Cov neeg mob hawb pob paub tias nws tseem ceeb npaum li cas kom tau txais kev pab nrog bronchospasm hauv lub sijhawm. Qee lub sij hawm qhov ua tau zoo hauv qhov teeb meem nyuaj no tuaj yeem cawm tau txoj sia. Bronchodilators ua lub luag haujlwm tseem ceeb hauv kev tshem tus neeg mob ntsws.
Kev piav qhia
"Teopek" (300 mg), cov lus qhia rau kev siv uas tau muab rau hauv tsab xov xwm no, yog cov ntsiav tshuaj dawb ntawm lub tiaj tiaj-cylindrical puag ncig, uas tau ntim rau hauv ib lub pob contour.
Cov khoom xyaw tseem ceeb ntawm cov tshuaj yog theophylline. Nws cov concentration hauv ib ntsiav tshuaj ntawm cov tshuaj no yog 300 mg.
cov tshuaj no ua haujlwm li cas?
Raws li nws cov tshuaj siv tshuaj, theophylline, uas yog cov txiaj ntsig ntawm purine, muaj cov nyhuv inhibitory ntawm phosphodiesterase. Lub active tivthaiv ntawm cov tshuaj blocks tshwj xeeb purine receptors, nkoos lub tsub zuj zuj ntawm cAMP nyob rau hauv cov ntaub so ntswg depots, txo lub peev xwm ntawm cov leeg nqaij daim tawv nqaij daim ntawv cog lus, txo tus nqi ntawm dawb calcium ions uas migrate los ntawm.cell membranes.
Muaj cov txiaj ntsig vasodilatory hais txog kev noj tshuaj "Teopek" (300 mg). Cov lus qhia rau kev siv piav qhia txog cov cuab yeej no ua rau cov hlab ntsha peripheral. Theophylline txhim kho txoj hlab ntshav ntawm lub raum, pab kom cov leeg du ntawm bronchi thiab cov hlab ntsha. Tsis tas li ntawd, qhov kev txiav txim ntawm cov khoom xyaw nquag no yog tus cwj pwm los ntawm cov tshuaj diuretic. Theophylline tiv thaiv kev tso tawm thiab tawm ntawm cov tshuaj uas ua rau muaj kev tsis haum tshuaj, thiab tseem ua rau kom muaj kev ruaj ntseg ntawm mast cell membranes. Yog tias tus neeg mob muaj hypokalemia, cov tshuaj nquag ua kom lub ntsws ua pa kom nrawm dua.
Theophylline pab txhawb rau kev ua haujlwm ntawm cov pa ua haujlwm, ua kom lub cev sib txuas hauv lub hlwb, vim tias cov ntshav zoo dua saturated nrog oxygen, cov pa roj carbon dioxide ntau dua. Cov tshuaj "Teopek" muaj cov nyhuv stimulating ntawm lub diaphragm, ua rau nws cog lus. Nws kuj nce tus nqi ntawm mucociliary clearance Performance index, intensifies cov kev ua ntawm lub pa thiab intercostal nqaij.
Theophylline normalizes ntshav microcirculation, txo cov ntshav txhaws, suppresses ib qho tseem ceeb thiab tshem tawm cov platelet cell aggregation. Tsis tas li ntawd, cov tshuaj pab txhim kho cov ntshav rheological zoo, ua rau muaj kev tiv thaiv ntawm erythrocytes rau deforming yam.
"Teopek" (300 mg) pab txo qis tag nrho lub siab hauv cov hlab ntsws, thiab tseem txo cov hlab ntsha hauv lub ntsws. Yog li ntawd, lub suab ntawm integument ntawm daim tawv nqaij, ob lub raum thiablub hlwb raug txo. Raws li qhov tshwm sim ntawm kev noj cov tshuaj theophylline, stimulation ntawm coronary ntshav txaus, nce plawv dhia, xav tau oxygen nyob rau hauv myocardial hlwb, nce mem tes, thiab lub zog ntawm lub plawv contractions nce.
Pharmacokinetics thiab pharmacodynamics ntawm cov tshuaj
Tom qab tus neeg mob tau noj cov tshuaj theophylline, cov tshuaj no tau nqus tag nrho los ntawm txoj hnyuv. Cov zaub mov noj muaj feem cuam tshuam rau tus nqi ntawm kev nqus ntawm cov tshuaj, tab sis qhov clearance thiab npaum li cas ntawm absorption tseem tsis hloov. 40% ntawm cov tshuaj nquag khi rau plasma proteins. Metabolism ntawm theophylline tshwm sim hauv lub siab los ntawm cytochrome P450 isoenzymes.
Kev tshem tawm cov metabolites hauv daim ntawv nquag yog ua nrog kev pab ntawm lub raum, txawm li cas los xij, 10% ntawm cov tshuaj raug tshem tawm hauv daim ntawv qub. Ntau yam muaj feem cuam tshuam rau cov metabolism ntawm theophylline. Kev haus luam yeeb, noj qee yam tshuaj, kev noj zaub mov zoo, kev tsis sib haum xeeb, lub hnub nyoog tuaj yeem hloov kho cov metabolism ntawm cov tshuaj nquag hauv tib neeg lub cev. Txo kev tshem tawm ntawm theophylline tau sau tseg hauv pulmonary edema, kab mob siab, COPD, thiab lub plawv tsis ua haujlwm.
Leej twg qhia kom kho qhov no?
Muaj qee yam xwm txheej uas siv "Teopek" (300 mg) tau qhia. Cov lus qhia rau kev siv npe cov kab mob hauv qab no:
- chronic obstructive bronchitis;
- pw tsaug zog apnea;
- emphysema;
- bronchial hawb pob;
- pulmonary hypertension;
- cor pulmonale.
TsiCov tshuaj "Teopek", tshuaj xyuas ntawm qhov zoo, tuaj yeem siv ua ke nrog lwm cov tshuaj hauv kev kho mob ntawm lub raum mob.
Cov neeg mob nco txog qhov ua tau zoo ntawm cov tshuaj no thiab nws qhov kev lees paub rau kev kho mob ntawm cov kab mob ua pa.
YContraindications
Txawm li cas los xij, tsis yog txhua tus neeg tuaj yeem siv cov tshuaj no, vim muaj ntau cov lus ceeb toom hauv cov tshuaj. Teopek muaj cov nram qab no contraindications:
- hemorrhagic type stroke;
- mob vwm;
- ntshav los ntawm plab hnyuv hauv keeb kwm;
- ulcerative formations nyob rau hauv lub plab zom mov;
- qib siab tachycardia;
- arterial hypertension lossis hypotension;
- kev nyuaj siab;
- gastritis nrog siab acidity;
- Cov menyuam yaus hnub nyoog qis dua 12.
Yog tias ib qho ntawm cov mob no lossis cov mob tshwm sim, theophylline yuav tsum txiav tawm
Side effects
Muaj ib pawg loj ntawm cov kev mob tshwm sim los ntawm kev noj tshuaj "Teopek" (300 mg). Cov lus qhia rau kev siv cais lawv los ntawm kev ua kom pom tseeb:
- mob ntawm lub paj hlwb: mob taub hau thiab kiv taub hau, pw tsaug zog, ntxhov siab, nce kev ntxhov siab thiab ntxhov siab, tshee;
- ua haujlwm ntawm lub plawv thiab cov hlab ntsha: tachycardia, arrhythmia, hypotension, nce zaus ntawm angina tawm tsam, cardialgia;
- ua txhaum ntawm kev ua haujlwm ntawm lub plab zom mov: xeev siab,gastralgia, ntuav, kub hnyiab, reflux, exacerbation ntawm ulcers, raws plab, tsis qab los noj mov;
- tshwm sim ntawm kev tsis haum tshuaj: daim tawv nqaij ua pob, ua npaws, khaus;
- ntawm lwm cov kev mob tshwm sim los ntawm kev noj tshuaj tau sau tseg: tachypnea, albuminuria, nce diuresis, mob hauv siab, hematuria, dej ntws tawm, tawm hws ntau, hypoglycemia.
Feem ntau, thaum cov koob tshuaj txo qis, qhov tshwm sim ntawm cov kev mob tshwm sim txo qis lossis nres tag nrho.
Yuav noj tshuaj li cas?
Txhais tau tias mob ntsws, xws li Teopek, tsuas yog kws kho mob tau sau tseg thiab lawv cov koob tshuaj raug xaiv los ntawm tus kheej. Qhov nruab nrab, lub npe niaj hnub ntawm theophylline yog 400 mg. Yog tias tus neeg mob zam cov tshuaj zoo, tom qab 2-3 hnub los ntawm kev noj thawj zaug ntawm cov tshuaj, qhov ntim tau nce 25% thiab tom qab ntawd txiav txim siab ntawm tus kws kho mob.
Thaum noj cov tshuaj rau bronchitis "Teopek" hauv ib hnub tsawg dua 900 mg, kev saib xyuas cov ntsiab lus ntawm theophylline hauv cov ntshav tsis tsim nyog. Yog hais tias qhov tshwm sim ntawm intoxication tau sau tseg, ces nws yuav tsum tau ceev nrooj los tswj cov theem ntawm concentration ntawm lub ntsiab active tshuaj nyob rau hauv cov ntshav. Cov txiaj ntsig zoo yog suav tias yog 10-20 mcg ib ml. Yog hais tias cov ntsiab lus ntawm theophylline nyob rau hauv tus neeg mob cov ntshav siab dua li qub, ces txoj kev loj hlob ntawm tsis zoo tshwm sim ntawm lub cev yog pom. Hauv qhov no, nws yuav tsum tau txo qhov koob tshuaj ntawm cov tshuaj, thiab cov txiaj ntsig kho yuav tsis muaj zog.
Puas tau noj tshuaj ntau dhau?
Cov tshuaj broncholytic xws li Teopak yuav yogua rau muaj kev puas tsuaj loj ntawm lub cev ua haujlwm nyob rau hauv rooj plaub ntawm overdose. Nrog rau qhov tsis raug xaiv txhua hnub noj cov tshuaj no, cov tsos mob hauv qab no yuav tshwm sim:
- txo qab los noj mov;
- insomnia;
- mob plab;
- ventricular arrhythmias;
- tachycardia;
- los ntshav ntawm lub plab zom mov;
- tachypnea;
- tremor;
- xov xwm;
- tawv nqaij hyperemia;
- excitability;
- ntshai lub teeb;
- ntuav ntshav.
Kev ua xua hnyav tuaj yeem tshwm sim, cov tsos mob ntawm cov hauv qab no:
- tshwm sim ntawm qaug dab peg;
- hypokalemia;
- raum tsis ua haujlwm, myoglobinuria;
- hypotension;
- tsis meej pem;
- hyperglycemia;
- metabolic acidosis
Yuav ua li cas rau qhov no?
Yog tias cov cim no tshwm sim lossis xav tias, nws yuav tsum tau ua kom lub plab zom mov, muab cov neeg mob nkag mus, tshuaj laxatives, thiab npaj cov tshuaj diuresis, ntshav sorption, hemodialysis thiab hemosorption. Yog hais tias tus neeg mob muaj convulsions, ces nws raug pom zoo kom ua pa oxygen kho thiab intravenously txhaj "Diazepam", uas yuav pab tau kom txhob qaug dab peg. Nyob rau hauv cov ntaub ntawv hais tias xeev siab thiab ntuav, kev txhaj tshuaj ntawm Ondansetron thiab Metaclopromide yuav tsum tau txhaj.
Yuav ua li cas cov tshuaj yuav tsum tsis txhob ua ke nrog Teopak?
Teopak-type bronchodilators tsis pom zooUa ke nrog cov tshuaj tua kab mob macrolide, Allopurinol, Cimetidine, Lincomycin, Isoprenaline, nrog rau cov tshuaj tiv thaiv kab mob hauv qhov ncauj, vim tias tag nrho cov tshuaj no pab txo qis kev tshem tawm ntawm theophylline..
Nws tsis pom zoo kom muab cov tshuaj beta-blockers, tshwj xeeb tshaj yog cov uas tsis xaiv, nrog rau cov tshuaj "Teopek", uas yuav ua rau bronchial constriction thiab txo qis hauv bronchodilatory nyhuv ntawm theophylline.
Yog tias "Teopek" siv nrog "Furosemide", caffeine thiab lwm yam tshuaj uas txhawb nqa beta-2-adrenergic receptors, ces cov haujlwm ntawm nws cov ntsiab lus tseem ceeb nce ntxiv. Yog tias koj muab cov theophylline nrog "Aminoglutitemide", ces thawj cov tshuaj pib tawm hauv lub cev thiab nws cov txiaj ntsig poob qis.
"Acyclovir" muaj peev xwm ua kom cov concentration ntawm cov khoom xyaw tseem ceeb "Teopek" thiab txhim kho qhov tsis zoo ntawm nws cov thawj coj. Cov xwm txheej zoo sib xws tau pom thaum noj theophylline ua ke nrog cov tshuaj Di alteazem, Felodipine, Verapamil, Nefedipine. Cov tshuaj no tsis hloov cov nyhuv bronchodilator, txawm li cas los xij, tus neeg mob yuav ntsib cov tsos mob ntawm kev phiv los yog overdose.
Cov tshuaj "Disulfiram" muaj peev xwm ua kom cov ntsiab lus ntawm theophylline hauv cov ntshav mus rau qib tseem ceeb, kev puas tsuaj rau tshuaj lom. "Propranolol", ntawm qhov tsis sib xws, txo qhov kev tshem tawm ntawm cov tshuaj nquag "Teopek". Theophylline concentration nce thaum nws noj ua ke nrog Enoxacin thiab fluoroquinolones. Nrog kev kho theophylline, kev ua haujlwm ntawm lithium ntsev txo qis.
Hauv kev kho mob nyuaj nrog Phenobarbital,"Carbamazepine", "Isoniazid", "Rifampicin", "Sulfinpyrazone" tsub kom lub clearance ntawm "Teopak" thiab txo nws cov hauj lwm zoo. Nrog rau kev tswj hwm ib txhij ntawm theophylline nrog Phenytoin, kev sib koom ua ke ntawm cov ntsiab lus ntawm cov khoom siv hauv cov neeg mob ntshav tau pom.
Cov lus qhia no tseem ceeb tshwj xeeb, tsis quav ntsej lawv yog qhov muaj teeb meem kev noj qab haus huv. Yog li ntawd, ua ntej noj Teopek, ua tib zoo nyeem cov lus qhia. Thiab yog tias koj noj ib yam ntawm cov tshuaj saum toj no, thov nrog koj tus kws kho mob tham.
Yuav ua li cas yuav cov tshuaj no thiab nqi npaum li cas?
Vim muaj cov contraindications hnyav thiab cov kev mob tshwm sim ntawm cov tshuaj no, "Teopek" raug tso tawm hauv cov khw muag tshuaj nkaus xwb.
Cov tshuaj "Teopek", tus nqi nruab nrab ntawm Russia yog 160 rubles, tau nthuav tawm hauv khw muag tshuaj los ntawm ntau lub tuam txhab. Ib qho ntawm ntau yam yog tshuaj los ntawm Ukrainian kws tshuaj lub tuam txhab Borshchahovsky KhPZ ZAO NPTs. Nws tus nqi yog 155 rubles. Lavxias teb sab zus tau tej cov tshuaj "Teopek", 300 mg yog nqa tawm nyob rau hauv lub qhauj ntawm ZAO Binnopharm thiab Valenta. Tus nqi ntawm cov tshuaj no yog 290 rubles thiab 190 rubles, feem.
Feem ntau, cov tshuaj "Teopek", tus nqi ntawm qhov kev lees paub, suav tias yog tshuaj pheej yig rau ntau tus pej xeem hauv peb lub tebchaws. Piv rau European counterparts, cov cuab yeej no yog pheej yig dua. Lavxias teb sab tsim ntawm Teopek ua rau nws pheej yig.
cov lus qhia tshwj xeeb rau kev noj tshuaj
Thaum noj Teopek,kev tshuaj xyuas uas yog qhov zoo, koj yuav tsum xyuam xim rau cov ntaub ntawv hauv qab no. Yog tias tus neeg mob muaj cov kab mob plawv lossis lub plawv tsis ua haujlwm, atherosclerosis, cardiomyopathy, gastrointestinal ulcer, daim siab pathology, prostate qog, reflux, cev xeeb tub, hypothyroidism, los yog ib qho kev xav ntawm convulsions, ces cov tshuaj theophylline yuav tsum tau ceev faj.
Cov menyuam yaus hnub nyoog qis dua 12 xyoos thiab cov neeg laus laus "Teopak" yog qhov tsawg heev.
Nws tuaj yeem siv cov tshuaj hauv qhov quav, tab sis lawv yuav tsum tau siv nrog ceev faj hauv cov kab mob hauv qhov quav thiab mob plab. Cov neeg mob uas muaj kev tiv thaiv kev haus luam yeeb ceeb toom txo qis ntawm kev kho Teopak.
Kev kho mob sib xyaw nrog theophylline thiab xanthine derivatives suav tias yog qhov tsis lees txais. Yog hais tias ib tug neeg laus muaj ib tug pronounced concomitant pathology, ib tug kab mob, pathologies ntawm daim siab, plawv thiab hlab ntsha, ces tus kws kho mob yuav tsum tau kho cov tshuaj.
Cov poj niam cev xeeb tub puas noj tshuaj?
Rau tus poj niam cev xeeb tub, cov tshuaj no tau sau tseg yog tias muaj cov lus qhia nruj, vim tias theophylline muaj peev xwm hla cov placenta. Yog tias Teopak tau qhia rau niam laus, ces yuav tsum tso lactation.
phau ntawv qhia no yog ib qho yooj yim version ntawm tag nrho cov lus qhia uas tuaj nrog Teopak. Thov nyeem kom zoo ua ntej siv. Yog tias muaj qee yam tsis meej pem koj lossis koj muaj kev tsis ntseeg, nrog koj tus kws kho mob tham.
