Medroxyprogesterone acetate yog ib qho hluavtaws analogue ntawm poj niam txiv neej hormone progesterone. Nyob rau hauv tej yam ntuj tso, cov tshuaj hormones progesterone yog tsim nyob rau hauv lub cev nyob rau hauv lub thib ob ib nrab ntawm kev coj khaub ncaws. Cov tshuaj raws li cov tshuaj no yog siv nyob rau hauv gynecology thiab oncology. Progesterone analogue ua raws li cov tshuaj tiv thaiv kab mob thiab antineoplastic tus neeg sawv cev. Tsis tas li ntawd, medroxyprogesterone tuaj yeem nres qhov tshwm sim ntawm menopause. Hauv tsab xov xwm, peb yuav txiav txim siab nthuav dav cov lus qhia thiab contraindications rau kev siv tshuaj raws li medroxyprogesterone.
Pharmacological action
Medroxyprogesterone acetate cuam tshuam rau lub cev li cas? Cov tshuaj no tsis muaj androgenic lossis estrogenic zog, txawm li cas los xij, nws inhibits zus tau tej cov gonadotropic cov tshuaj hormones los ntawm lub caj pas pituitary. Yog li ntawd, cov txheej txheem maturation yog inhibited nyob rau hauv lub zes qe menyuam.follicles thiab ovulation nres. Medroxyprogesterone ua raws li kev tiv thaiv kab mob vim tias nws thaiv kev tsim cov qe. Feem ntau cov tshuaj raws li medroxyprogesterone yog siv rau kev tiv thaiv kab mob.
Cov tshuaj hormones hluavtaws no tiv thaiv kev loj hlob ntawm lub tsev menyuam mucosa, uas tso cai rau nws siv rau polyposis thiab endometriosis. Medroxyprogesterone kuj txo cov tsos mob ntawm tus neeg mob lub cev tsis muaj zog (xws li kub, dej ntws).
Tshuaj nrog medroxyprogesterone inhibit qhov kev loj hlob ntawm cov qog. Yog tias qhov kev loj hlob ntawm neoplasm nyob ntawm kev tsim cov tshuaj hormones, tom qab ntawd cov tshuaj progesterone tuaj yeem nres qhov kev faib tawm ntawm cov hlwb tsis zoo.
npe lag luam
Muaj ntau hom tshuaj uas muaj medroxyprogesterone acetate. Cov npe tshuaj ntawm cov tshuaj no yuav txawv. Lawv yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj thiab nyob rau hauv daim ntawv ntawm suspensions rau txhaj. Cov tshuaj hauv qab no feem ntau pom muaj nyob hauv cov khw muag tshuaj:
- "Depo-Provera";
- "Medroxyprogesterone LENS";
- "Veraplex".
Tag nrho cov tshuaj no yog cov qauv analogues. Lawv muaj tib yam active ingredient - medroxyprogesterone acetate. Tsuas yog daim ntawv tso tawm thiab cov chaw tsim khoom ntawm cov tshuaj no txawv.
Ib daim ntawv
Depo-Provera thiab Medroxyprogesterone (LENS) yog tsim nyob rau hauv daim ntawv ntawm suspensions rau intramusculartxhaj tshuaj. Txhua lub raj mis muaj 150, 500 lossis 1000 mg ntawm cov khoom xyaw nquag.
Veraplex yog tsim nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj muaj 100, 250 lossis 500 mg ntawm cov khoom xyaw nquag. Daim ntawv tshuaj no yog npaj rau kev tswj qhov ncauj.
Kev qhia
Hauv oncology thiab gynecology, muaj cov lus qhia hauv qab no rau kev siv medroxyprogesterone acetate:
- kab mob oncological ntawm endometrium thiab qog mammary hauv cov poj niam;
- raum mob cancer;
- mob qog noj ntshav prostate hauv txiv neej;
- kev tsis sib haum xeeb thaum cev xeeb tub;
- uterine los ntshav;
- endometrial polyps;
- endometriosis.
Nws yog ib qho tseem ceeb uas yuav tsum nco ntsoov tias txhua yam tshuaj hormonal tuaj yeem noj tau tsuas yog nrog kev tso cai los ntawm kws kho mob. Kev npaj nrog hluavtaws analogues ntawm progesterone raug xa tawm los ntawm cov khw muag tshuaj nruj me ntsis los ntawm kev sau ntawv, thiab kev siv tshuaj rau tus kheej hauv qhov no tsis tuaj yeem lees txais.
Cov lus qhia rau kev siv "Depo-Provera" kuj tso cai rau kev siv tshuaj txhaj tshuaj tiv thaiv kab mob. Cov tshuaj yog yooj yim siv, raws li nws muaj ib tug ntev kev txiav txim. Ib qho tshuaj txhaj tshuaj tiv thaiv kab mob txhim khu kev qha rau 1 lub hlis. Txawm li cas los xij, ua ntej siv cov tshuaj no, koj yuav tsum sab laj nrog gynecologist. Cov tshuaj tiv thaiv ntev ntev muaj ntau yam contraindications.
YContraindications
Kev npaj nrog medroxyprogesterone acetate yog kiag li contraindicated nyob rau hauv cov kab mob hauv qab no thiabxeev:
- Y cev xeeb tub thiab lactation;
- vaginal los ntshav;
- kab mob siab;
- ua xua rau hluavtaws progesterone analogues.
Tseem muaj cov txheeb ze contraindications rau kev sau tshuaj uas muaj cov analogues hluavtaws ntawm progesterone:
- mob vwm;
- tom qab mob stroke;
- kab mob plawv;
- migraine;
- raum tsis ua haujlwm;
- thrombophlebitis;
- ntshav siab calcium ntau ntau.
Hauv cov xwm txheej no, cov tshuaj tau muab tshuaj tsuas yog thaum tsim nyog. Lawv tsuas yog yuav tsum tau saib xyuas kev noj qab haus huv ze.
Tsis xav tau
Nws yog ib qho tseem ceeb kom nco ntsoov tias kev npaj tshuaj hormonal nrog medroxyprogesterone muaj ntau yam kev phiv. Yog li ntawd, lawv tsuas yog siv nyob rau hauv kev ua tib zoo saib xyuas tus neeg mob tus mob. Feem ntau, cov neeg mob muaj qhov tshwm sim tsis zoo hauv qab no:
- mob taub hau;
- Khiachim siab, chim siab, pw tsaug zog;
- ob lub zeem muag;
- pom muaj hnub nyoog me ntsis thiab pob txuv ntawm daim tawv nqaij;
- dyspepsia (xeev siab, raws plab);
- mis loj;
- hormonal ntshawv siab hauv lub cev;
- libido mob;
- ua xua ntawm daim tawv nqaij (ua pob khaus, khaus).
Nyob tsis tshua muaj, cov neeg mob tsim Itsenko-Cushing's syndrome, nrog rau kev rog hnyav ntawm lub cev thiab lub plab, ntau dhau.lub ntsej muag plaub hau, cov tsos ntawm stretch marks ntawm daim tawv nqaij. Nyob rau hauv tas li ntawd, cov tshuaj yuav tsum tau txiav.
Cov lus qhia rau kev siv "Depo-Provera" ceeb toom txog kev ua txhaum cai ntev ntawm kev coj khaub ncaws thiab ovulation tom qab siv tshuaj. Yog li ntawd, gynecologists tsis pom zoo kom siv cov tshuaj tiv thaiv no rau cov ntxhais hluas. Kev txhaj tshuaj tiv thaiv kab mob feem ntau yog muab rau cov poj niam hnub nyoog laus. Cov tshuaj ua kom ntev ntev yog qhia rau cov neeg mob uas twb muaj menyuam lawm thiab tsis npaj cev xeeb tub yav tom ntej.
Qhov kev txiav txim ntawm medroxyprogesterone ntawm tus poj niam lub cev yog qhov thim rov qab. Txawm li cas los xij, hauv ntau tus neeg mob, kev coj khaub ncaws tsis xwm yeem thiab ovulation tuaj yeem kav li ntawm 12 txog 30 lub hlis. Feem ntau, cov txheej txheem ua me nyuam rov qab tau ntev tom qab txhaj tshuaj Depo-Provera.
Yuav siv li cas
Cov ntawv txhaj tshuaj ntawm Depo-Provera thiab Medroxyprogesterone-LENS tau muab tshuaj intramuscularly ntawm thawj koob tshuaj ntawm 50 txog 500 mg. Lub tswv yim thiab lub sij hawm ntawm kev kho mob yog txiav txim los ntawm qhov xwm ntawm tus kab mob. Thaum lub sijhawm kho, nws yog ib qho tsim nyog los tswj cov ntsiab lus ntawm daim siab enzymes hauv cov ntshav, nrog rau qib ntawm cov piam thaj siab. Nws yog ib qho tseem ceeb los saib xyuas tus neeg mob qhov hnyav, vim tias kev kho mob nrog cov tshuaj hormones progesterone feem ntau ua rau kev rog.
Yog tias Depo-Provera siv los ua cov tshuaj tiv thaiv ntev, ces150 mg raug tshem tawm ib hlis ib zaug. Kev txhaj tshuaj yuav tsum tau ua nyob rau thawj 5 hnub txij thaum pib cev xeeb tub.
Cov lus qhia rau kev siv "Veraplex" hauv cov ntsiav tshuaj pom zoo pib kho nrog koob tshuaj 200-600 mg ib hnub. Cov tshuaj no tau muab faib ua ob peb koob tshuaj. Rau kev mob qog noj ntshav mis, kev siv tshuaj ntau dua txhua hnub ntawm 400 txog 1200 mg ib hnub twg yuav raug siv.
Reviews
Koj tuaj yeem nrhiav ntau yam tshuaj xyuas ntawm cov tshuaj raws li medroxyprogesterone. Kev xav ntawm cov neeg mob qog noj ntshav txog cov tshuaj no feem ntau yog qhov zoo. Yog tias siv medroxyprogesterone nyob rau hauv cov theem pib ntawm cov qog nqaij hlav hormone-dependent, tom qab kev kho mob muaj qhov txo qis hauv kev loj hlob ntawm neoplasm.
Cov neeg mob raug mob los ntawm qhov tshwm sim hnyav heev ntawm kev ua poj niam cev xeeb tub kuj teb zoo rau cov tshuaj. Siv Depo-Provera pab lawv tshem tawm cov kub flashes, kub flashes thiab mus ob peb vas hloov ntawm menopause.
Muaj kev tsis sib haum xeeb txog kev tiv thaiv mus ntev los ntawm kev txhaj tshuaj Depo-Provera. Cov neeg mob nco txog qhov yooj yim ntawm kev siv cov cuab yeej no. Txhawm rau kom ua tiav cov txiaj ntsig tiv thaiv kab mob, koj tsis tas yuav noj tshuaj txhua hnub, tab sis tsuas yog ib qho kev txhaj tshuaj ib hlis xwb. Txawm li cas los xij, ntau tus poj niam yws yws txog cov kev phiv ntawm cov tshuaj tiv thaiv no. Feem ntau, cov neeg mob tau ntsib qhov hnyav nce, dyspeptic thiab ua xua tshwm sim.
Qee tus poj niam tau tshaj tawm ntev amenorrhea thiab anovulation tom qab txiav cov tshuaj. Restoration ntawm reproductive muaj nuj nqisiv sij hawm ntev heev. Yog li ntawd, ua ntej siv cov tshuaj tiv thaiv ntev, nws yog ib qho tsim nyog yuav tsum tau kuaj xyuas gynecological thiab kho. Qhov no yuav pab coj mus rau hauv tus account tag nrho cov indications thiab contraindications rau kev siv xws li tshuaj.
