Kev mob yog hom kev sim ntawm lub cev kom nyiam tus neeg, hu rau kev pab. Qhov no txhais tau hais tias ib yam dab tsi tsis ncaj ncees lawm "hauv lub nceeg vaj Danish", thiab lub cev cov peev txheej tsis txaus los kho qhov teeb meem, xav tau kev txhawb nqa sab nraud.
Ntawm cov neeg siv khoom lag luam ntawm Lavxias Federation muaj ntau pua cov tshuaj tsim los pab tus neeg mob. Tag nrho cov tshuaj muaj qhov sib txawv, muaj peev xwm thiab cov txheej txheem ntawm kev cuam tshuam. Ib qho zoo tshaj plaws yog cov tshuaj los ntawm cov pab pawg ntawm cov tshuaj uas tsis yog-steroidal anti-inflammatory. Ntawm lawv muaj cov tshuaj ncua thiab Nimesulide ntsiav tshuaj.
Kev sib sau thiab tso tawm daim ntawv
Cov ntsiav tshuaj puag ncig muaj cov duab biconvex. Cov xim tuaj yeem yog lub teeb daj lossis tsuas yog daj. Cov khoom xyaw tseem ceeb yog cov tshuaj nimesulide, txhua ntsiav tshuaj muaj 100 mg. Lwm yam muaj xws li microcrystalline cellulose, starch (pob kws), sodium starch glycolate, colloidal silicon dioxide.
Ntxiv rau, cov tshuaj muaj rau cov neeg siv khoom hauv daim ntawv ntawm cov hmoov rauKev npaj ntawm kev ncua "Nimesulide". Cov muaj pes tsawg leeg yog tib yam li cov ntsiav tshuaj, txhua lub hnab muaj 100 mg ntawm cov khoom xyaw tseem ceeb.
Pharmacodynamics
Nimesulide xaiv inhibits cyclooxygenase-2, nrog rau cyclooxygenase-1 nws cov txiaj ntsig tau hais tsawg dua. Hauv qhov no, inhibition ntawm cov synthesis ntawm prostaglandins, provoked los ntawm cov tshuaj tiv thaiv inflammatory, yog pom. Txawm li cas los xij, nimesulide tsis tshua pom muaj txiaj ntsig ntawm kev tsim cov prostaglandins ntawm hom kev tswj hwm, uas ua rau muaj kev phiv tsawg los ntawm kev zom zaub mov.
Tsis tas li ntawd, qhov kev ua haujlwm zoo ntawm nimesulide tau tshwm sim hauv qhov inhibition ntawm kev tsim cov dawb radicals. Txawm li cas los xij, cov txheej txheem ntawm hemostasis thiab phagocytosis tsis cuam tshuam los ntawm cov khoom no. Hauv cov txheej txheem ntawm cov tshuaj tiv thaiv kab mob, nws lub peev xwm los tawm tsam qhov kev tso tawm ntawm myeloperoxidase tseem nyob hauv qhov chaw tseem ceeb (hauv ntau cov kab mob inflammatory nws tuaj yeem ua rau cov ntaub so ntswg puas tsuaj, nws yog ib qho kev kuaj mob zoo tshaj plaws uas qhia tau tias muaj kev pheej hmoo. ntawm kev tsim mob plawv lossis mob stroke).
Cov lus qhia rau kev siv
Lub peev txheej ntawm cov tshuaj "Nimesulide" yog qhov dav heev. Dab tsi pab tau cov tshuaj no? Txij li thaum cov tshuaj muaj ib tug complex nyhuv rau tib neeg lub cev - antioxidant, analgesic, antipyretic thiab anti-inflammatory - nws yog sau rau ib tug xov tooj ntawm inflammatorykab mob. Cov tshuaj kuj tseem siv tau thaum muaj osteoarthritis (kev puas tsuaj rau cov pob qij txha, pob txha pob txha pob txha raug puas tsuaj ua ntej), tendinitis (kev puas tsuaj thiab degeneration ntawm cov leeg nqaij), bursitis (mob ntawm lub hnab mucous, feem ntau hauv cov pob qij txha).
Cov txiaj ntsig zoo tau pom los ntawm "Nimesulide" hauv kev kho mob rheumatoid mob caj dab, cov kab mob rheumatoid ntxiv. Ua tau zoo tua cov kab mob sib kis nrog cov txheej txheem inflammatory. Heev feem ntau, Nimesulide ntsiav tshuaj yog siv nyob rau hauv gynecology, nyob rau hauv kev kho mob ntawm ntau yam keeb kwm. Cov neeg mob tham txog kev tshem tawm qhov mob thaum lub sijhawm rov ua haujlwm tom qab phais.
Contraindications rau noj "Nimesulide"
Txij li cov tshuaj belongs rau pab pawg ntawm PVNS niaj hnub no, nws muaj cov npe dav dav ntawm contraindications rau kev siv. "Nimesulide" (los ntawm cov tshuaj pab - tau tham ua ntej) yuav tsum tsis txhob noj los ntawm cov neeg uas muaj siab rhiab heev rau ib yam khoom nyob rau hauv nws muaj pes tsawg leeg. Tsis txhob muab cov tshuaj rau cov neeg mob uas muaj keeb kwm ntawm hepatotoxic cov tshuaj tiv thaiv thiab cov tshuaj tiv thaiv hypersensitivity nyob rau hauv daim ntawv ntawm rhinitis, bronchospasm, urticaria (thaum noj cov tshuaj aspirin lossis lwm cov tswv cuab ntawm pawg NSAID).
A contraindication rau kev siv cov tshuaj yog qhov muaj cov kab mob erosive thiab ulcerative lesions ntawm lub plab zom mov, ib tug nyiam tsim los ntshav ntawm tej keeb kwm (piv txwv li, deviations nyob rau hauv kev ua hauj lwm ntawm cov ntshav coagulation system).
TshuajCov lus qhia "Nimesulide" txwv tsis pub noj cov neeg mob uas muaj lub raum, mob siab, lub plawv tsis ua haujlwm. Cov neeg mob uas muaj "aspirin" mob hawb pob, haus cawv thiab haus tshuaj yeeb yuav tsum tsis txhob noj tshuaj.
Tsis txhob muab tshuaj yog tias tus neeg mob ua npaws lossis lwm yam tsos mob xws li mob khaub thuas. Tsis tas li ntawd, nws tsis tuaj yeem noj "Nimesulide" rau cov menyuam yaus, cev xeeb tub thiab lactating poj niam.
Muaj peev xwm tshwm sim tsis zoo rau Nimesulide
Kev siv cov tshuaj tuaj yeem ua rau muaj kev phiv los ntawm ntau lub cev thiab lub cev ntawm tib neeg lub cev.
Cov tshuaj tiv thaiv nquag tshaj plaws tau sau tseg los ntawm lub plab zom mov, thiab lawv tau tshwm sim los ntawm xeev siab, ntuav, raws plab, kev loj hlob ntawm flatulence thiab gastritis. Tsis tshua muaj tshwm sim los ntshav ntawm plab hnyuv, ulcers mus txog rau perforation. Qee zaus koj tuaj yeem hnov txog dyspepsia, stomatitis, mob plab.
Muaj peev xwm ua rau "Nimesulide" cov kev mob tshwm sim los ntawm cov kab mob hepatobiliary, feem ntau qhia txog kev nce qib ntawm daim siab enzymes, tsis tshua muaj kev loj hlob ntawm kab mob siab (xws li fulminant), cholestatic jaundice.
Peb tuaj yeem tham txog cov tshuaj tiv thaiv kab mob plawv yog tias muaj ntshav siab nce ntxiv, tsawg dua cov neeg mob txhawj xeeb txog plawv plawv, hemorrhages, kub flashes, dhia ntshav siab.
Cov kab mob tso zis tuaj yeem ua rau muaj qhov tshwm sim ntawm edema (tsis ntau), tsawg zaus - tso zis, hematuria, dysuria. Tsis tshua muaj, lub raum tsis ua haujlwm yuav tshwm sim.interstitial nephritis, oliguria.
Cov tshuaj tiv thaiv tuaj yeem los ntawm lub hauv nruab nrab lub paj hlwb feem ntau tshwm sim los ntawm kiv taub hau, mob plab, asthenia. Tsawg zaus, koj tuaj yeem hnov txog mob taub hau, kev loj hlob ntawm kev tsis pom kev (zoo ib yam li kev pw tsaug zog hypnotic), Reye's syndrome (encephalopathy), hypothermia (txo qis hauv lub cev kub hauv qab theem uas tsim nyog los tswj cov metabolism hauv ib txwm). Qee zaum, koj tuaj yeem hnov txog cov tshuaj tiv thaiv Nimesulide xws li kev ntxhov siab, kev ntxhov siab, npau suav phem.
Raws li rau cov kab mob lymphatic thiab cov kab mob hematopoietic, "Nimesulide" (cov lus qhia, tshuaj xyuas cov neeg ua haujlwm noj qab haus huv tau lees paub cov ntaub ntawv no) tuaj yeem ua rau muaj ntshav tsis txaus, eosinophilia, thrombocytopenia, pancytopenic purpura tsim txawm tsawg dua.
Tsis tshua muaj, tab sis koj tuaj yeem hnov txog kev ua txhaum ntawm cov txheej txheem metabolic (hyperkalemia), lub cev tsis muaj zog (hypersensitivity, anaphylaxis), lub cev tsis pom kev (tsis pom kev, qhov muag plooj), cov kab mob ua pa, mediastinum (ua tsis taus pa, bronchospasm, mob hawb pob). Muaj kev cuam tshuam ntawm daim tawv nqaij thiab cov ntaub so ntswg subcutaneous (ntau tawm hws, khaus, dermatitis, urticaria, erythema, tsis tshua muaj - tshuaj lom epidermal necrolysis, Stevens-Johnson syndrome).
Kev noj tshuaj thiab cov txheej txheem ntawm daim ntawv thov
cov neeg mob laus raug qhia kom noj Nimesulide ntsiav tshuaj ib zaug (100 mg) ob zaug ib hnub. Nws yog qhov zoo dua los ua qhov no tom qab noj mov thiab haus cov tshuaj nrog dej txaus. Yog hais tias peb tab tom tham txog cov hmoov rau kev npaj ntawm kev ncua, ces cov ntsiab lus ntawm ib sachetdiluted hauv 100 ml dej. Cov tub ntxhais hluas hnub nyoog tshaj 12 xyoos tsis tas yuav hloov cov koob tshuaj, thiab cov tshuaj no raug txwv rau cov menyuam mos. Nyob rau hauv cov ntaub ntawv ntawm kev kho mob ntawm cov neeg laus, tsis kho koob tshuaj.
Rau cov neeg mob los ntawm lub siab tsis txaus, nrog rau kev tshem tawm creatine hauv thaj tsam ntawm 30-80 ml / min, cov tshuaj tsis raug kho. Yog tias qhov ntsuas no qis dua (30 ml / min. lossis tsawg dua), cov tshuaj raug txwv.
Cov no yog cov lus qhia tseem ceeb rau kev noj Nimesulide. Cov koob tshuaj raug xaiv kom ua tau zoo tsawg thiab rau lub sijhawm luv tshaj plaws, uas yuav txo qhov kev pheej hmoo ntawm qhov tsis zoo. Qhov siab tshaj plaws ntawm kev kho nrog Nimesulide yuav tsum tsis pub tshaj 15 hnub.
Ntau dhau: cov tsos mob, kev kho mob
Thaum noj cov tshuaj Nimesulide, koj yuav tsum ua raws li cov koob tshuaj pom zoo hauv cov lus qhia lossis xaiv los ntawm koj tus kws kho mob. Kev tswj hwm tus kheej ntawm cov tshuaj thiab (lossis) nws qhov kev siv tsis tswj tau tuaj yeem ua rau muaj kev noj ntau dhau. Hauv qhov no, cov tsos mob hauv qab no feem ntau pom: xeev siab, ntuav, los ntshav ntawm plab hnyuv, tsaug zog, tsis txaus siab, kub siab (siab ntshav siab), ua pa nyuaj siab, mob raum tsis ua haujlwm.
Kev kho mob thaum noj tshuaj ntau dhau yog cov tsos mob thiab txhawb nqa. Tam sim no tsis muaj tshuaj tua kab mob rau nimesulide. Yog tias ntau tshaj 4 teev tsis tau dhau los txij li kev siv tshuaj ntau dhau lossis noj cov tshuaj ntau, tus neeg mob tau txais kev tso pa tawm hauv tsev kho mob, nws raug nquahu kom noj cov tshuaj nqus dej (piv txwv li,activated charcoal 60-100 mg rau cov neeg laus) thiab qee yam osmotic laxative.
Lub sijhawm tag nrho ntawm kev kho mob, kev ua haujlwm ntawm lub siab thiab lub raum yuav tsum tau ua tib zoo saib xyuas los ntawm cov neeg ua haujlwm noj qab haus huv. Cov ntaub ntawv hais txog qhov ua tau ntawm kev tshem tawm nimesulide los ntawm lub cev siv cov txheej txheem hemodialysis tsis muaj. Vim tias muaj cov tshuaj tiv thaiv kab mob siab rau cov protein, yuam diuresis yuav tsis ua haujlwm.
Cov lus qhia tshwj xeeb
Nimesulide, uas tsis xav tau daim ntawv xaj hauv khw muag tshuaj, txawm li cas los xij yuav tsum tau ceev faj. Kev siv tshuaj sib xyaw ua ke thiab lwm yam tshuaj uas tsis yog-steroidal anti-inflammatory, concomitant analgesics yuav tsum zam. Nrog rau kev loj hlob ntawm cov neeg mob ntawm cov tsos mob ntawm daim siab puas (xeev siab, ntuav, anorexia, darkening ntawm cov zis) los yog ib tug nce nyob rau hauv cov theem ntawm hepatic transaminases, kev siv ntawm Nimesulide yuav tsum tau tso tseg. Yog ua npaws lossis cov tsos mob xws li mob khaub thuas tshwm sim, kev kho mob yuav tsum tau txiav tam sim ntawd.
Cov neeg mob uas, ua ke nrog Nimesulide, noj cov tshuaj uas ua rau muaj kev pheej hmoo ntawm plab hnyuv thiab los ntshav yuav tsum tau saib xyuas lawv tus kheej. Qhia tshuaj kom ceev faj rau cov neeg uas raug kev txom nyem los ntawm cov kab mob ulcerative colitis lossis Crohn tus kab mob, nrog rau keeb kwm ntawm rwj, cov neeg laus.
Cov neeg uas yuav tsum tau noj "Nimesulide" ua ke nrog cov tshuaj aspirin hauv cov koob tshuaj plawv yuav tsum tau muab tshuaj ua ke nrog cov tshuaj tiv thaiv kab mob.
Kev siv "Nimesulide" (lossis lwm yam NSAIDs) hauv cov ntim loj thiab lub sijhawm ntev ua rau muaj kev pheej hmoo ntawm kev tsim cov kab mob thromboembolic (stroke, myocardial infarction, thiab lwm yam).
Nimesulide tuaj yeem muab tshuaj rau cov neeg mob uas muaj ntau yam teeb meem ntawm cov hlab plawv tsuas yog tias cov txiaj ntsig xav tau tshaj qhov kev pheej hmoo ntawm kev phiv.
Cov tshuaj cuam tshuam rau qib ntawm platelet kev ua haujlwm. Cov ntaub ntawv no tseem ceeb rau cov neeg mob uas muaj hemorrhagic diathesis. Cov tawv nqaij mob hnyav feem ntau tshwm sim nrog kev siv Nimesulide ntev. Thaum cov pob khaus tshwm sim, kev puas tsuaj rau cov qog nqaij hlav ua rau pom, lossis lwm yam kev tshwm sim ntawm kev tsis txaus siab tau sau tseg, kev kho tshuaj yuav tsum txiav tawm.
Kev siv "Nimesulide" los ntawm cov poj niam cev xeeb tub tuaj yeem ua rau lub cev kaw lub ductus botulinum ua ntej nws tsim nyog, txo qhov ntim ntawm amniotic kua. Tej zaum yuav muaj kev pheej hmoo ntawm cov ntshav hauv lub cev, ua haujlwm tsis muaj zog, qhov tsos ntawm edema. Rau cov laj thawj no, cov niam txiv uas muaj kev cia siab tsis pom zoo kom noj Nimesulide thaum lub sij hawm thawj thiab thib ob ntawm cev xeeb tub.
Cov lus teb rau lo lus nug ntawm seb Nimesulide thiab cawv puas tuaj yeem noj tib lub sijhawm yog pom tseeb: qhov kev sib xyaw ua ke no tsis tuaj yeem lees txais!
Analogues
Raws li cov analogues ntawm "Nimesulide" txhais tau tias cov tshuaj los ntawm pab pawg NSAIDs uas muaj cov ntsiab lus tseem ceebactive ingredient nimesulide (tus nqi rau lawv yuav fluctuate kwv yees li ntawm ib tug ntau yam, tab sis ntau ntxiv nyob rau hauv qab no). Cov npe nrov tshaj plaws thiab nquag tshaj tawm los ntawm cov neeg ua haujlwm noj qab haus huv suav nrog kev npaj "Nise" (gel, ntsiav tshuaj, ncua kev kawm), "Nimesil" (hmoov), "Nimika" (ntsiav tshuaj), "Nimulid" (gel, ntsiav tshuaj, ncua kev kawm, lozenges).
Tag nrho cov analogues tau txais txiaj ntsig zoo thiab raug tshuaj los tawm tsam ntau yam kab mob inflammatory.
Tus nqi rau Nimesulide nws tus kheej thiab nws cov analogues yog kwv yees li qub, txawm hais tias cov tshuaj peb tab tom txiav txim siab yog pheej yig dua rau ntau tus neeg yuav khoom. Cov ntsiav tshuaj "Nimesulide" (20 daim hauv ib pob) yuav raug nqi 85-90 rubles ib pob. Tib tus naj npawb ntawm Nyza ntsiav tshuaj yuav raug nqi 110-140 rubles, Nimiki (kuj 20 pcs.) - 115-134 rubles. Ib pob "Nimulid" ntawm 30 ntsiav tshuaj raug nqi 180-220 rubles. Cov ntsiab lus ntawm lub ntsiab active ingredient (nimesulide) nyob rau hauv tag nrho cov analogues yog tib yam - 100 mg.
Hloov cov ntsiav tshuaj Nimesulide (tus nqi qis tshaj), koj tuaj yeem yuav, piv txwv li, Nise ncua kev kawm ntawm tus nqi ntawm 200-300 rubles ib 60 ml lossis Nimulide - 75-105 rubles rau tib tus nqi ntawm cov tshuaj.. Nimulid lozenges kuj muaj rau ntau tus neeg siv khoom: 20 daim ntawm tus nqi ntawm 130-155 rubles ib pob.
Tej zaum qhov kim tshaj plaws ntawm cov tshuaj tso tawm nrog nimesulide raws li cov khoom tseem ceeb yog Nimesil hmoov. 30 hnab (packing) yuav raug nqi rau cov neeg siv khoom los ntawm 560 txog 645 rubles.
rau sab nraum zoovdaim ntawv thov, gels nrog nimesulide zoo heev. Yog li, "Nise" yuav raug nqi tus neeg yuav khoom 120-145 rubles rau ib lub raj ntawm 20 g lossis 215-275 rubles (50 g). Gel "Nimulid" yog pheej yig dua: 115-150 rubles rau ib lub raj ntawm 30 g.
Nyob rau hauv xaus, kuv xav hais hauv qab no. Kev txiav txim siab siv Nimesulide, ib qho ntawm nws cov analogues lossis lwm yam NSAIDs yuav tsum tau ua los ntawm tus kws kho mob tuaj koom. Tsuas yog tus kws kho mob tuaj yeem ntsuas qhov mob hnyav ntawm nws tus neeg mob qhov kev noj qab haus huv, suav nrog txhua yam kab mob sib kis, xaiv cov tshuaj, xaiv ntau npaum li cas thiab txhim kho kev kho mob kom txo qis qhov tshwm sim ntawm cov kev mob tshwm sim thiab tau txais txiaj ntsig zoo tshaj plaws.
