Cov neeg uas mus ntau zaus, thiab tshwj xeeb tshaj yog nyob rau sab av loj Africa, nws yog ib qho tseem ceeb kom paub txog cov kab mob xws li pw tsaug zog. Tus neeg sawv cev ua rau pw tsaug zog mob - trypanosoma - tuaj yeem nkag mus rau tib neeg lub cev tom qab tsetse ya. Tsis ntev los no, tau muaj kev nce zuj zus mus rau qhov txo qis ntawm cov neeg mob African trypanosomiasis. Qhov no yog vim muaj ntau yam, qhov tseem ceeb yog kev txhim kho kev ua neej nyob hauv cov tebchaws no.
Pawg mob pw tsaug zog kab mob
Tus kabmob tseem ceeb ntawm tus kabmob yog tsetse ya. Nws yog ib nqi sau cia hais tias muaj ntau ntau yam kab mob. Thawj hom cuam tshuam rau tsiaj (ob leeg qus thiab hauv tsev). Gambian hom yog yam ntxwv ntawm thaj chaw uas muaj av noo siab (piv txwv li, sab hnub poob Africa). Daim ntawv Rhodesian feem ntau pom nyob rau sab hnub tuaj, qhov chaw huab cua qhuav dua.
Tus neeg sawv cev ntawm kev pw tsaug zog yog eukaryote, nws qhov ntev tsis tshaj 20 microns. Cov kab mob muaj ib qho elongated fusiform zoo li. Thaum lub sij hawm yoov yog ntxeev siabib tug loj tus naj npawb ntawm trypanosomes - txog 400 txhiab. Nws yuav tsum raug sau tseg tias muaj txog 400 tus kab mob cab txaus kom kis tau tus neeg. Tus yoov muaj peev xwm ua tus nqa tau thoob plaws nws lub neej.
Kev kis mob tshwm sim li cas
Thaum yoov nkag mus rau hauv lub cev, tus neeg sawv cev ntawm kev pw tsaug zog mob pib nce zuj zus. Tom qab ob peb hnub, cov ntaub ntawv trypomastigote twb muaj nyob rau hauv cov qog ua kua qaub. Nyob ntawd lawv tau hloov kho rau hauv daim ntawv tshwj xeeb - epimastigotes. Lawv qhia ntau zaus. Cov theem invasive (trypomastigotes) yog tsim los ntawm complex morphological hloov. Ob peb hnub tom qab ib tug neeg tom, cov ntshav trypomastigts nkag mus rau hauv cov hlab ntsha, lymphatic kua, thiab ces kis mus thoob plaws lub cev. Nrog rau kev txhim kho ntxiv ntawm tus kab mob, cov kab mob nkag mus rau hauv nruab nrab paj hlwb. Nyob rau hauv lub hlwb, cov kab mob muaj feem xyuam rau ob qho tib si grey thiab dawb teeb meem, ua o, thiab ua rau degenerative hloov. Hauv cov neeg mob, cov tshuaj tiv thaiv rau cov kab mob no tau pom (raws li txoj cai, hauv cov pej xeem hauv zos). Nyob rau hauv cov ntaub ntawv no, tus kab mob yuav mus ntev. Rau cov neeg tuaj ncig tebchaws uasi, pw tsaug zog feem ntau mob heev.
Symptoms of disease
Thaum yoov tom, chancre tsim ntawm qhov chaw ntawm qhov txhab. Qhov no yog ib tug mob pob caus khaus. Nws yog tsim nyog sau cia tias tus neeg sawv cev ntawm kev pw tsaug zog mob tsuas yog nyob rau hauv me me tam sim ntawd nkag mus rau hauv cov hlab ntsha. Qhov ntau tseem nyob ntawm qhov chaw ntawm qhov tom, qhov twg nws multiplies intensively. Lub chancre ploj tom qab ob peb hnub, qee zaum nws tseem nyob hauv nws qhov chawcaws pliav. Hauv thawj lub sijhawm, tus neeg mob pw tsaug zog yog qhov tshwm sim los ntawm cov tsos mob hauv qab no: mob taub hau, tsis xis nyob hauv cov pob qij txha. Tsis tas li ntawd, cov neeg mob nco ntsoov qhov nce hauv cov qog ntshav qog. Tej zaum kuj yuav ua npaws thiab ua npaws. Cov theem hemolymphatic ua rau poob qab los noj mov, tsis muaj zog, thiab lub plawv dhia tsis xwm yeem. Kuj tseem muaj teeb meem hauv kev ua haujlwm ntawm cov khoom nruab nrog cev. Nrog rau hom Gabmian, tus kab mob tuaj yeem raug txheeb xyuas tau ntev.
Tam sim no Rhodesian hom pw tsaug zog
Rhodesian daim ntawv ntawm tus kab mob yog qhov nyuaj thiab hnyav dua. Tag nrho cov tsos mob tau tshaj tawm. Nws yuav tsum raug sau tseg tias tus neeg sawv cev ua rau ntawm hom kev pw tsaug zog no cuam tshuam rau cov qog nqaij hlav kom tsawg dua. Ob peb lub lis piam (mus txog 6) tom qab kis kab mob, lub hauv paus paj hlwb raug cuam tshuam. Qhov no ua rau clouding ntawm kev nco qab, kev sib koom tes ntawm kev txav yog cuam tshuam, kev pw tsaug zog tuaj yeem pom: kev pw tsaug zog nruab hnub nce. Heev feem ntau muaj ib tug swb ntawm lub cev ntawm cov hlab plawv system. Nws tseem tsim nyog sau cia tias yuav luag tam sim ntawd tom qab kis mob nrog Rhodesian daim ntawv ntawm kev pw tsaug zog, lub cev yog depleted. Cov theem kawg yog tus cwj pwm los ntawm kev hais lus tsis zoo, tuag tes tuag taw, tej zaum yuav tsis nco qab. Hauv qhov mob hnyav tshaj plaws, kev tuag tuaj yeem tshwm sim (feem ntau los ntawm kev noj zaub mov tsis txaus, teeb meem plawv, kev sib kis kab mob).
Tus kab mob no kuaj tau li cas? Kev kho mob
Vim tias pw tsaug zog mob ua rau xws li kev nkag mus ntawm cov kab mob cab mus rau hauv cov hlab ntsha, yuav tsum kuajtus neeg mob kuaj ntshav. Lub xub ntiag ntawm trypanosomes nyob ua rau nws ua tau kom ntseeg tau kev kuaj mob. Tej zaum koj yuav tau kuaj xyuas cov kua cerebrospinal. Qhov no yog qhov tsim nyog los txiav txim siab txog theem ntawm kev pw tsaug zog mob, muaj peev xwm xaiv cov tshuaj. Nws yog ib qho tseem ceeb heev uas yuav tau pib kho sai li sai tau. Thaum pib, cov tshuaj arsenic, suramin, pentamidine yog siv. Nrog rau daim ntawv Gambian, eflornithine zoo. Kev kho mob pw tsaug zog nrog cov tshuaj no tshwm sim nyob rau hauv kev saib xyuas nruj ntawm cov kws kho mob tshwj xeeb, vim lawv txhua tus muaj tshuaj lom heev, thiab tuaj yeem ua rau muaj qhov tshwm sim loj heev.
Txoj kev kho tau zoo npaum li cas, txiav txim siab los ntawm cov ntshav (thiab cov kua cerebrospinal), uas yuav tsum tau ua txhua xyoo. Qhov no yog vim qhov tseeb tias tus kab mob cab tuaj yeem ua haujlwm tau ntev, thiab tus kab mob tuaj yeem rov zoo txawm tias ob peb lub hlis tom qab kev kho mob hnyav.
Yuav tiv thaiv koj tus kheej li cas ntawm tus kab mob no
Ua ntej tshaj plaws, koj yuav tsum tsis txhob mus xyuas thaj chaw uas muaj tus kab mob pw tsaug zog pom muaj ntau yam tsis tas yuav tsum muaj huab cua. Yog tias qhov no tsis tuaj yeem zam tau, ces koj yuav tsum nco ntsoov txog cov tshuaj tua kab. Muaj cov tshuaj tua kab mob tshwj xeeb uas tua yoov, thiab lwm yam. Cov khaub ncaws yuav tsum tau xaiv nrog lub tes tsho ntev, lub teeb xim. Tsis tas li ntawd, thaum muaj mob hnyav ntawm kev pw tsaug zog, nws raug nquahu kom muab cov tshuaj pentamidine. Hauv cov tebchaws African, cov hav txwv yeem raug txiav kom ze ze, thiab tsetse yoov raug tshem tawm nrog kev pab ntawm cov tshuaj. NtawmNrog rau kev kho mob raws sij hawm, cov neeg mob rov qab mus txog 100%. Yog tias kev kho mob pib lig, lossis yog tias pw tsaug zog mob yog tshwm sim los ntawm Rhodesian hom kab mob cab, ces qhov kev tshwm sim hauv qhov no tsis yog qhov txhawb nqa. Nws tsim nyog nco ntsoov tias kev pw tsaug zog yog qhov mob hnyav yog tias tsis kho.
