Benzathine benzylpenicillin yog tshuaj tua kab mob thiab belongs rau pawg penicillin. Nws yog siv los kho txhua yam kab mob sib kis los ntawm cov kab mob uas muaj kev phom sij rau nws qhov kev ua. Nyob rau hauv tsab xov xwm no, peb yuav nthuav dav cov lus qhia rau kev siv, indications thiab contraindications rau noj cov tshuaj, thiab kuj sau ob peb analogues.
Benzathine benzylpenicillin: tshuaj piav qhia
Cov tshuaj no yog ib qho ntawm thawj cov tshuaj tua kab mob ntawm pab pawg penicillin. Txawm hais tias siv sijhawm ntev heev, nws tsis tau poob nws qhov cuam tshuam vim nws qhov dav spectrum ntawm kev ua thiab muaj peev xwm ua kom puas ntau yam kab mob pathogenic. Cov tshuaj, piv txwv li, tuaj yeem cuam tshuam nrog anthrax, meningococci, syphilis, thiab ntau yam streptococci thiab staphylococci. Nws yog siv los ntawm kev txhaj tshuaj, txij li benzathine benzylpenicillin tsis absorbed hauv plab hnyuv.
Recipe in LatinCov kws kho mob feem ntau sau ntawv, thiab tom qab ntawd nws nyuaj rau tus neeg mob kom nkag siab txog qhov nws tau sau tseg. Txhawm rau zam qhov kev nkag siab tsis zoo, koj tsuas yog xav paub lub npe ntawm cov tshuaj hauv hom lus no - Benzathine benzylpenicillinum.
Feem ntau cov tshuaj yog muab tso rau hauv cov hlab ntsha lossis intramuscularly. Tab sis nws kuj tseem ua tau rau cov tshuaj nkag mus rau hauv lub cev los ntawm tus txha caj qaum, subcutaneously, lossis los ntawm thaj chaw cuam tshuam.
Benzylpenicillin yog tshuaj tua kab mob uas muaj cov tshuaj nquag ntawm tib lub npe. Tab sis nws muaj nyob rau hauv cov tshuaj muaj pes tsawg leeg nyob rau hauv daim ntawv ntawm ntsev. Yog li cov khoom tuaj yeem khaws cia rau lub sijhawm ntev heev yam tsis muaj kev sib cais. Thiab twb tom qab kev taw qhia rau hauv lub cev, benzylpenicillin raug tso tawm los ntawm cov ntsev thiab pib nws cov tshuaj tua kab mob.
Nyob ntawm cov ntsev uas cov tshuaj nquag nyob, muaj ntau hom tshuaj. Txawm li cas los xij, lawv txhua tus muaj cov txiaj ntsig zoo ib yam, tab sis txawv ntawm txoj kev tswj hwm thiab lub sijhawm ntawm cov txiaj ntsig.
Kev qhia
Benzathine benzylpenicillin yog tshuaj rau cov kab mob hauv qab no:
- kis kab mob ntawm cov kab mob ua pa (pleurisy, pneumonia, bronchitis, pleural empyema, thiab lwm yam).
- Kab mob ntawm cov kab mob genitourinary (syphilis, gonorrhea, urethritis, cystitis, adnexitis, salpingitis).
- Kab mob ENT kab mob (scarlet fever, tonsillitis, sinusitis, otitis media, sinusitis, laryngitis, thiab lwm yam).
- Purulent kis kab mob ntawm lub cev pom, pob txha thiab tawv nqaij, daim nyias nyias (blenorrhea, dacryocystitis, blepharitis, osteomyelitis, mediastinitis, erysipelas, phlegmon, mob txhab, thiab lwm yam).
- Ascesshlwb.
- Purulent meningitis.
- Septicemia, sepsis.
- mob caj dab.
- Peritonitis.
- Kab mob tshwm sim los ntawm spirochetes (yaws, anthrax, thiab lwm yam).
- Kab mob tshwm sim los ntawm Listeria, Clostridium, Pasteurella.
Tsis tas li ntawd, cov tshuaj tau muab tshuaj rau kev tiv thaiv kev mob ntshav qab zib thiab cov teeb meem ntawm cov kab mob streptococcal (endocarditis, rheumatism, glomerulonephritis, thiab lwm yam).
YPharmacokinetics
Benzathine benzylpenicillin (hauv Latin Benzathine benzylpenicillinum) tam sim ntawd tom qab txhaj tshuaj pib decompose, tso cov tshuaj nquag. Hauv qhov no, cov tshuaj tseem nyob hauv cov ntshav rau 3 lub lis piam tom qab txhaj tshuaj. Hauv cov kua, cov tshuaj nkag mus zoo dua li hauv cov ntaub so ntswg. Nws yuav tsum raug coj mus rau hauv tus account tias benzylpenicillin muaj peev xwm kov yeej lub placental barrier thiab xaus rau hauv cov kua mis ntawm niam laus. Tshem tawm ntawm lub cev los ntawm lub raum tsis hloov. Hauv thawj 8 hnub, kwv yees li 33% ntawm cov tshuaj tau muab tso tawm.
Raws li tau sau tseg saum toj no, cov tshuaj muaj peev xwm hla lub placental barrier thiab nkag mus rau cov kua mis. Yog li ntawd, thaum muab tshuaj, kev pub niam mis yuav tsum raug tso tseg.
Thaum cev xeeb tub, kev teem sijhawm tshuaj tsuas yog ua tau yog tias qhov txiaj ntsig rau tus poj niam tshaj qhov txaus ntshai rau tus menyuam. Qhov kev txiav txim siab yuav tsum tau ua los ntawm tus kws kho mob, ceeb toom rau leej niam ntawm txhua yam ua taukev tshwm sim.
YContraindications
Benzathine benzylpenicillin (tsuas yog kws kho mob sau ntawv tau) muaj ntau yam contraindications. Nws yuav tsum tsis txhob muab rau cov neeg muaj kab mob hauv qab no:
- Kev tsis haum rau penicillins lossis cephalosporins, kev tsis haum rau lawv.
- Ntau cov poov tshuaj hauv cov ntshav (hyperkalemia).
- Arrhythmia.
- YAsthma bronchial.
- raum tsis ua haujlwm.
- YPseudomembranous colitis.
Nrog ceev faj, cov tshuaj tau muab rau cov menyuam yaus hnub nyoog qis dua rau lub hlis thiab cov menyuam mos ntxov ntxov.
Side effects
Benzathine benzylpenicillin tuaj yeem ua rau muaj ntau yam tsis xav tau, teev hauv qab no.
Ntau yam kev ua xua tshwm sim:
- kub nce;
- urticaria;
- tawm pob ntawm cov mucous thiab daim tawv nqaij;
- mob pob qij txha;
- eosinophilia;
- erythema multiforme;
- Quicke's edema;
- Yexfoliative dermatitis;
- anaphylactic shock.
Cov tshuaj tsis zoo ntawm cov hlab plawv:
- thrombocytopenia;
- ntshav qab zib;
- kev tsis sib haum xeeb;
- leucopia.
Also:
- stomatitis;
- mob taub hau;
- glossy;
- mob ntawm qhov chaw txhaj tshuaj;
- abscesses;
- infiltrates;
- nephritis peripheral;
- fistula.
Nrog rau kev siv ntev, muaj kab mob fungi thiabCov kab mob tuaj yeem txhim kho tsis kam, thiab tom qab ntawd cov tshuaj yuav poob nws cov txiaj ntsig.
Benzathine benzylpenicillin: cov lus qhia rau kev siv
Rau cov neeg mob hnub nyoog tshaj 12 xyoos, cov tshuaj tiv thaiv thiab kho cov kab mob sib kis tau muab tshuaj ib zaug ib lim tiam ntawm kev noj tshuaj ntawm 300 txog 600 txhiab units lossis ob zaug hauv ib hlis rau 1.2 lab units.
Raws li kev tiv thaiv kab mob rheumatism, kev kho mob yog txhaj rau 6 lub lis piam, ib lub lis piam, 600 txhiab units. Tib lub sijhawm, acetylsalicylic acid lossis lwm yam NSAIDs tau muab tshuaj rau tib lub sijhawm.
Cov neeg mob hnub nyoog qis dua 12 xyoos tau muab tshuaj ib zaug ib lub lis piam ntawm tus nqi ntawm 5-10 txhiab units ib 1 kg.
Yuav tsum muaj tsawg kawg yog 8 hnub ntawm kev txhaj tshuaj. Qhov nruab nrab noj yog 2.3 lab units.
Ua ntej siv, cov tshuaj yog yaj hauv saline, dej tshwj xeeb rau kev txhaj tshuaj lossis novocaine (2.5% lossis 5%).
Cov tshuaj tuaj yeem siv tau raws li hauv qab no:
- intramuscular;
- subcutaneous;
- lumbar (los ntawm tus txha caj qaum);
- pleural (los ntawm pulmonary pleura);
- subconjunctival (los ntawm cov ntaub so ntswg qhov muag);
- drip dhau pob ntseg;
- drip los ntawm qhov ntswg;
- ncaj qha rau hauv cov ntaub so ntswg ntawm lub cev cuam tshuam.
Kev sib xyaw nrog lwm yam tshuaj
Benzathine benzylpenicillin (cov lus qhia ncaj qha qhia qhov no) tuaj yeem cuam tshuam nrog lwm yam tshuaj. Nyob rau tib lub sijhawm, benzylpenicillin nws tus kheej tuaj yeem muajCov kev ua hauv qab no: kev sib koom ua ke, antagonistic thiab bacteriostatic.
Ntxiv rau, cov tshuaj ua kom muaj txiaj ntsig zoo ntawm cov tshuaj cuam tshuam rau cov tshuaj tiv thaiv tsis ncaj qha. Thiab txo qhov kev ua tau zoo ntawm ethinylestradiol thiab ntau yam tshuaj tiv thaiv qhov ncauj.
Siv ua ke nrog NSAIDs, allopurinol, diuretics ua rau txo qis hauv tubular secretion thiab nce qhov concentration ntawm cov tshuaj nquag. Tsis tas li ntawd, allopurinol ua rau muaj kev pheej hmoo ntawm kev ua xua.
Kev Tiv Thaiv
Ua ntej txhaj tshuaj thawj zaug, nws yuav tsum tau ua qhov kev kuaj pom. Yog tias cov tshuaj no nkag mus rau hauv cov hlab ntsha, ces ischemia lossis embolism tuaj yeem tshwm sim. Tsis tas li ntawd, tej zaum yuav muaj kev ntxhov siab, kev nyuaj siab, tsis pom kev tsis pom kev.
Thaum yuav tsum tau txhaj ob zaug ib zaug, cov tshuaj txhaj rau hauv pob tw lossis caj npab.
Thaum thawj qhov kev ua xua tshwm sim tshwm sim, nws tseem ceeb heev kom cuam tshuam kev kho mob. Nyob ntawm qhov xwm txheej, tus kws kho mob yuav sau tshuaj tiv thaiv kab mob.
Feem ntau Levorin lossis Nystatin tau sau nrog benzylpenicillin, vim tias muaj kev pheej hmoo ntawm cov kab mob fungal. Tias yog vim li cas nrog kev kho mob ntev ntev, kev tawm tsam ntawm plab hnyuv microflora uas tsim cov vitamins B tuaj yeem tshwm sim.
Cov lus qhia tshwj xeeb
Benzathine benzylpenicillin tau sau nrog ceev faj rau cov neeg mobNyob rau hauv uas muaj ntau yam kev ua txhaum ntawm lub raum ua hauj lwm, muaj ib tug predisposition rau allergic manifestations, nrog siab rhiab heev rau lub active tshuaj. Qhov kev txiav txim zaum kawg ib txwm nyob nrog tus kws kho mob tuaj koom, uas yuav tsum paub txog keeb kwm ntawm nws tus neeg mob zoo.
Nws tsis pom zoo kom sau tshuaj rau kev kho mob neurosyphilis, vim tias nrog tus kab mob no, qhov xav tau ntawm cov tshuaj nquag hauv cov ntshav tsis tuaj yeem ua tiav.
Analogues
Muaj lwm yam tshuaj uas muaj txiaj ntsig zoo ib yam li benzathine benzylpenicillin. Analogues, ntawm chav kawm, kuj yog cov pab pawg neeg penicillin. Peb teev cov npe nrov tshaj plaws thiab muaj txiaj ntsig:
- "Gramox-D" - muaj nyob rau hauv daim ntawv ntawm cov hmoov npaj rau dilution thiab kev tswj qhov ncauj.
- "Amosin" - tsim nyob rau hauv cov tshuaj ntsiav, ntsiav tshuaj thiab hmoov rau kev tswj qhov ncauj.
- "Ospen" - yog tsim nyob rau hauv daim ntawv ntawm syrup.
- "Hiconcil" - muaj nyob rau hauv daim ntawv tshuaj ntsiav thiab hmoov rau kev tswj qhov ncauj.
- Azlocillin sodium ntsev yog cov hmoov hmoov los ntawm kev daws cov tshuaj txhaj rau hauv cov hlab ntsha.
- "Ampicillin" - muaj nyob rau hauv cov ntsiav tshuaj, tshuaj ntsiav, granules, tom kawg yog ua rau hauv kev ncua thiab noj qhov ncauj.
- Ecobol - tsim tawm hauv cov ntsiav tshuaj.
- "Ospamox" - yog tsim los ntawm cov ntsiav tshuaj, tshuaj ntsiav thiab hmoov rau kev tswj qhov ncauj.
- "Phenoxymethylpenicillin" - muaj nyob rau hauv cov ntsiav tshuaj, dragees, granules thiab hmoov.
- Star Pen - ua hauvnyob rau hauv daim ntawv ntawm granules uas yog diluted thiab noj qhov ncauj.
- "Oxacillin" - yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, tshuaj ntsiav, hmoov, los ntawm cov tshuaj rau kev txhaj tshuaj yog npaj.
- "Standacillin" - muaj nyob rau hauv cov tshuaj ntsiav.
- Carbenicillin disodium ntsev - tsim nyob rau hauv daim ntawv ntawm cov hmoov rau kev txhaj tshuaj.
Yog li, txawm tias siv cov tshuaj ntev ntev hauv cov tshuaj, nws tseem yog ib qho ntawm cov tshuaj zoo tshaj plaws tiv thaiv ntau yam kab mob.
