Ib tus neeg sawv cev ntawm pab pawg ntawm cov tshuaj uas tsis yog-steroidal anti-inflammatory yog cov tshuaj "Indomethacin" (cov ntsiav tshuaj). Vim nws cov tshuaj tiv thaiv kab mob, tshuaj tua kab mob thiab tshuaj tua kab mob, nws yog siv los kho cov kab mob inflammatory, tshem tawm qhov mob, txo qhov o thiab rov ua kom sib koom ua ke.
Kev piav qhia
Lub ntsiab active ingredient ntawm cov tshuaj yog indomethacin, uas belongs rau lub derivatives ntawm indoleacetic acid. Cov lus qhia piav qhia txog cov ntsiav tshuaj nyob rau hauv lub pob ntawm cov tshuaj "Indomethacin" raws li cov ntsiab lus nrog ib tug tiv thaiv enteric txheej, uas tso cai rau cov active tshuaj tso tawm nyob rau hauv txoj hnyuv, bypassing lub plab. Cov ntsiav tshuaj yog puag ncig, biconvex nyob rau hauv cov duab, npog nrog lub teeb xim av plhaub rau saum.
ntsiav tshuaj tuaj nyob rau hauv ntau npaum li cas: 25 mg, 50 mg thiab 100 mg ntawm indomethacin. Muaj nyob rau hauv pob ntawm 10 lossis 40.
Txhua daim foos tshuaj
Tsuasntsiav tshuaj, muaj lwm hom tshuaj "Indomethacin" rau kev siv ntawm qhov ncauj, piv txwv li, tshuaj ntsiav nrog kev ua haujlwm ntev nrog kev noj tshuaj ntawm 75 mg. Rau kev tswj hwm qhov quav, suppositories nrog koob tshuaj 50 mg yog siv. Rau kev siv sab nraud, tshuaj pleev 5% thiab 10% thiab gel 3% raug tsim.
Mechanism of action
Cov tshuaj yog cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj uas muaj cov tshuaj tiv thaiv, decongestant, analgesic thiab antipyretic teebmeem. Cov lus qhia txuas nrog rau cov tshuaj "Indomethacin" (cov ntsiav tshuaj) muaj cov lus piav qhia ntawm cov txheej txheem ntawm kev ua haujlwm ntawm nws cov khoom nquag, cuam tshuam nrog kev txo qis hauv cyclooxygenase kev ua ntawm hom 1 thiab 2. Nyob rau hauv lem, cov enzyme no muaj tsawg dua cov nyhuv ntawm arachidonic acid, uas txo nws cov hloov mus rau prostaglandins. Nws yog cov tshuaj no ua rau mob thiab mob.
Indomethacin muaj cov nyhuv antiplatelet, txo qis cov ntshav platelets. Cov tshuaj no pab txo qhov mob ntawm kev sib koom ua ke hauv lub xeev ntsiag to thiab txawb, txo cov tawv nqaij thaum sawv ntxov thiab o, ua kom muaj zog ntau ntxiv.
Qhov kev txiav txim ntawm indomethacin yog txhawm rau txo qhov mob. Cov nyhuv no tshwm sim ntau tshaj plaws nyob rau hnub xya ntawm kev kho mob nrog cov tshuaj ntsiav tshuaj.
Nyob zoo
Raws li cov txheej txheem ntawm kev ua, Indomethacin ntsiav tshuaj cov lus qhia rau kev siv qhia siv rau kev kho mob:
- articular syndrome;
- kab mob inflammatory ntawm musculoskeletal system tshwm sim los ntawmrheumatic, psoriatic, rheumatoid, juvenile mob caj dab, humeroscapular periarthritis, ankylosing spondylitis, kev puas tsuaj nrog osteitis deformans thiab urethrooculosynovial syndrome;
- degenerative kab mob ntawm cov musculoskeletal system tshwm sim los ntawm osteochondrosis nyob rau hauv radicular syndrome, deforming osteoarthritis ntawm cov pob qij txha, tsis suav nrog hip thiab intervertebral arthrosis;
- diffuse kab mob cuam tshuam nrog cov ntaub so ntswg;
- rheumatism;
- purulent inflammatory lesions ntawm periarticular bursa thiab tendons;
- mob mob hauv qab nraub qaum thiab lwm qhov chaw ntawm tus txha nraub qaum nrog neuralgia ntawm sciatic thiab lwm cov hlab ntsha, cov leeg mob;
- mob o ntawm cov nqaij mos lossis pob qij txha.
Nws tuaj yeem siv los daws qhov mob taub hau, mob plab, mob hniav, algomenorrhea.
Raws li cov tshuaj tiv thaiv kab mob sib kis thiab mob xws li pharyngitis, tonsillitis, otitis media, tshuaj "Indomethacin" (cov ntsiav tshuaj) yog siv. Cov lus qhia rau kev siv suav nrog kev kho mob cystitis, adnexitis, prostatitis.
Cov tshuaj no muaj txiaj ntsig zoo rau kev txo cov mob febrile cuam tshuam nrog lymphogranulomatosis, lymphoma, qog metastases, thaum paracetamol thiab acetylsalicylic acid tsis ua haujlwm.
Yuav ua li cas thiaj yog
Cov tshuaj "Indomethacin" hauv cov ntsiav tshuaj tau muab rau tus neeg mob hauv ib koob lossis lwm qhov raws li qib ntawm tus kabmob. Cov neeg laus feem ntau pib nrog koob tshuaj 25 mg peb zaug ib hnub.ib hnub tom qab noj mov.
Yog tias cov txiaj ntsig ntawm kev kho mob tsis txaus, qhov koob tshuaj yog ob npaug rau 50 mg 3 zaug hauv ib hnub. Qhov siab tshaj plaws koob tshuaj yuav tsum tsis pub tshaj 200 mg ntawm indomethacin. Tom qab kev txhim kho pom tau zoo los ntawm kev kho tshuaj, kev kho mob tsuas yog nres tom qab 4 lub lis piam, siv tib yam lossis txo cov koob tshuaj thaum lub sijhawm no. Yog tias cov neeg mob noj cov ntsiav tshuaj Indomethacin ntev, cov lus qhia rau kev siv pom zoo kom siv ib koob tshuaj tsis pub ntau tshaj 75 mg ntawm cov tshuaj nquag ib hnub.
Kev kho me nyuam
Rau tus menyuam, koob tshuaj txhua hnub yog xam los ntawm kev muab 2, 5 lossis 3 mg los ntawm nws lub cev hnyav, nws tau noj 3-4 zaug. Rau txhua pawg hnub nyoog, kev siv thawj koob tshuaj txhua hnub yog muab:
- Cov menyuam yaus hnub nyoog 3 txog 7 tau muab tshuaj 50mg txog 75mg, sib npaug rau 2 lossis 3 ntsiav tshuaj;
- cov menyuam yaus hnub nyoog 7 txog 12 xyoos raug tshuaj los ntawm 75 mg rau 100 mg, uas sib haum rau 3 lossis 4 ntsiav tshuaj;
- cov menyuam yaus hnub nyoog 12 xyoos raug tshuaj los ntawm 100 mg txog 125 mg, uas sib haum rau 4 lossis 5 ntsiav tshuaj.
Thawj ob peb hnub, koj yuav tsum paub seb cov tshuaj ua haujlwm li cas ntawm tus menyuam lub cev, yog li siv tshuaj me me. Lub sijhawm ntawm kev kho mob nrog cov tshuaj "Indomethacin" (cov ntsiav tshuaj) yog qhia los ntawm kev qhia raws li lub sijhawm ntawm 6 mus rau 7 hnub.
Reception nta
Vim muaj peev xwm ua rau muaj kev phom sij los ntawm kev noj cov tshuaj Indomethacin, nws yog qhov zoo tshaj plaws tsis txhob siv nws los kho tus mob rheumatic kub taub hau thaum yau. Nkag mus rau hauv cov kua mis, cov tshuaj nquag nkag mus rau hauvtus me nyuam cov ntshav, txhim khu lub cev nqaij daim tawv jaundice ntawm tus me nyuam thiab kev puas tsuaj rau daim siab hlwb. Txhawm rau tiv thaiv qhov no, lawv tso tseg kev pub niam mis.
kab mob. Nws yog ib qho tsim nyog los tswj kev ua haujlwm ntawm lub cev muaj teeb meem, ib zaug txhua 7 hnub txhawm rau kuaj ntshav peripheral.
Yog tias muaj kev fab tshuaj rau cov tshuaj uas tsis yog-steroidal anti-inflammatory tshuaj tau pom yav dhau los, ces Indomethacin (cov ntsiav tshuaj) tau muab tshuaj rau hauv cov xwm txheej hnyav.
Nws tsis pom zoo kom ua cov haujlwm txaus ntshai thaum kho, vim tias kev saib xyuas thiab kev xav ntawm lub hlwb tsis zoo.
Thaum tsis tau
Muaj cov kab mob uas cov tshuaj "Indomethacin" (cov ntsiav tshuaj) yog contraindicated. Siv tsis tau:
- nrog qhov tsis haum rau indomethacin;
- nyob rau hauv lub xub ntiag ntawm erosive thiab ulcerative lesions ntawm lub digestive system nyob rau hauv lub mob theem;
- nrog "cov tshuaj aspirin triad", tus yam ntxwv los ntawm intolerance rau acetylsalicylic acid, qhov ntswg polyps thiab bronchial hawb pob;
- nrog rau qhov tsis zoo hematopoiesis;
- nrog kev hloov pauv hauv kev ua haujlwm ntawm lub siab thiab lub raum;
- nrog ntsev thiab kua dej tuav nrog ua tau peripheral edema;
- mob myocardial insufficiencychronic;
- ntshav siab;
- rau bronchial hawb pob;
- nrog rau tus mob pancreas;
- nyob rau hauv peb lub hlis twg ntawm kev xeeb tub;
- thaum pub niam mis;
- rau cov menyuam yaus hnub nyoog qis dua 3 xyoos.
kev tawm tsam tsis zoo
Kev noj tshuaj "Indomethacin" (cov ntsiav tshuaj) tuaj yeem nrog cov kev mob tshwm sim uas cuam tshuam rau lub xeev ntawm tib neeg lub cev. Cov kev phiv tshwm sim muaj xws li xeev siab, anorexia, mob plab, flatulence, cem quav, plab zom mov.
Hauv cov xwm txheej cais, cov kev mob tshwm sim tuaj yeem tshwm sim raws li cov kab mob erosive thiab ulcerative, los ntshav thiab perforation ntawm cov phab ntsa ntawm lub plab thiab cov hnyuv; aplastic lossis hemolytic anemia, leukopenia, thrombocytopenia, agranulocytosis, tawm pob, plaub hau poob, khaus tawv nqaij, convulsions, Quincke's edema, bronchospasm.
Cov cim tsis tshua muaj tshwm sim ntawm Lyell's syndrome, anaphylactic shock, erythema nodosum.
Thaum kho, tej zaum yuav muaj kev ua txhaum ntawm kev ua haujlwm ntawm lub raum thiab daim siab, uas ua rau cov ntsiab lus ntawm bilirubin, hepatic transaminase.
Kev siv sijhawm ntev ntawm cov tshuaj "Indomethacin" (cov ntsiav tshuaj) tsis suav nrog kev cuam tshuam tsis zoo cuam tshuam nrog kev pw tsaug zog, kiv taub hau, peripheral neuropathy, mob taub hau, ntxhov siab, chim siab, qaug zog. Lawv yog cov cim los ntawm clouding ntawm lub cornea, conjunctivitis, tsis hnov lus, tinnitus, ntshav siab,o.
Reviews
Nws yog ib qho tseem ceeb heev uas yuav tsum ua raws li tag nrho cov cai rau kev siv tshuaj, kom tsis txhob suav tag nrho cov contraindications.
Kev tshuaj xyuas tsis meej txog kev siv tshuaj "Indomethacin". Cov ntsiav tshuaj muaj kev phiv ntau dua li cov ntawv siv tshuaj rau kev siv sab nraud. Tsis tas li ntawd, cov tshuaj no belongs rau hom 1 thiab hom 2 cyclooxygenase inhibitors, uas suav hais tias tsis muaj txiaj ntsig thiab ua rau muaj ntau yam tsis zoo los ntawm txoj hnyuv.
Rheumatologists thiab kws phais mob feem ntau sau tshuaj niaj hnub ntau dua los ntawm pab pawg oxicam rau lawv cov neeg mob. Lawv tsuas inhibit hom 2 cyclooxygenase yam tsis muaj kev cuam tshuam rau hom 1 enzyme, uas ua kom muaj cov prostaglandins uas tiv thaiv lub plab zom mov. Tias yog vim li cas oxycams ua rau muaj kev phom sij tsawg dua rau lub plab dua li cov tshuaj "Indomethacin" (cov ntsiav tshuaj). Cov lus qhia suav nrog kev tshuaj xyuas tsis zoo hauv cov lus piav qhia ntawm cov kev mob tshwm sim, tab sis qhov no tsis txhais tau tias lawv txhua tus yuav tsum tshwm sim thaum kho. Txhua yam nyob ntawm tus yam ntxwv ntawm lub cev.
Ntau tus neeg mob qhov kev kho no txuag ntawm qhov mob nraub qaum, myalgia, intercostal neuralgia, thaum lwm yam tshuaj tsis pab. Thiab cov teebmeem tsis zoo yuav tsis tshwm sim los ntawm kev kho mob nrog tshuaj "Indomethacin". Kev tshuaj xyuas cov ntsiav tshuaj los ntawm cov neeg mob rov zoo yog qhov zoo. Txawm hais tias muaj kev pheej hmoo ib txwm muaj, thiab tsuas yog tus kws kho mob tuaj koom tuaj yeem sau cov tshuaj hnyav li no.
Analogues
Pills nrog cov khoom xyaw nquag indomethacin yog tsim los ntawm ntauKev lag luam txawv teb chaws thiab hauv tsev, xws li Sopharma, Ludwig Meckle, Nycomed, Farmakhim, Berlin Hemi Menarini, Altfarm. Tsuas yog txhua yam tshuaj muaj nws tus kheej lub npe lag luam, nws tus kheej muaj pes tsawg leeg ntawm cov khoom pabcuam. Tag nrho cov analogues muaj tib cov lus qhia rau kev siv, phiv, contraindications.
Cov tshuaj nrov tshaj plaws yog "Indomethacin Sopharma" (cov ntsiav tshuaj). Ua nyob rau hauv ib koob ntawm 50 thiab 100 mg los ntawm Sopharma (Bulgaria). Hais txog cov tshuaj uas tsis yog steroidal anti-inflammatory.
Lwm ob peb qhov sib npaug zoo sib xws yog cov tshuaj Indomethacin 50 mg Berlin-Chemie thiab Indomethacin 100 mg Berlin-Chemie. Ua nyob rau hauv ob koob tshuaj (50 thiab 100 mg txhua) los ntawm Italian lub tuam txhab Berlin-Chemie Menarini.
Indomethacin (cov ntsiav tshuaj) muaj cov lus Lavxias. Lawv raug tsim nyob rau hauv ntau hom tshuaj. Lub ntsiab analogues yog:
- "Indomethacin-Akri" ntawm cov tshuaj-tshuaj nroj tsuag JSC "Akrikhin";
- Indomethacin-Altpharm, LLC Altpharm;
- "Indomethacin-Biosintez", OJSC "Biosintez";
- Vero-Indomethacin, OJSC Veropharm.
