Nyob rau hauv tsab xov xwm, peb yuav txiav txim siab nyob rau hauv kom meej qhov muaj pes tsawg leeg ntawm Pulmicort thiab cov lus qhia rau nws. Qhov no yog Swedish anti-inflammatory tshuaj siv rau inhalation. Cov tshuaj feem ntau yog siv tsis tau tsuas yog raws li kev kho mob qhia ncaj qha, tab sis kuj rau hnoos ntawm ntau yam keeb kwm nyob rau hauv cov neeg laus thiab cov me nyuam los ntawm 6 lub hlis.
Kev sib xyaw ntawm "Pulmicort" thiab tso tawm daim ntawv
Cov tshuaj no muaj nyob rau hauv daim ntawv ntawm ib tug dawb metered ncua kev kawm ntawv uas yog yooj yim resuspendable. Lub ntsiab lus tseem ceeb yog budesonide (micronized) ntawm ib koob ntawm 500 mcg ib 1 ml.
Cov khoom siv pabcuam hauv cov muaj pes tsawg leeg ntawm "Pulmicort" rau kev nqus pa yog: disodium edetate, sodium chloride, polysorbate 80, sodium citrate, anhydrous citric acid, dej huv.
Kev kho mob ntim rau hauv ib koob tshuaj polyethylene ntim thiab cov hnab ntawv foil, nrog rau hauv thawv.
Cov ntsiab lus ntawm Pulmicort tau piav qhia meej hauv cov lus qhia.
tshuaj muaj txiaj ntsig ntawm tshuaj
Qhov no yog glucocorticosteroid rau kev nqus pa. Budesonide ua ib feem ntawm "Pulmicort" nyob rau hauv cov koob tshuaj pom zoo muaj cov tshuaj tiv thaiv kab mob ntawm lub bronchi, txo qhov hnyav ntawm cov tsos mob thiab qhov zaus ntawm kev mob hawb pob nrog qhov tsawg tshaj plaws ntawm cov kev mob tshwm sim tshaj li thaum siv cov kab mob corticosteroids. Tsis tas li ntawd, cov tshuaj no txo qhov hnyav ntawm edema ntawm cov mucous daim nyias nyias ntawm lub bronchi, hnoos qeev, tsim cov hnoos qeev thiab siab reactivity ntawm cov pa raws. Cov tshuaj no tau txais txiaj ntsig zoo hauv kev kho mob mus ntev, tsis muaj cov haujlwm mineralocorticoid.
Cov txiaj ntsig kho mob tom qab nqus tau ib zaug ntawm cov tshuaj no tshwm sim yuav luag tam sim ntawd thiab kav ntev li ob peb teev. Qhov siab tshaj plaws yog ua tiav 1-2 lub lis piam tom qab kev kho mob. Cov tshuaj tseem ceeb hauv cov tshuaj "Pulmicort" muaj kev tiv thaiv kev tiv thaiv kab mob thiab tsis cuam tshuam rau nws cov tsos mob hnyav.
Qhia cov nyhuv ntawm koob tshuaj ntawm cov ntsiab lus ntawm cortisol hauv cov zis thiab ntshav thaum noj tshuaj. Ntawm cov qib pom zoo, nws muaj qhov cuam tshuam tsawg dua rau kev ua haujlwm ntawm adrenal dua li prednisone, raws li qhia hauv ACTH kev xeem.
Pharmacokinetic indicators
Budesonide ua ib feem ntawm Pulmicort yog nqus sai sai tom qab nqus pa. Hauv cov neeg laus, kev ua haujlwm bioavailability tom qab nqus tau los ntawm lub tshuab nqus tsev yog kwv yees li 15% ntawm tag nrho cov tshuaj noj thiab txog 40-70% ntawm qhov tau txais. Qib siab tshaj hauvplasma ua tiav 30 feeb tom qab nqus tau cov tshuaj.
Plasma protein khi nruab nrab yog 90%. Budesonide nyob rau hauv daim siab mob siab heev biotransformation nrog tsim cov metabolites nrog tsawg hormonal kev ua si. Kev ua haujlwm ntawm glucocorticoid ntawm cov tshuaj no (16α-hydroxyprednisolone thiab 6β-hydroxy-budesonide) tsawg dua 1% ntawm cov haujlwm ntawm budesonide, uas tau tawm hauv cov zis hauv daim ntawv ntawm conjugated lossis tsis hloov pauv metabolites. Cov khoom muaj kev tshem tawm siab (1.2 l / min).
Pharmacokinetic yam ntxwv ntawm budesonide ua ib feem ntawm Pulmicort rau kev nqus pa thaum yau thiab cov neeg uas lub raum tsis ua haujlwm tsis tau kawm.
Cov lus qhia rau cov tshuaj
Cov tshuaj tau sau rau hauv cov xwm txheej zoo li no:
- rau mob hawb pob xav tau kev kho mob nrog corticosteroids;
- rau tus kab mob obstructive pulmonary (COPD).
Pulmicort yog dab tsi rau kev nqus pa? Cov lus qhia yuav pab peb nkag siab qhov teeb meem no.
Txoj cai noj tshuaj
Cov tshuaj noj yog teem rau tus kheej. Yog tias qhov koob tshuaj pom zoo los ntawm tus kws kho mob tsis ntau tshaj 1 mg / hnub, nws raug muab tshuaj rau ib zaug. Nyob rau hauv cov ntaub ntawv ntawm kev qhia txog cov koob tshuaj loj dua, nws raug nquahu kom faib lawv ua 2 qhov kev txhaj tshuaj inhalation.
Cov koob tshuaj thawj zaug rau cov neeg laus yog 1-2 mg ib hnub. Kev saib xyuas koob tshuaj yog 0.5-4 mg ib hnub twg. Thaum lub sij hawm exacerbations, lub ntim ntawm cov tshuaj tau muab yuav nce.
Thaum muaj hnub nyoog 6 hli thiab ntau dua, thawj koob tshuaj yog0.25-0.5 mg ib hnub twg. Yog tias tsim nyog, nws tau nce mus rau 1 mg ib hnub.
Ua ntej siv Pulmicort rau kev nqus, cov tshuaj yuav tsum tau diluted nrog 0.9% sodium chloride tov kom tag nrho cov ntim ntawm cov tshuaj yog 2 ml.
Yog tias nws tsim nyog kom tau txais cov txiaj ntsig kho mob ntxiv, kev nce qib ntawm cov tshuaj tuaj yeem raug pom zoo siv nws cov kev sib xyaw nrog GCS rau kev siv sab hauv, vim tias tsis tshua muaj kev pheej hmoo ntawm kev tsim cov tshuaj tiv thaiv kab mob.
Qhov no lees paub cov lus qhia rau "Pulmicort" rau kev nqus pa rau cov neeg laus.
Cov lus qhia rau cov neeg mob tau txais HSCs qhov ncauj
Kev tshem tawm ntawm qhov ncauj corticosteroids yuav tsum tau pib tom qab kev ruaj ntseg ntawm tus neeg mob lub xeev kev noj qab haus huv. Tsis pub dhau 10 hnub, cov koob tshuaj Pulmicort siab tau raug tshuaj tiv thaiv keeb kwm yav dhau los ntawm kev siv GCS hauv cov koob tshuaj niaj hnub. Nyob rau hauv lub neej yav tom ntej, nyob rau hauv ib lub hlis, cov koob tshuaj ntawm GCS yuav tsum tau maj mam txo mus rau ib tug tsawg kawg nkaus ntim. Feem ntau, cov neeg mob tswj kom tsis txhob siv cov tshuaj no kiag li.
Siv nrog lub nebulizer
Kev siv "Pulmicort" yog ua los ntawm kev nqus pa, siv lub tshuab nqus tsev nrog lub ntsej muag tshwj xeeb thiab lub qhov ncauj. Cov cuab yeej txuas nrog lub compressor kom tau txais cov huab cua uas yuav tsum tau ua, lub ntim ntim ntawm lub thawv nebulizer yuav tsum yog tsawg kawg 2-4 ml. Txij li thaum cov tshuaj raug coj mus rau hauv lub ntsws thaum nqus tau, nws yog ib qho tseem ceeb uas yuav tsum tau qhia tus neeg mob kom nqus tau cov tshuaj los ntawm lub qhov ncauj tusyees thiab calmly. Yog tias tus txheej txheem tau ua rau tus menyuam, thiab nws tsis tuaj yeem ua nws tus kheejUa pa, siv lub npog ntsej muag tshwj xeeb.
Tus neeg mob yuav tsum tau ceeb toom txog qhov yuav tsum tau nyeem cov lus qhia rau kev siv cov tshuaj no, thiab cov ultrasonic nebulizers tsis siv rau nws siv nyob rau hauv daim ntawv ntawm kev ncua. Kev ncua yuav tsum tau tov nrog 0.9% sodium chloride tov los yog nrog cov kev daws teeb meem ntawm cov tshuaj xws li terbutaline, salbutamol, fenoterol, sodium cromoglycate, acetylcysteine និង ipratropium bromide. Tom qab nqus pa, nws raug nquahu kom yaug lub qhov ncauj nrog dej kom txo tau qhov tshwm sim ntawm oropharyngeal candidiasis. Txhawm rau txo qhov kev pheej hmoo ntawm cov tawv nqaij khaus tom qab siv lub npog ntsej muag, yaug koj lub ntsej muag nrog dej. Tsis tas li ntawd, nws yog ib qho tseem ceeb kom paub tias qhov kev ncua sij hawm tiav ntawm cov tshuaj Pulmicort yuav tsum tau siv tom qab qhov siab kawg ntawm 30 feeb, tom qab ntawd nws suav tias tsis tsim nyog rau kev tswj hwm.
Nws kuj tau pom zoo kom yaug lub nebulizer tsis tu ncua raws li cov chaw tsim khoom cov lus qhia.
Cov Cai Siv
Yog li, siv "Pulmicort" thaum hnoos li cas? Lub thawv uas muaj ib koob tshuaj ib zaug yog cim nrog ib kab. Yog hais tias koj tig nws upside down, ces kab no yuav txhais tau tias ib tug ntim sib npaug zos rau 1 ml. Thaum raws nraim qhov kev ncua no yuav tsum tau thov, cov ntsiab lus ntawm lub pob raug nyem tawm kom txog thaum cov kua nce mus txog qib uas tau hais los ntawm kab. Lub thawv qhib yog khaws cia rau hauv qhov chaw tsaus rau tsis pub ntau tshaj 12 teev. Co cov ntsiab lus ntawm lub thawv yas ua ntej siv cov khoom seem ntawm cov kua.
Side effects
Txog 10%Cov neeg mob uas siv cov tshuaj no tuaj yeem ntsib cov kev mob tshwm sim no:
- Kev ua pa ua pa: khaus ntawm cov mucous ntawm lub pharynx, candidiasis ntawm oropharynx, hnoos, qhov ncauj qhuav, hoarseness, bronchospasm.
- CNS: cephalalgia, tuaj yeem ntxhov siab, kev nyuaj siab, chim siab, kev coj cwj pwm tsis zoo.
- Kev ua xua tshwm sim: angioedema.
- Cov tshuaj tiv thaiv kab mob dermatological: tiv tauj dermatitis, urticaria, tawm pob.
- Lwm cov tsos mob: tej zaum yuav muaj cov tsos mob ntawm kev ua txhaum ntawm kev mob tshwm sim los ntawm kev raug rau corticosteroids (suav nrog nce adrenal ua haujlwm). Qee zaum, muaj qhov tshwm sim ntawm hemorrhages ntawm daim tawv nqaij, khaus.
YContraindications
tshuaj npaj "Pulmicort" yog contraindicated rau siv nyob rau hauv xws li mob:
- qis dua 6 lub hlis;
- siab rhiab heev rau budesonide.
Cov neeg mob yuav tsum tau saib xyuas kom zoo (siv cov tshuaj nrog ceev faj) yog tias lawv muaj cov kab mob ntsws ntsws, cov kab mob fungal, kab mob, kab mob ua pa, mob siab rau daim siab.
Thaum siv, qhov ua tau zoo ntawm cov tshuaj corticosteroids yuav tsum raug coj mus rau hauv tus account.
Thaum cev xeeb tub thiab lactation
Kev soj ntsuam ntawm cov neeg mob cev xeeb tub uas tau noj budesonide ua ib feem ntawm cov tshuaj "Pulmicort" tsis tau qhia txog qhov tshwm sim ntawm qhov tsis zoo ntawm tus menyuam hauv plab, tab sis qhov kev pheej hmoo ntawm lawv qhov tshwm sim tsis tuaj yeem txiav tawm. Yog li ntawd, hauvThaum cev xeeb tub, nws raug pom zoo kom siv qhov tsawg kawg nkaus ntawm cov tshuaj.
Budesonide nkag mus rau hauv niam cov kua mis, txawm li cas los xij, thaum siv Pulmicort hauv cov tshuaj kho mob, tsis muaj kev cuam tshuam rau tus menyuam, yog li cov tshuaj raug tso cai siv thaum pub niam mis.
Special Recommendations
Yuav kom txo qis qhov tshwm sim ntawm tus kab mob fungal ntawm lub pharynx, tus neeg mob yuav tsum tau qhia kom yaug qhov ncauj kom huv si tom qab txhua qhov nqus tau pa. Ntxuav koj lub ntsej muag kom tsis txhob khaus tawv nqaij.
Kev siv budesonide nrog itraconazole, ketoconazole thiab lwm yam CYP3A4 inhibitors yuav tsum zam. Yog tias qhov kev sib xyaw ua ke no tsim nyog, nws raug pom zoo kom nce lub sijhawm ntawm cov tshuaj mus rau qhov siab tshaj plaws.
Vim qhov muaj feem cuam tshuam ntawm kev ua haujlwm adrenal tsis txaus, yuav tsum tau them nyiaj tshwj xeeb rau cov neeg mob uas tau hloov los ntawm kev noj cov tshuaj corticosteroids rau kev noj Pulmicort. Tsis tas li ntawd, yuav tsum tau saib xyuas tshwj xeeb rau cov neeg mob uas tau noj cov tshuaj corticosteroids siab lossis tau txais kev nqus tau siab tshaj plaws ntawm corticosteroids ntev. Thaum muaj kev ntxhov siab, cov neeg no tuaj yeem pom cov tsos mob ntawm adrenal tsis txaus. Nyob rau hauv cov xwm txheej ntawm kev cuam tshuam kev phais, cov neeg mob zoo li no raug pom zoo kom mus kho ntxiv nrog cov kab mob corticosteroids.
Nyob hauv tus txheej txheem ntawm kev hloov ntawm qhov ncauj corticosteroids mus rau Pulmicort, cov neeg mob yuav ntsib cov tsos mob yav dhau los, xws li mob pob qij txha thiab mob leeg. Hauv cov xwm txheej zoo li no, nws yuav tsim nyognce ib ntus ntawm cov tshuaj corticosteroids rau kev siv sab hauv. Qee zaum, cov tsos mob xws li mob taub hau, qaug zog, ntuav thiab xeev siab tuaj yeem tshwm sim, qhia tias GCS tsis txaus. Nws tseem tuaj yeem ua rau mob rhinitis thiab eczema uas twb muaj lawm, kev tsis haum tshuaj uas yav tas los raug tshem tawm los ntawm cov tshuaj hauv lub cev.
Dab tsi yog "Pulmicort" rau kev nqus pa rau cov menyuam raws li cov lus qhia?
Kev siv menyuam yaus
Cov tub ntxhais hluas thiab cov menyuam yaus tau txais kev kho mob corticosteroid (hauv txhua daim ntawv) rau lub sijhawm ntev, kev saib xyuas kev loj hlob tsis tu ncua yog pom zoo. Thaum siv GCS, nws yog ib qho tsim nyog los ntsuas qhov piv ntawm cov txiaj ntsig ntawm kev siv cov tshuaj no thiab qhov muaj feem cuam tshuam ntawm kev loj hlob qeeb hauv tus menyuam.
Kev teem sijhawm ntawm budesonide ntawm qhov ntau npaum li 400 mcg / hnub hauv cov menyuam yaus tom qab 3 xyoos, raws li cov ntaub ntawv txheeb cais, tsis tau ua rau muaj kev cuam tshuam hauv lub cev. Biochemical cov cim qhia txog kev ua haujlwm ntawm cov tshuaj tuaj yeem tshwm sim thaum nws siv ntawm koob tshuaj 400 txog 800 mcg / hnub. Nrog rau qhov nce ntawm qhov koob tshuaj no, cov teebmeem hauv lub cev muaj ntau heev.
Kev siv corticosteroids rau kev kho mob bronchial hawb pob tuaj yeem ua rau dysplasia. Cov txiaj ntsig ntawm ntau qhov kev soj ntsuam ntawm cov tub ntxhais hluas thiab cov menyuam yaus uas tau txais budesonide ntev (txog 11 xyoos) tau ua pov thawj tias kev loj hlob mus txog qhov kev xav tau rau cov neeg laus. Cov lus qhia rau "Pulmicort" yuav tsum nruj me ntsis saib.
cuam tshuam raumuaj peev xwm tsav tsheb thiab cov txheej txheem txaus ntshai
Cov tshuaj tsis cuam tshuam rau kev muaj peev xwm tsav tsheb thiab lwm yam kev ua haujlwm nyuaj. Qhov tseem ceeb tshaj plaws yog kom paub ua ntej tias Pulmicort tuaj yeem noj ntau npaum li cas hauv ib hnub.
Cov tsos mob ntau dhau
Nrog kev siv tshuaj ntau dhau, cov tsos mob tshwm sim feem ntau tsis pom.
Nrog rau kev ua kom nqus tau ntev ntawm cov tshuaj ntawm koob tshuaj ntau dua li kev pom zoo, cov teebmeem dav dav ntawm corticosteroids tuaj yeem txhim kho nyob rau hauv daim ntawv ntawm kev ua haujlwm ntawm adrenal ua haujlwm thiab hypercortisolism.
Kev Sib Tham Tshuaj
Tsis muaj kev cuam tshuam ntawm budesonide hauv Pulmicort rau cov neeg laus thiab menyuam yaus nrog lwm cov tshuaj siv los kho mob hawb pob bronchial.
Thaum noj concomitantly, ketoconazole (ntawm ib koob ntawm 200 mg ib hnub twg) tuaj yeem ua rau kom cov ntshav plasma concentration ntawm budesonide los ntawm qhov nruab nrab ntawm 6 zaug. Thaum lub sijhawm siv ketoconazole 12 teev tom qab budesonide, qib tom kawg hauv cov ntshav nce ntxiv los ntawm qhov nruab nrab ntawm 3 zaug. Yog tias tsim nyog yuav tsum noj budesonide thiab ketoconazole ib txhij, lub sijhawm luv ntawm kev noj cov tshuaj no yuav tsum tau nce mus rau qhov siab tshaj plaws. Kev txiav txim siab yuav tsum tau muab los txo cov koob tshuaj budesonide.
Itraconazole, lwm qhov muaj peev xwm inhibitor ntawm CYP3A4, kuj tseem ua rau cov ntshav plasma ntau ntxiv ntawm budesonide. Kev nqus pa ua ntej ntawm beta-adrenergic stimulants pab txhawb kev nthuav dav ntawm bronchi, txhim kho kev nkag mus ntawm budesonide mus rau hauv lub ntsws thiab.txhim kho nws txoj kev kho mob.
Phenytoin, phenobarbital, rifampicin, thaum siv ua ke, tuaj yeem txo cov txiaj ntsig ntawm Pulmicort, vim yog induction ntawm microsomal oxidation enzymes.
Estrogens thiab methandrostenolone txhim kho cov teebmeem ntawm budesonide.
Storage rules
Tus neeg sawv cev tshuaj no yuav tsum khaws cia ntawm qhov kub tsis tshaj 30 ° C, tawm ntawm cov menyuam yaus. Lub txee lub neej ntawm Pulmicort yog 2 xyoos. Tom qab qhib lub hnab ntawv laminated, cov thawv ntim hauv nws yuav tsum siv li ntawm 3 lub hlis. Cov thawv ntim tau khaws cia rau hauv ib lub hnab ntawv los tiv thaiv tshav ntuj. Lub thawv qhib yog siv li ntawm 12 teev.
Thaum xaiv cov analogues, nws yog ib qho tseem ceeb kom nkag siab tias cov lus qhia rau kev siv "Pulmicort", tus nqi thiab kev tshuaj xyuas cov tshuaj ntawm cov tshuaj zoo sib xws tsis siv. Nws yog ib qho tseem ceeb uas yuav tau mus ntsib kws kho mob thiab tsis txhob hloov cov tshuaj koj tus kheej.
Tus nqi hauv khw muag tshuaj yog li ntawm 812 txog 1200 rubles.
Analogues
Cov tshuaj hauv qab no tuaj yeem siv los ua analogues ntawm cov tshuaj "Pulmicort":
- "Benacort" - tshuaj raws li budesonide, uas muaj nyob rau hauv daim ntawv ntawm cov tshuaj thiab hmoov rau nqus tau pa. Qhov no analogue yog muab rau bronchial hawb pob raws li lub ntsiab tshuaj tiv thaiv. Cov koob tshuaj yog teem rau tus kheej los ntawm tus kws kho mob. Kev kho mob nrog tus neeg sawv cev no pib ntawm lub sijhawm ruaj khov ntawm cov txheej txheem pathological. Thawj 2-3 lub lis piaminhalations yog nqa tawm tawm tsam keeb kwm ntawm kev noj tshuaj hormonal. Rau cov menyuam yaus, cov tshuaj "Benacort" yog contraindicated. Cov tshuaj no muaj txiaj ntsig zoo ib yam, tsuas yog siv tau txij li hnub nyoog kaum rau.
- "Berodual" yog ib qho tshuaj uas siv tau los ua ib qho analogue ntawm "Pulmicort" hauv kev kho mob bronchial hawb pob thiab mob bronchitis. Cov khoom xyaw tseem ceeb yog ipratropium bromide thiab fenoterol hydrobromide. Cov tshuaj yog tsim los ua kua rau inhalation. "Berodual" yog ib qho pheej yig dua analogue ntawm "Pulmicort", thiab tuaj yeem muab tshuaj rau cov menyuam yaus hnub nyoog 6 xyoos.
- Budenitis Steri-Neb yog cov tshuaj glucocorticosteroid npaj rau cov txheej txheem nqus pa. Cov tshuaj no muaj anti-exudative, anti-inflammatory thiab anti-allergic zog. Cov tshuaj yog ua raws li cov tshuaj nquag budesonide. Cov tshuaj muaj nyob rau hauv daim ntawv ntawm ib tug tsis muaj ntxhiab tsw thiab yuav siv tau rau cov me nyuam los ntawm 6 lub hlis.
Reviews
Cov kws kho mob qhia cov tshuaj no yog cov tshuaj niaj hnub zoo rau ntau yam hnoos. Nws yog siv tsis tau tsuas yog tshem tawm cov mob hawb pob, tab sis nyob rau hauv kev kho mob ntawm pathologies xws li laryngitis, pharyngitis, thaum muaj kev hem thawj ntawm tsim ib tug cuav croup. Qhov no yog qhov tseeb tshwj xeeb tshaj yog rau cov menyuam yaus, thiab qhov txiaj ntsig tseem ceeb ntawm cov tshuaj no, raws li cov kws kho mob, yog qhov ua tau ntawm nws txoj kev siv thaum yau.
Cov neeg mob uas siv Pulmicort rau hnoos nco ntsoov tias cov tshuaj no pab lawv zoo, sai sai nres qhov mob hawb pob, nws yooj yim.hauv kev siv. Cov tshuaj yog kim heev, raws li cov neeg mob, tab sis zoo heev.
Peb tau tshuaj xyuas cov tshuaj muaj pes tsawg leeg rau kev nqus pa "Pulmicort" thiab cov lus qhia rau nws. Peb cia siab tias cov ntaub ntawv muab yuav muaj txiaj ntsig rau koj.
