Loperamide Hydrochloride yog dab tsi? Koj yuav pom cov lus teb tag nrho rau cov lus nug hauv cov ntaub ntawv ntawm cov kab lus nthuav tawm. Ntxiv thiab, peb yuav qhia rau koj paub meej txog yuav ua li cas noj cov tshuaj no, nyob rau hauv dab tsi thiab nyob rau hauv dab tsi noj.
cov ntaub ntawv dav dav
Loperamide hydrochloride yog ib yam tshuaj kho mob uas feem ntau siv los kho mob raws plab thiab mob ntev. Cov tshuaj no tau muab xa mus yam tsis muaj kws kho mob sau ntawv thiab muag hauv yuav luag txhua lub tsev muag tshuaj ntawm tus nqi tsim nyog.
Pharmacological action
Cov tshuaj "Loperamide hydrochloride", cov lus qhia uas tau muab ntim rau hauv ib lub thawv ntawv, txo qhov kev txav thiab lub suab ntawm cov leeg nqaij ntawm txoj hnyuv, thiab tseem inhibits peristalsis ntawm lub cev, ua kom lub sijhawm nws nce. yuav siv sij hawm kom dhau nws cov ntsiab lus. Yog li, cov tshuaj tau nthuav tawm muaj cov nyhuv antidiarrheal. Nws yuav tsum raug sau tseg tias cov tshuaj "Loperamide hydrochloride"pib ua hauj lwm sai heev. Tom qab noj cov tshuaj no los ntawm qhov ncauj, cov nyhuv kho yuav kav li 4-6 teev.
YPharmacokinetics
Cov tshuaj no nqus tau rau hauv plab hnyuv tsis zoo (kwv yees li 40%). Vim muaj qhov sib xws nrog cov receptors ntawm cov phab ntsa hauv cov hnyuv, nrog rau cov qib siab ntawm kev hloov pauv hauv lub cev thaum thawj zaug dhau los ntawm lub siab, qib plasma ntawm cov khoom tsis hloov pauv tom qab noj 2 mg ntawm tus neeg sawv cev (1 ntsiav tshuaj) tsawg dua. ntau tshaj 2 ng / ml. Qhov siab tshaj plaws ntawm cov tshuaj nquag tom qab siv cov tshuaj tau mus txog tom qab li 2.5 teev, thiab tom qab cov tshuaj ntsiav - tom qab 5 teev. Plasma protein binding tshwm sim hauv 97%. Cov tshuaj no yog metabolized nyob rau hauv daim siab thiab ib nrab tawm hauv cov zis, nyob rau hauv daim ntawv ntawm conjugates nrog bile, thiab kuj nrog rau faeces.
Daim ntawv tso tshuaj thiab muaj pes tsawg leeg
Loperamide hydrochloride, kev siv uas tau piav qhia hauv qab no, yog ua lag luam li:
- Tshuaj-hmoov rau kev npaj tshuaj.
- 2 mg ntsiav tshuaj uas haum rau hauv ib lub thawv ntawm 50, 30, 20 lossis 10 daim.
- 2mg capsules hauv pob ntawm 30, 20 lossis 10.
- Gelatin nyuaj capsules ntawm cov xim daj, uas muaj cov hmoov dawb nrog cov khoom xyaw nquag - loperamide hydrochloride. Txhua yam tshuaj ntsiav muaj 2 mg ntawm cov tshuaj nquag. Tsis tas li ntawd, cov tshuaj tau nthuav tawm muaj nyob rau hauv nws cov muaj pes tsawg leeg thiab cov khoom pabcuam: talc, pob kws starch, lactose, magnesium.stearate thiab colloidal silicon dioxide. Gelatin capsules yog muag hauv ib lub thawv ntawm 20 lossis 10 daim.
Loperamide hydrochloride nyob qhov twg ntxiv? Kev siv cov tshuaj no hauv pharmacology tso cai rau kev tsim cov tshuaj xws li Imodium thiab Diara. Txawm li cas los xij, nws feem pua ntawm cov kev npaj no tsawg dua li cov tshuaj saum toj no.
Cov tshuaj "Loperamide hydrochloride": nws npaj rau dab tsi?
Raws li cov lus qhia, cov tshuaj no yuav tsum tau noj nyob rau hauv cov xwm txheej hauv qab no:
- Kom normalize quav thaum lub sij hawm ileostomy.
- Thaum muaj kev cuam tshuam cov metabolism thiab kev nqus ntawm plab hnyuv, uas yog tshwm sim los ntawm kev hloov pauv ntawm kev noj zaub mov lossis kev coj noj coj ua (piv txwv li, thaum noj zaub mov, thaum mus ncig).
- Ua ib qho tshuaj tiv thaiv kab mob raws plab.
- Raws li kev kho mob rau mob raws plab lossis mob raws plab (kev ua xua, hluav taws xob, tshuaj lossis kev xav).
Contraindications rau kev siv tshuaj
Thaum twg yuav tsum tsis txhob siv Loperamide (cov ntsiav tshuaj)? Cov lus qhia rau cov tshuaj no hais tias nws tsis pom zoo siv thaum:
- plab hnyuv;
- raws plab vim kab mob dysentery, mob pseudomembranous enterocolitis lossis lwm yam kab mob hauv nruab nrog cevGIT;
- diverticulosis;
- mob plab ulcerative colitis;
- hypersensitivity.
Nws tseem yuav tsum tau muab sau tseg tias cov tshuaj tiv thaiv kab mob rau cov menyuam yaus yuav tsum tau muab tshuaj txij li hnub nyoog 4 xyoos xwb. Tsis tas li ntawd, raws li cov lus qhia, Loperamide yog contraindicated nyob rau hauv lub 1st trimester ntawm cev xeeb tub thiab thaum lub sij hawm lactation. Nrog kev ceev faj heev, cov tshuaj no tau muab rau daim siab tsis ua haujlwm.
Tshuaj "Loperamide hydrochloride": cov lus qhia rau kev siv
Tablets thiab capsules ntawm cov tshuaj no yuav tsum tau noj ntawm qhov ncauj tsis zom. Qhov ntau npaum li cas ntawm cov tshuaj no nyob ntawm qhov hnyav ntawm tus kab mob thiab hnub nyoog ntawm tus neeg mob.
Rau cov neeg laus uas muaj mob raws plab, thawj koob tshuaj yog 4mg tom qab 2mg tom qab txhua lub plab zom mov (yog tias cov quav tseem xoob).
Rau qhov mob raws plab, thawj koob tshuaj yuav tsum yog 2mg. Kev saib xyuas kev kho mob rau cov neeg laus yuav tsum tau tsim kom tus neeg mob cov quav ntau zaus yog 1 lossis 2 zaug hauv ib hnub. Qhov siab tshaj plaws noj txhua hnub yog 16 mg.
Cov txiaj ntsig kho mob ntawm kev noj cov tshuaj no tshwm sim hauv 48 teev. Yog tias, rau 2-4 hnub, siv txog li 16 mg ntawm cov tshuaj txhua hnub, nws tsis tuaj yeem ua tiav cov txiaj ntsig xav tau, ces koj yuav tsum sab laj nrog kws kho mob uas yuav rov xav txog nws qhov kev kuaj mob. Kev siv cov tshuaj tuaj yeem rov ua dua, tab sis tsuas yog kev kho tshwj xeeb lossis kev noj zaub mov tsis zoo rau cov quav.
Rau cov menyuam yaus, cov tshuaj no yuav tsum tau muab tshuaj txij li hnub nyoog 4 xyoos xwb. Nws cov koob tshuaj kuj nyob ntawm lub hnub nyoog ntawm tus neeg mob thiab qhov hnyav ntawm tus kab mob.
Cov menyuam yaus hnub nyoog 4 txog 7 xyoos, cov tshuaj yuav tsum tau muab 3-4 zaug hauv ib hnub, 1 mg. Lub sijhawm kho yog 3 hnub. Cov menyuam yaus hnub nyoog 7 txog 12 xyoos raug tshuaj 1 ntsiav tshuaj plaub zaug hauv ib hnub rau 5 hnub. Nyob rau hauv mob raws plab, thawj koob tshuaj rau cov me nyuam yuav tsum yog 1 capsule. Qhov siab tshaj plaws txhua hnub koob tshuaj rau cov menyuam mos yog 8 mg.
Yog tus menyuam muaj quav quav tom qab txhua qhov kev tso quav mus ntev, ces txhua zaus nws yuav tsum tau muab 1 capsule, tab sis tsis pub ntau tshaj 6 mg rau 20 kg ntawm lub cev hnyav ib hnub. Yog hais tias tus me nyuam tsis mus rau hauv chav dej ntau tshaj 12 teev, thiab tom qab lub normalization ntawm cov quav, nws raug nquahu kom tsis txhob noj cov tshuaj uas tau hais.
Tshuaj ntau dhau
Yog tias muaj tshuaj ntau dhau ntawm cov tshuaj no, tus neeg mob yuav ntsib qhov sib txawv hauv qab no:
- kev cuam tshuam hauv kev sib koom tes ntawm kev txav;
- tub kawm ntawv constriction;
- supor;
- drowsy;
- nce pob txha pob txha tone;
- plab hnyuv;
- ua pa nyuaj.
Rau kev kho mob ntawm cov kab mob pathological, cov kws kho mob feem ntau siv cov tshuaj "Naloxone" nrog rau kev kho mob ib txhij.
Side effects
Nws yuav tsum tau muab sau tseg tshwj xeeb tshaj yog tias tom qab siv cov tshuaj "Loperamide hydrochloride" cov neeg mob yuav ntsib ntau yam kev mob tshwm sim. Tshwj xeeb tshaj yog feem ntau lawv tshwm sim nrog kev siv ntev ntawm cov tshuaj. Yog li, cov tshuaj uas tau nthuav tawm tuaj yeem ua rau muaj kev phiv hauv qab no:
- flatulence;
- electrolyte disorders;
- ntua;
- plab hnyuv;
- kiv taub hau;
- gastralgia;
- nausea;
- hypovolemia;
- drowsy;
- dry mouth.
Hauv cov menyuam yaus, cov tshuaj no feem ntau ua rau mob plab, nrog rau cov pob khaus tawv nqaij. Tsis tshua muaj heev, cov tshuaj "Loperamide hydrochloride" tuaj yeem ua rau muaj kev tso zis los yog plab hnyuv.
Yog tias tom qab 2 hnub cov xwm txheej no tsis ploj mus, thiab tus neeg mob tsis zoo, ces koj yuav tsum sab laj nrog kws kho mob uas yuav tsum tau sau lwm yam tshuaj (zoo sib xws). Yog tias cov tshuaj no pab tsis tau koj, ces zoo dua mus kuaj seb puas muaj tus kab mob uas ua rau raws plab.
Kev Sib Tham Tshuaj
Raws li cov lus qhia, nrog rau kev siv tib lub sijhawm ntawm cov tshuaj "Loperamide hydrochloride" thiab "Colestyramine", qhov ua tau zoo ntawm thawj zaug yuav txo qis. Yog tias koj xav siv cov tshuaj no nrog Co-trimoxazole lossis Ritonavir, koj yuav tsum paub tias nws cov bioavailability tau nce ntau.
Cov lus qhia tshwj xeeb
Loperamide hydrochloride yuav tsum tau noj nrog ceev faj heev hauv daim siab tsis ua haujlwm. Nws kuj tsis pom zoo kom siv nws hauv cov xwm txheej zoo li no thaum tsim nyoginhibition ntawm txoj hnyuv motility. Yog tias tsis muaj cov txiaj ntsig kho tau zoo 2 hnub tom qab siv cov tshuaj no, nws yog ib qho tsim nyog yuav tsum paub meej qhov kev kuaj mob nrog kws kho mob thiab tsis suav nrog cov kab mob sib kis ntawm cov kab mob raws plab.
