Cov tshuaj nquag ntawm Akineton yog biperiden hydrochloride. Cov ntsiav tshuaj muaj 2 mg ntawm cov khoom xyaw nquag. Tsis tas li ntawd, muaj cov khoom xyaw ntxiv (pob kws hmoov txhuv nplej siab, qos yaj ywm starch, lactose monohydrate, magnesium stearate, microcrystalline cellulose, copovidone, calcium hydrogen phosphate dihydrate, talc, dej ntshiab) qhia txog cov muaj pes tsawg leeg ntawm Akineton..
Cov lus qhia rau kev siv, cov duab qhia tias cov ntsiav tshuaj daim ntawv ntawm cov tshuaj muaj cov xim yuav luag dawb, lub tiaj-cylindrical zoo li. Ntawm ib sab ntawm cov ntsiav tshuaj muaj kev pheej hmoo nrog chamfered cruciform duab.
1 ml ntawm cov tshuaj muaj biperiden lactate nyob rau hauv tus nqi ntawm 5 milligrams. Cov khoom siv ntxiv yog: dej txhaj tshuaj thiab sodium lactate.
Pharmacological action
Cov tshuaj tseem ceeb biperiden yog lub hauv paus ua haujlwm anticholinergic.
Kev cuam tshuam cuam tshuam txog kev nyuaj siab ntawm kev ua sicholinergic neurons nyob rau hauv lub striatum, uas yog lub structural unit ntawm lub extrapyramidal system.
Cov tshuaj ua rau muaj kev cuam tshuam ganglioblocking, antispasmodic thiab nruab nrab m-cholinoblocking nyhuv ntawm periphery (antispasmodic).
Kev siv tshuaj pab tshem tawm qhov tshee tshee, uas tshwm sim thaum siv cov tshuaj cholinergic (piv txwv li, pilocarpine), nrog rau catalepsy thiab cov leeg nqaij rigidity thaum noj tshuaj tiv thaiv kab mob. Muaj peev xwm ua rau muaj kev ntxhov siab psychomotor.
YPharmacokinetics
"Akineton" yog 91-94% khi rau cov ntshav plasma proteins. Plasma clearance yuav yog 11.6 ± 0.8 ml / min / kg lub cev hnyav. Daim ntawv ib koob ntawm qhov ncauj muaj bioavailability txog 33 ± 5%.
Yuav nkag mus rau hauv niam mis.
Biperiden yog metabolized tag nrho hauv tib neeg lub cev. Cov tshuaj no tsis pom nyob rau hauv cov zis tsis hloov. Cov metabolites tseem ceeb yog bicycloheptane thiab piperidine, uas tau tawm hauv cov quav thiab zis.
Kev tshem tawm yog ua nyob rau hauv ob theem, nrog ib nrab-lub neej (T 1/2) ntawm 90 feeb nyob rau theem thawj thiab 24 teev - theem thib ob. Hauv cov neeg mob laus, ib nrab lub neej yuav nce ntxiv.
Cov lus qhia rau kev siv
"Akineton" yog siv rau cov kab mob extrapyramidal tshwm sim los ntawm kev noj qee yam tshuaj(Neuroleptics, tshuaj tiv thaiv kab mob).
Tsis tas li, cov tshuaj tau qhia rau kev kuaj mob Parkinson's disease, parkinsonism syndrome (cov tshuaj tau muab tshuaj ua ke nrog kev kho mob yooj yim),
YContraindications
Lub hom phiaj ntawm cov tshuaj no tsis qhia rau tus neeg intolerance rau cov tshuaj nquag ntawm cov tshuaj "Akineton".
Cov lus qhia rau kev siv qhia tias koj yuav tsum tsis txhob muab tshuaj thaum kuaj pom tus neeg mob uas muaj kab mob xws li prostate o, lub kaum sab xis kaw glaucoma, obstructive hloov hauv plab hnyuv (pyloric stenosis, plab hnyuv txhaws ntawm paralytic genesis).
Arrhythmias, qaug dab peg, pub niam mis, hnub nyoog siab tshaj ntawm tus neeg mob, cev xeeb tub yog yam uas Akineton tau sau nrog kev saib xyuas zoo.
Side effects
Los ntawm ib sab ntawm lub hauv paus paj hlwb, lawv tau tshwm sim los ntawm asthenia, qaug zog, tsaug zog, tsis muaj zog, loog loog, kiv taub hau, ntxhov siab vim, tsis nco qab, tsis meej pem, hnov lus, catalepsy, tshuaj dependence ntawm cov tshuaj Akineton.
Cov lus qhia rau kev siv hais txog cov kev mob tshwm sim ntawm ib feem ntawm lub cev ntawm lub zeem muag - mydriasis, cuam tshuam ntawm kev pab.
Los ntawm sab ntawm cov hlab plawv system yog tus cwj pwm los ntawm kev nce hauv lub plawv dhia (tachycardia); qee zaum - txo qis (bradycardia); thaum siv daim ntawv txhaj tshuaj ntawm cov tshuaj - txo cov ntshav siab(Hypotension).
Los ntawm lub plab zom mov - qhov ncauj qhuav, cov tsos mob dyspeptic, cem quav.
Rau ib feem ntawm cov txheej txheem metabolic - txo tawm hws.
Rau ib feem ntawm cov zis - hauv cov neeg mob uas loj (hypertrophy) ntawm cov qog prostate - tuaj yeem tso zis nyuaj.
Kev ua xua tshwm sim: pob khaus ntawm daim tawv nqaij, khaus.
Uss
Rau intramuscular, intravenous tswj, nrog rau kev tswj qhov ncauj ntawm cov ntsiav tshuaj, Akineton yog qhov tsim nyog.
Cov lus qhia rau kev siv hais tias Akineton txoj kev kho feem ntau pib nrog me me, tom qab ntawd cov koob tshuaj yuav nce mus ntxiv nyob ntawm qhov xav tau kev kho mob thiab muaj cov kev mob tshwm sim.
Cov neeg laus siv cov tshuaj hauv qhov ncauj pib kho nrog koob tshuaj 1 mg hauv 1-2 koob tshuaj thaum nruab hnub lossis 2 mg muab faib ua ob zaug ib hnub. Tsis tas li ntawd, cov koob tshuaj tuaj yeem nce mus rau 8 mg hauv ob mus rau plaub koob. Txawm li cas los xij, koob tshuaj yuav tsum tsis txhob nce ntau tshaj 2 mg ib hnub twg. Tsis txhob tshaj qhov ntau npaum li cas ntawm tus neeg sawv cev hauv 6-16 mg thaum nruab hnub. Ib koob tshuaj ntawm cov tshuaj txhaj tshuaj yuav tsum tsis pub tshaj 2.5-5 mg. Cov koob tshuaj no tuaj yeem rov qhia dua tom qab ib nrab teev, tab sis tus naj npawb ntawm kev txhaj tshuaj ib hnub yuav tsum tsis pub tshaj 4 zaug. Qhov siab tshaj plaws ntawm cov tshuaj nyob rau hauv daim ntawv txhaj tshuaj yog 20 mg ib hnub twg. Thaum qhov kev pom zoo ntawm cov tshuaj mus txog, cesNws tuaj yeem hloov mus rau qhov txais tos ntawm "Akineton retard".
Txawm li cas los xij, tsis txhob hnov qab txog tus kheej txoj hauv kev rau txhua tus neeg mob thaum muab tshuaj kho biperiden.
Extrapyramidal pathology uas tshwm sim los ntawm kev noj qee yam tshuaj (antipsychotics lossis neuroleptics) yuav tsum tau teem sijhawm ntawm cov tshuaj no hauv ib koob ntawm 2 mg ntawm qhov ncauj lossis parenterally. Koj tuaj yeem rov hais dua cov lus qhia ntawm cov tshuaj uas tau teev tseg txhua ib nrab teev. Txawm li cas los xij, raws li tau hais los saum no, tus naj npawb ntawm kev txhaj tshuaj yuav tsum tsis pub tshaj 4 zaug. Qhov koob tshuaj ntawm qhov ncauj yuav tsum muab faib ua ib mus rau peb koob.
Parkinson tus kab mob cuam tshuam nrog kev tswj hwm ntawm cov tshuaj no ntawm 6-8 mg ntawm qhov ncauj hauv 2-4 koob tshuaj ib hnub, maj mam nce mus rau 6-16 mg.
Cov menyuam yaus hnub nyoog txog ib xyoos qhia tias muaj peev xwm sau cov tshuaj no hauv daim ntawv txhaj tshuaj maj mam, ib koob tshuaj yog 1 mg lossis 0.2 ml. Thaum muaj hnub nyoog los ntawm ib xyoos mus rau 6 xyoo, 2 mg lossis 0.4 ml raug tshuaj. Los ntawm 6 mus rau 10 xyoo - 3 mg lossis 0.6 ml. Cov koob tshuaj no tuaj yeem rov muab tshuaj dua hauv ib nrab teev yog tias tsim nyog. Thaum muaj kev phiv los ntawm kev siv tshuaj, kev txhaj tshuaj yuav tsum raug tso tseg. Thaum ua kev kho mob nrog rau qhov ncauj ntawm cov tshuaj los ntawm hnub nyoog 3 txog 15 xyoos, noj 1-2 koob tshuaj. mg hauv 1-3 koob tshuaj thaum nruab hnub.
Cov tshuaj yuav tsum tsis txhob noj thaum lub plab khoob, tab sis yuav tsum tau noj nrog dej me me. Yog tias koj muaj kev phiv tsis xav tau los ntawm qhov systemKev zom zaub mov, cov tshuaj yuav tsum tau noj tam sim tom qab noj mov, uas txo qhov hnyav ntawm cov teebmeem ntawm Akineton.
Cov lus qhia rau kev siv qhia tias yog tias muaj nicotine lom rau cov neeg laus, cov tshuaj no kuj tau sau tseg hauv cov txheej txheem kho mob, thiab nws cov koob tshuaj yog 5-10 mg rau cov ntawv txhaj tshuaj, tab sis tsuas yog hauv cov neeg mob hnyav..
Yog tias muaj tshuaj lom nrog cov organic phosphorus sib tov, kev siv tshuaj biperiden yog nqa tawm ib tus zuj zus, nyob ntawm qhov mob hnyav. Pib nrog koob tshuaj 5 mg nyob rau hauv cov ntaub ntawv ntawm kev txhaj tshuaj intravenously, rov txhaj tshuaj ntxiv mus kom txog rau thaum cov tsos mob ntawm lom ploj.
Ntau tshaj
Kev noj ntau dhau yog tshwm sim los ntawm kev hais tawm cov tshuaj anticholinergic tshwm sim los ntawm cov tshuaj "Akineton".
Cov lus qhia rau kev siv, kev tshuaj xyuas ntawm cov kws kho mob ua rau pom qhov tseeb tias kev kho mob ntawm tus mob no yog cov tsos mob (kev tu lub plawv thiab cov hlab ntsws, kev kho cov pa oxygen, kho hyperthermia, yog tias tsim nyog, tso zis catheter). Nws yog ib qho tsim nyog los qhia cholinesterase inhibitors (feem ntau physostigmine).
Kev sib tham
"Akineton" thaum siv ib txhij nrog m-cholinergic blockers, tshuaj nrog tshuaj tiv thaiv kab mob thiab tshuaj tiv thaiv kab mob, txhim kho qhov mob ntawm qhov kawg. Txawm li cas los xij, kev siv ib txhij nrog metoclopramide ua rau nws cov txiaj ntsig kho tsis muaj zog. Muaj categorical incompatibility ntawm cov tshuaj nrog ethanol. Lub hom phiajquinidine ua rau muaj kev pheej hmoo ntawm kev tsim cov tsos mob ntawm dyskinesia. Cov nyhuv M-cholinergic yog txhim kho nrog levodopa.
Cov ntsiab lus cia thiab muag
Cov tshuaj no yuav tsum tau tus kws kho mob cov tshuaj yuav muab rau tus kws muag tshuaj. Txhawm rau khaws Akineton, koj yuav tsum saib xyuas qhov ntsuas kub, uas yog, qhov ntsuas kub ntawm qhov ntsuas kub yuav tsum tsis pub tshaj 25 degrees (Celsius scale). Yuav tsum muaj kev nkag tsis tau rau cov menyuam yaus txhais tau tias "Akineton".
Kev qhia muab lub neej txee ntawm cov tshuaj - tsib xyoos.
Cov lus qhia tshwj xeeb
Lub sijhawm teem sijhawm ntawm biperiden thaum cev xeeb tub thiab pub niam mis (lactation) yuav tsum muaj kev qhia nruj.
Biperiden tuaj yeem nkag mus rau hauv lub cev ntawm tus menyuam uas muaj mis nyuj, uas yog vim li cas rau qhov tsis kam pub niam mis ib ntus kom txog thaum cov tshuaj "Akineton" raug txiav.
Cov lus piav qhia ntawm cov tshuaj ua rau pom qhov tseeb tias thaum txiav txim siab txog kev teem caij ntawm biperiden thaum cev xeeb tub thiab lactation, qhov muaj feem yuav tshwm sim rau tus menyuam mos, tus menyuam hauv plab yog coj mus rau hauv tus account.
Lub hnub nyoog siab ntawm tus neeg mob dhau los ua qhov pheej hmoo rau kev kho mob nrog cov tshuaj no. Yog li ntawd, Akineton tau muab tshuaj rau pawg neeg no nrog kev saib xyuas zoo.
Qhov tsis muaj pov thawj ntawm cov ntaub ntawv qhia txog kev nyab xeeb ntawm kev siv thaum yau yog vim li cas Akineton tsis siv rau menyuam yaus.
Kev piav qhia ntawm cov tshuaj (qhia rau kev siv) qhia qhov tseeb tias yuav tsum ceev faj thaum siv cov tshuaj no hauvcov neeg mob qaug dab peg los yog arrhythmia.
Kev quav yeeb tshuaj tuaj yeem tshwm sim nrog kev siv ntev.
Qhov kev pheej hmoo ntawm kev txhim kho tus mob thim rov qab cuam tshuam nrog kev maj mam tso tseg ntawm Akineton kho.
dej cawv yuav tsum zam thaum kho.
Kev kho mob nrog cov tshuaj no qhia tias yuav tsum tsis txhob tsav tsheb thiab koom nrog cov haujlwm uas yuav tsum tau muaj kev mloog ntau ntxiv thiab cov tshuaj tiv thaiv psychomotor ceev, vim qhov no ua rau muaj kev phom sij vim muaj kev pheej hmoo ntawm kiv taub hau.
"Akineton". Cov lus qhia rau kev siv. Analogues
Cov tshuaj hauv qab no yog qhov sib txuas nrog cov tshuaj: "Biperiden", "Mendilex", "Biperiden hydrochloride".
"Akineton". Reviews
Cov tshuaj no muaj txiaj ntsig zoo hauv kev kho mob ntawm tus mob parkinsonism, qhov tshee tshee nyob rau hauv lub caj dab nres tom qab lub sijhawm luv luv. Muaj qhov ua siab ntev ntawm cov tshuaj "Akineton"
Kev tshuaj xyuas ntawm lub rooj sab laj qhia tau tias muaj qee qhov kev mob tshwm sim thaum lub sijhawm noj tshuaj.
Tus nqi ntawm Akineton. Yuav qhov twg
Tus nqi ntawm cov tshuaj tuaj yeem kwv yees li 800 rubles.
Tus nqi ntawm qhov ncauj ntawm Akineton yog 560-580 rubles.
