Rau cov neeg muaj mob los ntawm cov pob txha, pob qij txha thiab cov leeg, cov kws kho mob feem ntau muab Nimid (cov ntsiav tshuaj) ua cov tsos mob. Cov lus qhia rau kev siv muaj cov ntaub ntawv hais tias cov tshuaj no tsis tsuas yog txo qhov mob, tab sis kuj muaj cov nyhuv anti-inflammatory. Cia peb sim kawm cov yam ntxwv ntawm cov tshuaj kom ntxaws ntxiv thiab txheeb xyuas qhov xwm txheej twg nws tuaj yeem pab tau.
Cov tshuaj thiab lawv cov muaj pes tsawg leeg
Raws li cov ntaub ntawv ntawm cov tshuaj, hnub no koj tuaj yeem yuav cov ntsiav tshuaj, ncua kev kawm, granules thiab gel hauv khw muag tshuaj. Lub ntsiab active ingredient ntawm lawv yog nimesulide. Cov ntsiav tshuaj daim ntawv ntawm cov tshuaj muaj nyob rau hauv hlwv ntawm 10 pcs. Ib ntsiav tshuaj muaj 100 mg ntawm nimesulide, thiab cov kws muag tshuaj tau siv cov microcrystalline cellulose, sodium stearate, sodium croscarmellose thiab aerosil 200 ua cov khoom pabcuam.(cov ntsiav tshuaj) cov lus qhia rau kev siv.
Cov hmoov muaj nyob hauv cov hnab ntim tshuaj. Daim ntawv no ntawm cov tshuaj yog yooj yim siv rau kev kho mob ntawm cov me nyuam. Tseeb, ntxiv rau nimesulide, povidone K-30, tabletose 80 thiab aerosil 200, muaj pes tsawg leeg muaj xws li cov khoom siv xws li sodium saccharin, citric acid thiab flavors. Tus me nyuam yuav zoo siab haus cov khoom qab zib "cocktail" npaj los ntawm nws niam nws txiv.
1 ml ntawm kev ncua thiab 1 g ntawm gel muaj 100 mg ntawm nimesulide. Cov khoom pabcuam hauv ob daim ntawv no yog propylene glycol, sodium hydroxide, carbomer 940, disodium edelate, tshuaj tsw qab, dej huv thiab methylparaben.
Pharmacological kev txiav txim ntawm cov tshuaj
Nimesulide, uas yog cov tshuaj nquag ntawm cov tshuaj no, belongs rau pawg ntawm non-steroidal anti-inflammatory sulfonanilides. Ib zaug nyob rau hauv tib neeg lub cev, nws xaiv inhibits COX-2 thiab suppresses lub synthesis ntawm prostaglandins nyob rau hauv lub tsom xam ntawm lub inflammatory txheej txheem. Analgesic, antipyretic thiab anti-inflammatory nyhuv yog tiav tom qab noj ib ntsiav tshuaj "Nimide". Cov lus qhia rau kev siv muaj cov lus qhia ntxiv txog kev siv tshuaj.
Ntxiv rau tag nrho cov saum toj no, cov tshuaj muaj peev xwm inhibit qhov tso tawm ntawm oxygen dawb radicals thiab inhibit qhov tso tawm ntawm myeloperoxidase, thaum tsis cuam tshuam rau cov txheej txheem ntawm phagocytosis thiab chemotaxis.
Raws li cov tshuaj tiv thaiv kab mob, nws tau ua tiav vim muaj peev xwm ntawm nimesulideinhibit tus neeg nruab nrab ntawm cov txheej txheem inflammatory thiab txo cov qog necrosis yam. Los ntawm inhibiting cov synthesis ntawm interleukin-6 thiab urokinase, Nimid npaj (qhia rau kev siv paub tseeb tias qhov tseeb) tiv thaiv kev puas tsuaj ntawm proteoglycans thiab collagen nyob rau hauv cov pob txha mos. Tsis tas li ntawd, nimesulide thaiv qhov kev ua ntawm qhov mob impulses los ntawm qhov nociceptive system.
Yog tias peb xav txog cov txheej txheem ntawm kev ua kom tsis zoo, nws cuam tshuam nrog inhibition ntawm kev tso tawm ntawm histamine los ntawm ntau lub hlwb mast thiab cov nyhuv ntawm cov tshuaj nquag ntawm glucocorticosteroid receptors.
Yog tus kws kho mob tau sau tshuaj Nimid (cov ntsiav tshuaj), cov lus qhia rau kev siv yuav tsum tau ua tib zoo kawm txawm tias ua ntej noj cov tshuaj. Tom qab tag nrho, daim ntawv no muaj cov lus pom zoo uas yuav tsum tau coj mus rau hauv tus account thoob plaws hauv txoj kev kho.
YPharmacokinetics
Tom qab noj cov tshuaj pom zoo, cov tshuaj tau nquag nqus los ntawm txoj hnyuv. Thiab tom qab 1.5-2.5 teev, qhov siab tshaj plaws ntawm cov tshuaj nquag hauv cov ntshav ntshav tau sau tseg. Ib tug yam ntxwv feature ntawm cov tshuaj yog nws muaj peev xwm mus cuam tshuam nrog cov proteins, raws li zoo raws li nkag mus rau hauv cov ntshav-hlwb hlwb thiab hematoplacental teeb meem. Nyob rau hauv siab concentrations, nimesulide yog txiav txim nyob rau hauv lub tsom xam ntawm lub inflammatory txheej txheem thiab nyob rau hauv lub synovial kua.
Cov tshuaj yog metabolized nyob rau hauv daim siab, ces, feem ntau nyob rau hauv lub unchanged daim ntawv ntawm active metabolites, nws yog excreted los ntawm ob lub raum (nrog rau cov zis), tsawg - nrog quav. Ib nrab-lub neej ntawm cov active tshuajua tiav hauv 3.5-5 teev. Muaj cov ntaub ntawv tshuaj pharmacokinetic ntau ntxiv ntawm cov tshuaj "Nimide" cov lus qhia rau kev siv.
Kev qhia
tshuaj zoo rau ua npaws, uas nrog cov kab mob ntawm cov kab mob ENT thiab cov kab mob ua pa sab saud. Feem ntau, cov tshuaj tau muab rau cov neeg uas muaj mob rheumatoid mob caj dab, myalgia, osteoarthritis, bursitis, tendinitis, thiab lwm yam kab mob ntawm cov leeg, pob qij txha thiab pob txha, nrog rau qhov mob. Hauv kev kho hniav thiab gynecological, rau kev mob tom qab phais thiab tom qab mob rheumatic, cov tshuaj Nimid kuj tau siv. Cov lus qhia rau kev siv hauv cov xwm txheej zoo li no pom zoo yuav cov ntsiav tshuaj, hmoov lossis granules.
Raws li cov tshuaj nyob rau hauv daim ntawv ntawm ib tug gel, nws yog npaj rau tshuaj pleev ib ce rau o ntawm cov ntaub so ntswg (mos), uas yog tshwm sim los ntawm ntau yam kev raug mob. Cov kev kho mob kuj tseem siv tau rau cov txheej txheem inflammatory thiab degenerative kab mob ntawm cov musculoskeletal system, osteoarthritis, Bechterew tus kab mob, thiab lwm yam
Kev txais tos thiab kev noj tshuaj
Yog tias peb tab tom tham txog kev noj tshuaj hauv cov ntsiav tshuaj, kev ncua, ces koj yuav tsum siv nws tsuas yog tom qab noj mov. Nws yog ntshaw tias tsawg kawg 20 feeb dhau los tom qab noj mov, txwv tsis pub cov tshuaj pharmacokinetic ntawm nimesulide qeeb. Raws li qhov ntau npaum ntawm cov tshuaj thiab lub sijhawm ntawm kev kho mob, cov lus nug noTus kws kho mob tuaj koom yuav tsum teb ncaj qha, suav nrog tus kheej tus yam ntxwv ntawm tus neeg mob thiab qhov hnyav ntawm tus kab mob. Yog li ntawd, peb yuav txiav txim siab tsuas yog cov lus qhia dav dav uas cov lus qhia rau kev siv muaj txog cov tshuaj Nimid.
ntsiav tshuaj rau cov neeg laus feem ntau yog muab ob zaug ib hnub rau 100 mg. Nyob rau hauv cov ntaub ntawv hnyav ntawm tus kab mob, koob tshuaj txhua hnub tuaj yeem ua ob npaug. Cov tub ntxhais hluas hnub nyoog 12 txog 18 xyoo raug pom zoo kom suav cov tshuaj noj ntawm tus nqi ntawm 1.5 mg rau 1 kg ntawm lub cev hnyav. Yog tias yuav tsum tau kho tus menyuam yaus hnub nyoog qis dua 12 xyoos, thiab nws qhov hnyav tshaj 40 kg, nws raug muab 100 mg ntawm cov tshuaj ib hnub, faib tus nqi ua ob koob. Hauv cov xwm txheej tshwj xeeb, tus kws kho mob tuaj yeem nce qhov koob tshuaj pom zoo.
Cov khoom lag luam hauv daim ntawv granules yog tshuaj rau cov menyuam yaus hnub nyoog 12 xyoos thiab cov laus, 1 sachet thaum sawv ntxov thiab yav tsaus ntuj. Cov ntsiab lus ntawm lub hnab yog diluted hauv 100 ml ntawm dej sov thiab haus dej haus tom qab noj mov.
Raws li rau Nimid gel, nws yog siv (tsis muaj rub) hauv ib txheej nyias - tsis pub ntau tshaj 4 zaug hauv ib hnub - mus rau thaj tsam ntawm lub cev nrog cov tsos mob tshwm sim tshaj plaws. Tom qab siv tshuaj, ntxuav koj txhais tes kom huv si nrog xab npum thiab dej ntws.
leej twg yog tshuaj contraindicated rau?
Tsis txhob muab tshuaj rau cov neeg uas muaj kab mob peptic, mob hnyav hauv daim siab thiab lub raum, nrog rau keeb kwm ntawm cov tshuaj tiv thaiv hepatotoxic rau nimesulide. Cov tshuaj yog categorically contraindicated nrog ib tug nyiam rau ntau yam los ntshav, lub plawv tsis ua hauj lwm thiab hypersensitivity rau ib los yog ntau yam ntawm cov tshuaj Nimid Forte. Cov lus qhia raudaim ntawv thov kuj muaj cov ntaub ntawv hais txog kev txwv tsis pub siv cov tshuaj ua ke nrog cov tshuaj muaj peev xwm ua rau hepatotoxic, ua npaws, zoo li mob khaub thuas thiab xav tias mob hnyav rau kev phais mob.
Raws li cov khoom lag luam hauv daim ntawv gel, nws tsis raug tshuaj rau cov neeg mob hnub nyoog qis dua 12 xyoos thiab cov neeg muaj kev fab tshuaj. Kev siv cov tshuaj tuaj yeem ua rau cov kab mob ua rau mob dermatitis, kab mob ntawm daim tawv nqaij thiab kab mob, nrog rau kev mob ntsws asthma, uas tshwm sim los ntawm ASA. Yog li ntawd, nrog rau cov kab mob saum toj no, cov tshuaj Nimid tsis tau sau tseg. Cov lus qhia rau kev siv cov tshuaj nyob rau hauv xws li mob kuj tsis pom zoo siv nws.
Kuv puas noj tshuaj thaum cev xeeb tub?
Cov kws tshawb fawb tau pom tias nisumelide tuaj yeem cuam tshuam rau kev xeeb tub. Tsis tas li ntawd, nws inhibits prostaglandin synthesis, uas paub tias yog ua rau oligohydramnios, pulmonary hypertension, oliguria, thiab ntxov ntxov ua rau ntawm Batal duct. Kev pheej hmoo ntawm kev ua haujlwm tsis muaj zog, qhov tshwm sim ntawm peripheral edema thiab los ntshav yuav nce ntxiv thaum siv cov tshuaj Nimid. Cov lus qhia rau kev siv cov ntsiav tshuaj thiab lwm hom tshuaj yog txwv tsis pub nruj me ntsis thaum cev xeeb tub thiab lactation.
Tom qab tag nrho, cov tshuaj nquag, ua ke nrog cov kua mis, tuaj yeem nkag mus rau tus menyuam lub cev thiab cuam tshuam kev ua haujlwm ntawm nws lub cev tseem ceeb. Hauv cov xwm txheej uas nws tsis tuaj yeem ua yam tsis muaj tshuaj, thiab cov txiaj ntsig zoo rau leej niam tshaj qhov kev pheej hmooua rau muaj kev phom sij rau tus menyuam, qhov ntau npaum li cas thiab kev kho mob yog txiav txim los ntawm tus kws kho mob.
Side effects
Ntxiv rau qhov loj ntawm cov yam ntxwv zoo tshuaj, cov tshuaj kuj muaj cov npe zoo ntawm cov kev mob tshwm sim. Yog li, cia saib dab tsi tshwm sim tuaj yeem tshwm sim thaum siv Nimid. Cov ntsiav tshuaj (cov lus qhia hauv Lavxias muab cov ntaub ntawv no) tuaj yeem ua rau khaus, urticaria, ntau daim tawv nqaij ua pob, angioedema, thiab qee zaum txawm tias Stevens-Johnson syndrome thiab epidermal necrolysis. Lub plab zom mov tuaj yeem, dhau los, teb rau cov tshuaj nrog cem quav, raws plab, qee zaum cov neeg mob ntsib qhov mob hauv plab, xeev siab. Tsis tshua muaj heev, noj tshuaj tuaj yeem ua rau perforation ntawm rwj thiab peptic rwj ntawm lub plab thiab duodenum.
Txij li cov txheej txheem ntawm cov metabolism hauv lub siab, nws kuj raug kev txom nyem los ntawm nws. Yog li ntawd, kev siv tshuaj ntev ntev hauv qee kis tuaj yeem ua rau muaj kev hloov pauv hauv kev ua haujlwm ntawm transaminases, cholestasis, kev loj hlob ntawm jaundice thiab txawm mob siab. Tib yam kab mob hauv daim siab yog tshwm sim tsis tau tsuas yog los ntawm cov ntsiav tshuaj thiab granules, tab sis kuj los ntawm Nimid hmoov.
Cov lus qhia tshwj xeeb piav qhia txog qhov tshwm sim ntawm cov kab mob genitourinary thaum noj cov tshuaj. Nws tuaj yeem yog ob qho tib si edema, dysuria, tso zis, thiab oliguria, mob raum tsis ua haujlwm, interstitial nephritis. Ntawm ib feem ntawm txoj kev ua pa, dyspnea thiab bronchospasm yog ua tau, kev siv mus sij hawm ntev tuaj yeem ua rau kev loj hlob ntawm bronchial hawb pob.
Ntxiv rau cov teebmeem saum toj no,Tus neeg mob yuav tsim tachycardia, arterial hypertension, hypothermia, asthenia thiab lwm yam kab mob. Nyob rau hauv yuav luag tag nrho cov kev phiv tshwm sim, nws raug nquahu kom nres cov tshuaj thiab tam sim ntawd mus ntsib kws kho mob. Txhawm rau kom tsis txhob muaj qhov xwm txheej zoo li no, nws yog ib qho tsim nyog yuav tsum ua tib zoo kawm tag nrho cov ntaub ntawv hais txog cov tshuaj thiab tsuas yog tom qab ntawd noj Nimid Forte (cov ntsiav tshuaj). Cov lus qhia rau kev siv, uas yog nyob rau hauv txhua lub pob ntawm cov tshuaj, yuav pab nrog qhov no.
Drug overdose thiab first aid algorithm
Yog tias cov tshuaj tau tso cai dhau lawm, koj yuav tsum mus tom tsev kho mob tam sim ntawd. Tom qab tag nrho, qhov tshwm sim ntawm qhov ua yuam kev no tuaj yeem ua rau qaug zog, xeev siab, ntuav, mob hauv espigastria, apathy, thiab nce ntshav siab. Thiab qhov no yog ib daim ntawv teev npe ntawm tsuas yog qhov mob me tshaj plaws ntawm lub cev rau kev nce koob tshuaj Nimid. Ntsiav tshuaj - cov lus qhia ceeb toom txog qhov no - noj nyob rau hauv ib tug npaum li ntawm 2-3 daim saum toj no cov cai, tuaj yeem ua rau los ntshav, thiab tseem ua rau lub raum tsis ua haujlwm. Hauv kev xyaum kho mob, tsis tshua muaj tshwm sim ntawm cov tshuaj tiv thaiv anaphylactoid, kev nyuaj siab ua pa thiab coma vim kev siv tshuaj ntau dhau ntawm cov tshuaj no txawm raug kaw.
Yog tias cov koob tshuaj tso cai tau dhau lawm, nws tsis tsim nyog tos rau kev kuaj mob tshwm sim. Nws yog ib qho tsim nyog los ntxuav lub plab tam sim ntawd, noj cov tshuaj osmotic laxative thiab enterosorbents. Nws raug nquahu kom mus rau tom tsev kho mob tom qab cov kev ntsuas saum toj no, uas cov kws kho mob tshwj xeeb yuav kho cov tsos mob mus ntxiv. Nws yog tsim nyog sau cia tias tam sim no tsis muaj tshuaj tiv thaiv tshwj xeeb.
Cov neeg mob xav li cas txog tshuaj?
Tau kawg, hauv cov kab mob uas muaj mob hnyav, yuav luag txhua tus neeg mob hais lus zoo ntawm cov tshuaj uas peb tab tom xav txog. Lawv nco ntsoov tias cov nyhuv ntawm kev siv cov tshuaj tshwm sim sai heev, uas yog xov xwm zoo. Cov lus sib txawv tuaj yeem hnov thaum cov neeg mob tau txais kev kho mob ntev nrog Nimid. Cov ntsiav tshuaj (cov lus qhia pom zoo kom ua tib zoo saib xyuas cov cuab yeej tshuaj no ntawm cov tshuaj) sai sai txo qhov mob, tab sis tom qab ob peb hnub ntawm kev noj, cov kev mob tshwm sim ua rau lawv tus kheej hnov. Thawj qhov tshwm sim rau nimesulide yog lub plab zom mov, tom qab ntawd lub paj hlwb (qhov no tshwm sim los ntawm kev chim siab, hloov pauv sai ntawm lub siab thiab nyiam ua rau tsis xis nyob).
Tau kawg, nws tsis tuaj yeem hais categorically tias cov tshuaj ua rau muaj kev phom sij ntau dua li qhov zoo. Tom qab tag nrho, nws yeej pab tau. Tab sis nws tsis pom zoo kom coj nws yam tsis muaj kev qhia thiab teem caij ntawm tus kws tshaj lij.
Yog tias, tom qab cov ntaub ntawv saum toj no, muaj kev tsis ntseeg txog seb puas yuav Nimid (cov ntsiav tshuaj), cov lus qhia, kev tshuaj xyuas tus neeg mob thiab kev sab laj nrog tus kws kho mob tuaj koom yuav pab koj txiav txim siab yog.
