Kev npaj los ntawm pab pawg ntawm adrenergic blockers tau dav siv hauv kev kho mob ntau yam kab mob plawv. Ntawm cov tshuaj nyob rau hauv cov pab pawg neeg no, "Nebivolol" sawv tawm ho. Analogues ntawm cov tshuaj no kuj tau txais koob meej vim lawv cov hauj lwm zoo. Cov tshuaj no yog dab tsi, nws ua haujlwm li cas, thiab thaum twg siv tau?
tshuaj no yog dab tsi?
"Nebivolol" belongs rau pab pawg ntawm beta-blockers. Lub luag haujlwm tseem ceeb ntawm cov tshuaj no yog antihypertensive (cov tshuaj txo cov ntshav siab). Cov txiaj ntsig tau pom vim qhov kev xaiv thaiv ntawm beta receptors nyob hauv cov hlab ntsha (cuam tshuam rau beta-1-adrenergic receptors).
Tam sim no siv Nebivolol Sandoz.
Cov tshuaj no yog ib qho ua ke, muaj ntau lub isomers (D- thiab L-rotating). Xws li kev sib xyaw ua ke ntawm cov tshuaj muaj txiaj ntsig zoo rau kev txhim kho ntawm cov tshuaj kho mob. Ib qho ntawm isomers yog lub luag haujlwm rau kev txhim kho cov nyhuv antihypertensive, thaum qhov thib ob muaj kev cuam tshuam ntau dua ntawm lub plawv dhia.
Tshuaj tshwm simkuj tsis ntev los no, nyob rau hauv nruab nrab ntawm lub xyoo pua xeem. Txij thaum ntawd los, nws tau dav siv nyob rau hauv ib puag ncig cardiological. "Nebivolol Sandoz" yog cov tshuaj xaiv hauv kev kho mob ntshav siab, nrog rau qee lub plawv arrhythmias.
Cov tshuaj ua haujlwm li cas thiab cov kabmob twg yog lub luag haujlwm rau nws nqus?
YPharmacokinetics
Nebivolol Sandoz yog qhov nqus tau zoo tshaj plaws. Cov tshuaj yog absorbed zoo nyob rau hauv lub plab zom mov. tuaj yeem noj nrog zaub mov (kev nqus tsis zoo). Bioavailability yog qhov tsawg - txog 12 feem pua. Yog tias ua tau, kev siv tshuaj nrog cawv yuav tsum zam, vim tias muaj kev phiv tshwm sim.
Ib zaug hauv cov ntshav plasma, cov tshuaj khi rau albumin thiab tsim cov complexes insoluble. Nyob rau hauv daim ntawv no, qhov muaj ntawm cov tshuaj yog hais txog 98 feem pua, uas yog, yuav luag tag nrho cov Nebivolol Sandoz yog absorbed. Nws cov analogues dhau los ntawm tib txoj kev ua ntej lawv nkag mus rau hauv cov ntshav plasma thiab tsis khi rau cov protein.
tshuaj Unabsorbed yog tawm los ntawm txoj hnyuv thiab lub raum. Ua tiav hauv daim siab, qhov twg nws khi rau glucuronic acid.
Ib nrab-lub neej ntawm cov tshuaj nyob rau hauv cov tib neeg nrog ib tug ceev metabolite yog hais txog ib hnub. Nyob rau hauv cov ntaub ntawv ntawm cov metabolism qeeb, "Nebivolol" tuaj yeem khaws thiab khaws cia hauv cov ntshav ntshav li 48 teev.
Cov tshuaj tsis sib xyaw hauv cov ntaub so ntswg, uas zam nwsoverdose (nws tsuas yog ua tau yog tias nws siv rau cov neeg mob raum lossis daim siab pathology).
Cov lus qhia rau kev siv
Yuav ua li cas yog Nebivolol tau sau tseg, analogues ntawm cov tshuaj no lossis cov tshuaj uas muaj cov tshuaj pharmacological zoo sib xws?
thawj qhov qhia rau kev sau tshuaj yog arterial hypertension. Kev siv cov beta-blockers yog siv los ntawm kev siv cov tshuaj ACE inhibitors (Enalapril, Captopril). Tsis tas li ntawd, Nebivolol kuj tseem siv rau endocrine hypertension.
Lwm qhov qhia tseem ceeb sib npaug rau kev siv "Nebivolol" yog kab mob plawv. Nrog nquag exacerbations ntawm angina pectoris, nrog rau kev tiv thaiv kev tawm tsam, Nebivolol tau qhia. Nws cov analogues nyob rau hauv cov ntaub ntawv no tej zaum yuav txawm zoo dua cov tshuaj ntshiab nws tus kheej.
Nebivolol kuj yog ib feem ntawm kev sib xyaw ua ke hauv kev kho mob plawv tsis ua haujlwm. Hauv qhov no, cov tshuaj pab txhim kho kev ua haujlwm ntawm lub plawv, txo qis ua ntej thiab tom qab kev thauj khoom ntawm cov khoom nruab nrog cev, nrog rau txo qhov siab.
Cov tshuaj no kuj tseem siv tau los tiv thaiv kev txhim kho ntawm kev kub ntxhov, nrog rau cov tib neeg uas ua rau cov kab mob atherosclerotic ntawm lub paj hlwb.
YContraindications
Thaum twg koj yuav tsum tsis txhob siv "Nebivolol"? Cov lus qhia rau kev siv feem ntau suav nrog tag nrho cov xwm txheej uas tau txheeb pom hauv chaw kho mob, thaum tawm tsam keeb kwm yav dhaukev siv txoj kev txhim kho ntawm cov teeb meem no tau pom. Vim muaj cov nyhuv antihypertensive muaj zog, nws tsis tuaj yeem sau tshuaj kho mob rau cov hlab ntsha loj heev.
Ua ntej tshaj plaws, txwv tsis pub siv cov tshuaj hauv lub plawv tsis ua haujlwm. Qhov no yog vim qhov tseeb tias nws muaj cov nyhuv inotropic, uas tuaj yeem cuam tshuam rau lub cev vim lub plawv tsis txaus.
Nrog rau kev loj hlob ntawm pheochromocytoma, nws tseem txwv tsis pub siv "Nebivolol". Cov lus qhia rau kev siv qhia tau hais tias nrog cov qog endocrine no, cov tshuaj tsuas yog siv tau ua ke nrog alpha receptor blockers.
Tsis txhob muab tshuaj rau menyuam yaus, nrog rau cov neeg muaj kev puas siab puas ntsws uas twb muaj lawm.
"Nebivolol" yog contraindicated nyob rau hauv cov neeg uas muaj ib tug neeg intolerance tshuaj. Thaum thawj cov tsos mob tshwm sim (lacrimation, ua pa nyuaj), koj yuav tsum tam sim ntawd tso tseg kev siv tshuaj ntxiv thiab hloov mus rau qhov kev xaiv zoo dua.
Side effects
Zoo li txhua yam tshuaj, Nebivolol muaj nws cov kev phiv. Thawj ntawm lawv yog:
Rau ib feem ntawm lub paj hlwb - mob taub hau, kev nyuaj siab, tsaug zog, insomnia, hallucinations, fainting, kiv taub hau.
Kev mob plab hnyuv muaj xws li xeev siab, cem quav, qhov ncauj qhuav, thiab ntuav. Tej zaum qhov tshwm sim ntawm cov kab mob dyspeptic, thiab thaum noj ua ke nrog tshuaj tua kab mob -dysbacteriosis.
Cov kab mob plawv reacts rau kev qhia txog "Nebivolol" nrog bradycardia, ua tsis taus pa, edema, kev loj hlob ntawm mob plawv tsis ua hauj lwm, atrioventricular blockade, Raynaud's syndrome. Kev noj tshuaj ntau dhau tuaj yeem ua rau tsis muaj kev tswj hwm ntawm arterial hypotension, uas tuaj yeem cuam tshuam los ntawm kev sib tsoo thiab qaug zog. Hauv qhov xwm txheej hnyav, kev poob siab tshwm sim.
Cov teebmeem ntawm "Nebivolol" tuaj yeem tshwm sim ua pob liab liab, psoriasis.
Hauv qhov mob hnyav, angioedema tshwm sim (Quicke's edema). Hauv cov mob me me, qhov txham lossis hnoos tsis tuaj yeem tshwm sim.
Txoj kev siv tshuaj
Cov tshuaj no yog siv nrog ceev faj rau cov neeg mob lub raum tsis ua haujlwm, ntshav qab zib mellitus lossis ntau cov thyroid hormones. Kev tshem tawm ntawm cov tshuaj yog nqa tawm maj mam, tsis pub dhau 10-14 hnub. Thaum pib ntawm kev kho mob, ntshav siab thiab lub plawv dhia yuav tsum tau saib xyuas. Yog tias ua tau, koj yuav tsum tsis txhob haus luam yeeb thaum siv tshuaj. Ua ntej kev ua haujlwm tom ntej, nco ntsoov ceeb toom tus kws tshuaj loog tias tus neeg mob siv beta-blockers.
Lub sijhawm tag nrho ntawm kev siv tshuaj, nws yog ib qho tsim nyog los tswj cov suab thaj hauv cov ntshav, tshwj xeeb tshaj yog rau cov neeg mob ntshav qab zib. Tsis tas li ntawd, qhov pom muaj peev xwm ntawm lub raum (tshwj xeeb tshaj yog cov qib ntawm creatinine thiab urea) yuav tsum tau soj ntsuam yog tias Nebivolol raug tshuaj rau lub sijhawm ntev. Cov lus qhia rau kev siv (analoguesmuaj cov nyhuv zoo sib xws) ceeb toom tias kev txhim kho lub raum tsis ua haujlwm tuaj yeem ua tau nrog kev teem caij tsis sib haum xeeb ntawm cov tshuaj no.
Nws yog txwv tsis pub siv cov tshuaj rau cov menyuam yaus hnub nyoog qis dua 18 xyoo, nrog rau cov neeg laus uas muaj lub plawv tsis ua haujlwm decompensated. Qhov kev txwv no feem ntau yog vim muaj peev xwm tsim cov kab mob metabolic thiab pom cov teeb meem nrog lub siab.
Vim tias kev siv tshuaj yuav ua rau kiv taub hau, yuav tsum tsis txhob muab tshuaj rau cov neeg tsav tsheb thiab kws kho mob.
Kev siv tshuaj los ntawm cov poj niam cev xeeb tub
Kev muab cov tshuaj no rau tus poj niam cev xeeb tub yog ua tau tsuas yog tom qab kev sab laj nrog gynecologist thiab kws kho mob. Cov tshuaj no tsis tshua muaj siv vim muaj kev cuam tshuam tsis zoo rau lub cev ntawm niam thiab menyuam.
Cov tshuaj no tsuas yog muab rau thaum muaj xwm txheej ceev, raws li nws muaj peev xwm tsim bradycardia, arterial hypotension, hypoglycemia, tuag tes tuag taw ntawm qhov chaw ua pa, qaug dab peg.
Peb hnub ua ntej yuav yug, koj yuav tsum tsum tsis txhob siv cov tshuaj no. Yog tias qhov no ua tsis tau, ua tib zoo saib xyuas kev noj qab haus huv ntawm leej niam thiab tus menyuam yog qhov tsim nyog nyob rau lub sijhawm ntxov tom qab yug menyuam. Thaum siv tshuaj loog ntawm tus txha caj qaum, nws yog ib qho tsim nyog yuav tsum ceeb toom tus kws tshuaj loog txog kev kho mob tsis tu ncua nrog adrenergic blockers.
Nws yuav tsum nco ntsoov tias tiv thaiv keeb kwm yav dhau los ntawm kev siv tshuaj, kev loj hlob ntawm fetal hypoxia yog ua tau. Cov nyhuv teratogenic ntawm cov tshuaj tsis tau raug pov thawj, tab sis muaj cov xwm txheej zoo li no rau tus menyuam hauv plab.
Yog tias, txawm li cas los xij, "Nebivolol" raug tshuaj rau tus poj niam cev xeeb tub, cov lus qhia raudaim ntawv thov ceeb toom tias qhov kev kho mob ntawm cov tshuaj yuav raug cuam tshuam thaum siv cov tshuaj magnesium intravenous.
Kev sib tham nrog tshuaj los ntawm lwm pawg tshuaj
Kev siv ua ke ntawm "Nebivolol" thiab chav kawm 1 antiarrhythmics tuaj yeem ua rau muaj kev nce hauv qhov tsis zoo inotropic. AV block tuaj yeem txhim kho. Cov txiaj ntsig zoo sib xws tau pom yog tias calcium channel blockers thiab Nebivolol Sandoz tau siv ib txhij.
Cov lus qhia rau kev sau tshuaj ceeb toom tias thaum nws tau txhaj tshuaj hauv cov hlab ntsha, lub plawv nres tau ua tau (muab tias cov tshuaj tau muab tshuaj ua ke nrog Verapamil). Hauv qhov no, yuav tsum muaj kev kho mob xwm txheej ceev uas siv hluav taws xob kho hluav taws xob.
Muaj kev pheej hmoo tseem ceeb ntawm kev tsim cov hlab ntsha loj heev thaum muab tshuaj nrog Nitroglycerin.
Kev tswj hwm ib txhij ntawm sympathomimetics thiab "Nebivolol" pab txhawb rau qhov inhibition tom kawg.
Kev siv cov tshuaj loog ua ke tuaj yeem ua rau cov ntshav siab poob qis, uas yuav ua rau muaj kev cuam tshuam rau lub tshuab ua pa thiab siv cov tshuaj hypertensive.
Thaum muab tshuaj nrog insulin, nws muaj peev xwm tsim cov tshuaj hormones ntau dhau thiab zais cov tsos mob ntawm hypoglycemia.
Tshuaj ntau ntau
Yog li cov tshuaj yuav tsum siv npaum li cas txhawm rau txhim kho qhov kev xav tau ntawm kev kho mob? Yog ibNebivolol Sandoz yog siv, cov lus qhia rau kev siv qhia cov tshuaj hauv qab no.
Cov koob tshuaj zoo tshaj plaws rau tus neeg laus yog 20 milligrams ib hnub. Cov tshuaj yog noj thaum sawv ntxov ntawm lub plab khoob. Qhov siab tshaj plaws ntawm cov tshuaj siv tau tsim tom qab ib mus rau ob lub lis piam txij thaum pib kho. Yog tias tsim nyog, cov tshuaj niaj hnub tuaj yeem nce mus rau 10 milligrams. Rau cov neeg laus, qhov siab tshaj plaws txhua hnub koob tshuaj yog 5 milligrams, thiab qhov zoo tshaj plaws rau kev kho mob yog 2.5 milligrams ib hnub twg. Rau cov poj niam cev xeeb tub, tus nqi ntawm cov tshuaj raug xaiv raws li cov tsos mob thiab lub cev hnyav. Nws yog qhov zoo tshaj plaws los siv Nebivolol Sandoz (5mg) ntsiav tshuaj.
Yog tias daim siab lossis lub raum ua haujlwm tsis zoo, nws yog qhov zoo dua kom tsis txhob siv Nebivolol lossis tshuaj noj tsawg kawg nkaus.
Nrog rau kev teem sijhawm ib txhij ntawm sympathomimetics thiab Nebivolol, cov nyhuv yuav muaj zog, vim tias nws tuaj yeem txo qis me ntsis ntawm cov tshuaj uas tau sau tseg.
Kev tshuaj xyuas cov tshuaj me me tsis muaj txiaj ntsig rau lub cev. Nws muaj peev xwm txhim kho receptor kam rau cov tshuaj nrog kev tswj xyuas mus sij hawm ntev ntawm cov tshuaj me me.
Analogues ntawm cov tshuaj
Nws tsis tuaj yeem nrhiav cov tshuaj tsim nyog hauv cov khw muag tshuaj, yog li koj yuav tsum siv cov tshuaj analogues. Vim muaj kev nthuav dav ntawm kev lag luam tshuaj, nws tsis yooj yim los nrhiav cov tshuaj zoo sib xws. Cov tshuaj twg tuaj yeem hloov Nebivolol?
Analogues (synonyms) ntawm cov tshuaj no yog raws li nram no:
- "Binelol";
- "Nebivator";
- "Nebivolol canon";
- "Nebivolol stada";
- "Nebivolol teva;
- "Nebicar";
- "Tsis yog daim pib";
- "Nebilong";
- "ib lub ntuj".
Txhua yam tshuaj no muaj nws qhov zoo thiab qhov tsis zoo. Qee tus ntawm lawv tau txhim kho zoo dua li cov classic "Nebivolol". Cov lus qhia rau kev siv ntawm txhua tus ntawm lawv, txawm li cas los xij, ceeb toom txog kev cuam tshuam ntau dua. Yog li ntawd, tsuas yog ib tus kws kho mob uas tsim nyog thiab muaj peev xwm tuaj yeem pab txiav txim siab seb cov tshuaj twg zoo dua.
Koj yuav tsum tsis txhob siv cov tshuaj no ntawm koj tus kheej yam tsis tau ntsib kws kho mob ua ntej, vim li no koj tsuas tuaj yeem ua rau koj tus mob hnyav dua thiab ua rau koj noj qab haus huv thiab noj qab haus huv ntawm cov phooj ywg thiab cov neeg koj hlub.
tshuaj tshuaj xyuas
Ntau tus neeg mob nquag qhuas ntawm cov rooj sab laj xws li tshuaj "Nebivolol Sandoz". Kev tshuaj xyuas txog nws feem ntau yog qhov zoo, vim tias cov tshuaj no tau pab kho lossis nres cov tsos mob ntawm tus neeg mob feem ntau.
Txawm hais tias muaj pes tsawg tus ntawm cov tshuaj muaj, nws suav hais tias yog ib qho tseem ceeb hauv kev kho cov ntshav siab thiab lub plawv tsis ua haujlwm.
Ntshiab "Nebivolol" kuj muaj ntau qhov kev tshuaj xyuas zoo. Analogues ntawm cov tshuaj yog ntau haum rau ib tug neeg, tsawg dua rau ib tug neeg, vim hais tias ntawm cov kev xavcov neeg mob sib txawv. Nws kuj tseem yuav tsum tau coj mus rau hauv tus account lub comorbidity, uas tuaj yeem cuam tshuam cov nyhuv ntawm cov tshuaj.
Nco ntsoov ua tib zoo xav txog hnub nyoog ntawm cov neeg mob uas siv cov tshuaj no.
Ntawm tag nrho cov beta-blockers siv rau cov neeg mob plawv, Nebivolol (analogues) yog thawj qhov chaw. Kev tshuaj xyuas txog cov tshuaj no tso cai rau peb hu nws tias cov tshuaj zoo tshaj plaws ntawm pawg tshuaj no.
