Fibrinogen yog ib qho ntawm cov ntshav proteins koom nrog hauv cov txheej txheem ntawm nws coagulation. Koj tuaj yeem pom tus nqi ntawm qhov ntsuas no hauv coagulogram - qhov tshwm sim ntawm kev tsom xam rau ntshav txhaws. Cov qauv ntawm fibrinogen rau cov neeg laus noj qab nyob zoo yog li ntawm 1.5 mus rau 5 grams ib liter ntawm cov ntshav. Cov protein yog dab tsi, nws ua haujlwm li cas thiab cov qauv sib txawv li cas, koj yuav kawm los ntawm peb tsab xov xwm.
Fibrinogen hauv tib neeg lub cev
Fibrinogen yog tsim los ntawm daim siab hlwb thiab nkag mus rau hauv cov hlab ntsha nrog rau lwm cov proteins. Nws yog xim tsis muaj xim, yooj yim soluble hauv cov kua thiab muaj qhov loj. Ntxiv rau qhov hnyav dua li lwm cov proteins, fibrinogen muaj peev xwm tsim cov ntshav txhaws, yog li qhov nce ntxiv ntawm nws cuam tshuam rau lwm qhov kev tshuaj ntsuam, xws li ESR (erythrocyte sedimentation rate). Yog tias fibrinogen siab dua li qub, ESR yuav nce.
Tib lub sijhawm, cov protein no yooj yim nkag mus rau hauv qhov chaw extravascular, nyob hauv cov qog thiab cov ntaub so ntswg. Nrog mob hnyavpathologies, nws cov nyiaj sab nraud tuaj yeem ncav cuag 80% ntawm tag nrho cov ntim hauv lub cev.
Peb twb tau tham me ntsis txog cov qauv ntawm fibrinogen. Cov ntsiab lus ntawm cov protein no hauv cov ntshav ntawm cov neeg noj qab haus huv yog qhov ruaj khov, nws cov nyiaj tsis hloov nyob ntawm lub sijhawm ntawm hnub, poj niam txiv neej thiab hnub nyoog ntawm tib neeg. Qhov tshwj xeeb yog cov menyuam yug tshiab thiab cov poj niam cev xeeb tub, tus nqi nce me ntsis hauv cov neeg laus.
Fibrinogen yog tus cwj pwm los ntawm kev rov ua dua tshiab hauv lub cev, lub neej ib nrab yog peb hnub. Los ntawm 1.5 mus rau 5 grams protein yog tsim txhua hnub. Thiab nyob rau hauv ib hnub, lub cev muaj peev xwm rov qab mus txog ib feem peb ntawm tag nrho cov ntim tam sim no.
Fibrinogen muaj nuj nqi
Fibrinogen ua nws lub cev ua haujlwm tom qab cuam tshuam nrog lwm cov protein, thrombin, uas rhuav tshem nws thiab hloov mus ua fibrin. Fibrin molecules yog ib hom ntawm cov hlua protein uas ua ke rau hauv ib qho mesh uas erythrocytes ua entangled. Raws li qhov tshwm sim ntawm cov kev hloov pauv no, cov ntshav txhaws tshwm - lub thrombus uas kaw cov hlab ntsha puas. Yog li, fibrinogen koom nrog hauv cov txheej txheem ntawm kev tso ntshav thiab kho cov ntaub so ntswg puas.
Fibrinogen tseem ua haujlwm tiv thaiv, tiv thaiv kev nkag mus ntawm cov kab mob los ntawm qhov txhab. Yog li, nws pom tseeb tias qhov txo qis hauv fibrinogen ua rau txoj kev loj hlob los ntshav.
Tsis tas li ntawd, cov protein cuam tshuam rau kev ua haujlwm ntawm cov qe ntshav liab, raws li cov qauv ntawm fibrinogen hauv cov ntshav, lawv muaj peev xwm xa oxygen ntau tshaj.thiab cov as-ham rau hauv lub cev ntawm lub cev.
Txoj kev kuaj ntshav rau fibrinogen
Fibrinogen feem ntau yog ib feem ntawm kev tsom xam ntawm cov ntshav coagulability - ib coagulogram. Tam sim no nws yog feem ntau hu ua hemostasiogram. Nws yog tib txoj kev kawm.
Kev txiav txim siab ntawm fibrinogen concentration yog ua tiav feem ntau los ntawm Clauss txoj kev nrog ntau tshaj ntawm thrombin. Nyob rau hauv xws li ib tug system, lub sij hawm tsim los ntshav nyob ntawm seb lub concentration ntawm active fibrinogen nyob rau hauv tus qauv.
Kev sib xyaw yog txiav txim siab hauv cov ntshav plasma tau los ntawm cov ntshav venous. Ua ntej txoj kev tshawb fawb, cov qauv tuaj yeem khaws cia rau 4 teev ntawm chav tsev kub, 8 teev nyob rau hauv lub tub yees, yog li kev soj ntsuam yog nqa tawm nyob rau hnub kuaj ntshav. Yog tias qhov tshwm sim sai yog qhov tseem ceeb rau koj, koj tuaj yeem tiv tauj rau chav kuaj ntiag tug.
Ntshav rau hemostasis yog muab los ntawm cov hlab ntsha mus rau hauv lub tshuab nqus tsev nrog sodium citrate. Tus qauv xim xaiv yog lub kaus mom xiav. Nws yuav muaj txiaj ntsig zoo los soj ntsuam cov txheej txheem ntsuas ntawm koj qhov. Qhov tseeb yog tias feem ntau cov qauv nws yog ib qho tseem ceeb rau invert lub raj ob peb zaug tom qab kuaj ntshav thiaj li yuav sib tov cov ntshav nrog cov reagent. Rau cov ntshav rau hemostasis, tshee yog txwv tsis pub, nws tuaj yeem ua rau muaj kev cuam tshuam loj ntawm qhov kev soj ntsuam.
Koj tuaj yeem nug seb qhov kev tshawb fawb yuav ua li cas. Nws muaj peev xwm los ua ib qho kev kawm phau ntawv los ntawm ib tus kws kuaj mob tshwj xeeb, semi-automatic (thaum ib tus neeg npaj cov qauv, thiab tshuaj xyuas cov cuab yeej) thiab kev kawm ntawm lub tshuab ntsuas tsis siv neeg yam tsis muaj kev cuam tshuam rau tib neeg. Qhov thib peb yog qhov tseeb tshaj plaws.kev xaiv. Thiab yog tias koj tsis ntseeg cov txiaj ntsig ntawm koj qhov kev tshuaj ntsuam, ces nws yog qhov zoo tshaj rau hu rau lub tsev haujlwm uas muaj lub tshuab coagulometer.
Npaj rau kev tshuaj ntsuam
Kev tshuaj ntsuam rau hemostasis yog coj los ntawm cov hlab ntsha, thaum sawv ntxov, ntawm plab khoob.
- Tom qab noj mov, 8 mus rau 14 teev yuav tsum dhau.
- Tsis txhob haus luam yeeb tsawg kawg 40 feeb ua ntej pub ntshav.
- Yuav txwv tsis pub haus cawv ib hnub ua ntej.
- Kev tawm dag zog thiab kev ntxhov siab yuav tsum zam ib teev ua ntej kev tshuaj ntsuam.
Qee cov tshuaj kuj cuam tshuam qhov tshwm sim ntawm kev tshuaj ntsuam. Lawv qhov kev txais tos yuav tsum tau nres, lossis nws raug qhia rau tus kws kho mob uas tau xa mus rau txoj kev kawm:
- heparin;
- estrogen, androgen, tshuaj tiv thaiv qhov ncauj;
- tshuaj steroid;
- asparaginase;
- valproic acid;
- ntses roj.
Fibrinogen test: tus qauv
Raws li twb tau sau tseg lawm, kev ruaj ntseg ntawm cov protein ntau hauv cov ntshav tsis ua rau muaj kev sib tw loj hauv qhov ntau ntawm nws cov qauv. Kev sib txawv me me raug tso cai nyob ntawm lub hnub nyoog ntawm tus neeg mob thiab thaum cev xeeb tub thaum cev xeeb tub.
- Ntshai - 1.3-3 g / l.
- Cov menyuam yaus hnub nyoog qis dua 7 xyoos - 1.5-4 g / l.
- txiv neej thiab poj niam 2-4 g/l.
- Cov laus 3-6g/l.
Nquag, kev kuaj ntshav rau fibrinogen yog sau tseg: ua ntej kev phais, rau cov kab mob plawv, rau kab mob siab, rau kev xav tias mob ntawm lub cev thiab saib xyuas lub sijhawm cev xeeb tub.
Nyob zoo thaum cev xeeb tub
Fibrinogen qib hauv cov poj niam cev xeeb tub nce hauv peb lub hlis thib peb. Qhov no yog vim qhov kev npaj ntawm lub cev rau kev ua haujlwm ntuj thiab tiv thaiv cov ntshav ntau thaum lub sijhawm nws.
Tus nqi ntawm fibrinogen hauv cov ntshav cuam tshuam rau lub sijhawm cev xeeb tub, yog li hauv txhua lub peb hlis ntuj nws qib tau ua tib zoo saib xyuas. Cov qauv raug qhia hauv lub rooj.
| Obstetric gestational age in weeks | Yam tsawg kawg nkaus tso cai fibrinogen concentration, g / l | Qhov siab tshaj plaws tso cai ntawm fibrinogen, g / l |
| 1-13 | 2, 12 | 4, 33 |
| 13-21 | 2, 90 | 5, 30 |
| 21-29 | 3,00 | 5, 70 |
| 29-35 | 3, 20 | 5, 70 |
| 35-42 | 3, 50 | 6, 50 |
siab fibrinogen thaum cev xeeb tub
Feem ntau, hauv thawj peb lub hlis twg, theem ntawm fibrinogen hauv cov poj niam (saib cov qauv saum toj no) txo qis vim qhov tshwm sim ntawm toxicosis tau ntsib. Hauv qhov thib ob, nws pib loj hlob dua thiab thaum kawg ntawm qhov thib peb nce mus txog nws qhov siab tshaj plaws - los ntawm 4 mus rau 6 g / l ntawm cov ntshav. Cov nqi siab dua ua rau muaj teeb meem hauv daim ntawv ntawm cov ntshav txhaws hauv txoj hlab ntaws, kev rho menyuam tawm tsis tu ncua, tshem tawm ntawm cov placenta li qub thiab preeclampsia. Txhua yam kev kho mob hauv qhov xwm txheej no tsuas yog muab los ntawm gynecologist thiab gemologist ua tus cev xeeb tub.
Txo cov fibrinogen ntawmcev xeeb tub
Qhov xwm txheej rov qab tsis muaj kev phom sij tsawg dua. Txij li thaum fibrinogen yog lub luag haujlwm rau cov ntshav txhaws, nws qhov tsis txaus tuaj yeem ua rau hnyav los ntshav thaum yug menyuam thiab txawm tuag. Qib ntawm fibrinogen hauv cov ntshav qis dua cov qauv hauv cov poj niam feem ntau nrog rau cov ntaub ntawv hnyav ntawm toxicosis lig thiab DIC. Nrog txoj kev kho mob zoo, qhov no tuaj yeem kho tau. Qhov tseem ceeb tshaj plaws yog kev ntsuas tsim nyog nyob rau lub sijhawm, thiab rau qhov no, yuav tsum tau kuaj xyuas raws sijhawm.
Ntau fibrinogen hauv tib neeg lub cev
Yog tias qib ntawm fibrinogen hauv cov ntshav siab dua li qub, nws txhais li cas? Fibrinogen feem ntau raug xa mus rau theem mob protein ntau hauv tshuaj. Qhov no txhais tau hais tias cov hauv qab no: nyob rau hauv cov mob hnyav, cov kab mob txaus ntshai ntawm cov kab mob hauv nruab nrog cev, tib neeg lub cev coj tag nrho nws lub zog rau lawv txoj kev kho. Tshwj xeeb, ntau cov fibrinogen raug tso rau hauv cov ntshav - cov protein ua lub luag haujlwm kho cov ntaub so ntswg, kom tsis txhob los ntshav.
Yog li, nrog rau qhov tseem ceeb tshaj ntawm cov qauv ntawm fibrinogen hauv cov ntshav, qhov tshwm sim ntawm tus kab mob no tau tshwm sim. Nws tau txiav txim siab ntxiv los ntawm cov tsos mob thiab kev sim.
Kev sib txawv ntawm qhov kev lees paub ntawm fibrinogen yuav tsis yog tshwm sim los ntawm ib qho kab mob, tab sis muaj kab mob autoimmune (uas yog, kev ua txhaum ntawm lub cev tawm tsam nws tus kheej). Qhov tshwm sim ntawm qhov nce no tuaj yeem ua rau thrombosis thiab thrombophlebitis, uas yog, txhaws ntawm cov hlab ntsha los ntawm cov ntshav txhaws.
Txo cov fibrinogen hauv tib neeg lub cev
Tus qauv ntawm fibrinogen hauv cov ntshavtej zaum yuav underestimated vim ob qho tib si congenital thiab kis kab mob. Qhov ua rau tuaj yeem tsis yog cov kab mob ntshav xwb, tab sis kuj yog lub luag haujlwm rau kev tsim cov fibrinogen, lub siab.
Qhov tshwm sim ntawm nws qhov tsis muaj cov ntshav yog nws cov liquefaction nce thiab nyiam los ntshav. Cov ntshav uas tsis txaus ntawm fibrinogen tsis tuaj yeem ua tiav nws txoj haujlwm. Tsawg oxygen nkag mus rau hauv lub cev, cov kab mob thiab kab mob kis tau zoo dua. Txawm tias kev raug mob me me tuaj yeem ua rau los ntshav ntau, thiab qhov tshwm sim ntawm kev raug mob hnyav yog kev tuag vim qhov poob ntawm cov ntshav tseem ceeb.
Qhov ua rau txo qis fibrinogen tuaj yeem ua rau ntau yam kab mob ntshav, xws li hemophilia, DIC, myeloid leukemia, polycythemia, ntshav qog noj ntshav. Ntawm cov kab mob kis tau, kab mob siab ua rau txo qis hauv nws qib. Tsis tas li ntawd, hypofibrinogenemia tuaj yeem yog qhov tshwm sim tom qab kev phais thiab tom qab yug me nyuam, qhov tsis muaj cov vitamins B thiab C, thiab kev raug mob hnyav heev.
Recommendations
Rau cov kab mob nyuaj, kev kho tshuaj yog muab los ntawm tus kws kho mob. Raws li kev pom zoo nrog nws, kev hloov pauv hauv kev noj haus tau tso cai kom txo lossis nce qib ntawm fibrinogen hauv cov ntshav.
txhawm rau txo cov qib fibrinogen hauv cov ntshav, txoj kev pheej yig tshaj plaws yog kho cov protein ntau hauv cov zaub mov. Nws ntseeg tau tias noj cov ntses rog lossis ntses roj, cov khoom noj uas muaj cov vitamins B12 thiab C, txo qis fibrinogen, pom zoo kom noj cov kua qaub xws li raspberries, lingonberries. Sib nrug los ntawmntau cov vitamins nyob rau hauv raspberries muaj ntuj acetylsalicylic acid, uas thins cov ntshav.
muaj txiaj ntsig zoo ntawm kev txo qis ntawm fibrinogen, thiab ntawm lub cev tag nrho, kev ua kom lub cev ntxiv.
Ib yam tuaj yeem hais txog qis fibrinogen. Raws li qhov tshwm sim, kev kho tshuaj yog muab los ntawm kws kho mob, tom qab sab laj nrog nws, koj tuaj yeem kho koj cov zaub mov thiab pab lub cev.
Cov khoom noj uas nce qib fibrinogen muaj xws li buckwheat thiab lwm yam nplej, soy, qos yaj ywm, zaub qhwv, txiv tsawb, spinach, walnuts thiab qe.
Nco ntsoov tias txhua yam teeb meem kev noj qab haus huv tuaj yeem daws tau los ntawm kev sib koom ua ke. Thaum tau txais cov ntaub ntawv, tsis txhob kho tus kheej, nws yog qhov zoo dua, twb paub txog cov nuances, los txhim kho txoj kev kho kom zoo ua ke nrog tus kws kho mob. Saib xyuas koj tus kheej thiab noj qab haus huv.
