Cov tshuaj "Prosulpin" yog nyob rau hauv cov lus qhia rau kev siv raws li ib tug haib antipsychotic neeg sawv cev uas yog siv nyob rau hauv kev kho mob ntawm ntau yam kab mob ntawm lub paj hlwb thiab lwm yam kab mob. Nyeem ntxiv txog qhov kev npaj saum toj no.
Drug summary
Cov tshuaj no yog pab pawg ntawm cov tshuaj benzamines hloov pauv. Hauv lwm txoj kev, peb tuaj yeem hais tias cov tshuaj "Prosulpin" yog ib qho tshuaj tiv thaiv kab mob. Kev tshuaj xyuas ntawm cov kws tshaj lij qhia tau hais tias nws qhov kev ua haujlwm yog txhawm rau thaiv cov dopamine receptors (D2 thiab D3). Vim li no, cov tshuaj saum toj no tsim cov tshuaj tiv thaiv kev puas hlwb.
50 lossis 200 mg ntawm cov tshuaj sulfuride muaj ib ntsiav tshuaj ntawm cov tshuaj "Prosulpin".
Cov kev mob tshwm sim thaum noj cov tshuaj no, tau kawg, qee qhov tshwm sim. Yog li ntawd, tus neeg mob thaum lub sijhawm kho nrog cov tshuaj tiv thaiv kab mob saum toj no yuav tsum nyob rau hauv kev saib xyuas nruj ntawm tus kws kho mob.
Cov tshuaj no los ntawm ntau hom. Nws muaj nyob rau hauv cov ntsiav tshuaj daim ntawv, raws li zoo raws li nyob rau hauv daim ntawv ntawm tsiav tshuaj, tshuaj rau intramuscular txhaj thiab kua rau noj.sab hauv.
Cov tshuaj yuav tsum khaws cia rau hauv chav tsev kub ib txwm, tab sis tsis siab tshaj 25 degrees Celsius. Qhov chaw yuav tsum muaj kev tiv thaiv zoo ntawm lub teeb thiab noo noo. Txog ob xyoos yog lub txee lub neej ntawm cov tshuaj "Prosulpin". Nws cov analogues yog yooj yim mus nrhiav. Lub khw muag tshuaj muaj ntau yam kev hloov pauv rau cov tshuaj saum toj no.
Pharmacological kev txiav txim ntawm cov tshuaj saum toj no
Cov tshuaj "Prosulpin", daim duab uas tau muab hauv qab no, yog ib qho tshuaj tiv thaiv kab mob, uas yog, tshuaj tiv thaiv kev puas siab puas ntsws. Cov tshuaj sulpiride, vim yog qhov thaiv ntawm dopamine receptors hauv thaj tsam tuberoinfudibular, pab txhawb kom nce qib ntawm prolactin. Nws yuav tsum raug sau tseg tias qib ntawm kev thaiv ntawm dopamine receptors hloov pauv hauv thaj tsam ntawm 60-80%.
Cov tom kawg yog qhov txawv los ntawm qhov zoo sib xws nrog benzamides, uas yog tus cwj pwm los ntawm cov yam ntxwv xws li cov nyhuv biphasic ntawm neurotransmitter dopamine system. Tsis tas li ntawd, lawv thaiv qhov nce hauv dopamine synthesis hauv thaj tsam synaptic, uas yog, lawv yog cov antagonists ntawm presynaptic D2 D3 auto-receptors.
Nws yuav tsum tau muab sau tseg tias cov tshuaj saum toj no muaj cov tshuaj tiv thaiv kab mob nruab nrab. Cov yav tas yog ua ke nrog thymoanaleptic thiab stimulating los ntawm cov tshuaj no.
Cov tshuaj saum toj no muaj cov tshuaj hauv qab no:
- antiemetic (dopamine receptors thaiv thaj tsam ntawm qhov chaw ntuav);
- tshuaj tiv thaiv kev nyuaj siab;
- tshuaj tiv thaiv kab mob.
Sulpiride muaj cov tshuaj tiv thaiv kev nyuaj siab hauv koob tshuaj txog 600 mg. Tshaj li tus qauv no, cov nyhuv antipsychotic ntawm cov tshuaj no ntawm lub cev twb pom lawm.
Ntxiv rau, cov tshuaj "Prosulpin", cov lus qhia qhia qhov no, ua rau muaj kev xaiv rau lub hypothalamus nrog cov tsos mob ntawm gastric ulcer thiab gastroduodenitis. Nyob rau tib lub sijhawm, lub siab excitation ntawm lub sympathetic paj hlwb yog suppressed, lub plab zom mov cov hlab ntsha txhim kho, proliferation ntawm granulation ntaub so ntswg thiab cov txheej txheem ntawm mucus secretion nyob rau hauv lub plab yog ceev, ib tug regenerated epithelium yog tsim, thiab cov txheej txheem ntawm cov mucus secretion nyob rau hauv lub plab yog accelerated, ib tug regenerated epithelium yog tsim. Kev loj hlob ntawm capillaries hauv cov ntaub so ntswg txhim kho.
Leej twg pom zoo los kho qhov no?
Dab tsi yog cov lus qhia rau kev siv tshuaj "Prosulpin"? Rau kev siv tshuaj, cov tshuaj saum toj no yog siv rau cov kab mob xws li:
- mob hlwb;
- kev nyuaj siab ntawm lub plab zom mov;
- mob rwj;
- gastroduodenitis;
- plab plab;
- irritable bowel syndrome (colon);
- tshuaj rwj;
- ulcerative colitis;
- kev nyuaj siab ntawm ntau yam kev xav;
- neuroses;
- reactive kev nyuaj siab;
- dysphoric mob;
- schizophrenia;
- kev puas siab puas ntsws ntev;
- migraine;
- mob hlwb tsis zoo;
- kiv taub hau ntawm ntau yam etymologies (vestibular neuritis,vertebrobasilar insufficiency, Meniere's kab mob, otitis media).
Cov tshuaj "Prosulpin" cov lus qhia rau kev siv qhia siv rau kev kho tus cwj pwm tsis zoo thiab kev puas siab puas ntsws hauv cov neeg mob hluas, uas yog, hauv cov menyuam yaus. Cov no yog cov kab mob xws li tus kheej-mutilation, agitation, stereotypy. Tsis tas li ntawd, cov tshuaj "Prosulpin" cov lus qhia rau kev siv tau tawm tswv yim zoo siv nws ua ib feem ntawm kev kho mob rau menyuam yaus autism. Cov cuab yeej no yog siv los kho cov neeg mob me hnub nyoog 6 xyoo.
Contraindications rau kev siv cov tshuaj saum toj no
Cov tshuaj "Prosulpin" cov lus qhia rau kev siv tsis pom zoo siv yog tias tus neeg mob muaj cov tsos mob ntawm cov kab mob hauv qab no:
- hypersensitivity rau tshuaj tivthaiv;
- hyperprolactinemia;
- prolactin-dependent qog (mob cancer mis, pituitary prolactinomas);
- kev mob nkeeg;
- mob hnyav los ntawm cov dej haus uas muaj cawv;
- tus cwj pwm nruj;
- pheochromocytoma;
- mob hnyav los ntawm tshuaj los yog tshuaj tsaug zog;
- manic psychosis.
Txhua yam kev mob no yog nruj contraindications. Tsis tas li, cov tshuaj "Prosulpin" cov lus qhia rau kev siv txwv tsis pub cov poj niam pub niam mis rau menyuam, cov menyuam yaus hnub nyoog qis dua 18 xyoo (rau 200 mg tshuaj), cov neeg mob me hnub nyoog qis dua 6 xyoo (rau 50 mg tshuaj).
Ntxiv rau, nws yuav tsum nco ntsoov tias nrog lub cev tsis muaj lactose,malabsorption ntawm qabzib-galactose, lactose intolerance kuj tsis xav kom siv cov tshuaj "Prosulpin". Contraindications rau kev siv cov tshuaj saum toj no kuj siv rau cov poj niam cev xeeb tub. Nws tsuas yog yuav tsum tau siv rau hauv cov neeg mob no yog tias qhov kev xav tau ntawm cov tshuaj muaj ntau dua qhov muaj feem cuam tshuam rau tus menyuam hauv plab.
Side effects
Thaum noj tshuaj "Prosulpin" (cov lus qhia qhia qhov no), qee qhov kev phiv tshwm sim:
- los ntawm cov kab mob endocrine - galactorrhea, dysmenorrhea, amenorrhea, frigidity, impotence;
- los ntawm ib sab ntawm cov hlab ntsha - sedation, tshee, kiv taub hau, dyskinesia thaum ntxov, extrapyramidal syndrome, tsaug zog, akinesia nrog nqaij hypertonicity, akathisia, lub cev muaj zog agitation;
- nce enzyme kev ua haujlwm (los ntawm kev zom zaub mov);
- hemolytic anemia, leukocytosis, aplastic anemia, granulocytosis, thrombocytopenic purpura tshwm sim nrog nce koob tshuaj Prosulpin (ua haujlwm los ntawm cov qog ntshav thiab cov ntshav);
- tachycardia, orthostatic hypotension, txo qis lossis nce ntshav siab, ncua sijhawm QT lub sijhawm, qee zaum, kev loj hlob ntawm cov kab mob txaus ntshai xws li torsade des pointes syndrome (los ntawm lub plawv thiab nws lub cev).
Tsis tas li, lwm yam kev mob tshwm sim tshwm sim los ntawm kev noj cov tshuaj no. Cov tshuaj "Prosulpin" (cov lus qhia, cov kws kho mob tshuaj xyuas thiab cov neeg mob cov lus teb qhia qhov no) tuaj yeem ua tauprovoke xws unpleasant phenomena li tardive dyskinesia, uas yog yus muaj los ntawm involuntary rhythmic zog ntawm lub ntsej muag los yog tus nplaig (nrog rau ib tug ntev kev kho mob ntawm neuroleptics ntawm tag nrho cov pab pawg neeg), hyperthermia. Cov kws tshaj lij ceeb toom tias nyob rau yav tas los, nws yog ib qho tseem ceeb tshwj xeeb tshaj yog kom tshem tawm cov kev kho saum toj no hauv lub sijhawm, vim tias qhov kub thiab txias tuaj yeem ua rau muaj kev cuam tshuam ntawm cov kab mob txaus ntshai xws li neuroleptic malignant syndrome.
Nyhav nce, tawm hws ntau dhau, ua pob khaus thiab khaus khaus - tag nrho cov kev mob tshwm sim no tuaj yeem ua rau cov tshuaj "Prosulpin". Cov lus qhia, cov kws tshaj lij tshuaj xyuas pom zoo rau cov xwm txheej zoo li no kom tsis txhob noj cov tshuaj saum toj no thiab sab laj nrog kws kho mob tam sim rau kev pab kho mob thiab cov lus qhia.
Siv cov tshuaj saum toj no thaum cev xeeb tub
Teratogenic nyhuv ntawm cov tshuaj tsis pom los ntawm kev sim ntawm cov tsiaj. Qee cov poj niam uas tau noj cov tshuaj no thaum cev xeeb tub kuj tsis pom cov nyhuv saum toj no. Tab sis cov neeg mob no tau noj cov tshuaj Prosulpin nruj me ntsis. Cov lus qhia rau kev siv, kev tshuaj xyuas cov kws tshaj lij tsis muaj cov ntaub ntawv tshwj xeeb hais txog kev siv ntau dua ntawm cov tshuaj xws li sulfiride. Kuj tseem tsis muaj ntaub ntawv hais txog cov txiaj ntsig ntawm cov tshuaj saum toj no ntawm kev loj hlob ntawm lub paj hlwb ntawm fetal.
Raws li kev ceev faj, cov kws tshaj lij tsis pom zoo siv cov tshuaj no rau cov poj niam cev xeeb tub. Txawm hais tias qee zaum nws tseem tuaj yeem kho cov saum toj noib qho tshuaj rau cov neeg mob uas xav tias yuav xeeb tub, tab sis nruj me ntsis hauv koob tshuaj tsawg.
Cov kws kho mob tshwj xeeb tau sau tseg tias yog leej niam tau txais kev kho mob rau lub sijhawm ntev, cov menyuam mos yug tshiab muaj teeb meem nrog kev ua haujlwm ntawm lub plab zom mov (piv txwv li, tsam plab).
Yog tus poj niam noj tshuaj nyob rau lub sijhawm ua ntej yug menyuam, ces tswj nws lub cev thiab kev loj hlob ntawm tus menyuam hauv plab los ntawm tus kws kho mob.
Nws tseem yuav tsum nco ntsoov tias cov tshuaj "Prosulpin" nkag mus rau hauv cov kua mis. Cov lus qhia rau kev siv, tshuaj xyuas ntawm cov kws tshaj lij tsis pom zoo kom noj nws thaum lactation.
YYuav noj Prosulpin li cas?
Kev qhia qhia tias cov neeg mob noj cov tshuaj tiv thaiv kab mob saum toj no txhua 8 teev, ib ntsiav tshuaj. Nws tsis pom zoo kom noj cov tshuaj tom qab 16.00 teev, vim tias nws cov haujlwm tau nce siab heev nyob rau lub sijhawm no. Nws yuav tsum raug sau tseg tias cov tshuaj "Prosulpin" yog siv tsis hais noj mov thiab ntxuav nrog cov kua dej txaus.
Cov ntsiav tshuaj uas muaj 200 mg ntawm sulpiride tau noj rau cov tsos mob ntawm tus mob schizophrenia, delirious psychosis thiab kev nyuaj siab. Cov tshuaj tuaj yeem noj hauv ob peb koob. Nws cov koob tshuaj ntau tshaj txhua hnub yog 100 mg, uas yog, txog 5 ntsiav tshuaj.
ntsiav tshuaj, uas suav nrog 50 mg ntawm sulpiride, cov lus qhia qhia tias noj yog tias tus neeg mob muaj cov tsos mob ntawm neurosis, ntxhov siab. Hauv 4 lub lis piam, cov neeg mob zoo li no yuav tsum haus tsawg kawg ib zaug thiab ntau tshaj 3ntsiav tshuaj ib hnub.
Tsis tas li, cov tshuaj no tuaj yeem noj los ntawm cov menyuam yaus uas muaj kev coj cwj pwm tsis zoo. Lub hnub nyoog ntawm cov neeg mob no yuav tsum tau siab dua 6 xyoo. Qhov siab tshaj plaws txhua hnub koob tshuaj rau cov neeg mob hauv pawg no yog los ntawm 5 mus rau 10 mg rau 10 kg ntawm lub cev qhov hnyav ntawm tus menyuam.
Ntau tshaj
Cov lus qhia qhia tias cov ntaub ntawv ntawm kev noj tshuaj sulfiride ntau dhau yog txwv. Cov tsos mob hauv qab no tuaj yeem pom hauv tus neeg mob:
- tus nplaig protrusion;
- dyskinesia nrog spastic torticollis;
- fuzziness ntawm qhov pom kev pom;
- dry mouth;
- yuav tsim NMS;
- cov tsos mob tshwm sim ntxiv;
- tawm hws ntau dhau;
- nausea;
- sedation;
- gynecomastia;
- parkinsonism;
- nce ntshav siab.
Tus neeg mob saum toj no raug kho raws li hauv qab no:
- tus neeg mob lub plab ntxuav;
- assigned activated carbon;
- siv txoj kev kho mob.
Yog tias tsim nyog, tshwj xeeb tshaj yog mob hnyav, tus kws kho mob tuaj yeem sau tshuaj ntxiv, xws li yuam diuresis nrog rau cov tshuaj alkaline los yog saib xyuas cov haujlwm tseem ceeb hauv lub cev.
Nws yuav tsum tau muab sau tseg tias cov tshuaj no tau tawm ib feem thaum lub sij hawm hemodialysis.
Qee pawg ntawm cov neeg mob yuav tsum tau ceev faj tshwj xeeb thaum siv cov tshuaj "Prosulpin". Qhov no feem ntau siv rau cov poj niam nrogLub sijhawm tsis sib xws, cov neeg mob uas muaj mob hnyav thiab cov neeg mob ntshav siab.
Nws tseem yog ib qho tseem ceeb rau kev kuaj ua ntej electrophysiological thiab soj ntsuam hauv cov neeg mob uas muaj mob vwm. Nws yuav tsum nco ntsoov tias cov tshuaj "Prosulpin" txo qis qhov pib rau qaug dab peg.
Ntxiv rau, thaum tsav tsheb, yuav tsum tau saib xyuas tshwj xeeb thaum lub sijhawm kho nrog cov tshuaj saum toj no. Nws tseem yog ib qho tseem ceeb los txwv cov kev ua ub no uas yuav tsum tau ceev cov kev xav ntawm psychomotor thiab nce concentration.
Kev sib tham nrog lwm cov khoom siv tshuaj
Cov lus qhia nruj me ntsis tsis pom zoo suav nrog cov tshuaj saum toj no hauv kev kho mob nrog levodopa. Ob tug active tshuaj yog antagonists. Yog tias tus neeg mob uas muaj tus kab mob Parkinson tau noj levodopa, ces tus kws kho mob yuav tsum xaiv ib qho uas muaj cov nyhuv extrapyramidal tsawg.
Arrhythmia zoo li torsades de pointes tuaj yeem tshwm sim los ntawm kev sib xyaw ntawm Prosulpin nrog:
- tshuaj tiv thaiv kab mob uas muaj nyob rau hauv chav kawm Ia (cov tshuaj "Disopyramide", "Quinidine");
- Y Pimozide, Haloperidol, Thioridazine, Cisapride, Pentamidine, imipramine antidepressants;
- tshuaj tiv thaiv kab mob, uas suav nrog hauv chav kawm thib 3 (Sotalol, Kakamiodarone);
- tshuaj uas ua rau cov tsos mob ntawm bradycardia (beta-calcium channel blockers);
- tshuaj uas pab txhawbCov tsos mob ntawm hypokalemia (laxatives uas yog stimulant, hypokalemic diuretics, tetracosactides, glucocorticoids);
- dopamine antagonists (antiparkinsonian): Apomorphine, Amantadine, Lizuride, Ropinirole, Entacapone, Bromocriptine, Selegiline, Pramipexole, Piribedil);
- neuroleptics uas muaj peev xwm ua rau cov tsos mob ntawm torsades de pointes (Chlorpromazine, Amisulpride, Cyamemazine, Pimozide, Droperidol, Levomepromazine, Tiapride, Sertindol, Veraliprid), "Sulpiride");
- npaj uas muaj lithium (tom kawg ua rau muaj kev pheej hmoo ntawm cov kab mob extrapyramidal).
Tsis tas li, tsis muaj qhov xwm txheej yuav tsum tau siv Prosulpin nrog cawv. Qhov kawg potentiates cov nyhuv sedative ntawm neuroleptics.
Ntxiv rau, yog tias cov tshuaj saum toj no tau noj ua ke nrog cov tshuaj stimulating hauv nruab nrab (anti-asthma, anorectics), tus neeg mob yuav muaj cov tsos mob ntawm kev ntxhov siab, ntxhov siab, ntxhov siab, tsis xis nyob.
Nco ntsoov tias cov tshuaj tiv thaiv kev puas siab puas ntsws txo cov txiaj ntsig ntawm ropinirole.
Hloov rau tus neeg saib xyuas kho "Prosulpin"
Analogues ntawm cov tshuaj tiv thaiv kab mob saum toj no:
- "Betamak T100";
- "Vero-Sulpiride";
- "Betamax T50";
- "Depral";
- "Betamax";
- "Dogmatil";
- "Betamax T200";
- "Sulpiride";
- "Eglonil";
- "Sulpiril";
- "Eglek".
Tab sis hloov yam tsis muaj kev sib tham ua ntej nrog tus kws kho mob tsis pom zoo "Prosulpin" cov lus qhia rau kev siv. Nws cov analogues kuj muaj lawv tus kheej cov kev mob tshwm sim. Lawv tuaj yeem ua rau mob hnyav rau tus neeg mob.
Tshuaj xyuas txog tus neeg sawv cev kho "Prosulpin"
Kev tshuaj xyuas txog cov tshuaj saum toj no feem ntau yog qhov zoo. Ntau tus neeg mob coj nws mus rau kev nyuaj siab. Lawv thov tias qhov kev kho no pab tshem tawm cov tsos mob ntawm tus kab mob no yuav luag 100%.
Ntxiv rau, muaj ntau cov lus teb los ntawm cov neeg mob uas, nrog cov kab mob xws li schizophrenia, enterocolitis, colitis, psychosis, enteritis, peptic ulcer, chim siab plob tsis so tswj, noj tshuaj "Prosulpin". Lawv cov kev txheeb xyuas qhia tau hais tias nyob rau hauv txhua rooj plaub qhov kev kho no ua rau muaj txiaj ntsig zoo kawg. Tsis tas li ntawd, cov neeg mob nco ntsoov tias cov kev mob tshwm sim tsawg heev.
Cov tshuaj tau tham saum toj no muaj cov kev mob tshwm sim loj heev, yog li txwv tsis pub siv nws yam tsis tau ntsib kws kho mob ua ntej.
