ntawm cov hmoov dawb zoo, soluble hauv dej thiab tsis muaj ntxhiab. 374.9 grams ib mole yog qhov hnyav molecular ntawm compound.
Clinico-pharmacological pawg
Cov tshuaj muaj sedative, anxiolytic nyhuv. Qhov no yog vim muaj cov nyhuv inhibitory ntawm kev ua haujlwm ntawm qee cov qauv subcortical ntawm lub hauv paus paj hlwb nrog rau kev cuam tshuam ntawm lub hauv paus H_1-histamine thiab m-cholinergic receptors.
"Hydroxyzine", analogues ntawm cov tshuaj muaj cov nyhuv sedative thiab kev ua haujlwm tsis zoo. Lawv muaj cov nyhuv stimulating ntawm kev txawj ntse, txhim kho kev mloog thiab nco. Kev puas siab puas ntsws thiab kev quav yeeb quav tshuaj tsis tshwm sim, tom qabKev siv mus sij hawm ntev ntawm kev tshem tawm syndrome tsis pom. Anticholinergic, antihistamine, antispasmodic kev ua kuj tshwm sim. "Hydroxyzine" relieves cov leeg nqaij spasm, yog li ua rau bronchodilating thiab analgesic nyhuv, muaj ib tug antiemetic nyhuv thiab ib tug nruab nrab inhibitory nyhuv ntawm gastric secretion. Nrog urticaria, dermatitis, eczema, thiab lwm yam., khaus qis thaum kho nrog Atarax (hydroxyzine yog cov tshuaj nquag).
Cov lus qhia hais tias cov nyhuv sedative tau ua tiav, raws li txoj cai, hauv 10-45 feeb tom qab noj (nyob ntawm daim ntawv ntawm cov tshuaj), tshuaj tua kab mob - ib teev tom qab noj. Hauv cov neeg mob uas muaj kab mob siab, cov tshuaj tiv thaiv kab mob tuaj yeem tshwm sim hauv 96 teev.
Tsis muaj mutagenic thiab carcinogenic cuam tshuam ntawm cov tshuaj.
YPharmacokinetics
Thaum noj, cov tshuaj tau nrawm nrawm los ntawm txoj hnyuv, C_max tau pom tom qab ob teev. Cov tshuaj "Hydroxyzine" dhau los ntawm cov placenta thiab BBB (lub degree ntawm concentration nyob rau hauv cov ntaub so ntswg ntawm lub embryo yog tseem ceeb tshaj nyob rau hauv cov ntaub so ntswg ntawm leej niam). Nyob rau hauv cov txheej txheem ntawm metabolism hauv lub siab, cetirizine yog tsim - lub ntsiab metabolite. Tus nqi ntawm T_1/2 nyob ntawm lub hnub nyoog ntawm tus neeg mob thiab tej zaum yuav yog 7 teev rau cov menyuam hnub nyoog 2-10 xyoo, 20 teev rau cov neeg laus, 29 teev rau cov neeg laus thiab cov neeg laus; Hauv cov neeg mob uas muaj kab mob siab, nws tuaj yeem nce mus txog 37 teev, kev tso tawm yog nqa tawm rau feem ntau ntawm lub raum (0.8% hauv thawj zaug.form).
Cov lus qhia rau kev siv
"Hydroxyzine hydrochloride" yog siv rau:
- tshem tawm kev ntxhov siab thiab hyperexcitability ntawm lub paj hlwb;
- thaum rho tawm rau cov neeg quav cawv;
- kho mob rau cov kab mob psychoneurotic;
- ua ib feem ntawm kev kho mob nyuaj hauv lub sijhawm tom qab phais thiab tom qab qee qhov raug mob;
- premedication;
- txo qis kev ntxhov siab sab hauv, kev ntxhov siab dav dav, kho cov txheej txheem hloov pauv, hauv kev kho mob nyuaj ntawm cov kab mob somatic;
- txhawm rau txo cov tsos mob ntawm eczema, pruritic dermatosis, urticaria, atopic dermatitis;
- rau cov tshuaj tiv thaiv raws li qhia.
Contraindications rau cov tshuaj "Hydroxysin Canon"
Kev tshuaj xyuas ntawm cov kws kho mob qhia tias cov tshuaj tsis pom zoo rau kev siv:
- cov neeg mob glaucoma;
- nrog prostate hypertrophy (prostate caj pas);
- tus neeg mob uas muaj kev qaug dab peg ntau ntxiv;
- cov neeg mob myasthenia;
- tus neeg mob kuaj pom tias muaj lub raum thiab lub siab tsis ua haujlwm;
- rau cov neeg mob dementia.
Cov tshuaj yog contraindicated:
- poj niam cev xeeb tub;
- neeg mob Porphyria;
- thaum lub sijhawm pub niam mis (thaum lub sijhawm kho nws yuav tsum tsis txhob pub mis niam);
- nrog kev tsis haum tshuaj rau cov khoom siv (tseem nyob rau hauv rooj plaub uas yav dhau loshypersensitivity rau lwm yam derivatives ntawm cetirizine, aminophylline, piperazine los yog ethylenediamine tau raug sau tseg);
- thaum ua haujlwm.
About side effects
Cov neeg mob yuav muaj kev qaug zog, tsis muaj zog, kiv taub hau thiab mob taub hau thaum pib ntawm Hydroxyzine therapy. Kev tshuaj xyuas cov neeg mob noj cov tshuaj no hais txog cov kev mob tshwm sim hauv qab no:
- tshuaj tsis haum, palpitations, xeev siab;
- tso zis, cem quav;
- dryness ntawm pom mucous daim nyias nyias, nce tawm hws;
- qhov tsis pom kev tsis pom kev (tej zaum cuam tshuam ntawm chaw nyob);
- txo cov ntshav siab, ua kom lub siab ua haujlwm enzymatic;
- yuav muaj bronchospasm.
Tsis tshua muaj tshwm sim ntawm convulsions, tremors thiab disorientation, ataxia, paradoxical excitement thiab nce lub cev muaj zog ua si thaum siv cov tshuaj.
Ntau tshaj
Lub gag reflex feem ntau yog ntxias los yog lub plab raug ntxuav tawm thaum noj tshuaj ntau dhau ntawm "Hydroxysin". Cov lus qhia rau kev siv qhia tias qee zaus nws yog ib qho tsim nyog los saib xyuas cov haujlwm tseem ceeb ntawm tus neeg mob, kev qhia txog caffeine-sodium benzoate, norepinephrine thiab txawm tias cov ntshav hloov pauv, tag nrho cov kev ntsuas tsim nyog tau coj los tswj kev ua haujlwm ntawm lub cev. Cov tshuaj no tsis muaj cov tshuaj tiv thaiv tshwj xeeb, hemodialysis tsis raug cai.
Feem ntau cov teebmeem no thim rov qab lossis lawv qhov tshwm sim ploj tom qab kev hloov kho ntawm cov tshuaj txhua hnub.
Kev noj tshuaj thiab kev tswj hwm
Cov tshuaj yog muab qhov ncauj los yog txhaj tshuaj intramuscular. Qhov koob tshuaj nyob ntawm nosology, hnub nyoog ntawm tus neeg mob thiab nyob rau hauv daim ntawv ntawm cov tshuaj "Hydroxyzine" yog tsim nyob rau hauv lub hnub. Cov koob tshuaj ntau tshaj plaws yog 12.5mg thaum sawv ntxov thiab yav tav su thiab 25mg thaum yav tsaus ntuj.
Nyob rau hauv menyuam yaus, nyob rau lub sijhawm ua ntej, 1 mg ib kg ntawm qhov hnyav nyob ib hnub ua ntej thaum yav tsaus ntuj thiab 60 feeb ua ntej tus txheej txheem nws tus kheej.
Rau lub hom phiaj ntawm kev sedation, cov neeg laus tau muab "Hydroxyzine" ntawm qhov tshuaj ntawm 50-200 mg ntawm qhov ncauj lossis txhaj tshuaj intramuscular ntawm 1.5-2.5 mg rau ib kg ntawm tus neeg mob qhov hnyav ib teev ua ntej kev phais.
Rau lub hom phiaj ntawm kev tsis khaus khaus, qhov koob tshuaj zoo yog los ntawm 25 mus rau 100 mg ntawm cov tshuaj hauv 3-4 koob.
Cov menyuam yaus hnub nyoog ib txog rau 6 xyoo, koob tshuaj tsis pub tshaj 1-2.5 mg ib kg ntawm lub cev hnyav ib hnub hauv ntau koob.
Nyob rau hauv tib txoj kev siv tshuaj, cov menyuam yaus hnub nyoog 6 xyoo thiab laus dua tau muab 1-2 mg rau ib kg ntawm lub cev hnyav thaum nruab hnub.
Qhov siab tshaj plaws txhua hnub noj yog suav tias yog 300 mg. Qhov siab tshaj plaws ib koob tshuaj yog 200 mg.
Kev pib kho cov lausIb nrab noj yog pom zoo.
Daim siab thiab lub raum tsis ua haujlwm yuav tsum tau hloov kho ntawm cov tshuaj "Hydroxyzine".
Cov lus qhia ceeb toom tias txhawm rau ua tiav cov txiaj ntsig kho tau sai tshaj plaws, cov tshuaj tau muab tshuaj intramuscularly, sib sib zog nqus ntawm koob tshuaj 50-100 mg ib zaug. Nws raug nquahu kom muab cov tshuaj hauv 4-6 koob tshuaj ib hnub.
Nyob rau hauv kev puas siab puas ntsws, cov tshuaj yog siv ntawm qhov ntau npaum li 300 mg thaum nruab hnub. Lub sijhawm ntawm txoj kev kho no yog 4 lub lis piam.
Yog cov kev mob tshwm sim xws li qaug zog, tsaug zog ntev ntev rau ob peb hnub, txo qhov koob tshuaj.
Kev Tiv Thaiv
Nrog rau kev tswj hwm ib txhij ntawm "Hydroxyzine" nrog "Adrenaline", qhov ua tau zoo ntawm qhov kawg txo qis.
Cov tshuaj muaj txiaj ntsig zoo rau cov nyhuv sedative ntawm narcotic analgesics, dej cawv, tranquilizers, barbiturates, hypnotics, thiab lwm yam tshuaj uas ua rau lub hauv paus paj hlwb.
Kev siv cov tshuaj no ua ke nrog MAO inhibitors lossis anticholinergics tsis pom zoo.
Thaum ua ke nrog phenytoin, cov nyhuv anticonvulsant ntawm kev noj cov tom kawg txo qis.
Kev siv ib txhij ntawm cov tshuaj no nrog cholinesterase blockers yog qhov tsis xav tau.
Kev nce qib hauv cov ntshav plasma ntawm cov tshuaj yuav tshwm sim los ntawm kev siv nrog daim siab enzyme inhibitors.
Kev kho tib lub sijhawm nrog cov tshuaj uas ua rau kev ua haujlwm ntawm lub hauv nruab nrab lub paj hlwb, lossis nrog cov tshuaj anticholinergics yuav tsum tau hloov koob tshuaj.
yuav tsum tau ceev faj zoo rau cov neeg mob uas ua rau arrhythmias lossis cov uas tau noj tshuaj tiv thaiv arrhythmic, nrog rau cov neeg mob uas muaj qhov ua rau muaj qhov tshwm sim ntawm convulsive.
Txoj kev kho yog contraindication rau kev siv dej cawv. Yog tias tsim nyog los ua qhov kev ntsuam xyuas kev ua xua, kev noj tshuaj "Hydroxyzine" yuav tsum tau muab tso tseg 5 hnub ua ntej txoj kev tshawb fawb tau teem tseg. Kev ceev faj kuj tseem tsim nyog thaum siv cov tshuaj thaum tsav tsheb los ntawm cov neeg tsav tsheb thiab cov neeg mob uas nws txoj haujlwm yuav tsum tau ua kom muaj kev mloog zoo.
Nws yuav tsum tau nco ntsoov tias kev siv cov ntawv txhaj tshuaj tsuas yog ua tau hauv daim ntawv txhaj tshuaj intramuscular xwb. Kev txhaj tshuaj subcutaneous lossis tom kawg nkag mus rau cov hlab ntsha loj tuaj yeem ua rau cov ntaub so ntswg puas.
Kev kho mob nrog tus neeg sawv cev no tuaj yeem ua rau qhov kev kuaj pom tsis raug.
Cov ntsiab lus siv thiab khaws cia
Hydroxyzine tshuaj yuav tsum tau.
Cov lus qhia rau kev siv hais tias qhov ncauj cov ntaub ntawv ntawm cov tshuaj yog khaws cia tsis pub tshaj 5 xyoo.
Y"Hydroxyzine". Patient Testimonials
Thaum menyuam yaus, kev siv tshuaj kho mob siab, txo qis ntawm kev mloog pab tus menyuam kom ntseeg tau tus kheej,concentrated thiab attentive, excludes ib tug ntse hloov nyob rau hauv mus ob peb vas. Nyob rau tib lub sijhawm, thaum kho nrog Atarax (Hydroxysin), cov lus qhia rau kev siv kom ntseeg tau tias qhov kev ua si thiab kev zoo siab ntawm tus menyuam nyob ib yam. Cov kev mob tshwm sim tsawg tsawg.
Raws li cov lus hais ntawm cov neeg mob uas siv "Hydroxysine" (analogues ntawm cov tshuaj) hauv qee qhov xwm txheej, nws ua raws li nws ua rau kom muaj kev thaj yeeb nyab xeeb thiab kev ntseeg siab ntawm tus kheej mus rau ntau dua li ntau lwm yam tshuaj. Nrog kev ntshai thiab insomnia, cov tshuaj no ua rau kom tsaug zog zoo dua thiab pw tsaug zog zoo dua. Muaj tseeb tiag, kev tshem tawm ntawm cov tshuaj thawj ob peb hnub cuam tshuam rau cov txheej txheem ntawm kev tsaug zog, tab sis nyob rau hauv txoj cai, cov nyhuv ntawm kev kho mob yog heev txhawb nqa.
Tus nqi tshuaj
Koj tuaj yeem yuav cov tshuaj "Hydroxyzine", analogues uas muaj hydroxyzine, ntawm lub tsev muag tshuaj nrog kws kho mob cov tshuaj. Tus nqi yuav yog 270-300 rubles rau 25 ntsiav tshuaj ntawm ib koob ntawm 25 mg.
Y"Hydroxyzine". Synonyms
Synonyms rau "Hydroxyzine" yog: "Hydroxyzine Canon", "Atarax", "Masmoram", "Aterax", "Hydroxyzine", "Hydroxyzine Hydrochloride", "Alamon", "Durax".
