Cov tshuaj tshiab tshaj plaws ntawm peb lub sijhawm "Azilect" yog cov tshuaj kho mob Parkinson's disease, uas yog ib qho kev xaiv inhibitor ntawm monoamine oxidase, uas yog ib qho enzyme uas pib ua cov txheej txheem tshem tawm cov amino pawg ntawm cov molecules. Ib qho ntawm cov kev ua ntawm MAO (monoamine oxidase) yog kev puas tsuaj ntawm dopamine, uas ua raws li cov neurotransmitter uas xa cov paj hlwb los ntawm lub xov tooj mus rau ntawm tes. Dopamine deficiency nrog rau kev tuag ntawm paj hlwb provoke kev loj hlob ntawm Parkinson tus kab mob nyob rau hauv tib neeg. Kev xaiv inhibitor "Azilect" tiv thaiv kev puas tsuaj ntawm monoamines nrog kev pab los ntawm MAO enzyme. Yog li, cov khoom no khaws cov dopamine, serotonin, norepinephrine, tryptamine, phenylethylamine thiab octopamine, ua rau muaj kev nce hauv lawv cov concentration ntawm paj hlwb thiab effector hlwb. Tom ntej no, cia peb tham txog cov tshuaj tshiab ntawm peb lub sijhawm "Azilect" kom ntxaws ntxiv.
Kev piav qhia
YogCov tshuaj uas tau nthuav tawm no yog hu ua cov tshuaj antiparkinsonian. Nws cov khoom xyaw nquag yog ib qho muaj zog xaiv irreversible inhibitor ntawm monoamine oxidase, uas ua rau kom cov ntsiab lus extracellular ntawm dopamine nyob rau hauv lub hlwb.
Nyob rau hauv cov chav kawm ntawm kev sim, cov kws tshawb fawb tau ua pov thawj nce qib ntawm cov tshuaj neurotransmitter no thiab nce ntxiv hauv dopaminergic kev ua, uas ua rau muaj txiaj ntsig zoo ntawm cov tshuaj. Cov tshuaj tuaj yeem nqus tau zoo, thiab nws qhov siab tshaj plaws tau mus txog tom qab peb caug feeb.
"Azilect" - cov tshuaj tshiab ntawm peb lub sijhawm, hnub no nws tau lees paub tias yog ib qho tshuaj zoo tshaj plaws tiv thaiv tus kab mob Parkinson. Nws yog tus cwj pwm los ntawm kev nqus sai thiab pib ua haujlwm sai. Tus neeg sawv cev no raug rhuav tshem, raws li txoj cai, hauv daim siab thiab tawm ntawm tib neeg lub cev nrog cov zis. Nws txawv ntawm lwm cov tshuaj nyob rau hauv ntau npaum li cas stability thiab, tseem ceeb, nyob rau hauv tsis muaj ntau yam kev phiv.
Parkinson's disease
Tus lej ICD-10 rau Parkinson tus kab mob yog G20. Qhov no yog ib tug maj mam tsim kab mob ntawm lub hauv nruab nrab paj hlwb, tus cwj pwm los ntawm slowness ntawm lub zog, trembling ntawm so, thiab impaired reflexes. Hauv plawv ntawm tus kab mob yog kev puas tsuaj rau cov paj hlwb ntawm lub paj hlwb qia. Kev kho mob yog nqa tawm thoob plaws hauv tus neeg mob lub neej.
Ib daim foos
ntsiav tshuaj "Azilect" yog tsim nyob rau hauv ib lub hlwv ntawm kaum daim, nyob rau hauv cardboard ntim. Cov tshuaj yog tiaj thiab puag ncig, xim dawb nrog lub logo GIL 1 thiab lub chamfer ntawm ib sab. Lub active tivthaiv ntawm lub xamCov tshuaj ua haujlwm li rasagiline mesylate.
Kev sib sau ntawm cov ntsiav tshuaj
Ib ntsiav tshuaj ntawm Azilect muaj 1.56 milligrams ntawm rasagiline mesylate. Cov tshuaj pab yog pob kws thiab pregelatinized starch, colloidal silicon dioxide, nrog rau mannitol, talc thiab stearic acid.
Pharmacological action
Cov tshuaj rasagiline muaj zog heev tiv thaiv MAO (monoamine oxidase) thiab pab ua kom dopamine ntau ntau, txo qhov tsim ntawm cov dawb radicals uas yog tus yam ntxwv ntawm tus kab mob Parkinson. Tsis tas li ntawd, cov tshuaj no muaj cov nyhuv neuroprotective uas tsis thaiv cov metabolism ntawm biogenic amines los ntawm cov zaub mov. Vim qhov no tshwm sim, tyramine-induced hypertensive syndrome tsis tshwm sim. Cov tshuaj no tau txais txiaj ntsig zoo ntawm kev tshee ntawm tus kab mob Parkinson.
YPharmacokinetics
Cov khoom xyaw nquag hauv cov ntsiav tshuaj "Azilect" rasagiline tau nqus sai sai hauv lub cev tom qab noj qhov ncauj. Qhov siab tshaj plaws hauv cov ntshav ntshav tau mus txog, raws li txoj cai, twb nyob hauv ib nrab teev. Qhov tseeb bioavailability ntawm cov tshuaj tom qab siv ib zaug yog hais txog peb caug-rau feem pua. Nws yog ib qho tsim nyog hais tias cov khoom tsis cuam tshuam rau lub sijhawm kom ncav cuag cov ntsiab lus siab tshaj plaws ntawm rasagiline hauv cov ntshav, txawm li cas los xij, thaum siv cov khoom noj rog, daim duab no tuaj yeem txo tau nees nkaum feem pua. Lub pharmacokinetics ntawm cov tshuaj yog linear nyob rau hauv cov koob tshuaj ntawm 0.5 mus rau 2 milligrams. Txuas nrogntshav cov protein ntau ntawm rau caum mus rau xya caum feem pua.
Cov lus qhia rau kev siv
Cov khoom kho mob uas tau nthuav tawm yog npaj rau kev kho mob Parkinson tus kab mob hauv tib neeg (raws li ICD-10 G20). Nws tuaj yeem siv rau kev kho mob monotherapy, nrog rau ua ke nrog Levodopa.
Nws tsim nyog nco qab tias koj yuav tsum tsis txhob xaiv cov tshuaj tiv thaiv Parkinsonian yam tsis tau sab laj nrog kws tshaj lij. Qhov tseeb yog tias cov nyhuv ntawm cov tshuaj no feem ntau yog ib tus neeg heev, thiab yog li ntawd nws yuav tsum tau muab tshuaj tshwj xeeb los ntawm tus kws kho mob.
YContraindications
Raws li cov lus qhia rau kev siv rau Azilect, cov tshuaj tsis haum rau kev siv hauv kev kho yog tias cov neeg mob muaj cov kab mob hauv qab no:
- Tawm tsam keeb kwm yav dhau los ntawm kev sib koom ua ke nrog Pethidine lossis lwm yam MAO inhibitors (nws yuav tsum tau sau tseg tias lub sijhawm nruab nrab ntawm kev tshem tawm ntawm Azilect thiab pib ntawm kev kho mob nrog cov tshuaj no yuav tsum yog tsawg kawg ob lub lis piam).
- Rau lub siab mob hnyav lossis nruab nrab.
- Raws li ib feem ntawm kev kho mob sib koom nrog sympathomimetics (xws li pseudoephedrine lossis ephedrine), nrog rau lwm cov tshuaj decongestants thiab cov tshuaj npaj uas muaj lawv. Azilect's contraindications yuav tsum tau soj ntsuam nruj me ntsis.
- Nrog pheochromocytoma.
- Nyob rau menyuam yaus thiab hluas (txog kaum yim xyoo).
- Kev cev xeeb tub, zoo li lub sijhawm lactation, kuj yog txwv tsis pub siv Azilect, raws li muajkev pheej hmoo ntawm inhibition ntawm cov kua mis ntau lawm vim inhibition ntawm prolactin ntau lawm.
- Yog tias koj mob siab rau rasagiline lossis ib qho ntawm cov khoom ntawm cov kws tshuaj hauv nqe lus nug.
Cov tshuaj antiparkinsonian tau sau tseg nrog kev ceev faj thaum lub siab tsis ua haujlwm, nrog rau thaum ua ke nrog cov tshuaj tiv thaiv kab mob (Fluoxetine thiab Fluvoxamine), tetracyclic thiab tricyclic antidepressants.
Kev qhia thiab kev thov
Cov tshuaj tau piav qhia yog muab rau cov neeg mob ntawm qhov ncauj ntawm qhov ntau npaum li 1 milligram ib hnub ib zaug nrog lossis tsis muaj Levodopa. Cov tshuaj tuaj yeem siv tsis hais txog kev noj cov khoom. Rau cov neeg laus, feem ntau tsis tas yuav hloov koob tshuaj.
Cais, nws tsim nyog qhia cov neeg mob uas raug kev txom nyem los ntawm daim siab ua haujlwm tsis zoo. Lawv yuav tsum zam kom tsis txhob rasagiline yog tias kuaj pom lub cev tsis ua haujlwm. Nrog kev ceev faj zoo, nws raug tso cai los ua kev kho mob rau cov neeg mob siab tsis ua haujlwm. Tab sis, txawm li cas los xij, nyob rau hauv cov neeg mob zoo li no, nyob rau hauv qhov kev tshwm sim ntawm qhov pib ntawm kev loj hlob thiab kev loj hlob ntawm tus mob, kev kho mob nrog Azilect yuav tsum tau nres tam sim ntawd.
Rau cov neeg uas muaj lub raum tsis ua haujlwm, nws yuav tsum tau muab sau tseg tias tsis tas yuav hloov tshuaj rau lawv.
Side effects
Thaum noj cov tshuaj, tej zaum yuav muaj kev cuam tshuam rau hauv daim ntawv ntawm anorexia, convulsions, kev nyuaj siab, mob taub hau, xeev siab thiab kiv taub hau. Tej yam tsis zoo tshwm sim tuaj yeem ua rau raug mobheev heev, yog li nws tsim nyog xav txog cov lus nug no kom ntxaws:
- Lub paj hlwb tuaj yeem hnov mob taub hau, kev nyuaj siab, kiv taub hau, anorexia, convulsions, tsis tshua muaj mob cerebrovascular.
- Lub plab zom mov feem ntau teb nrog txo qis qab los noj mov, dyspepsia, thiab lwm yam.
- Arthralgia tuaj yeem pom hauv kev ua haujlwm ntawm cov pob txha thiab cov leeg nqaij nrog rau kev mob caj dab thiab mob hauv caj dab.
- Cov tshuaj tiv thaiv kab mob muaj xws li cov pob khaus vesiculobullous cuam tshuam nrog kev sib cuag dermatitis, thiab tsis tshua muaj kab mob ntawm daim tawv nqaij yuav tshwm sim.
- Cov kab mob plawv thiab vascular hnov mob nrog cov tsos mob ntawm angina pectoris. Myocardial infarction yog qhov tsawg heev.
- Lwm yam tsis xav tau tshwm sim, raws li cov lus qhia, suav nrog kev txhim kho ntawm tus mob khaub thuas zoo li ua npaws, leukopenia, rhinitis, tsis muaj zog, conjunctivitis, mob urinary system thiab kev tsis haum tshuaj.
Yog tias Azilect tau noj ua ke nrog Levodopa, cov tsos mob hauv qab no yuav tshwm sim:
- Lub paj hlwb qee zaum teb nrog dyskinesia, leeg nqaij dystonia, anorexia, npau suav txawv txawv, ataxia, tsis tshua muaj kev ua txhaum ntawm lub paj hlwb thiab tsis meej pem.
- Lub plab zom mov tuaj yeem ua rau cem quav, ntuav, mob plab lossis qhov ncauj qhuav.
- Kev ua haujlwm ntawm cov pob txha thiab cov leeg nqaij yog nrog kev mob caj dab, mobhauv caj dab thiab tendosynovitis.
- Cov tshuaj tiv thaiv kab mob muaj xws li pob khaus, tsis tshua muaj melanoma ntawm daim tawv nqaij.
- Los ntawm sab ntawm lub plawv thiab vascular systems, postural hypotension yog ua tau. Tsis tshua muaj, angina pectoris tshwm sim hauv qhov no.
- Lwm cov kev mob tshwm sim suav nrog kev poob qis nrog rau kev poob phaus thiab kev tsis haum tshuaj.
Txog hnub no, muaj ob qhov kev tshaj tawm ntawm rhabdomyolysis thiab teeb meem hauv kev tso tawm ntawm cov tshuaj hormones antidiuretic. Ob qhov xwm txheej tau pom tias yog ib feem ntawm kev kuaj tom qab sau npe yam tsis muaj kev tswj hwm cov placebo. Kev sib raug zoo ntawm cov teeb meem no thiab kev siv rasagiline yog teeb meem los txiav txim.
Ntau tshaj
Cov tsos mob ntawm kev noj tshuaj ntau dhau ntawm cov tshuaj "Azilect" zoo ib yam li cov uas muaj ntau tshaj ntawm cov tsis xaiv MAO inhibitors. Hauv qhov no, cov neeg mob tuaj yeem ntsib cov hlab ntsha thiab postural hypotension. Raws li ib feem ntawm txoj kev kho mob, cov kws kho mob ua rau lub plab lavage, noj activated charcoal thiab symptomatic therapy. Tsis muaj tshuaj tiv thaiv tshwj xeeb.
Cov lus qhia tshwj xeeb
Nws raug pom zoo kom zam kev siv rasagiline nrog Fluoxetine lossis Fluvoxamine. Tag nrho kev so ntawm kev tshem tawm ntawm cov tshuaj "Fluoxetine" thiab pib kho "Azilect" yuav tsum yog tsawg kawg tsib lub lis piam. Thiab ntawm qhov kev tshem tawm ntawm rasagiline thiab pib kho nrog Fluvoxamine, qhov no yuav tsum yog tsawg kawg kaum plaub hnub.
Tshuaj manufacturers tsis qhia kev siv rasagiline nrog"Dextromethorphan" los yog nrog sympathomimetics, xws li cov uas muaj nyob rau hauv qhov ncauj thiab qhov ntswg vasoconstrictor tshuaj los yog tshuaj txias uas muaj ephedrine los yog pseudoephedrine. Raws li tau hais ua ntej, nws yuav tsum tau pib kho nrog Azilect nrog kev ceev faj zoo ntawm cov neeg mob uas raug kev puas tsuaj rau daim siab.
Nws yog ib qho tseem ceeb, ntawm lwm yam, coj mus rau hauv tus account tias lub ntsiab lus tseem ceeb ntawm cov tshuaj rasagiline tuaj yeem ua rau qaug zog rau cov neeg mob thaum nruab hnub, thiab qee zaum, tshwj xeeb tshaj yog thaum siv tib lub sijhawm nrog lwm cov tshuaj dopaminergic, nws txawm yuav pw tsaug zog los ua ib qho kev ua ub ua no.
Nrog rau qhov no hauv siab, cov neeg mob yuav tsum tau ceeb toom kom ceev faj thaum tsav tsheb lossis siv lub tshuab ua haujlwm. Thiab nws yog qhov zoo tshaj kom tsis kam ua li no rau lub sijhawm kho.
Kev tshuaj xyuas cov neeg mob Parkinson txog "Azilect"
Hauv Internet koj tuaj yeem nyeem cov lus pom zoo txog cov tshuaj. Tib neeg tham txog kev ua kom zoo. Nws yog ib qho tsim nyog sau cia tias kev tshuaj xyuas txog kev ua tau zoo ntawm cov tshuaj tau tso tseg los ntawm cov neeg mob uas muaj hnub nyoog sib txawv. Yog li, feem ntau cov ntawv tshaj tawm lees paub qhov ua tau zoo ntawm cov tshuaj hauv nqe lus nug.
Tab sis kuj tseem muaj cov lus tsis zoo uas cov neeg mob sau tias ntau zaus, tshwj xeeb tshaj yog nyob rau thawj ob peb lub hlis ntawm kev nkag, lawv tau ntsib kev txhim kho ntau yam kev mob tshwm sim, uas, txawm li cas los xij, tom qab ntawd ploj mus.
Kev kho mob, hauv kojtig, lawv tawm tswv yim txog qhov no los ntawm qhov tseeb tias qhov tsis tshua muaj tshwm sim tuaj yeem ua rau muaj teeb meem ntawm tus kab mob hauv qab, cov txiaj ntsig zoo li no feem ntau pom ntawm cov neeg mob thiab tsis siv Azilect rau kev kho mob ntawm Parkinsonism syndrome. Thaum noj cov tshuaj no, koob tshuaj tsis tau nce ntxiv, thiab qhov tshwm sim tsis zoo tshwm sim tsawg dua li thaum kho nrog lwm cov tshuaj antiparkinsonian.
Kuv puas tuaj yeem noj tshuaj no hmo ntuj?
Ntau tus neeg txaus siab rau lo lus nug ntawm seb nws puas tau tso cai siv cov tshuaj niaj hnub tshiab "Azilect" ua ntej yuav mus pw. Cov lus teb hauv qhov no yog qhov zoo. Qhov xwm txheej tseem ceeb yog cov tshuaj no yuav tsum haus txhua hnub, nyiam dua tib lub sijhawm.
Tus nqi
Tus nqi ntawm Azilect feem ntau nyob ntawm txoj cai nqi ntawm cov khw muag tshuaj uas nws muag. Raws li txoj cai, nruab nrab hnub no nws yog 5.5 txhiab rubles ib pob. Hauv qhov no, nws yuav tsum raug coj mus rau hauv tus account tias cov tshuaj no tsis pheej yig, thiab rau kev kho mob yuav tsum tau npaj rau kev siv nyiaj loj. Cov tshuaj no yog tsim nyob rau hauv Israel.
Azilect: INN
Lub npe thoob ntiaj teb (INN) ntawm cov tshuaj hauv nqe lus nug yog lub npe Rasagiline (rasagiline). Lub ntsiab txhais ntawm cov khoom xyaw nquag muab cov ntaub ntawv yooj yim txog cov tshuaj nyob rau hauv lub khw muag tshuaj thoob ntiaj teb. Qhov tseeb yog tias feem ntau cov tshuaj nrog tib cov khoom xyaw nquag raug tso tawm hauv qabtxawv cov npe lag luam, uas yog, qhov tseeb, nws yog tib yam tshuaj, tab sis tsim los ntawm cov tuam txhab sib txawv. Nws yog INN uas muab sijhawm rau cov kws kho mob los tshawb txog ntau yam tshuaj uas tam sim no tau muag thoob ntiaj teb.
