"Baraclude" yog hais txog cov tshuaj tiv thaiv kab mob, suav nrog hauv pawg nucleoside analogues. Nws raug sau tseg rau kev kho mob HBV mob ntev. Lub active tivthaiv ntawm cov tshuaj entecavir sai inhibits replication ntawm kab mob siab kab mob.
Ua ntej noj cov tshuaj, cov lus piav qhia yuav tsum tau kawm. Cov lus qhia rau kev siv qhia li cas? "Baraclud" (Baraclud) - ib qho tshuaj uas tsim los pib qhov rov qab ntws ntawm cov txheej txheem fibrotic hauv cov neeg mob uas mob siab rau daim siab.
Cov tshuaj
Cov tshuaj yog tsim nyob rau hauv ob txoj kev xaiv - 0, 5 thiab 1 mg ntawm cov khoom xyaw nquag ntawm entecavir, pom qhov sib txawv ntawm cov xim ntawm cov xim (dawb lossis paj yeeb, raws li).
Cov tshuaj muaj pes tsawg leeg kuj suav nrog:
- polysorbate;
- magnesium stearate;
- lactose monohydrate;
- hypromellose;
- povidone;
- Opadry dye.
Pharmacological action
Cov khoom xyaw nquag entecavir, uas yog ib qho analogue ntawm guanosine nucleoside, muaj kev xaiv cov txiaj ntsig ntawm tus kab mob siab B.
Entecavir yog phosphorylated rau ib qho active triphosphate nrog ib nrab-lub neej ntawm li 15 teev, cov ntsiab lus intracellular uas muaj feem xyuam rau cov concentration ntawm entecavir sab nraum lub cell. Nyob rau tib lub sijhawm, tsis muaj qhov pom tseeb ntawm cov khoom siv hauv lub cev. Cov tshuaj "Baraclude", cov lus qhia rau kev siv uas qhia tau hais tias nws high efficiency, inhibits cov kev ua ntawm lub polymerase ntawm tus kab mob, cuam tshuam rau ib txhij peb yam:
- synthesis ntawm HBV zoo DNA strand;
- reverse transcription ntawm qhov tsis zoo strand ntawm pregenomic mRNA;
- YHBV enzyme priming.
Triphosphate tsis yog qhov muaj zog inhibitor ntawm cellular DNA enzymes, txawm tias muaj cov ntsiab lus tseem ceeb nws tsis cuam tshuam rau mitochondrial DNA synthesis.
Drug action
Cov tshuaj nquag ntawm cov tshuaj tuaj yeem nqus tau los ntawm lub plab zom mov hauv lub sijhawm luv thiab ncav cuag nws cov ntsiab lus siab tshaj 30-90 feeb tom qab noj tshuaj.
Ib qho kev nce ntxiv hauv Cmax thiab AUC qhov ntsuas tshwm sim nrog kev siv tom qab ntawm 0.1-1 mg ntawm cov tshuaj "Baraclude". Cov lus qhia rau kev siv qhia txog qhov ua tiav ntawm qhov sib npaug ntawm 6-10 hnub ntawm ib koob tshuaj ib hnub. Kev siv cov khoom noj muaj roj ua rau nws nyuaj rau kev nqus ntawm entecavir, txoCmax thiab AUC ntsuas los ntawm 45% thiab 20% raws.
Cov tshuaj no sai sai absorbed rau hauv cov ntaub so ntswg thiab yog 13% khi rau plasma proteins. Cov tshuaj nquag ntawm cov tshuaj tsis siv rau substrates, inhibitors lossis enzyme inducers raws li P450 system. Nws muaj peev xwm khaws cia hauv lub cev thiab raug tso tawm los ntawm lub raum system los ntawm glomerular pom thiab tubular secretions.
Cov lus qhia rau kev siv
Tshuaj "Baraclude" raug pom zoo kom noj nyob rau hauv txoj kev kho kab mob siab B:
- Nrog cov tsos mob ntawm tus kab mob txuas ntxiv mus thiab nce qib ntawm kev ua haujlwm transaminase hauv cov ntshav ntshav, nyob rau hauv lub xub ntiag ntawm histological manifestations ntawm tam sim no o ntawm daim siab.
- Kev kho lub siab tsis zoo.
Kev txo qis ntawm cov tsos mob ntawm daim siab mob tshwm sim tom qab noj tshuaj "Baraclude". Cov lus qhia rau kev siv pom zoo kom noj cov neeg mob uas muaj kab mob siab B ntev, nyuaj los ntawm cov kab mob siab hauv qab no:
- nyob rau theem decompensation;
- kab mob ntawm daim siab nyob rau theem rov qab los nrog tsim cov kab mob sib kis, kuaj pom pom ntawm daim siab fibrosis nrog nce AST thiab ALT.
YContraindications
Cov tshuaj "Baraclude" muaj cov nram qab no contraindications:
- nce susceptibility rau entecavir thiab lwm yam tshuaj uas tsim cov tshuaj;
- kab mob lactose intolerance, qabzib-galactose malabsorption, deficiency lossis tsis muaj enzyme lactase hauv lub cev;
- hnub nyooghnub nyoog qis dua 18 xyoo.
Cov neeg lub raum tsis txaus yuav tsum tau noj tshuaj raws li qhia thiab nyob rau hauv kev saib xyuas tas li.
Baraclud tsis pom zoo thaum cev xeeb tub, thaum kho nws yog qhov tsim nyog kom tsis txhob pub niam mis.
Side effects
Ntau yam kab mob ntawm lub plab zom mov tuaj yeem pom thaum kho nrog Baraclude. Cov lus qhia rau kev siv kom meej piav qhia cov kev mob tshwm sim:
- plab hnyuv;
- mob plab;
- xeev siab thiab ntuav;
- dyspepsia.
Migraines, insomnia lossis tsaug zog, txo qis qab los noj mov thiab kev tsis haum tshuaj kuj tuaj yeem tshwm sim.
Kev siv tshuaj tsuas yog siv tshuaj kho mob lossis ua ke nrog lwm cov tshuaj tiv thaiv kab mob tuaj yeem ua rau mob hepatomegaly nrog steatosis, uas tuaj yeem ua rau tus neeg mob tuag.
Nyob rau hauv cov neeg mob uas decompensated daim siab puas, lactic acidosis tej zaum yuav pom, uas yog yus muaj los ntawm:
- cov leeg tsis muaj zog;
- ua pa nrawm thiab ua tsis taus pa;
- nauseous;
- poob ceeb thawj;
- mob hauv peritoneum, epigastrium.
Tsis tas li, kev noj tshuaj tuaj yeem ua rau lwm yam kev cuam tshuam ntawm lub cev:
- siab siab transaminases;
- pob khaus;
- tshuaj tiv thaiv anaphylactoid.
Nyob rau hauv cov neeg mob kuj raug kev txom nyem los ntawmdecompensated lesions ntawm daim siab, ntxiv rau, cov kev tshwm sim hauv qab no ntawm lub cev tau tshwm sim:
- lub raum tsis ua haujlwm (tsis tshua muaj);
- ntshav siab bilirubin;
- qis platelet suav rau 50,000/mm3 thiab hauv qab;
- txo qis cov ntshav bicarbonate;
- nce ALT;
- ntau dua li peb npaug ntawm kev ua haujlwm lipase;
- qis albumin cov ntsiab lus.
Tshuaj "Baraclude": txoj kev tswj hwm thiab koob tshuaj
Cov tshuaj yuav tsum tau noj thaum lub plab khoob, lub sijhawm ntawm noj mov kawg mus rau noj tshuaj yuav tsum ntau tshaj li ob teev.
Nrog rau lub siab puas tsuaj, nws raug nquahu kom noj "Baraclud" ntawm koob tshuaj 0.5 mg ib hnub. Yog tias kuaj pom cov tshuaj tiv thaiv lamivudine, qhov koob tshuaj yuav tsum tau muab faib ua ob npaug.
Cov neeg mob uas tsis tau them nyiaj rau daim siab puas tsuaj yog muab 1 mg txhua hnub. Rau cov neeg laus thiab cov neeg mob lub raum tsis txaus, koob tshuaj yuav tsum raug kho raws li qib CK (kev sib xyaw ntawm creatinine) hauv cov ntshav.
Ntau tshaj
Tsis muaj ntaub ntawv txaus txog cov xwm txheej ntawm kev siv tshuaj ntau dhau.
Cov neeg ua haujlwm pab dawb hauv kev sim tshuaj tau txais ib koob tshuaj txhua hnub ntawm 20 mg rau ob lub lis piam lossis tau txais ib koob tshuaj ntxiv ntawm 40 mg ntawm Baraclude. Cov lus qhia rau kev siv hais tias tsis muaj kev cuam tshuam tsis zoo tau raug txheeb xyuasyog.
Kev kho mob Posyndromic raws li kev tswj hwm kev kho mob pom zoo.
Kev sib tham nrog lwm yam tshuaj
Vim qhov tseeb tias cov khoom xyaw nquag ntawm entecavir tau tawm ntawm lub cev feem ntau los ntawm lub raum, txoj kev kho nyuaj ua ke nrog lwm cov tshuaj uas muaj kev cuam tshuam ncaj qha lossis tsis ncaj rau kev ua haujlwm ntawm lub raum thiab cuam tshuam rau tubular secretion. Tej zaum yuav ua rau muaj kev nce hauv cov ntsiab lus hauv lub cev entecavir thiab cov tshuaj nquag ntawm cov tshuaj no.
Kev sib cuam tshuam ntawm "Baraclud" nrog adenovir, tenofovir, lamivudine tsis tau kaw.
Kev Tiv Thaiv
Nyob rau hauv cov neeg mob uas refractory rau lamivudine, cov tshuaj no muaj feem xyuam rau cov kev tiv thaiv.
Tseem muaj cov ntaub ntawv hais txog qhov tshwm sim ntawm qhov tshwm sim ntawm tus kab mob siab hepatitis tom qab tso tseg cov tshuaj "Baraclude". Cov lus qhia rau kev siv piav qhia txog kev tshem tawm ntawm qhov exacerbations yam tsis muaj kev kho ntxiv.
Cov lus qhia tshwj xeeb
Kev lees txais "Baraclud" ob qho tib si raws li kev kho mob monotherapy thiab hauv kev kho mob nyuaj nrog lwm cov tshuaj tiv thaiv kab mob tuaj yeem ua rau lactic acidosis, hepatomegaly, nrog rau steatosis. Txawm li cas los xij, muaj kev pheej hmoo ntawm kev tuag.
Cov pawg neeg mob hauv qab no muaj kev pheej hmoo:
- mob hepatomegaly;
- kho nrog nucleoside analogues;
- overweight;
- tus neeg mob poj niam.
Cov lus qhia rau kev siv tshuaj "Baraclude" sau txog qhov muaj peev xwm tsim cov kab mob HIV tiv taus. Cov tshuaj nquag ntawm cov tshuaj entecavir tsis pom zoo rau kev kho mob ntawm tib neeg kev tiv thaiv kab mob tiv thaiv kab mob, txij li nws cov txiaj ntsig ntawm qhov kev taw qhia no tseem tsis tau kawm tag nrho.
Nyob rau hauv kev kho cov neeg mob nrog pathologies ntawm lub raum system, nws yog ib qho tsim nyog yuav tau kho cov koob tshuaj.
Kev nyab xeeb thiab kev ua tau zoo ntawm kev siv Baraclude hauv kev kho mob ntawm daim siab hloov cov neeg mob tsis paub thiab yuav tsum tau ceev faj tshwj xeeb.
khaws cia thiab nqi
Kev khaws cia thiab kev thauj mus los ntawm cov ntsiav tshuaj yuav tsum tau ua nyob rau hauv qhov kub ntawm 15-25 ° C. Cov tshuaj tsim nyog siv tau ob xyoos txij li hnub tsim khoom.
Cov tshuaj muaj nyob rau hauv ib pab pawg tshwj xeeb ntawm cov tshuaj tseem ceeb, thiab yog li qee pawg ntawm cov pej xeem tau muab faib dawb ntawm cov tshuaj "Baraclud". Cov lus qhia rau kev siv sau qhov tseeb no.
Tus nqi ntawm cov nyiaj hauv khw muag tshuaj hauv Moscow pib los ntawm 12 txhiab rubles.
Patient opinions
Qhia txog qhov ua tau zoo ntawm cov tshuaj "Baraclud" cov lus qhia rau kev siv. Tus nqi, kev tshuaj xyuas uas ua pov thawj rau nws txoj kev ywj pheej hauv kev sib piv nrog cov tshuaj analogues ntawm 12-17 txhiab ib pob, uas muaj 30 ntsiav tshuaj. Nws uaCov tshuaj no nrov heev thiab xav tau ntawm cov neeg mob hauv kev kho kab mob siab B.
Kev tshuaj xyuas tsis zoo feem ntau hais txog contraindications thiab kev phiv ntawm cov tshuaj, xws li insomnia thiab xeev siab.
