Kab lus no yuav saib yuav ua li cas txo homocysteine.
Nws yog cov organic qis molecular hnyav compound, uas tsis yog-protein sulfur-muaj amino acid uas tsis tuaj nrog zaub mov, tab sis tau txais los ntawm qee cov txheej txheem biochemical uas tas li tshwm sim hauv tib neeg lub cev. Lub synthesis ntawm cov khoom no tshwm sim thaum lub sij hawm cov txheej txheem ntawm metabolism ntawm cov amino acid, uas yog hu ua methionine, tshwm sim nyob rau hauv ntau theem. Cov amino acid no yog cais raws li qhov tseem ceeb.
lub cev tau li cas?
Vim tib neeg lub cev tsis tuaj yeem ua rau nws tus kheej, nws raug yuam kom tau methionine los ntawm cov khoom tsiaj (qe, nqaij, khoom tsev cheese). Nyob rau tib lub sijhawm, nrog rau cov nyiaj txaus ntawm folic acid hauv lub cev, nrog rau cov vitamins B, uas nquag koom nrog hauv cov metabolism ntawm homocysteine,tuaj yeem rov suav nrog hauv cov txheej txheem metabolic thiab rov ua methionine. Tib neeg xav li cas thiaj txo homocysteine ?
Kev phom sij ntawm qib siab yog dab tsi?
Muaj qee qhov kev pheej hmoo ntawm kev noj qab haus huv cuam tshuam nrog qib ntshav siab homocysteine.
- Cov tshuaj no ua rau muaj kev pheej hmoo ntawm kev txhim kho pathologies ntawm lub plawv thiab cov hlab ntsha. Lub cim xeeb meej, lub plawv noj qab haus huv, thiab kev paub txog kev ua haujlwm puv ntoob yog ncaj qha ntsig txog qib ntawm homocysteine hauv lub cev. Ib qho kev sib txuas ncaj qha ntawm qib siab ntawm cov amino acid no hauv cov neeg laus thiab cov kab mob ntawm cov hlab plawv thaum kawg ntawm lub xyoo pua xeem tau xav tias yog ib tus kws tshawb fawb los ntawm Tebchaws Meskas, Kilmer S. McCulley. Nws tau tso "homocysteine txoj kev xav ntawm atherosclerosis", qhov twg tus kws tshawb fawb tau lees tias nws tsis yog cov roj cholesterol uas yog lub hauv paus ua rau muaj kev cuam tshuam ntawm cov hlab ntsha, uas yog homocysteine . Vim tias nws yog qhov sib xyaw ua ke uas pib muaj kev puas tsuaj rau cov phab ntsa sab hauv ntawm cov hlab ntsha - endothelium. Tsis yog txhua tus paub tias homocysteine tau qhia li cas. Yuav ua li cas downgrade?
- Deteriorates kev txawj ntse muaj nuj nqi. Tsis ntev los no, cov kev tshawb fawb tshawb fawb tau pom tias muaj kev sib raug zoo ntawm kev siv ntawm hyperhomocysteineemia thiab tshwm sim ntawm atrophy thiab ziab ntawm cov teeb meem grey ntawm lub hlwb, nrog rau cov tsos mob ntawm cov txheej txheem pathological no. Alzheimer's kab mob, dementia, senile dementia - yog ncaj qha nyob ntawm theem siab ntawm homocysteine . Yog hais tias nyob rau hauv lub cev cov txheej txheem ntawm reverse synthesis ntawm cov tshuaj no mus rau hauv lub tsis muaj kev puas tsuaj tej zaum yuav tshwm sim nyob rau hauv peb txoj kev, ces nyob rau hauv lub hlwb qhov no tsuas yog txwv rau ib hom.tshuaj tiv thaiv. Qhov no predetermines lub predisposition ntawm cov neeg laus nrog ib tug siab concentration ntawm homocysteine rau cov txheej txheem ntawm kev nco thiab kev txawj ntse kev nyuaj siab, nrog rau cov kev hloov nyob rau hauv orientation nyob rau hauv qhov chaw thiab lub sij hawm.
- Pab txhawb rau txoj kev loj hlob ntawm lub xeev kev nyuaj siab - tsis muaj kev ntxhov siab yog txaus ntshai rau kev loj hlob ntawm kev nyuaj siab nyob rau hauv ib tug neeg niaj hnub no, tab sis qhov tsis txaus ntawm nws lub hlwb ua haujlwm kom kov yeej lawv qhov zoo. Yog li ntawd, lub sij hawm ntev kev nyuaj siab tshwm sim ua rau ntau yam txaus ntshai pathologies, ob qho tib si lub cev thiab lub hlwb. Thiab nyob rau hauv cov ntaub ntawv no, cov kws tshawb fawb xav tias cov amino acid no yog lub ntsiab culprit ntawm xws li mob, vim hais tias nws yog nws inhibits lub peev xwm ntawm lub hlwb hlwb rov qab. Vim li cas thiaj li yuav tsum tau txo qis homocysteine ntau?
- Nws yog tus yeeb ncuab ntawm cov xeeb ntxwv noj qab haus huv. Cov txheej txheem kom raug ntawm placental metabolism yuav tsum tau txo qis hauv qib ntawm homocysteine hauv cov poj niam cev xeeb tub, thiab thaum cev xeeb tub, qhov haujlwm no yog tswj hwm los ntawm lub cev nws tus kheej hauv lub thib ob thiab thib peb peb lub hlis twg. Nrog rau cov ntshav siab ntawm cov tshuaj no, cov kws kho mob tsis pom zoo kom npaj lub tswv yim thiab sau cov tshuaj tshwj xeeb (chav B vitamins thiab folic acid). Cov tshuaj tiv thaiv kab mob ua kom cov qib homocysteine . Qhov txaus ntshai ntawm hyperhomocysteineemia rau tus menyuam hauv plab yog vim muaj kev phom sij ntawm cov hlab ntsha, vim tias qhov kev pheej hmoo ntawm ntau yam pathologies nce. Hauv cov txiv neej, qhov nce ntxiv kuj muaj qhov cuam tshuam tsis zoo rau qhov yuav tshwm sim.
Yuav ua li cas txo homocysteine, saib hauv qab no.
Lub hauv paus ntsiab lus ntawm qhov tshwm sim ntawm pathological teeb meem
Homocysteine yog ib qho amino acid uas tsis koom nrog hauv kev tsim cov protein. Cov tshuaj no yog homologue ntawm lwm cov amino acid, cysteine, uas yog metabolized los ntawm methionine thaum lub sij hawm demethylation. Nrog rau kev ua haujlwm zoo ntawm lub cev, homocysteine yog ib hom kev thauj mus los thaum lub sij hawm cov txheej txheem metabolic. Nws tsis nyob hauv nws daim ntawv dawb huv hauv lub cev, tab sis tam sim ntawd hloov mus rau hauv cysteine los yog methionine, nrog rau tom qab tshem tawm ntawm lub cev hauv txoj kev ntuj. Nws yog nyob rau theem ntawm kev rov ua dua tshiab uas qee qhov kev ua txhaum cai yuav tshwm sim. Yog vim li cas rau qhov tshwm sim no yog vim qhov tseeb hloov dua siab tshiab ntawm homocysteine , muaj qee cov vitamins B - B6, B1, B9 thiab B12 yog qhov yuav tsum tau ua. Kev ncua ntev hauv lub cev ntawm cov tshuaj cuam tshuam rau kev tswj hwm ntawm cov rog metabolism, tshem tawm cov tshuaj lom thiab lwm yam, uas ua rau muaj kev cuam tshuam ntxiv ntawm kev ua haujlwm ntawm cov ntsiab lus tseem ceeb xws li adenosine, taurine, glutathione, thiab lwm yam.
Highly toxic acid
Homocysteine ntawm lub cev yog cov kua qaub uas muaj kuab lom heev uas ua rau cov phab ntsa hauv cov hlab ntsha, tsim cov kab nrib pleb thiab qhov txhab. Thaum tiv thaiv, tib neeg lub cev pib npog cov kev puas tsuaj nrog cov roj cholesterol plaques thiab ntshav txhaws. Raws li qhov tshwm sim, kev cuam tshuam tshwm sim hauv cov hlab ntsha, uas tom qab ntawd ua rau muaj kev mob stroke thiab plawv nres.
Yuav ua li cas txo homocysteine, koj yuav tsum paub ua ntej.
Ntau qib
Qhov ib txwm muaj ntawm cov tshuaj hauv cov ntshav tsis ntau tshaj 15 micromoles ib liter. Txawm li cas los xij, cov kws kho mob noj zaub mov thiab kws kho mob pom zoo kom txo qis cov ntsiab lus mus rau 7 micromoles.
Qee tus neeg muaj caj ces tsis muaj peev xwm los tsim cov vitamin B rau hauv lawv cov ntaub ntawv nquag, txhais tau tias lawv muaj kev cuam tshuam hauv lub voj voog folate, ua rau (tshwj xeeb tshaj yog tom qab hnub nyoog 35) hauv siab ntau homocysteine.
Yuav txo qis li cas hauv ib hlis? Hauv cov xwm txheej zoo li no, nws yog qhov nyuaj rau kev ua tiav cov txiaj ntsig zoo tsuas yog los ntawm kev tso tus cwj pwm phem thiab kev noj zaub mov, yog tias peb tham txog qib dav dav tsis ntau tshaj 7 micromoles. Nws yuav tsum raug sau tseg tias yav dhau los cov kws kho mob tau sau cov tshuaj folic acid hauv nws daim ntawv ntshiab, txawm li cas los xij, cov tshuaj folate nquag lossis cov tshuaj raws li lawv (methyltetrahydrofolic acid) tau dhau los ua cov tshuaj niaj hnub no, vim tias tsis muaj B9 nrog cov tshuaj tiv thaiv kab mob yuav tsis muab cov txiaj ntsig tsim nyog.
Yuav ua li cas txo homocysteine thaum npaj cev xeeb tub?
Cov kev tshawb fawb tshawb fawb tau pom tias qhov ntau dua ntawm methionine noj nrog cov zaub mov muaj protein ntau, nws yuav ua rau cov qib homocysteine siab dua thiab ntau dua cov vitamins B xav tau kom dawb los ntawm nws. Yog li ntawd, kev noj cov protein ntau, tshwj xeeb, ntawm cov tsiaj keeb kwm, tsis muaj cov khoom noj uas muaj vitamin B (zaub, tshuaj ntsuab thiab cereals), yog qhov tseem ceeb ua ntej rau kev nce.
Yuav ua li cas txo homocysteine thaum npaj cev xeeb tub? Qhov nocov lus nug coob leej nug hnub no.
Nws yuav zoo li tias qhov kev daws teeb meem no yooj yim heev: txo qis kev noj cov khoom noj siv mis thiab nqaij, thiab ua kom cov zaub mov muaj txiaj ntsig zoo nrog cov nplej thiab zaub nyoos. Tab sis ntawm no nws yog ib qho tsim nyog los hais txog cov cwj pwm phem uas tuaj yeem tshem tawm tag nrho cov kev ua haujlwm zoo tshaj plaws. Kev haus luam yeeb, cawv thiab kas fes muaj qhov cuam tshuam tseem ceeb rau lub xeev ntawm cov xwm txheej, uas feem ntau ua tiav los ntawm kev ua neej nyob tsis muaj zog. Noj nqaij, haus dej cawv, nicotine thiab tsis muaj kev tawm dag zog yog tib pab pawg uas muaj cov roj (cholesterol) siab. Thiab raws li twb tau sau tseg lawm, cov amino acid no yog lub luag haujlwm tseem ceeb ntawm cov roj cholesterol hauv cov hlab ntsha.
Yog li, yuav ua li cas txo homocysteine thaum npaj cev xeeb tub?
Ua ntej tham txog kev noj zaub mov kom raug, koj yuav tsum kos kab txwv tsis pub dhau qhov tsis muaj kev noj haus yuav pab tau. Yog hais tias ib tug neeg saib xyuas nws cov hlab ntsha, thiab txawm ntau npaum li cas yog hais tias nws twb tau kuaj pom muaj ib yam ntawm cov kab mob saum toj no (atherosclerosis, kev pheej hmoo ntawm kev loj hlob ntawm lub plawv tsis ua hauj lwm, thrombosis, mob ntawm lub paj hlwb, kev nyuaj siab lub xeev), thiab. Raws li thaum npaj cev xeeb tub, koj yuav tsum ceev faj tsis txhob siv:
- yuav haus dej cawv;
- nicotine;
- khoom lag luam caffeinated.
Caffeine
Caffeine rhuav tshem cov enzymes methionine synthetase, uas yog lub luag haujlwm rau kev rov tsim cov methionine los ntawm homocysteine thiab lub sijhawm ua haujlwm ntawm lub voj voog folate (thaum B vitamins raug absorbed kom raug thiab ua qhov tsim nyog.functions). Cov qauv rau kev haus tshuaj yej thiab kas fes yog suav tias yog 2 khob ib hnub.
Yuav ua li cas txo homocysteine thaum npaj cev xeeb tub, tus kws kho mob yuav tsum qhia.
Smoking
Kev haus luam yeeb txo qis vitamin B6 thiab B12 qib vim muaj cyanide muaj nyob hauv cov pa luam yeeb. Qhov no yog qhov pov thawj ntxiv tias kev haus luam yeeb tsis muaj teeb meem ntau dua li kev haus luam yeeb, vim nws yog los ntawm cov pa luam yeeb uas cov neeg tsis haus luam yeeb tau txais cov tshuaj lom neeg tuag taus. Hauv cov neeg haus luam yeeb, txhua tus luam yeeb nce qib homocysteine 1% (hauv cov poj niam) thiab 0.5% (hauv txiv neej). Rau txhua lub sijhawm ntawm kev tshawb fawb tshawb fawb txog qhov tsis zoo ntawm homocysteine ntawm kev noj qab haus huv, qhov siab tshaj plaws tau pom hauv cov neeg haus luam yeeb.
Cov kev tshawb fawb hauv chaw soj nstuam ua los ntawm cov neeg haus cawv paub meej tias cov folate thiab vitamin B6 tsawg heev. Ethanol, cov dej cawv tseem ceeb, inhibits cov haujlwm ntawm methionine synthase, vim tias cov ntsiab lus ntawm homocysteine hauv cov ntshav nce mus rau qib tseem ceeb.
Khoom noj uas txo homocysteine
Cia nws nkag mus rau hauv lub cev los ntawm kev noj cov tsiaj proteins. Ntawm cov no, nyob rau hauv tus txheej txheem ntawm synthesis, cov amino acid methionine yog thawj tsim, uas yog tom qab hloov mus rau homocysteine. Yog li, kev noj zaub mov noj yuav txwv tsis pub noj cov tsiaj protein. Thiab ntxiv rau qhov no, kev noj zaub mov txhawb kev noj zaub mov nrog cov vitamins B, uas yog cofactors rau homocysteine hloov dua siab tshiab.
Yuav ua li cas txo homocysteine hauv cov poj niam uas noj zaub mov?
Restricted:
- Khoom noj ntawm tsiaj keeb kwm: nqaij liab, qaib ntxhw, nqaij qaib, nqaij npuas. Kwv yees li 6 teev tom qab noj zaub mov protein, theem ntawm homocytein hauv cov ntshav nce 10-15%.
- Cov khoom noj mis nyuj: mis nyuj, tsev cheese, cheese, fermented mis nyuj khoom. Hla kev noj zaub mov muaj protein ntau xws li qaub cream thiab tsev cheese thaum lawv nce homocysteine cov qib thaum sawv ntxov.
- taum ntau ntau. Txawm hais tias lawv yog qhov zoo ntawm cov vitamins B, thiab taum kuj tseem muaj cov folic acid, koj yuav tsum tsis txhob noj ntau dhau ntawm cov zaub mov no.
- Ua phem ua ke ntawm nqaij thiab legumes hauv ib pluas noj. Cov protein sib txawv xav tau kev sib txawv ntawm lub cev kom ua tiav lawv. Nyob rau hauv cov ntaub ntawv ntawm kev sib tov, tsis tsuas yog muaj teeb meem nyob rau hauv lub digestive txheej txheem, tab sis kuj ib tug tseem ceeb nce nyob rau hauv homocysteine.
Methionine nws tus kheej tsis txaus ntshai. Nws ua rau muaj kev cuam tshuam loj heev hauv kev noj tshuaj ntau dhau thiab hloov pauv hauv lub voj voog folate. Yog tias qhov kev hloov pauv no tsis yog qhov tshwm sim ntawm caj ces, tom qab ntawd cov qib ntawm homocysteine ib txwm tuaj yeem ua tiav nrog kev pab ntawm kev noj zaub mov kom zoo nrog lub luag haujlwm ntawm cov vitamins B1, B9, B6 thiab B 12.
Cov neeg mob feem ntau nug yuav ua li cas txo homocysteine . Kev kho mob yuav tsum ua kom tiav thiab raws sijhawm.
Khoom noj kom suav nrog hauv koj cov zaub mov tsis tu ncua:
- Qe, siab, ntses, uas qee zaum tuaj yeem hloov nqaij. Nws yog officially proven nrog ib tug ntses-vegan nojtib neeg ua tiav 15% txo qis hauv homocysteine ntau yam tsis muaj cov tshuaj vitamin ntxiv. Lub siab thiab qe kuj yog qhov chaw ntawm cov vitamins B, thiab tshwj xeeb tshaj yog B12, uas tsis pom muaj nyob hauv cov zaub mov uas muaj cov nroj tsuag.
- Spinach, arugula, parsley, broccoli, txiv lws suav, txhua yam zaub. Zaub thiab zaub ntsuab muaj ntau cov vitamins B, lawv muaj cov pab pawg methyl thiab cov ntsiab lus ntawm methionine txo. Qhov ntau khaus xim ntsuab ntawm cov khoom, qhov ntau folic acid nws muaj.
- Ntshav, tshwj xeeb tshaj yog txiv laum huab xeeb thiab walnuts. Cov txiv ntoo sib txawv muaj cov vitamins B sib txawv, yog li nws yog qhov zoo tshaj plaws kom muaj kev sib xyaw ntawm cov txiv ntoo sib txawv ua ntu zus.
- Cereals - noj tshais cereals, cereals los ntawm raw cereals. Qhov tseem ceeb tshaj plaws yog oatmeal thiab buckwheat.
- Sprouted nplej, uas muaj ntau cov vitamin B thiab ntau lwm yam tseem ceeb. Yog li ntawd, lub sijhawm los txhawb kev noj zaub mov nrog cov zaub ntsuab ntsuab yuav tsum tsis txhob raug saib xyuas.
- Cov poov xab, uas tuaj yeem ntxiv rau txhua yam khoom noj ua kua, tib yam mus rau bran.
- qos yaj ywm nplua nuj nyob rau hauv vitamin B6.
- Rye qhob cij nplua nuj hauv folic acid thiab vitamin B9.
Nyob zoo ib tsoom niam txiv kwv tij neej tsas sawv daws.
Cov poj niam kuj xav paub yuav ua li cas txo homocysteine thaum cev xeeb tub.
Kev nce qib ntawm cov tshuaj hauv cov ntshav ntawm cov poj niam cev xeeb tub pab txhawb txoj kev loj hlob ntawm pathologies, ob qho tib si rau tus me nyuam hauv plab thiab leej niam. Cov kev tshawb fawb tshawb fawb tau pom tias muaj kev sib raug zoo ntawm qib nceHomocysteine thiab hypoxia, preeclampsia, yug ntxov ntxov, ob lub ceg hauv plab hauv plab, tseem yug me nyuam, Down's syndrome, thiab lwm yam kab mob caj ces.
Yog li ntawd, ntawm qhov muaj nuj nqis ntau dua 7 micromoles, cov kws kho mob tsis tso cai rau cov poj niam los npaj lub cev xeeb tub, thiab yog tias pom muaj tus kab mob siab heev hauv cov poj niam cev xeeb tub, lawv tau sau ntawv txwv kev noj zaub mov, sau cov koob tshuaj ntau ntxiv hauv chav kawm B. cov vitamins thiab folic acid txo qis homocysteine.
Kev noj zaub mov thaum ntxov ntawm cev xeeb tub yuav tsum muaj cov protein ntau, uas tsim nyog rau kev tsim tag nrho ntawm tus menyuam hauv plab. Yog li ntawd, cov poj niam cev xeeb tub yuav tsum tsis txhob tso tseg cov khoom noj siv mis thiab nqaij. Qee cov zaub mov tuaj yeem ua rau cov metabolism ntau dhau los yog plab zom mov. Yog tias tsis muaj qhov sib txawv, ces txoj hauv kev zoo tshaj plaws ntawm qhov xwm txheej no yuav yog:
- sib zaub mov;
- kev sib xyaw ntse ntawm tsiaj thiab zaub;
- mis nyuj thiab cereal tais;
- zaub mov muaj zaub thiab tshuaj ntsuab.
Peb saib yuav ua li cas txo homocysteine hauv cov poj niam.
