Diffuse loj B-cell lymphoma: ua rau, cov tsos mob, kev kuaj mob, kev kuaj mob, kev kho mob thiab kev kuaj mob

Cov txheej txheem:

Diffuse loj B-cell lymphoma: ua rau, cov tsos mob, kev kuaj mob, kev kuaj mob, kev kho mob thiab kev kuaj mob
Diffuse loj B-cell lymphoma: ua rau, cov tsos mob, kev kuaj mob, kev kuaj mob, kev kho mob thiab kev kuaj mob

Video: Diffuse loj B-cell lymphoma: ua rau, cov tsos mob, kev kuaj mob, kev kuaj mob, kev kho mob thiab kev kuaj mob

Video: Diffuse loj B-cell lymphoma: ua rau, cov tsos mob, kev kuaj mob, kev kuaj mob, kev kho mob thiab kev kuaj mob
Video: Hlub los txhaum tsis hlub los txhaum #2. 4/4/2018 2024, Hlis ntuj nqeg
Anonim

Diffuse loj B-cell lymphoma yog nyob deb ntawm ib qho ntawm feem ntau thiab txaus ntshai tshaj plaws ntawm txhua hom qog nqaij hlav uas tsim hauv cov kab mob lymphatic. Tus kab mob no yog tus cwj pwm los ntawm kev ua phem ntawm tes, thiab, ntxiv rau, kev loj hlob dynamic. Thaum tsis muaj kev kho mob txaus, cov kab mob metastatic hem ib tus neeg uas ua rau tuag taus. Raws li Asmeskas kev txheeb cais, txhua xyoo hauv Tebchaws Meskas hom mob qog noj ntshav no kuaj pom muaj nees nkaum peb txhiab tus neeg, nrog rau qhov no, kwv yees li kaum txhiab tus neeg tuag tau sau tseg. Txog rau tam sim no, tus kab mob no tau suav tias yog kho tsis tau, tab sis niaj hnub no cov chaw kho mob niaj hnub siv cov txheej txheem uas ua rau muaj txiaj ntsig zoo nyob rau hauv muaj cov kab mob txaus ntshai.

diffuse hauvloj cell lymphoma
diffuse hauvloj cell lymphoma

Tus yam ntxwv ntawm tus kab mob

Xav seb qhov twg yog qhov sib txawv loj B-cell lymphoma, nws yuav tsum tau sau tseg, ua ntej ntawm tag nrho cov, qhov xwm ntawm tus kab mob. Nws belongs rau cov pab pawg neeg ntawm oncologies uas tshwm sim nyob rau hauv lub lymphatic system vim txawv txav, thiab, nyob rau hauv tas li ntawd, uncontrolled cell faib. Tawm tsam keeb kwm yav dhau los no, cov hlwb qub, raws li qhov tsim nyog, tsis txhob tuag, tab sis cov tshiab twb tau tsim. Cov qog tuaj yeem tshwm sim hauv txhua qhov ntawm lub cev; nws tuaj yeem kuaj pom hauv ib lub qog ntshav lossis hauv ib pawg ntawm ob peb zaug ib zaug. Nyob rau hauv cov chav kawm ntawm kev loj hlob ntawm tus kab mob, nws muaj peev xwm cuam tshuam rau hauv lub cev thiab loj hlob mus rau hauv cov pob txha pob txha.

YYuav ua li cas rau lymphocytes?

Kev kuaj mob no qhia tias B-lymphocytes tau hloov pauv hauv lub cev. Cov no yog cov ntshav lub cev uas tsim los tawm tsam cov kab mob uas nkag mus rau tib neeg lub cev. Diffuse loj B-cell lymphoma tau txais nws lub npe los ntawm qhov tseeb tias cov kab mob nkag mus rau cov qog nqaij hlav, ua rau lawv puas tsuaj. Qhov ntawd yog, muaj qee qhov sib txawv hauv cov qog ntshav.

Hnub nyoog ntawm cov neeg mob

Tus kab mob no tau kuaj pom hauv cov neeg laus thiab cov hnub nyoog nruab nrab, pib txij li peb caug-tsib xyoo. Qhov mob, raws li txoj cai, cuam tshuam rau ob leeg poj niam txiv neej, txawm li cas los xij, cov poj niam raug kev txom nyem los ntawm qhov mob ntau dua. Puas tuaj yeem nthuav dav B-cell lymphoma kho tau rau tib neeg? Kev vam meej nyob ntawm kev kho mob raws sij hawm ntawm tus neeg mob hauv lub chaw kho mob tshwj xeeb, thiab, ntxiv rau, ntawm kev kho kom txaus.

diffuse loj cell non-Hodgkin's lymphoma prognosis
diffuse loj cell non-Hodgkin's lymphoma prognosis

theem ntawm pathology

Muaj qee qhov kev faib tawm ntawm B-cell loj cell lymphoma GCB-hom rau ntau yam hauv qab no: thawj cell puas, intravascular, thawj daim tawv nqaij koom nrog hauv cov txheej txheem pathological ntawm ob txhais ceg, tshwm sim tawm tsam cov keeb kwm yav dhau los. Epstein-Barr syndrome, txhim kho raws li qhov tshwm sim ntawm cov txheej txheem inflammatory thiab tus cwj pwm los ntawm ntau cov kab mob histiocytes. Diffuse lymphomas feem ntau nce mus rau plaub theem. Kev faib tawm yog nqa tawm raws li qib ntawm kev nthuav dav ntawm cov txheej txheem pathological.

  • Nyob rau theem pib, ib qho kev mob ntawm cov qog ntshav tau sau tseg.
  • Ntxiv mus, cov txheej txheem pathological tuaj yeem ua mus rau hauv ib pawg ntawm cov nodes uas nyob ntawm ib sab ntawm lub cev.
  • Nyob rau theem thib peb, cov kab mob cuam tshuam rau ntawm ob sab ntawm lub diaphragm.
  • Nyob rau theem plaub, cov qog kis mus rau cov kabmob tseem ceeb, xws li daim siab, pob txha, lub ntsws, thiab lwm yam.

Ntau tus neeg xav tsis thoob yog dab tsi yog qhov ciaj sia rau diffuse loj B-cell lymphoma.

Ua rau tuaj yeem ua rau pathology

Qhov laj thawj uas tuaj yeem ua rau muaj tus kabmob no tam sim no tseem tsis tau nkag siab tag nrho, hmoov tsis. Txawm li cas los xij, cov kws kho mob hais txog ntau yam uas muaj feem cuam tshuam uas tuaj yeem ua rau qhov tsis zoo no. Cov no suav nrog cov laj thawj hauv qab no:

  • muaj caj ces.
  • InfluenceKev hloov pauv ntawm hnub nyoog.
  • Qhov muaj ntau yam kab mob, piv txwv li, kev tiv thaiv kab mob, Epstein-Barr thiab lwm yam.
  • Ib tug neeg rog.
  • Txoj kev cuam tshuam ntawm hluav taws xob.
  • Kev cuam tshuam ntawm qhov tshwm sim ntawm kev hloov pauv kev kho mob qog nqaij hlav ntawm lwm qhov chaw.
  • Muaj lub cev tsis muaj zog nrog rau cov kab mob autoimmune.
  • Kev muaj cov txheej txheem inflammatory.
  • Kev cuam tshuam ntawm cov teeb meem organic hauv daim ntawv ntawm cov tshuaj tua kab, benzene, carcinogens thiab lwm yam.
  • Qhov cuam tshuam rau lub cev ntawm qee yam kab mob, xws li kab mob Helicobacter.

Dab tsi yog qhov kev cia siab rau kev nthuav dav B-cell non-Hodgkin's lymphoma? Xav paub ntau ntxiv hauv qab no.

Cov tsos mob ntawm kev txhim kho pathology

Kev txhim kho ntawm cov kab mob no tuaj yeem nrog ntau yam tsos mob, ncaj qha nyob ntawm thaj chaw ntawm cov qog tsim thiab qhov txhab ntawm qee qhov ntawm lub cev.

Qhov taw qhia tseem ceeb tshaj plaws yog qhov nce ntawm cov qog ntshav qog ntshav lossis lawv tag nrho pawg. Thaum xub thawj, qhov mob tsis tshwm sim, nrog rau thaum kuaj. Yog li, cov qog nqaij hlav tuaj yeem loj tuaj, thiab qhov mob tuaj yeem maj mam.

diffuse loj cell lymphoma gcb
diffuse loj cell lymphoma gcb

Kev sib koom ua ke

Ntawm cov kev tshwm sim uas tshwm sim nrog kev txhim kho ntxiv ntawm hom kab mob oncology, cov tsos mob hauv qab no tau sau tseg:

  • Qhov tshwm sim ntawm kiv taub hau thiab o. Hauv qhov no, feem ntau yog caj dab, ntsej muag lossislibs.
  • Zoo nqos.
  • Qhov ua tsis taus pa luv thiab hnov mob hauv cheeb tsam cuam tshuam.
  • Qhov tshwm sim ntawm hnoos, loog ntawm caj dab, thiab, ntxiv rau, kev loj hlob ntawm tuag tes tuag taw.
  • Qhov tshwm sim ntawm cov teeb meem nrog kev tshuav.

Tshwj xeeb rau cov uas tsis yog-Hodgkin lub loj B-cell diffuse lymphoma thiab cov tsos mob ntawm cov qog nqaij hlav hauv daim ntawv ntawm anemia, qaug zog, tsis muaj zog, tsis tsim nyog nce kub, tsis qab los noj mov, yuag sai, thiab lwm yam.

Tus kab mob no kuaj tau li cas?

Kev kuaj mob ntawm tus kab mob oncology yog txheej txheem nyuaj uas yuav tsum muaj kev sib koom ua ke. Ua ntej tshaj plaws, kev ntsuam xyuas sab nraud los ntawm tus kws kho mob tau ua nrog rau anamnesis thiab palpation ntawm cov qog ntshav. Nws kuj tseem yuav tsum tau ua ib qho biopsy (noj cov qog nqaij hlav los txiav txim seb hom cell thiab lawv qib ntawm malignancy). Kev kuaj yog nqa tawm los ntawm puncture ntawm cov qog nqaij hlav. Rau kev kuaj mob nyuaj, cov txheej txheem kho vajtse yuav tsum tau ua raws li cov hauv qab no:

  • Kev kuaj X-ray.
  • Kev sib nqus resonance imaging.
  • Computed tomography.
  • Ua lub tshuab xa hluav taws xob isotope.
  • Ua kev kuaj ultrasound ntawm tus neeg mob.

Nyob rau hauv tus txheej txheem ntawm kev kuaj mob diffuse loj B-cell lymphoma nyob rau hauv 83.3% ntawm cov neeg mob, ntxiv kev ntsuam xyuas caj ces yuav tsum tau, thiab, ntxiv rau, kuaj ntshav kuaj rauKev txiav txim siab ntawm cov cim oncological, txawm li cas los xij, kev tshuaj xyuas biochemical kuj tseem xav tau. Piv txwv li, yog tias daim siab raug cuam tshuam los ntawm cov hom lymphoma, daim siab transaminases yuav nce siab.

diffuse b-cell loj cell lymphoma
diffuse b-cell loj cell lymphoma

Kev kho mob ntawm pathology

Kev kho tus kab mob xws li diffuse cell lymphoma yog ua nrog kev cuam tshuam kev phais. Kev siv tshuaj ntau ntau yog feem ntau siv hauv kev kho mob. Lawv raug tswj hwm tom qab hloov cov qia cell. Txhawm rau tshem tawm qee yam teeb meem, cov neeg mob tau mus pw hauv tsev kho mob.

Hom lymphoma no feem ntau kho nrog tshuaj kho mob ntxiv rau hluav taws xob lossis kev sib xyaw ua ke. Vim qhov sib ntxiv ntawm irradiation nrog tus neeg sawv cev cytological, cov nyhuv txaus txaus yog tau los ntawm kev ua chemistry. Kev kho mob tseem ceeb yog ua tiav los ntawm kev tshem tawm cov kab mob qog noj ntshav. Kev ua haujlwm pab kom tau cov ntaub so ntswg rau kev kuaj mob, tab sis kev phais tsis tshua muaj kev tshem tawm cov teeb meem tom qab kev kho mob. Diffuse cellular lymphoma ntawm txoj hnyuv yog kho los ntawm kev siv cov txheej txheem, uas yog kev phais phais.

Tshuaj khomob

Kev kho yog ua nrog cov tshuaj hauv qab no: "Rituximab", "Cyclophosphamide", "Vincristine", "Doxorubine" thiab "Prednisolone". Intravenous tswj ntawm cov tshuaj nyiam cov lus teb zoo ntawm lub cev rau kev kho mob. Nws raug sau tseg tias cov neeg mob uas tau txais kev phais thiab tom qab ntawd tau txais chemo,tau txais kev kho mob qis dua li cov uas tau kho nrog hluav taws xob thiab kws khomob.

Tsis tas li ntawd, hom lymphoma tau piav qhia tuaj yeem kho nrog ntau pawg tshuaj, uas yog, tshuaj tua kab mob, tshuaj tiv thaiv kab mob, tshuaj tua kab mob, tshuaj tua kab mob thiab tshuaj tua kab mob, thiab lwm yam. Piv txwv ntawm cov tshuaj xws li Methotrexate, Epirubicin, Vinblastine, Etoposide, Doxorubicin, Rituximab, Mitoxantrone, thiab Asparaginase.

kev kho mob ntawm diffuse loj cell lymphoma
kev kho mob ntawm diffuse loj cell lymphoma

Immunostimulants

Ntawm cov tshuaj tiv thaiv kab mob hauv kev kho mob ntawm cov kab mob loj B-cell lymphoma, "Interferon" feem ntau nyiam. Cov neeg mob uas muaj kev pom zoo rau txoj kev loj hlob ntawm tus kab mob no (uas yog, cov neeg uas muaj tus kab mob no nyob rau hauv thawj los yog thib ob theem) yog kho nyob rau hauv ob theem raws li ib tug tshwj xeeb scheme siv tshuaj nyob rau hauv daim ntawv ntawm Bleomycin, Vinblastine, Dtoxorubicin thiab Dacarbazine..

Cov neeg mob uas nws muaj tus kab mob tsis zoo tau muab tshuaj kho mob hnyav hauv kev kho mob nrog tshuaj xws li Onkovin nrog rau Cyclophosphan, Doxorubicin thiab lwm yam. Tsis tas li ntawd, nrog rau qhov kev pom tsis zoo, cov kws kho mob tau sau tshuaj kho mob rau cov neeg mob. Tsis tas li ntawd, nyob rau hauv cov xwm txheej zoo li no, nws raug nquahu kom mus rau kev kho hluav taws xob, vim tias cov qog hlwb raug puas tsuaj los ntawm X-rays.

Kev kho hluav taws xob

Kev kho hluav taws xob tshwj xeeb yog pab cov neeg mob nyob rau theem thawj thiab thib ob ntawm tus kab mob. Rays nrog zoo sib xwskev kho mob raug xa ncaj qha mus rau thaj tsam cuam tshuam txhawm rau txhawm rau rhuav tshem, thiab, ntxiv rau, ua kom puas cov qog hlwb. Txoj kev kho no zoo heev pab txwv lawv txoj kev loj hlob.

Tus qauv ntawm kev saib xyuas los ntawm theem 4 diffuse loj b-cell lymphoma kho yog rau chav kawm ntawm cov tshuaj hu ua Rituximab. Nws yuav tsum raug sau tseg tias lub sijhawm ntawm kev kho mob, nrog rau kev sib xyaw ua ke ntawm cov tshuaj, yuav txawv, uas ncaj qha nyob ntawm lub hnub nyoog, thiab, ntxiv rau, ntawm kev ruaj ntseg ntawm cov neeg mob thiab qib kev puas tsuaj rau lawv lub cev.

non-Hodgkin's B cell diffuse loj cell lymphoma
non-Hodgkin's B cell diffuse loj cell lymphoma

kev kho mob ntxiv

Kev kho ntxiv tuaj yeem ua tiav nrog Rituximab, Dexamethasone, Cytarabine thiab Cisplastin. Cov khoom siv venous kuj tseem siv tau rau cov neeg mob uas tau txais ntau lub voj voog ntawm chemo. Cov cuab yeej zoo li no tau cog rau txhawm rau coj cov qauv rau kev tshuaj ntsuam xyuas, txiav txim siab qib ntawm toxicity thiab ua kev txhaj tshuaj.

Cov neeg mob uas muaj mob qog noj ntshav no feem ntau pom txhua peb lub lis piam, txawm tias lawv pom kev txhim kho ib ntus. Ntawm tag nrho cov naj npawb ntawm lymphomas, plaub caug feem pua yog diffuse loj cell variations ntawm tus kab mob no.

Tam sim no cia peb mus rau kev txiav txim siab txog qhov tshwm sim ntawm tus kab mob no thiab nrhiav seb yuav ua li cas cov neeg mob muaj sia nyob nrog tus kab mob oncology no.

Kev Ntsuas rau diffuse loj B-cell lymphoma

Kev kuaj mob yog tias tus neeg mob muajQhov no pathology nyob rau hauv tsawg zaus yog qhov zoo. Qhov xwm txheej ntawm qhov kev mob tshwm sim feem ntau nyob ntawm hom thiab theem ntawm tus kab mob, thiab, ntxiv rau, nyob rau hnub nyoog thiab kev noj qab haus huv ntawm tus neeg mob. Nyob rau hauv ntau txoj kev, qhov kev cia siab rau diffuse loj B-cell lymphoma kuj yog nyob ntawm qhov ua rau ua rau muaj qhov tshwm sim ntawm hom oncology. Nrog rau qhov kev pom zoo, cov neeg mob muaj cuaj caum-plaub feem pua ntawm kev muaj sia nyob ntau tshaj tsib xyoos tom qab kuaj mob. Tab sis nyob rau hauv qhov kev tshwm sim ntawm ib qho kev tshwm sim tsis zoo, qhov kev ciaj sia no poob rau rau caum feem pua.

diffuse loj cell lymphoma
diffuse loj cell lymphoma

Diffuse loj B-cell lymphoma tshuaj xyuas

Kev tshuaj xyuas txog kev kho mob ntawm cov kab mob no muaj ntau ntau. Diffuse lymphoma yog ib qho ntawm feem ntau oncologies nyob rau hauv lub ntiaj teb no niaj hnub no. Nws pib tsim hauv lub cev thaum tsim cov B-lymphocytes txawv txav. Qee zaum cov qog qog nyob hauv thaj chaw ntawm lub cev uas tsis muaj cov ntaub so ntswg lymphoid. Pathological cancer hlwb nyob rau hauv lub xub ntiag ntawm tus kab mob no nyob rau hauv cov neeg mob loj hlob sai heev. Kev tshuaj xyuas paub meej qhov no. Kev tsom xam ntawm pathological yuav tsis raug mob tib lub sijhawm, feem ntau cov chaw xws li nyob rau ntawm caj dab, hauv qab ntawm caj dab lossis hauv puab tais. Tib neeg hais tias qhov pom tus kab mob txaus ntshai no sai dua, tus neeg mob yuav muaj qhov tshwm sim zoo.

Pom zoo: