Kev kho mob ntawm cov kab mob ntawm lub plab mucous ntawm lub plab lossis plab hnyuv tag nrho yog txheej txheem nyuaj thiab ntev. Qhov no yog vim tsis tsuas yog rau lub fact tias hydrochloric acid, uas yog ib feem ntawm lub plab kua txiv, maj mam nce lub mucosal defect, digestive nws tus kheej cov ntaub so ntswg, tab sis kuj yog lub koom haum ntawm tus kab mob nrog lub xub ntiag ntawm microorganisms Helicobacter pylori. Txhawm rau tiv thaiv qhov kev nthuav dav ntawm qhov tsis xws luag thiab pab txhawb kom rov zoo sai ntawm tus neeg mob, cov kws kho mob tau sau tshuaj Omeprazole lossis Ultop. Qhov twg zoo dua, peb yuav txheeb xyuas hauv kab lus no.
Mechanism of action
Txawm hais tias cov tshuaj muaj npe sib txawv, cov khoom muaj nyob hauv lawv yog tib yam - omeprazole. Cov tshuaj no kho thiab sawv cev li cas?
Raws li cov yam ntxwv tshuaj, cov tshuaj no yog xyauminsoluble hauv dej, tab sis soluble heev nyob rau hauv ethyl cawv los yog methanol.
Hauv kev kho mob, omeprazole yog siv los ua ib feem ntawm ntau yam tshuaj, suav nrog kev sib xyaw ua ke, ua ib txoj hauv kev rau kev kho mob ntawm qhov txhab. "Omeprazole" lossis "Ultop" - qhov twg zoo dua? Feem ntau cov neeg mob thiab kws kho mob nug lawv tus kheej lo lus nug no.
Lub txheej txheem ntawm kev ua haujlwm yog ua raws li qhov inhibition ntawm lub twj tso kua mis proton - ib qho tshwj xeeb thauj cov protein nyob rau hauv cov cell membrane ntawm lub zais zis ntawm lub plab. Los ntawm kev txo cov dej ntws ntawm hydrogen ions mus rau hauv cytoplasm ntawm xws li secretory cell, tus nqi ntawm hydrochloric acid tsim los ntawm nws txo, thiab cov kua qaub ntawm gastric txo, uas ua rau kom txo qis hauv cov ntaub so ntswg puas tsuaj thiab txhawb kev kho mob ntawm qhov txhab.
YPharmacokinetics
Omeprazole zoo inhibits ob qho tib si stimulated thiab basal hydrochloric acid ntau lawm nrog rau cov koob tshuaj-nyob ntawm seb. Nrog rau ib koob tshuaj ntawm 20 mg ntawm "Omeprazole" los yog noj ib koob tshuaj "Ultop" - 20 mg, ib tug txo nyob rau hauv acidity yog pom nyob rau hauv thawj teev, vim hais tias cov tshuaj yog sai absorbed nyob rau hauv lub plab hnyuv lumen. thiab nkag mus rau hauv lub systemic ncig.
Txawm hais tias ib nrab-lub neej ntawm cov tshuaj nquag ntawm cov tshuaj yog li ob teev, inhibition ntawm hydrochloric acid ntau lawm yog pom nyob rau hauv ib hnub tom qab ib koob.
Omeprazole Tropene, faib los ntawm mucosadaim nyias nyias ntawm lub plab, siab thiab biliary ib ntsuj av, xyaum tsis nkag mus rau hauv cov ntshav-hlwb barrier thiab yog kiag li txuam nrog plasma proteins. Qib ntawm kev khi nrog cov tom kawg tuaj yeem ncav cuag li 90-95%.
Omeprazole feem ntau yog tawm hauv cov zis, nrog li 60-77% tawm hauv cov metabolites xws li hydroxyomeprazole thiab carboxylic acid. Feem ntau ntawm cov txiaj ntsig conjugates qhia tau hais tias tsis muaj kev ua haujlwm antisecretory, tshwj tsis yog sulfonomeprazole. Ib feem ntawm cov tshuaj uas tseem tshuav hauv lub cev yog tawm los ntawm txoj hnyuv nrog rau cov kua tsib thiab quav.
Kev saib xyuas tshwj xeeb yuav tsum tau them rau cov chaw muag tshuaj ntawm omeprazole hauv cov neeg mob uas muaj lub siab tsis txaus. Los ntawm kev txo cov metabolism ntawm cov tshuaj, nws bioavailability nce mus txog qhov siab tshaj plaws, thiab ib nrab-lub neej txuas ntxiv mus rau peb teev. Hauv cov neeg mob uas lub raum tsis ua haujlwm ntev, kev tso tawm ntawm omeprazole metabolites qeeb qeeb raws li kev tshem tawm cov ntshav ntshav los ntawm creatinine.
Cov lus qhia rau kev siv
Tshuaj "Omeprazole" thiab "Ultop" tau qhia rau kev siv hauv kev kho mob peptic ulcers ntawm lub plab zom mov, hyperacid mob (xws li gastritis), Zollinger-Ellison syndrome, postoperative mob, reflux kab mob. Cov tshuaj no tuaj yeem raug pom zoo rau kev kho mob ntawm cov kab mob uas tsis yog-ulcerative dyspepsia, hauv kev kho mob ntawm cov teeb meem tshwm sim los ntawm kev kho mob nrog cov tshuaj tsis-steroidal anti-inflammatory (analgesics, antipyretics), nrog rau kev kho mob.mob plawv tsis sib haum uas tshwm sim tsis pub dhau 2 zaug hauv ib lub lis piam.
Txawm hais tias cov lus qhia rau kev siv tshuaj "Omeprazole" hauv cov lus qhia, cov tshuaj no kho tau zoo li cas rau tus kws kho mob tshwj xeeb. Yog li ntawd, yog tias koj hnov mob hauv plab hnyuv, koj yuav tsum hu rau lub tsev kho mob thiab tsis yog tshuaj rau tus kheej.
YContraindications
Txhua hom tshuaj, suav nrog cov ntsiav tshuaj Omeprazole, yog contraindicated nyob rau hauv cov neeg mob hypersensitivity rau cov tshuaj, nrog rau cov me nyuam. Kev txo qis hauv kev ua haujlwm ntawm lub plab hauv cov mob hypoacid thiab atrophic gastritis kuj yog ib qho kev tsis txaus siab rau kev teem caij ntawm omeprazole.
Side effects
Txog cov tshuaj "Omeprazole" thiab "Ultop" tshuaj xyuas hais tias, vim qhov txo qis hauv cov kua qaub-ua haujlwm ntawm lub plab, cem quav, flatulence, cem quav, ntuav thiab mob hauv thaj tsam epigastric yuav tshwm sim. nyob rau hauv lub gastrointestinal ib ntsuj av. Candidiasis, qhov ncauj qhuav, kev loj hlob ntawm atrophic lossis hypoacid gastritis, plab hnyuv polyposis tsis tshua muaj.
Ntawm ib feem ntawm lub paj hlwb (afferent impulses), mob taub hau, kev xav ntawm malaise, kev xav ntawm kev ntxhov siab thiab kev ntxhov siab, kev nyuaj siab thiab kev puas siab puas ntsws tuaj yeem tshwm sim. Nws tsis suav nrog cov tsos mob ntawm qhov pom kev ua haujlwm, uas tuaj yeem dhau mus tas li.
Kev tsis haum rau omeprazole yog qhov tsawg. Qhov tshwm sim ntawm urticaria yog qhov ua tau,tawv nqaij khaus. Nrog ib tug tsawg zaus, muaj ib tug spasm ntawm cov nqaij mos hlwb ntawm lub bronchi, txoj kev loj hlob ntawm Quincke's edema nrog rau kev loj hlob ntxiv los ntawm hom anaphylactic cov tshuaj tiv thaiv thiab kev loj hlob ntawm lub xeev poob siab. Kev loj hlob ntawm gynecomastia, qhov tsos mob ntawm lub hauv siab tau raug sau tseg.
Yuav siv li cas
Omeprazole tau noj ntawm lub plab khoob nrog dej. Hauv ib pawg tshwj xeeb ntawm cov neeg mob, nws yuav nyuaj rau nqos cov tshuaj ntsiav ntawm cov tshuaj. Hauv qhov no, nws raug nquahu kom qhib lub capsule, thiab npaj cov dej-raws li kev ncua los ntawm nws cov ntsiab lus. Qhov kev ncua no yuav tsum tsis pub dhau ib nrab teev tom qab kev npaj. Tus kws kho mob uas tuaj koom qhia cov tshuaj noj txhua hnub, ib koob tshuaj ib zaug, nrog rau kev kho tshuaj.
Txoj kev siv thaum cev xeeb tub thiab pub niam mis
Tsis muaj ntaub ntawv hais txog kev nyab xeeb ntawm omeprazole hauv cov poj niam cev xeeb tub. Cov tshuaj muaj peev xwm qhia tau rau kev noj qab haus huv. Qeb ntawm cov nyhuv ntawm tus menyuam hauv plab tsis tau txhais.
Yog tias nws tsim nyog yuav tsum tau txhaj tshuaj omeprazole thaum pub niam mis, tom qab ntawd yuav tsum tau tso tseg thaum kho, vim tias cov tshuaj tuaj yeem nkag mus rau hauv cov kua mis.
Kev Sib Tham Tshuaj
Ob leeg "Omeprazole" thiab "Ultop" txo cov bioavailability ntawm tag nrho cov tshuaj, qhov nqus ntawm uas nyob ntawm acidity ntawm lub plab kua txiv. Nws kuj tseem ua rau qeeb tso cov tshuaj metabolized hauv daim siab. Npaj sterile txhaj tshuaj ntawm omeprazole tuaj yeem siv rau hauvtsis pub dhau 12 teev, yog tias lub cev muaj zog sodium chloride tov yog siv los ua cov kuab tshuaj, thiab ob peb teev tom qab kev npaj, muab cov tshuaj dextrose siv los ua cov kuab tshuaj. Omeprazole tsis sib haum nrog lwm cov tshuaj.
Nrog kev kho mob nrog Warfarin, qib ntawm cov tshuaj tiv thaiv kab mob hauv cov ntshav ntshav yuav tsum tau saib xyuas txhua hnub lossis lub sijhawm prothrombin yuav tsum tau saib xyuas raws sijhawm.
Tshuaj lom lom thiab ntau dhau
Omeprazole overdose cov tsos mob suav nrog qhov ncauj qhuav, kiv taub hau, mob taub hau thiab pom kev cuam tshuam. Nyob rau hauv cov ntaub ntawv ntawm lom, tsis meej pem, qhov tsos ntawm tsaug zog, palpitations, hnov ntawm lub ntsej muag yog ua tau.
Kev kho mob lom yog cov tsos mob, txhawm rau tshem tawm cov tshuaj ntawm lub cev kom sai li sai tau. Cov tshuaj tiv thaiv tshwj xeeb tsis paub. Vim muaj qib siab ntawm kev khi rau cov ntshav plasma proteins, kev siv cov txheej txheem lim ntshav ntawm detoxification yog irrational.
Cov lus qhia tshwj xeeb
Vim cov tshuaj tau siv los kho cov kab mob hauv plab thiab duodenal ulcers, etiological yam uas yog Helicobacter pylori kab mob, kev tswj hwm ntawm cov tshuaj tua kab mob tau pom zoo rau kev tshem tawm cov kab mob.
Ua ntej pib siv cov tshuaj hauv tus neeg mob, nws yog ib qho tsim nyog yuav tsum tsis lees paub cov kab mob qog nqaij hlav hauv plab hnyuv, txij li kev teem sijhawm ntawm "Omeprazole" yuavnpog cov tsos mob ntawm cov kab mob no thiab ua rau kev kuaj mob ntxov ntxov. Nws yog ib qho tsim nyog kom tshem tawm cov kab mob sib kis kab mob, nrog rau kev ntsuas lub peev xwm ua haujlwm ntawm lub siab thiab lub raum.
"Omeprazole" lossis "Ultop" - qhov twg zoo dua?
Nws nyuaj los teb cov lus nug no tsis meej, vim tias cov khoom muaj nyob hauv ob qho tib si yog omeprazole. Cia peb saib cov ntaub ntawv tso tawm ntawm cov tshuaj "Ultop". Capsules muaj nyob rau hauv ntau npaum li cas ntawm 10, 20 thiab 40 mg, nrog rau hauv daim ntawv ntawm lyophilized hmoov (40 mg nyob rau hauv ib lub vial) rau kev npaj ntawm kev txhaj tshuaj.
"Omeprazole" tau nthuav tawm hauv khw muag tshuaj hauv daim ntawv tshuaj ntsiav ntawm 10, 20 thiab 40 mg ntawm omeprazole hauv ib lub tshuaj ntsiav, nrog rau hauv daim ntawv ntawm lyophilized hmoov (40 mg hauv ib lub vial) rau kev npaj cov tshuaj txhaj tshuaj. Cov hmoov lyophilized nrog cov kuab tshuaj kuj muaj nyob rau hauv ib pob. Tsis tas li ntawd, cov tshuaj tuaj yeem muas tau hauv daim ntawv sachets (hmoov sachets) rau kev npaj ntawm qhov ncauj ncua kev kawm ntawv. Nws tsis tshua pom Omeprazole ntsiav tshuaj (pellets) nrog cov ntsiab lus tshuaj zoo sib xws.
Raws li kev tshuaj xyuas ntawm cov tshuaj no, lawv yog qhov zoo, vim tias omeprazole yog ib qho tshuaj zoo uas txo qis kev ua haujlwm ntawm lub plab. Cov tshuaj no zoo heev uas txawm tias cov kws kho mob xav tias: "Dab tsi yog qhov zoo dua li omeprazole?" Txawm li cas los xij, kev xav sib txawv ntawm cov neeg mob. Feem ntau, cov kev tshuaj xyuas sab laug txog kev npaj Ultop qhia qhov tshwm sim ntawm cem quav tom qab kev tswj hwm, mob taub hau thiab xeev siab.
Tus nqi tshuaj
Tau kawg, tus nqi ntawm cov tshuaj yuav nyob ntawm qhov tsis yog ntawm cov khw muag tshuaj uas lawv muag, tab sis kuj nyob ntawm qhov deb ntawm lub tsev muag tshuaj los ntawm lub tsev kho mob thiab, ntawm chav kawm, ntawm cov khw muag tshuaj nws tus kheej.. Rau cov tshuaj "Ultop" tus nqi yog los ntawm 212 mus rau 360 rubles ib pob. Tus nqi kawg nyob ntawm qhov koob tshuaj thiab tus naj npawb ntawm cov tshuaj ntsiav hauv pob. Rau cov tshuaj "Omeprazole" tus nqi nruab nrab yog los ntawm 80 mus rau 140 rubles. Tus nqi kuj nyob ntawm qhov koob tshuaj thiab tus naj npawb ntawm cov tshuaj ntsiav hauv pob.
Zoo kawg
Tsuas yog tus kws kho mob tuaj koom yuav tsum tau sau "Omeprazole" lossis "Ultop". Dab tsi yog qhov zoo tshaj plaws ntawm cov tshuaj no, tus kws tshaj lij tshwj xeeb paub, thiab nws qhov kev txiav txim siab yuav tsum ua raws li cov lus qhia rau kev teem caij thiab tus neeg mob tus mob. Nws yuav tsum tau nco ntsoov tias feem ntau lub sijhawm txiav txim siab hauv kev xaiv tshuaj yog nws tus nqi.
Cov neeg mob yuav tsum tau them sai sai rau "Omeprazole", tus nqi uas qis dua li cov analogue ntawm "Ultop". Cov neeg uas kam them ntau dua tuaj yeem saib cov analogues ntawm cov tshuaj no. Txawm hais tias tus nqi siab me ntsis ntawm Ultop, tus nqi tuaj yeem ua pov thawj qhov kev ua kom huv ntawm cov tshuaj, nrog rau qhov ua tau ntxiv cov tshuaj ntxiv hauv cov tshuaj nws tus kheej.
Ua li ntawd, koj yuav tsum nco ntsoov txoj cai golden: tsis txhob noj tshuaj rau tus kheej. Kev kuaj mob ntxov yog tus yuam sij rau kev kho kom zoo!
