Kev nce siab hauv qib ntawm serotonin yog ib qho mob hnyav heev, uas yog nrog los ntawm kev cuam tshuam loj hauv kev ua haujlwm ntawm tag nrho cov kab mob. Raws li txoj cai, cov kev hloov pauv no yog tshwm sim los ntawm kev noj qee yam tshuaj lossis kev siv tshuaj ntau dhau. Thaum tsis muaj kev kho mob raws sijhawm, qhov xwm txheej zoo li no yog qhov txaus ntshai, qee zaum cuam tshuam tsis tau. Tias yog vim li cas nws thiaj li tsim nyog xav txog cov ntaub ntawv hais txog dab tsi yog qhov laj thawj tseem ceeb thiab cov tsos mob ntawm serotonin syndrome. Cov kev kho mob dab tsi tuaj yeem muab cov tshuaj niaj hnub no thiab qhov kev pheej hmoo ntawm qhov tsis kho yog dab tsi?
Serotonin syndrome: nws yog dab tsi?
Qhov tseeb, thawj cov ntaub ntawv hais txog tus mob no tshwm sim tsis ntev dhau los. Nyob rau xyoo 1960, thawj qhov kev tshawb fawb ntawm cov ncauj lus no tau luam tawm hauv Tebchaws Meskas. Qhov tseeb yog qhov ua rau ntawm tus mob, uas, qhov tseeb, yog nrog los ntawm kev nce ntxiv ntawm cov tshuaj no hauv cov paj hlwb, yog qee qhov cuam tshuam nrog kev noj tshuaj tiv thaiv kab mob.
Raws li koj paub, tus mob ntawm serotonin deficiency ua rau muaj kev nyuaj siab. Thiab nyob rau hauv lub xyoo pua xeem, ib qho kev kho rau cov teeb meem no tau tsim, tam sim no hu ua"antidepressants". Cov tshuaj no pab nce qib ntawm serotonin, nrov npe hu ua "hormone ntawm kev zoo siab." Nyob rau hauv lawv cov cawv, qaug zog ntev thiab apathy maj mam ploj mus, thiab tus neeg maj mam rov qab mus rau lub neej zoo li qub. Txawm li cas los xij, nyob rau hauv ntau dhau lawm, serotonin ua cov tshuaj lom, ua rau cov paj hlwb puas, ua rau muaj ntau yam teeb meem hauv lub cev. Ib yam mob zoo sib xws tuaj yeem yog qhov tshwm sim ntawm kev noj tshuaj tiv thaiv kev ntxhov siab, lossis kev sib xyaw ntawm cov tshuaj tiv thaiv kev ntxhov siab thiab lwm yam tshuaj (piv txwv li, qee cov tshuaj hnoos hnoos, thiab lwm yam).
Qhov tseeb, nyob rau hauv lub ntiaj teb niaj hnub no, cov neeg mob ntawm serotonin syndrome tsis tau sau ntau zaus. Tab sis, raws li kws kho mob thiab cov kws tshawb fawb, qhov no tshwm sim tsuas yog vim tias qhov teeb meem no yog qhov txawv txav ntawm cov tsos mob me me uas feem ntau tshwm sim los ntawm kev ntxhov siab lossis qaug zog. Tias yog vim li cas nws thiaj tsim nyog paub tias yog vim li cas serotonin syndrome tuaj yeem tshwm sim, nws yog dab tsi thiab cov cim qhia nws tau nrog.
Lub luag haujlwm tseem ceeb ntawm serotonin
Nws tsim nyog paub txog cov txheej txheem ntawm kev ua ntawm "hormone ntawm kev zoo siab" ua ntej txiav txim siab yuav ua li cas thiab vim li cas serotonin syndrome tshwm sim. Cov khoom no yog dab tsi? Lub luag haujlwm tseem ceeb ntawm serotonin yog kev tswj hwm kev ua haujlwm ntawm qee lub hlwb neurons. Dhau los ntawm cov synaptic cleft los ntawm ib tug neuron, cov tshuaj no reacts nrog tshwj xeeb receptors nyob rau hauv daim nyias nyias ntawm ib tug nyob sib ze paj hlwb, activating nws thiab ua rau ib tug paj hlwb impulse.
Muaj ntau lub tshuablos tswj tus nqi ntawm serotonin hauv lub cev. Hauv particular, qhov no yog reuptake, uas cov molecule rov qab mus rau cov txheej txheem ntawm thawj neuron (los ntawm txoj kev, feem ntau cov tshuaj tiv thaiv kev nyuaj siab yog serotonin reuptake inhibitors), nrog rau cov kev cai enzymatic, nyob rau hauv uas tshwj xeeb active tshuaj zom cov tshuaj hormone molecule.
Serotonin tswj ntau txheej txheem hauv lub cev, suav nrog:
- sijhawm pw tsaug zog thiab tsaug zog;
- qab zib;
- kev txhim kho lossis ploj ntawm kev xav xeev siab;
- tib neeg kev coj cwj pwm;
- mechanisms ntawm thermoregulation;
- pain perception;
- txhawb lub suab nrov;
- mob plab hnyuv;
- kev tswj lub suab nrov;
- Serotonin tau raug pov thawj tias koom nrog hauv kev txhim kho migraine.
Raws li koj tuaj yeem pom, "hormones ntawm kev zoo siab" muab rau tib neeg lub cev tsis yog nrog kev zoo siab xwb. Tom qab kawm txog cov haujlwm ntawm cov tshuaj no, ib tus tuaj yeem xav txog cov tsos mob ntawm serotonin syndrome. Los ntawm txoj kev, qhov siab tshaj plaws concentration ntawm cov tshuaj hormones yog pom nyob rau hauv lub hlwb qia thiab reticular tsim.
Serotonin syndrome: biochemistry. Dab tsi tuaj yeem ua rau muaj kev ua txhaum cai?
Raws li twb tau hais lawm, qhov teeb meem no feem ntau tshwm sim thaum noj qee yam tshuaj lossis lawv ua ke. Yog li cov tshuaj dab tsi tuaj yeem ua rau muaj kev txhim kho ntawm cov kab mob txaus ntshai xws li serotonin syndrome?
- Cipralex thiab lwm yam hluavtaws inhibitorsReuptake ntawm serotonin thiab monoamine oxidase.
- Kev siv sib xyaw ntawm monoamine oxidase inhibitors thiab thyroid hormones, Clomipramine, Carbamazepine, Imipramine thiab Amitriptyline.
- Kev sib xyaw ntawm MAO inhibitors thiab qee cov tshuaj siv rau kev poob phaus, tshwj xeeb yog Desopimon, Fepranone.
- Kev sib xyaw ntawm SSRI lossis MAO inhibitors nrog cov tshuaj muaj L-tryptophan, St. John's wort extract thiab ecstasy.
- Kev sib xyaw ntawm cov tshuaj tiv thaiv kev ntxhov siab nrog kev npaj lithium, tshwj xeeb yog Contemnol thiab Quilonium.
- Kev noj ib txhij ntawm inhibitors nrog dextromethorphan (qhov no yog ib yam khoom muaj nyob hauv ntau cov tshuaj hnoos hnoos, suav nrog Caffetin Txias, Glycodin, Tussin Plus thiab lwm yam.
- Kev sib xyaw ntawm serotonin reuptake inhibitors nrog cov tshuaj xws li Dihydroergotamine, Sumatriptan (tshuaj kho mob migraine), Levodop (siv rau Parkinson's disease).
- Muaj pov thawj tias serotonin syndrome tuaj yeem txhim kho thaum haus cawv thaum noj tshuaj tiv thaiv kev nyuaj siab.
Nws tsim nyog hais tam sim ntawd nws yuav luag tsis tuaj yeem kwv yees seb tus mob puas yuav tshwm sim tawm tsam keeb kwm ntawm kev kho mob uas kws kho mob tau sau tseg. Nws tag nrho nyob ntawm qhov koob tshuaj, tus yam ntxwv ntawm tus neeg mob lub cev, nws lub hnub nyoog thiab ntau lwm yam. Txawm li cas los xij, yog tias koj tau txais cov tshuaj tiv thaiv kev ntxhov siab, nco ntsoov qhia koj tus kws kho mob txog txhua yam tshuaj uas koj tau noj thiab nco ntsoov sab laj txog kev qhia cov tshiab rau hauv txoj kev kho mob, txawm tias nws yog tshuaj hnoos tsis tu ncua.
yam ntxwv tseem ceeb ntawm daim duab kho mob
Serotonin syndrome tshwm sim li cas? Cov tsos mob ntawm nws nyob rau hauv ib nrab ntawm cov mob tshwm sim 2-4 teev tom qab noj cov tshuaj. Tab sis thawj cov tsos mob yuav tshwm sim hauv ib hnub. Hauv kev txuas nrog lub luag haujlwm tseem ceeb ntawm serotonin, txhua yam kev mob tshwm sim feem ntau yog muab faib ua peb pawg loj:
- kev puas hlwb;
- teeb meem nqaij leeg thiab peripheral paj hlwb;
- kev tsis sib haum xeeb.
Txhua cov tsos mob tshwm sim yuav tau piav qhia hauv qab no, tab sis ua ntej nws yuav tsum tau hais tias kev sib txawv ntawm tus kheej tsis yog lub hauv paus rau kev kuaj mob. Tsuas yog ib qho kev kuaj tag nrho, kev kuaj sim thiab muaj qhov nyuaj ntawm qee cov tsos mob thiab qhov ua rau muaj kev pheej hmoo ua rau nws muaj peev xwm kuaj tau ntau tshaj ntawm serotonin hauv cov paj hlwb.
Kev puas siab puas ntsws raws li tus mob
Yuav ua li cas thiaj paub txog serotonin syndrome? Cov tsos mob zoo li pib nrog kev puas siab puas ntsws, suav nrog:
- xov xwm zoo siab;
- piav tsis tau, ua rau muaj kev ntshai thiab kev ntxhov siab, qee zaum nce mus txog kev tawm tsam;
- qee zaum muaj lwm daim duab - ib tug neeg ntsib kev zoo siab, kev xyiv fab hnyav, muaj siab xav txav, tham tsis tu ncua thiab ua ib yam dab tsi;
- ua tau thiab tsis nco qab;
- nyob rau hauv qhov mob hnyav dua, kev xav thiab kev xav tsis zoo tshwm sim.
Nws tsim nyog sau cia tias cov tsos mob thiab lawv qhov hnyav ncaj qha nyob ntawmqhov hnyav ntawm cov tshuaj lom. Piv txwv li, qee zaum tsuas muaj kev xav tsis zoo xwb. Hauv lwm qhov xwm txheej, muaj qhov tshwm sim ntawm cov tsos mob ntawm tus kab mob hauv qab (piv txwv li, kev nyuaj siab), uas yog vim li cas cov tshuaj txuas ntxiv mus. Hauv qhov xwm txheej hnyav tshaj plaws, tus neeg mob raug kev txom nyem los ntawm kev tsis sib haum xeeb, tsis meej pem hauv ntiaj teb ib puag ncig nws thiab nws tus kheej tus cwj pwm, raug kev txom nyem los ntawm kev xav thiab ntau yam kev xav.
Basic autonomic tsos mob
Muaj lwm cov tsos mob uas nrog serotonin syndrome. Kev puas tsuaj los ntawm kev dhia ntse hauv qib ntawm cov khoom no yuav zoo li txawv. Tshwj xeeb, cov kab mob autonomic kuj tau pom, suav nrog cov hauv qab no:
- cov menyuam kawm ntawv nthuav dav thiab nce lacrimation;
- nce plawv dhia, tachycardia;
- nce pa ua pa;
- qee zaum muaj qhov nce hauv lub cev kub (feem ntau nws me me, tab sis kub taub hau ntawm 42 degrees tau sau tseg rau qee tus neeg mob);
- nce ntshav siab nrog cov tsos mob mus txog qhov tsis nco qab;
- pom lub qhov ncauj qhuav thiab qee qhov mucous;
- nrawm nrawm ntawm lub plab zom mov, uas, dhau los, tuaj yeem ua rau muaj teeb meem xws li raws plab, xeev siab thiab ntuav, flatulence, tsam plab thiab mob plab ntawm qhov sib txawv hnyav;
- xav txias;
- mob taub hau, qee zaum migraines.
Raws li koj tuaj yeem pom, cov tsos mob ntawm tus kab mob no tsis yog qhov tshwj xeeb, txij li cov tsos mob tib yam tuaj yeem ua taunrog los ntawm ntau yam kab mob.
Neuromuscular disorders txuam nrog cov syndrome
Raws li twb tau hais lawm, serotonin tswj kev sib kis ntawm cov hlab ntsha impulses. Tias yog vim li cas qhov kev hloov pauv ntawm cov tshuaj no cuam tshuam rau kev ua haujlwm neuromuscular. Nov yog ib daim ntawv teev cov kev mob tshwm sim:
- nce kev siv zog ntawm cov leeg reflexes (reflexes ntawm qis extremities yog tshwj xeeb tshaj tawm);
- nce nqaij pob txha, qee zaum nce mus rau cov leeg nruj;
- nrawm nrawm thiab tsis xwm yeem ntawm cov leeg nqaij ib leeg (qee zaum txawm tias tag nrho cov leeg nqaij);
- tshee tshee;
- tsis txhob txav ntawm lub qhov muag (hauv tshuaj, lo lus "nystagmus" yog siv rau qhov no);
- qee zaum muaj qhov muag qhov muag, uas yog nrog los ntawm kev tsis yeem dov ntawm lub qhov muag nce lossis nqis;
- qee zaus sau tseg kev qaug dab peg;
- kev sib cav;
- teeb meem nrog kev hais lus, nws qhov muag plooj thiab qhov tsis raug, uas tshwm sim vim tsis muaj kev cog lus ntawm cov leeg ntawm articulatory apparatus.
Nws yuav tsum nkag siab tias tag nrho cov cim saum toj no ntawm serotonin syndrome yog qhov tsawg heev. Feem ntau, cov neeg mob raug kev txom nyem los ntawm qee qhov kev mob, thiab yog li kev kuaj mob ntawm pathology yog ib qho nyuaj heev.
YKev mob hnyav ntawm pathology
Hauv cov tshuaj niaj hnub no, nws yog ib txwm ua kom paub qhov txawv ntawm peb theem ntawm kev loj hlob ntawm tus mob, xws li:
- mob me me pathologynrog, raws li txoj cai, los ntawm kev tawm hws ntau dhau, me ntsis tshee tshee ntawm tes thiab hauv caug, thiab tsis dhau qhov kev nce hauv qhov zaus ntawm lub plawv contractions. Cov reflexes kuj dhau los ua me ntsis, txawm hais tias lub cev kub tsis nce. Qee lub sij hawm tus neeg mob yuav pom cov menyuam kawm ntawv dilated. Nws tsuas yog ib qho uas cov neeg muaj cov tsos mob no tsis tshua pom tus kws kho mob thiab txuas ntxiv mus noj tshuaj, vim tias cov tsos mob saum toj no tuaj yeem tshwm sim los ntawm kev ntxhov siab lossis kev tawm dag zog ntau dhau.
- Nrog rau qhov mob hnyav ntawm tus kab mob, daim duab kho mob tau tshaj tawm. Cov neeg mob nco ntsoov qhov nce siab hauv lub cev kub (feem ntau mus txog 40 degrees) thiab ntshav siab, tsis tu ncua ntawm cov menyuam kawm ntawv, cov leeg nqaij ntawm caj dab, lub cev muaj zog thiab kev xav zoo siab. Raws li txoj cai, cov tsos mob no ua rau tus neeg nrhiav kev pab, tab sis hmoov tsis, nws tsis yog ib txwm ua tau kom kuaj tau qhov tseeb.
- Mob hnyav serotonin syndrome yog qhov txaus ntshai heev, vim nws tuaj yeem ua rau muaj teeb meem. Nrog rau daim ntawv no ntawm pathology, hnyav tachycardia, nce ntshav siab, ua npaws, nqaij spasms mus txog rigidity, poob siab, thiab disorientation. Cov neeg mob feem ntau muaj qhov pom tseeb tiag tiag. Thaum tsis muaj kev pab raws sijhawm, kev puas tsuaj rau cov leeg, daim siab thiab ob lub raum yog ua tau. Feem ntau cov neeg mob poob rau hauv coma. Qee zaum, ntau lub cev tsis ua haujlwm, uas feem ntau xaus rau hauv kev tuag.
Yog vim li cas koj yuav tsum tsis txhob hnov qab txog cov tsos mob, vim tias qib serotonin tuaj yeem npog tau raws li kev ua haujlwm dhau ib txwm.syndrome. Yuav tawm ntawm lub xeev no li cas thiab puas muaj txoj hauv kev kho tau zoo?
Kev pab xub thawj zoo ib yam
Yuav ua li cas yog tias ib tug neeg xav tias muaj serotonin syndrome? Kev saib xyuas xwm txheej kub ntxhov, raws li txoj cai, muaj nyob rau hauv qhov kev tso tseg tam sim ntawm cov tshuaj uas ua rau muaj tus mob no. Lawm, tus neeg mob yuav tsum tau coj mus rau lub tsev kho mob.
Ua ntej tshaj plaws, kev ua pa hauv plab yog nqa tawm, ua tsaug uas nws muaj peev xwm ntxuav lub cev ntawm cov tshuaj uas tseem tsis tau nqus. Rau tib lub hom phiaj, cov neeg mob tau muab tshuaj sorbents thiab lwm yam tshuaj uas tshem tawm toxins los ntawm lub cev. Hauv qhov mob me me, cov dej num zoo li no txaus los ua kom tus neeg zoo. Cov tsos mob tshwm sim tom qab 6-12 teev.
Tus mob no kho li cas?
Hmoov tsis zoo, kev tshem tawm cov tshuaj thiab ntxuav lub cev ntawm lawv cov seem tsis tas yuav txaus. Yog li cas hom kev kho mob serotonin syndrome xav tau? Kev kho mob, tau kawg, nyob ntawm theem thiab qhov hnyav. Raws li txoj cai, tus neeg mob tau muab tshuaj serotonin receptor antagonists, suav nrog Metisergide thiab Cyproheptadine. Tsis tas li ntawd, cov kev kho mob tau ua tiav, uas ncaj qha nyob ntawm seb muaj qee yam mob.
- Piv txwv li, rau kev qaug dab peg thiab cov leeg nqaij rigidity, benzodiazepines raug tshuaj, suav nrog Lorazepam thiab Sibazon.
- Thaum ua npaws, ua npaws txias thiab qee cov txheej txheem ua haujlwm. Qhov tseeb yog tias qhov kub nce hauv serotonin syndrome tsis cuam tshuam nrogo, tab sis nrog nce nqaij contractility, thiab yog li ntawd cov pa antipyretic thiab non-steroidal anti-inflammatory tshuaj tsis muaj zog. Tsuas yog qhov tshwj xeeb yog paracetamol, txawm hais tias nws yuav tsum tau siv kom zoo.
- Thaum qhov kub nce mus txog 40 lossis ntau dua, tus neeg mob tau muab cov leeg nqaij so. Cov tshuaj no pab txo cov leeg nqaij, txo qhov kub taub hau, thiab tiv thaiv ntau yam kab mob, nrog rau cov teeb meem ntshav txhaws.
- Kev txhaj tshuaj rau hauv cov hlab ntsha kuj tau muab tawm hws ntau dhau, cov leeg nruj thiab raws plab ua rau lub cev qhuav dej.
- Ntxiv rau, nws yuav tsum tau saib xyuas tus neeg mob cov ntshav siab thiab lub plawv dhia, yog tias tsim nyog, ua kom cov ntsuas no ua haujlwm nrog kev pab ntawm cov tshuaj.
Feem ntau, kev kho kom zoo tso cai rau koj kom kho tus neeg mob sai sai thiab zam qhov tshwm sim. Hmoov tsis zoo, tsis tshua muaj tshwm sim, tshwj xeeb tshaj yog tias tus neeg mob tsis tau txais kev kho mob raws sijhawm, serotonin syndrome tuaj yeem ua rau cov leeg nqaij puas tsuaj, ua rau lub raum thiab lub siab puas tsuaj, cov hlab ntsha, thiab thaum kawg tuag. Yog vim li ntawd koj yuav tsum tsis txhob xav tsis thoob noj tshuaj tiv thaiv kev nyuaj siab thiab lwm yam tshuaj.
