Ntau cov qauv ntawm Ketorol yog tsim tawm: hauv ampoules - cov khoom siv rau kev txhaj tshuaj, hauv cov raj txhuas - cov tshuaj pleev rau cov tshuaj pleev ib ce, hauv cov hlwv - ntsiav tshuaj rau kev tswj qhov ncauj. Cov kev xaiv tshwj xeeb yog xaiv los ntawm tus kws kho mob, raws li tus yam ntxwv thiab kev xav tau ntawm tus neeg mob. Nws tuaj yeem ua ke nrog kev siv sab nraud thiab sab hauv. Qee zaum kev txhaj tshuaj yog thawj zaug, tom qab ntawd cov tshuaj hloov nrog daim ntawv ntsiav tshuaj. Tus yuam sij rau kev kho kom zoo yog ua raws li tus kws kho mob cov lus qhia.
cov ntaub ntawv dav dav
Hauv ampoules "Ketorol" muaj nyob rau hauv daim ntawv ntawm cov tshuaj tshwj xeeb npaj rau kev txhaj tshuaj rau cov leeg nqaij. Cov khoom no tsis muaj xim lossis daj me ntsis. Kev daws yuav tsum yog pob tshab; thaum kawm nrog lub qhov muag liab qab, nws tsis tuaj yeem pom ib tus neeg hais. Nyob rau hauv rooj plaub ntawm kev ua txhaum ntawm cov qauv ntawm cov tshuaj, nag lossis daus los yog hloov xim rau lwm yam tshuaj, nws yuav tsum tau muab pov tseg. Kev siv cov khoom uas ua rau lwj yog qhov txaus ntshai rau kev noj qab haus huv thiab lub neej ntawm tus neeg mob.
Hauv ampoule "Ketorol" muaj nyob rau hauv ib qho nyiaj ntawm 1 ml,ntawm cov active ingredient yog 30 mg. Lub ntsiab compound yog ketorolac tromethamine. Raws li cov chaw tsim khoom ntxiv thov:
- sodium chloride thiab hydroxide;
- ethanol;
- purified dej kho;
- Ypropylene glycol;
- edetate disodium;
- octoxynol.
Ampoule nrog "Ketorol" yog ua los ntawm cov iav tinted, ntim rau hauv hlwv. Ib pob contour muaj ib lub kaum os ampoules. Cov hlwv yog muab tso rau hauv cov thawv ntawv, uas qhia lub npe ntawm cov tshuaj, tus nqi ntawm cov tshuaj nyob rau hauv, lub concentration ntawm active compound nyob rau hauv ib ampoule. Nyob rau sab nraud, lub npe ntawm cov chaw tsim khoom, cov cai rau kev xa nyiaj los ntawm cov chaw muag tshuaj, hnub tas sij hawm thiab hnub tsim khoom, cov xwm txheej hauv qab uas cov tshuaj yuav tsum tau khaws cia kuj tau qhia.
Ketorol: yog dab tsi?
Ketorol ua hauv ampoules muaj cov nyhuv analgesic uas depresses inflammatory foci. Cov tshuaj belongs rau tus xov tooj ntawm anti-inflammatory nonsteroidal tshuaj, uas yog, nws tsis muaj hormonal tshuaj. Ketorolac, nyob rau hauv uas cov tshuaj yog raws, muaj ib tug pronounced analgesic nyhuv. Cov cuab yeej inhibits o, txo kub taub hau. Qhov zoo tom kawg yog ntsuas raws li nruab nrab.
Ketorol, ib qho tshuaj loog uas tsim tawm hauv ampoules, ua haujlwm vim lub peev xwm ntawm ketorolac rau indiscriminately inhibit qhov kev ua ntawm enzymes - thawj, thib ob COX. Cov txheej txheem tshaj tawm tshwm sim hauv cov ntaub so ntswg peripheral. Slows zus tau tej cov prostaglandinscov tshuaj uas ua rau mob, nrog rau cov uas muaj lub luag haujlwm rau kev tswj xyuas qhov kub thiab txias hauv zos thiab kev ua haujlwm ntawm cov txheej txheem inflammatory. Ketorolac yog ib qho sib xyaw ntawm ntau hom enantiomers, ib qho ntawm cov kws tshawb fawb tau ua pov thawj, muaj cov nyhuv analgesic rau tib neeg lub cev.
Raws li cov lus qhia rau kev siv, Ketorol txhaj tshuaj (hauv ampoules - kua rau txhaj rau hauv cov leeg) muaj kev nyab xeeb, vim tias cov khoom xyaw nquag tsis cuam tshuam nrog opioid receptors. Raws li kev cuam tshuam ntawm non-steroidal anti-inflammatory, kev ua haujlwm ntawm kev ua pa tsis ua haujlwm qeeb. Qhov tsis muaj kev vam khom rau tus neeg sawv cev tau raug pov thawj. "Ketorol" tsis yog tus cwj pwm los ntawm sedative, anxiolytic teebmeem. Qhov hnyav ntawm cov nyhuv analgesic tso cai rau koj los sib piv cov tshuaj nrog morphine. "Ketorol" muaj zog ntau dua li lwm cov tshuaj tiv thaiv kab mob uas tsis yog tshuaj steroidal muaj rau cov txiv neej niaj hnub.
Cov chaw tsim khoom taw qhia rau Ketorol uas tsim tawm hauv ampoules hauv cov lus qhia rau kev siv: cov tshuaj intramuscularly tswj tau ua tiav 30 feeb tom qab txhaj tshuaj. Cov txiaj ntsig tshaj plaws yog ib teev lossis ob teev tom qab tus txheej txheem.
Kinetics
Nrog rau kev taw qhia ntawm "Ketorol" ua nyob rau hauv ampoules intramuscularly, bioavailability ntawm lub active tivthaiv nce mus txog 100%. Tsis ntev tom qab txhaj tshuaj, lub ntsiab compound yog absorbed los ntawm qhov chaw txhaj tshuaj. Ketorolac nkag mus rau hauv cov hlab ntsha. Thaum siv 30 mg ntawm cov tshuaj nquag, qhov siab tshaj plaws hauv cov ntshav ntshav nce mus txog qhov nruab nrab ntawm 3.1 μg / ml. Ntawm ob zaug koob tshuaj, tus parameter tuaj yeemnce mus rau 5.77 mcg / ml. Txhawm rau ua tiav cov txiaj ntsig zoo li no thaum siv 30 mg, 15-73 feeb yog txaus, rau ob zaug ntawm cov tshuaj, lub sijhawm yog los ntawm ib nrab teev mus rau ib teev.
Nrog rau cov ntshav plasma, raws li tau hais hauv cov lus qhia rau kev siv intramuscularly "Ketorol" (ampoules muag hauv khw muag tshuaj muaj cov tshuaj rau cov tshuaj no), nws tau qhia tias ketorolac tuaj yeem nkag mus rau hauv cov ntawv cog lus muaj zog nrog cov ntshav plasma protein. Qhov nruab nrab, 99% ntawm tag nrho cov khoom uas nkag mus rau hauv lub cev yog koom nrog cov tshuaj tiv thaiv zoo li no. Tej zaum yuav muaj qhov nce ntxiv hauv kev sib txuas dawb hauv cov hlab ntsha tawm tsam keeb kwm ntawm hypoalbuminemia.
Kev siv Ketorol, tsim nyob rau hauv ampoules, intramuscularly ua rau nws muaj peev xwm ua tiav qhov sib npaug ntawm Ketorolac hauv cov hlab ntsha nrog plaub zaug siv cov tshuaj hauv ib hnub twb 24 teev tom qab pib kev kho mob.. Thaum siv cov tshuaj hauv koob tshuaj 15 mg, qhov sib npaug ntawm cov concentration nce mus txog 1.13 μg / ml, nrog ob zaug ntau dua - 2.47 μg / ml. Qhov ntim ntawm kev faib tawm yog kwv yees li ntawm 0.15-0.33 L / kg.
Ketorolac tau pom tias kis mus rau hauv cov kua mis. Cov chaw tsim khoom qhia qhov no thaum piav txog cov yam ntxwv ntawm daim ntawv thov. "Ketorol" (hauv ampoules - kev daws rau kev txhaj tshuaj intramuscular), siv 10 mg plaub zaug hauv ib hnub, ua rau muaj kev nce ntxiv hauv cov ntsiab lus ntawm ketorolac hauv cov kua mis mus rau 7.3 ng / ml ob peb teev tom qab noj cov tshuaj. yam khoom. Ob peb teev tom qab rov ua cov txheej txheem, qhov siab tshaj plaws ntawm ketorolac hauv cov mis nyuj nce mus txog 7.9 ng / ml.
Yuav ua li cas hauv lub cev?
Rau Ketorol uas tsim tawm hauv ampoules, siv tau raug tso cai nruj me ntsis raws li tus kws kho mob saib xyuas. Tus kws kho mob coj mus rau hauv tus account tias ib nrab ntawm tag nrho cov tshuaj tau txais los ntawm tus neeg mob tau hloov pauv hauv daim siab. Cov metabolites tsim nyob rau hauv cov ntaub ntawv no tsis muaj pharmacological kev ua ub no, tab sis qhov tseeb heev ntawm cov metabolism hauv lub siab yuam ib tug mus sau cov tshuaj nrog ceev faj yog hais tias muaj kev ua haujlwm tsis zoo lossis cov kab mob hauv nruab nrog cev raug xav tias yog. Ketorolac cov khoom lag luam - glucuronides, hydroxyketorolac.
Ketorolac excretion feem ntau yog ua los ntawm ob lub raum. Yog li, txog li 91% ntawm cov tshuaj tau tawm ntawm lub cev. Txoj kev tshem tawm ntawm kwv yees li 6% ntawm cov tshuaj yog cov hnyuv. Glucuronides raug tshem tawm hauv cov zis.
Lub neej ib nrab kwv yees li ntawm 5.3 teev yog tias lub raum ua haujlwm zoo li qub. Nyob rau hauv cov lus qhia muaj nyob rau hauv lub pob nrog Ketorol ampoules, cov chaw tsim tshuaj paus yuav tsum tau qhia tias lub sij hawm sib txawv ntawm 3.5 mus rau 9.2 teev thaum txhaj tshuaj nrog 30 mg ntawm active compound. Cov ntaub ntawv no yuav tsum raug coj mus rau hauv tus account thaum xaiv qhov ntau npaum li cas thiab zaus ntawm kev tswj hwm rau ib tus neeg mob.
Thaum txhaj tshuaj, qhov kev tshem tawm mus txog 0.023 l / kg / h. Cov lus qhia txuas nrog Ketorol ampoules qhia tias cov ntsuas no yog cov yam ntxwv ntawm kev txhaj tshuaj ib zaug ntawm cov tshuaj uas muaj 30 mg ntawm Ketorolac.
Special Occasion
Cov kws kho mob, muab tshuaj txhaj tshuaj los ntawm Ketorol ampoules, xaiv qhov ntau npaum li cas, coj mus rau hauv tus account tus yam ntxwv ntawm rooj plaub. Hauv particular, nyob rau hauv cov ntaub ntawv ntawm lub raum insufficiency, nws yog tsim nyog los hloov cov koob tshuaj, zaus ntawm txhaj tshuaj, vim muaj kev pheej hmoo ntawm kev loj hlob.ob zaug ntawm qhov ntim ntawm kev faib khoom txheeb ze rau qhov qauv. Qhov ntim ntawm kev faib tawm ntawm cov nquag enantiomer, uas yog lub luag haujlwm rau cov nyhuv analgesic, yuav nce 20%.
Lub neej ib nrab ntawm ketorolac hauv cov neeg mob hluas tsawg dua qhov nruab nrab, hauv cov neeg laus nws ntev dua. Nws tau pom tias feem ntau tsis tas yuav kho cov koob tshuaj thaum siv cov tshuaj Ketorol ampoules yog tias lub siab ua haujlwm tsis zoo, vim tias kev ua haujlwm ntawm lub cev tsis cuam tshuam rau ib nrab lub neej. Nyob rau hauv ib rooj plaub tshwj xeeb, nws tseem tuaj yeem hloov pauv yog tias lwm tus yam ntxwv ntawm tus neeg mob lub cev xav tau.
Y Yog tias lub raum tsis ua haujlwm, kev ntsuas ntawm creatinine tshem tawm ntawm 19-50 mg / l, ib nrab lub neej ntawm ketorolac nce mus txog 10.8 teev. 13.6 teev.
Nrog creatinine tshem tawm hauv thaj tsam ntawm 19-50 mg / l, kev tshem tawm ntawm ketorolac kwv yees li ntawm 0.015 l / kg / h, yog tias tus neeg sawv cev siv ntau npaum li 30 mg. Rau cov neeg laus, qhov nruab nrab yog 0.019 l / kg / h.
Hemodialysis tsis muaj txiaj ntsig thaum nws tsim nyog tshem tawm cov tshuaj nquag ntawm lub cev.
Txoj kev siv
Koj tuaj yeem yuav tshuaj tsuas yog tias tus neeg mob muaj daim ntawv tshuaj rau Ketorol hauv ampoules. Kev faib tawm dawb ntawm cov tshuaj los ntawm cov chaw muag tshuaj yog txwv tsis pub siv, vim tias kev siv tsis raug tuaj yeem ua rau muaj qhov tshwm sim tsis zoo.
"Ketorol" raug tshuaj yog tias tus neeg mob txhawj xeeb txog qhov mob, ntsuas qhov nruab nrab, qib siab. Cov tshuaj no zoo nyob rau hauv qhov mob syndrome ntawm txawv keeb kwm. Nws raug sau tseg thaum lub sijhawm rov ua haujlwm tom qab phais. Rau kev siv "Ketorol" hauv ampoules, cov lus qhia yog cov kab mob oncological, nrog rau qhov mob hnyav. Koj tuaj yeem siv cov tshuaj uas tsis yog-steroidal anti-inflammatory tsuas yog tom qab kev sab laj nrog kws kho mob ua ntej. Nws yog ib qho tseem ceeb kom txhaj tshuaj kom raug, txwv tsis pub muaj kev pheej hmoo ntawm kev puas tsuaj hauv zos.
Qee zaum cov neeg mob nug, siv "Ketorol" hauv ampoules, koj tuaj yeem haus dej haus cawv lossis txwv tsis pub. Cov chaw tsim khoom ntawm cov khoom kos xim: kev sib xyaw ntawm cov tshuaj thiab cawv yog categorically tsis pom zoo.
Nuances of therapy
Ketorol yog muag hauv ampoules raws li kev tshuaj xyuas ntawm tus kws kho mob tuaj koom. Tus neeg sawv cev yog siv nyob rau hauv qhov tsawg kawg nkaus npaum li cas uas muab qhov xav tau. Kev xaiv cov ntim yuav tsum tau ua hauv kev xyaum. Cov tshuaj yog txhaj tob rau hauv cov leeg nqaij. Cov koob tshuaj tshwj xeeb raug xaiv raws li lub zog ntawm qhov mob, lub cev teb rau cov tshuaj tiv thaiv kab mob. Yog tias "Ketorol" tsis zoo ntawm nws tus kheej, koj tuaj yeem ntxiv cov tshuaj nonsteroidal nrog cov tshuaj tua kab mob opioid. Lawv siv rau qhov tsawg tshaj plaws uas tau ua tau.
Rau kev kho cov neeg laus hnub nyoog qis dua 65 xyoos, Ketorol yog siv raws li ib qho ntawm ob txoj haujlwm:
- 10-30mg ketorolac ib zaug;
- 10-30mg nrog 4-6 teev ntawm kev kho mob
Qhov kev pab cuam yog txiav txim los ntawm tus kws kho mob, ntsuas qhov mob hnyav.
Los ntawm 65 xyoo thiab laus dua, ntxiv rau hauv cov xwm txheej ntawm lub raum ua haujlwm tsis ua haujlwm, Ketorol yog siv hauv qhov ntau ntawm 10-15 mg. Tej zaumrov ua dua txhua 4-6 teev yog tias xav tau.
Rau cov neeg muaj hnub nyoog qis dua 65 xyoos, qhov siab tshaj plaws txhua hnub ntawm ketorolac yog 90 mg. Rau cov neeg mob laus, nrog rau cov neeg mob lub raum tsis ua haujlwm, tau tso cai txog 60 mg.
Raws li kev tshuaj xyuas tau lees paub, Ketorol ampoules tau siv tsis pub dhau tsib hnub. Yog tias tsim nyog los mus txuas ntxiv cov chav kawm kho mob, tus neeg mob raug xa mus rau ib daim ntawv siv qhov ncauj. Nyob rau hnub hloov cov tshuaj rau cov neeg uas muaj hnub nyoog qis dua 65 xyoos, 90 mg ntawm ketorolac raug tso cai, uas tsis ntau tshaj 30 mg yog ntsiav tshuaj. Rau cov neeg muaj hnub nyoog tshaj 65 xyoo - 60 mg, uas tsis ntau tshaj ib nrab yog ntsiav tshuaj.
Side effects
"Ketorol" hauv ampoules - cov tshuaj npaj rau kev txhaj tshuaj hauv zos rau cov leeg. Txij li thaum cov tshuaj nkag mus rau hauv lub cev, nws muaj cov nyhuv system, uas txiav txim siab qhov tshwm sim tshwm sim. Qee qhov tshwm sim feem ntau. Ua ntej tshaj plaws, cov no yog qhov tshwm sim rau lub plab zom mov - quav quav thiab mob hauv plab. Cov txiaj ntsig zoo li no tau pom ntau dua thaum siv cov tshuaj los ntawm cov neeg muaj hnub nyoog tshaj 65 xyoo uas yav dhau los muaj qhov mob los yog yaig ntawm txoj hnyuv.
Kev sim tshuaj qhia pom tias kev txhaj tshuaj Ketorol tuaj yeem ua rau:
- jaundice, kab mob siab, nce roj tsim, xeev siab, ntuav, melena, stomatitis;
- raum tsis ua haujlwm, mob nraub qaum, mob ntshav siab, thrombocytopenia, tso zis ceev, nephritis, edema;
- bronchospasm, apnea, kua ntswg, o ntawm lub larynx;
- mob lossiskiv taub hau, tsaug zog cravings, meningitis, hallucinations, kev nyuaj siab, psychosis, tinnitus, qhov muag tsis pom kev thiab hnov lus;
- ntshav siab, fainting, pulmonary edema;
- ntshav ntshav, leuko-, eosinophilia;
- xiav;
- tawv nqaij, urticaria;
- anaphylactic, anaphylactoid teb, tachy-, dyspnea, puffiness ntawm daim tawv muag, ua tsis taus pa, ua pa tsis ua hauj lwm;
- kub hnyiab, mob ntawm qhov chaw txhaj tshuaj;
- ua kom cov qog hws;
- febrile mob.
Tsis pub dhau
Txawm tias tus neeg mob tus mob nyob rau hauv cov npe ntawm cov uas Ketorol pab hauv ampoules, kev siv cov tshuaj tsis tuaj yeem lees paub yog tias kuaj pom muaj mob hawb pob, cov kev tawm tsam uas yog provoked los ntawm acetylsalicylic acid thiab lwm yam non-steroidal anti- tshuaj inflammatory. Contraindications kuj muaj xws li:
- bronchospasm;
- dej;
- hypovolemia;
- mob plab ulcers, erosion ntawm plab hnyuv;
- angioedema;
- tsis muaj lub siab thiab lub raum ua haujlwm;
- tsim, xav tias hemorrhagic stroke;
- peptic ulcer;
- tsis muaj zog txaus ntshav txhaws;
- hemorrhagic diathesis;
- chav kho mob, suav nrog cov tshuaj uas tsis yog steroidal anti-inflammatory;
- nce ntshav ntau;
- inhibition ntawm hematopoietic muaj nuj nqi;
- nqa ib tug me nyuam;
- lactation;
- hnub nyoog qis dua 16 xyoo;
- qib siab ntawm kev nkag mus rau ketorolac, lwm tusnyiaj los ntawm pab pawg ntawm nonsteroidal anti-inflammatory.
yim
Ketorol yuav tsum tsis txhob siv yog tias mob ntev.
rooj plaub tshwj xeeb: cov lus qhia rau kev siv
Kev tshuaj xyuas ntawm "Ketorol" hauv ampoules (nyob rau hauv daim ntawv tso tawm no, cov tshuaj yog npaj rau kev txhaj tshuaj) muaj cov ntaub ntawv hais tias kev kho mob qee zaum raug kho rau mob hawb pob. Qhov no yog kev xyaum yog tias tsis muaj cov khoom tsim nyog thiab siv tau zoo dua, thaum cov kws kho mob muaj lub sijhawm los tswj tus neeg mob tus mob, vim tias qhov tshwm sim ntawm cov kev mob tshwm sim yog siab dua li qhov dav dav.
Hauv cov lus qhia rau kev siv, cov chaw tsim khoom qhia qhov kev lees paub ntawm kev tswj hwm kev txhaj tshuaj ketorolac nkaus xwb yog tias nws muaj peev xwm tswj tau tus mob ntawm cov neeg ntawm pawg hauv qab no:
- cov neeg mob ntshav siab;
- neeg mob sepsis;
- cov neeg laus (tshaj 65).
Cov kev txwv zoo sib xws ua rau kuaj mob:
- cholestasis;
- mob plawv tsis ua hauj lwm;
- creatinine tshem tawm tsawg dua 50 mg / l;
- Ylupus erythematosus;
- lub raum tsis ua haujlwm;
- kab mob siab;
- Ypolyposis ntawm qhov ntswg mucosa, nasopharynx.
Ketorolac cuam tshuam rau platelet aggregation ib mus rau ob hnub tom qab kev tswj hwm zaum kawg ntawm cov tshuaj. Tawm tsam keeb kwm ntawm hypovolemia, qhov tshwm sim ntawm qhov tshwm sim tsis zoo tshwm sim. Thaum ua ke nrog paracetamol, Ketorol tuaj yeem siv ntev txog tsib hnub, tab sis tsis muaj ntxiv lawm. Raws li xav tau, cov tshuaj tau ua ke nrog cov tshuaj tua kab mob opioid. Kev ua txhaum ntawm cov ntshav txhaws "Ketorol"tso cai tsuas yog tias nws muaj peev xwm tswj tau tus naj npawb ntawm platelets hauv cov hlab ntshav. Qhov no yog qhov tseeb tshwj xeeb rau cov tib neeg uas nyuam qhuav tau txais kev phais. Hemostasis yuav tsum tau saib xyuas.
Txawm hais tias "Ketorol" yog cov cuab yeej muaj zog thiab siv tau, nws kuj muaj qhov tsis zoo: feem pua ntawm cov neeg mob uas siv Ketorolac tau ntsib ib qho kev mob tshwm sim. Txij li feem pua ntawm qhov tshwm sim ntawm kiv taub hau, xav pw tsaug zog thiab lwm yam kev cuam tshuam ntawm lub hauv nruab nrab lub paj hlwb yog qhov siab heev, kev ua haujlwm uas yuav tsum tau ua kom muaj zog ntxiv thiab cov tshuaj tiv thaiv ceev yuav tsum raug zam thaum lub sij hawm kho kev tswj xyuas kev thauj mus los.
Tau heev
Cov tsos mob ntau dhau yuav qhia tau cov hauv qab no:
- plab mob;
- ntuav, ntuav;
- txheej txheem ulcerative hauv plab hnyuv;
- gastritis;
- tsis ua haujlwm ntawm lub raum ua haujlwm;
- acidosis.
Tus neeg mob tau qhia txog kev kho mob txhawm rau tswj cov haujlwm tseem ceeb rau kev txhawb nqa lub neej. Dialysis tsis pom qhov tshwm sim, yog li nws tsis ua tiav.
Hais txog kev sib haum xeeb
Kev siv "Aspirin" thiab "Ketorol", nrog rau kev sib xyaw ntawm cov tshuaj nrog rau lwm cov tshuaj uas tsis yog-steroidal anti-inflammatory, ethanol, hormonal anti-inflammatory tshuaj, tshuaj calcium thiab corticotropin tuaj yeem ua rau mob plab. ntawm lub plab zom mov, los ntshav hauv cov kabmob no.
Kev sib xyaw nrog paracetamol ua rau muaj kev pheej hmoo ntawm lub raum lom. Thaum ua ke nrog methotrexate, nws muaj peev xwm ua kom cov tshuaj lomcuam tshuam rau lub raum thiab lub siab.
Kev tswj hwm ntawm "Ketorol" tuaj yeem ua rau tsis muaj zog ntawm kev tshem tawm ntawm methotrexate, lithium, thiab yog li ua rau muaj kev phom sij ntau ntxiv. Xws li kev sib xyaw ua ke tsuas yog tso cai nrog kev teem sijhawm ntawm methotrexate hauv qhov tsawg kawg nkaus thiab muaj peev xwm tswj hwm nws cov concentration hauv cov ntshav ntshav thoob plaws hauv chav kawm.
Ketorolac tshem tawm, nws qhov ntim ntawm kev faib tawm txo qis thaum cov khoom xyaw nrog probenecid. Nyob rau tib lub sijhawm, qhov concentration ntawm ketorolac hauv plasma feem ntawm cov ntshav nce, lub sijhawm ib nrab-lub neej lengthens.
Kev sib xyaw nrog cov tshuaj tiv thaiv tsis ncaj qha tuaj yeem ua rau los ntshav. Cov txiaj ntsig zoo sib xws tuaj yeem ua tau yog tias "Ketorol" siv ib txhij nrog cov pab pawg hauv qab no:
- thrombolytics;
- heparin;
- tshuaj tiv thaiv kab mob.
Muaj kev pheej hmoo los ntshav thaum sib txuas Ketorolac thiab:
- cefoperazone;
- cefotetan;
- pentoxifylline.
Paj siab
Raws li kev cuam tshuam ntawm Ketorolac, qhov ua tau zoo ntawm cov tshuaj diuretics, txhais tau tias txo qhov siab, cais tawm. Qhov no yog vim qhov inhibition ntawm kev tsim cov prostaglandins los ntawm lub raum.
Antacids tsis kho qhov nqus ntawm cov khoom nquag ntawm Ketorol.
Kev sib xyaw ua ke ntawm cov tshuaj tau piav qhia thiab insulin ua rau ua kom nws cov nyhuv hypoglycemic. Ib qho txiaj ntsig zoo sib xws yog pom nrog kev sib xyaw ntawm ketorolac thiab txhais tau tias kho cov concentration ntawm cov piam thaj hauv qhov ncauj. Txhawm rau tiv thaiv qhov tshwm sim tsis zoo, nws yog ib qho tsim nyog los xaiv ib tus neeg noj tshuajtau txais nyiaj.
"Ketorol" thiab cov tshuaj uas muaj sodium valproate, ua ke, tuaj yeem ua rau cov platelet sib txawv. Tawm tsam keeb kwm yav dhau los ntawm kev siv ketorolac, kev nce hauv cov ntsiab lus ntawm nifedipine, verapamil hauv cov ntshav ntshav yog ua tau. Kev sib xyaw ua ke nrog cov tshuaj lom rau lub raum ua rau muaj kev cuam tshuam ntau ntxiv ntawm cov tshuaj lom hauv lub cev. Qhov no kuj siv tau rau kev sib xyaw ua ke nrog kev npaj kub.
Kev siv cov tshuaj uas inhibit tubular secretion ua rau txo qis hauv kev tshem tawm ntawm ketorolac, uas txhais tau hais tias cov ntsiab lus ntawm cov tshuaj no hauv cov ntshav plasma ntawm cov ntshav nce.
txwv tseem ceeb
Nws tsis tuaj yeem sib xyaw "Ketorol" thiab sulfate compounds ntawm morphine, hydroxyzine, promethazine hauv lub koob txhaj tshuaj. Cov kev sib xyaw ua ke no tuaj yeem ua rau muaj kev puas tsuaj.
Qeb nws yog txwv tsis pub ua ke "Ketorol" thiab lithium npaj, tramadol - cov tshuaj no tsis sib xws, raws li qhia los ntawm cov kev tshawb fawb tshwj xeeb.
Kev daws teeb meem rau kev txhaj tshuaj thiab ntsev. Koj tuaj yeem ua ke "Ketorol" thiab tsib feem pua ntawm cov tshuaj dextrose, cov kev daws teeb meem:
- Ringer-lactate;
- Ringer.
Compatible with infusion solutions uas muaj:
- lidocaine;
- dopamine;
- aminophylline;
- insulin (cov nyhuv luv luv);
- heparin hauv daim ntawv ntawm sodium ntsev.
Nws puas pab tau?
Cov neeg mob uas tus kws kho mob tau sau "Ketorol" feem ntau tsis ntseeg tias yuav siv cov tshuaj no:qhov tshwm sim ntawm cov kev mob tshwm sim yog siab heev, tab sis nws puas yuav tshwm sim? Hauv kev tshuaj xyuas ntawm cov neeg siv Ketorol rau kev txhaj tshuaj intramuscular, ib tus tuaj yeem pom qhov tsis txaus ntseeg ntawm qhov tseeb tias kev kho mob zoo. Cov neeg mob uas tau txais cov tshuaj tua kab mob tau sau tseg tias qhov tshwm sim analgesic tau tshaj tawm, yog li qhov ua tau zoo ntawm kev txhaj tshuaj, hauv lawv txoj kev xav, yog qhov tseem ceeb tshaj qhov tsis zoo ntawm kev siv tshuaj.
Yuav hloov dab tsi
Muab rau hauv tus account thaum xaiv cov analogues: "Ketorol" hauv ampoules, ntsiav tshuaj thiab cov ntaub ntawv rau kev siv sab nraud (tshuaj pleev, gel) yog raws li ketorolac. Cov kev npaj hauv qab no rau kev txhaj tshuaj tau tsim los ntawm tib yam tshuaj nquag:
- Dolak.
- Ketanov.
- Ketorolac.
Tus nqi ntawm tag nrho cov tshuaj teev yog kwv yees li qub, sib txawv ntawm 80-120 rubles. Cov cim npe tshwj xeeb tsis yog nyob ntawm qhov khoom xwb, tab sis kuj nyob ntawm tus nqi txoj cai ntawm qhov muag.
Ketorol Lwm Cov Tshuaj:
- Ketorolac.
- Ketanov.
- Dolak.
- Ketokam.
Tus nqi sib txawv, nyob ntawm qhov khoom, tus naj npawb ntawm cov tshuaj hauv pob. Cov thawv uas muaj 20 capsules raug nqi ntau dua 30 rubles, thaum lub tsev muag tshuaj them txog 200 rubles rau ib pob ntawm 100 ntsiav tshuaj.
Cov analogues nrov tshaj plaws: "Ketokam"
Cov tshuaj no yog raws li Ketorolac thiab muaj nyob rau hauv daim ntawv ntsiav tshuaj. Nws yog pheej yig heev, nws yog muag nyob rau hauv yuav luag txhua qhov chaw hauv peb lub teb chaws, yog li ntawdsuav tias yog siv tau rau cov pej xeem. Feem ntau, nws yog nws cov kws kho mob uas sau ntawv yog tias tus neeg mob xav tau tshuaj loog. Cov tshuaj belongs rau cov chav kawm ntawm anti-inflammatory non-steroidal, relieves mob, inhibits foci ntawm o. Qhov cuam tshuam ntawm qhov kub thiab txias yog ntsuas li nruab nrab.
Cov tshuaj nquag "Ketokama", nkag mus rau tus neeg mob lub cev, cuam tshuam rau COX tsim los ntawm arachidonic acid. Qhov no tso cai rau koj los kho cov tshuaj tiv thaiv ntawm kev tsim ntawm prostaglandins, nyob rau hauv tus ntawm cov txheej txheem inflammatory yog qhib, mob cider. Kev cuam tshuam ntawm prostaglandins tso cai rau koj tshem tawm lub xeev febrile.
Tsis ntev tom qab cov ntsiav tshuaj nkag mus rau hauv lub cev, cov tshuaj nquag nqus tau nkag mus rau hauv cov hlab ntsha. Cov kev tshawb fawb tau pom tias qhov siab tshaj plaws nyob rau hauv cov ntshav plasma yog ua tiav hauv qhov nruab nrab ntawm 45 feeb. Cov txheej txheem nqus dej tsis raug kho los ntawm kev noj mov. Lub peev xwm ntawm cov tshuaj nquag los khi rau cov ntshav plasma protein nce mus txog 99%. Lub neej ib nrab yog plaub mus rau rau teev.
Txog li 90% ntawm cov tshuaj nkag mus rau hauv lub cev raug tshem tawm nrog cov zis. Kwv yees li 60% tshwm sim tsis hloov. Lwm qhov ntim tawm hauv lub cev los ntawm txoj hnyuv.
Nyob rau hauv rooj plaub ntawm kev ua txhaum ntawm lub raum kev ua haujlwm, thaum muab "Ketokam" rau cov neeg laus, koj yuav tsum nco ntsoov txog kev txo qis ntawm kev tshem tawm. Lub sijhawm ncua sij hawm xav tau rau ib nrab lub neej ntawm cov tshuaj nce.
Kev txais tos nta
"Ketokam" raug tshuaj yog tias tsim nyog los tshem tawmmob hnyav lossis mob nruab nrab. Cov tshuaj muaj txiaj ntsig zoo rau kev hnov mob ntawm ntau yam keeb kwm. Rau cov neeg laus, cov tshuaj tau pom zoo kom siv 10 mg ntsiav tshuaj nrog lub sijhawm ntawm 4-6 teev ntawm koob tshuaj. Yog tias tsim nyog, nws raug tso cai kom muab ob npaug rau ntim siv Ketocam peb mus rau plaub zaug ib hnub.
Qhov siab tshaj plaws txhua hnub noj yog 90 mg ntawm cov tshuaj nquag. Nrog qhov hnyav tsawg dua 50 kg, lub raum ua haujlwm tsis zoo, thaum muaj hnub nyoog 65 xyoo thiab laus dua, Ketocam tau qhia ib hnub hauv qhov ntau ntawm tsis pub tshaj 60 mg.
