"Pregnil" yog siv rau hauv kev kho mob ntawm anovulatory infertility hauv cov poj niam, nchuav menyuam, kev hem thawj ntawm kev rho menyuam tus kheej, nrog rau lub hom phiaj ntawm kev tswj zes qe menyuam hyperstimulation, ovulation induction thiab nce qib estrogen. Nws siv tau zoo hauv kev tswj hwm ntawm endogenous luteal hormone hloov kho los txhawb kev loj hlob ntawm follicles.
Cov lus qhia rau kev siv rau cov txiv neej yog ncua kev sib deev kev loj hlob cuam tshuam nrog hypofunction ntawm gonads, cryptorchidism, impaired spermatogenesis. Xav txog cov npe nrov tshaj plaws ntawm "Pregnil" hauv kab lus no.
Kev piav qhia ntawm cov tshuaj "Pregnil"
"Pregnil" muaj tib neeg chorionic gonadotropin (HCG). Cov tshuaj no pib tsim los ntawm cov ntaub so ntswg chorion tom qab cov txheej txheem ntawm implantation ntawm lub embryo tiav. CG muaj follicle-stimulating thiab luteinizing kev ua si, txhim khu estrogen secretion thiab pib txheej txheem ntawm ovulation. Nyob rau hauv lub neej yav tom ntej, nws tswj cov kev ua ub no ntawm lub corpus luteum mus txog rau thaum pibKev tsim cov tshuaj estrogen thiab progesterone los ntawm cov placenta.
Kev siv exogenous tib neeg chorionic gonadotropin tsis tsuas yog txhim kho qhov tso tawm ntawm cov tshuaj estrogen thiab progesterone los ntawm zes qe menyuam, tab sis kuj ua rau ovulation, txhawb nqa luteinization tom qab ntawm cov pob txha tawg.
Kev siv CG npaj tau zoo tshaj plaws nyob rau hauv cov tswv yim nrog rau kev teem caij ntawm tib neeg menopausal thiab follicle-stimulating hormones.
Kev kho mob
"Pregnil" (ib qho piv txwv ntawm "Pregnil" yog muaj nyob rau hauv tib cov tshuaj) muaj nyob rau hauv ntau npaum li cas ntawm 1500 thiab 5000 MO. Siv rau kev txhaj tshuaj intramuscular.
Nyob rau hauv kev kho mob anovulatory infertility hauv cov poj niam, ib qho kev txhaj tshuaj ntawm 5,000-10,000 IU raug pom zoo, tom qab ua tiav cov kev kho mob nrog FSH (follicle-stimulating hormone) lossis HMG (tib neeg menopausal gonadotropin).
Ua ntej puncture, rau kev tswj stimulation ntawm zes qe menyuam, tom qab kawg ntawm kev kho mob, 5000 MO yog muab.
Kev txhawb nqa theem Luteal yog muab los ntawm kev txhaj tshuaj cyclic ntawm ib koob ntawm 1000 txog 3000 IU txhua peb hnub - 3 zaug.
Hauv cov txiv neej, nws yog siv rau hypofunction ntawm gonads thiab impaired spermatogenesis nyob rau hauv ntau npaum li cas los ntawm 1000 mus rau 2000 MO ob peb zaug ib lub lim tiam (ib qho analogue ntawm Pregnil tuaj yeem noj raws li tib lub tswv yim).
Hauv kev kho mob cryptorchidism hauv cov menyuam yaus, cov tshuaj siv 2 zaug hauv ib lub lis piam, pom zoo ntau npaum li cas:
- txog 2 xyoos - 250 MO;
- mus txog 6 xyoo xaiv los ntawm 500 txog 1000 MO;
- tom qab 6 xyoo - 1500 MO.
Peb tau tshuaj xyuas cov txheej txheem rau kev siv tshuaj. Tab sis nws yog qhov zoo tshaj plaws ua ntej pib khomus ntsib kws kho mob thiab tau txais daim ntawv tshuaj los ntawm nws.
Analogues ntawm "Pregnil"
Dab tsi yog cov analogues ntawm cov tshuaj "Pregnil"? Qhov tseeb, muaj ntau ntau, muaj tshuaj pheej yig dua, muaj nqi kim.
Chorionic Gonadotropin
Chorionic Gonadotropin yog ib qho pheej yig analogue ntawm Pregnil. Ua nyob rau hauv ib koob ntawm 500; 1000; 1500 units Nws yog siv intramuscularly. Nws raug sau tseg ntawm qhov ntau npaum li cas ntawm 1500 IU txhua hnub lossis 3000 IU 2-3 zaug hauv ib lub lis piam hauv kev kho mob ntxiv rau cov poj niam. Hauv kev kho mob ntawm kev sib deev infantilism, 500 mus rau 1000 units tau muab ntau zaus hauv ib lub lis piam, txog li 2 lub hlis. Cov menyuam yaus raug muab tshuaj 500-1000 MO txog kaum xyoo, tom qab ntawd - 1500 IU mus txog ib hlis nrog cov kev kawm rov ua dua. Ntawd yog, cov tshuaj "Pregnil" muaj cov analogues pheej yig.
Ovitrelle
"Ovitrelle" muaj hCG alpha. Muaj nyob rau hauv ib koob ntawm 250 mcg (6500 IU). Nws yog siv subcutaneously. Stimulates tsim ntawm corpus luteum, maturation ntawm follicles thiab ovulation. 250 mcg sib npaug rau 5000 units ntawm tib neeg chorionic gonadotropin. Thaum stimulating zes qe menyuam thiab tau txais superovulation, 250 mcg yog siv, tom qab kev kho mob nrog tib neeg menopausal los yog follicle-stimulating hormones. Hauv kev kho mob ntawm anovulation, 1 koob tshuaj yog sau ib hnub ua ntej kev sib deev.
Horagon
Lwm analogue ntawm "Pregnil". Muaj nyob rau hauv ntau npaum li cas ntawm 1500 thiab 5000 MO. Nws yog siv intramuscularly. Nws yog siv rau dysmenorrhea, hypoplasia ntawm qhov chaw mos, kev sib deev infantilism txhawm rau txhawm rau txhawm rau txhim kho kev sib deev, kev hem thawj ntawm kev rho menyuam tawm, rausuperovulation induction. Rau qhov induction ntawm superovulation, nws raug sau nyob rau hauv ib koob ntawm 5,000 rau 10,000 IU ib zaug. Nyob rau hauv kev kho mob ntawm ib txwm rho menyuam, nws raug nquahu kom siv los ntawm thawj hnub ntawm cev xeeb tub mus txog 14 lub lis piam, ob zaug ib lub lim tiam rau 10,000 MO. Kev kho mob ntawm hypogonadism suav nrog kev teem sijhawm ntawm 1500 txog 6000 IU ib zaug hauv ib lub lis piam. Androgen deficiency hauv cov txiv neej raug kho nrog HCG ib zaug txhua ob lub lis piam rau peb lub hlis.
Horiomon
Tshuaj nyob rau hauv ib koob ntawm 5000 IU / ml, rau kev txhaj tshuaj intramuscular. Nws muaj txiaj ntsig zoo hauv kev kho mob amenorrhea thiab anovulatory voj voog. Nws yog siv ua ke nrog tib neeg menopausal gonadotropin (75 MO) txog li 10 hnub subcutaneously los yog intramuscularly kom nce estrogen secretion. Thaum lub follicle paub tab tshwm nyob rau hauv ultrasound los txhawb ovulation, los ntawm 5000 mus rau 10,000 MO ntawm Choriomon yog tswj. Cov tshuaj yog siv 1-2 hnub tom qab txhaj tshuaj kawg ntawm HMG lossis FSH. Kev sib deev raug pom zoo txhua hnub ua ntej ovulation.
Thaum muaj menyuam tsis taus vim yog luteal theem deficiency, Choriomon yog siv ntawm 5000 MO nyob rau 21st, 23rd thiab 25th hnub ntawm lub voj voog.
Profazi
"Profazi" - ib qho analogue ntawm "Pregnil 5000". Muaj nyob rau hauv ntau npaum li cas ntawm 2000 thiab 5000 MO. Nws yog siv intramuscularly. Kev kho mob ntawm anovulatory infertility yog ua los ntawm kev qhia txog 10,000 MO nyob rau hauv nruab nrab ntawm lub voj voog, tom qab kev kho mob nrog HMG lossis FSH. Txhawm rau ntxias superovulation, 10,000 MO raug sau hnub ua ntej sau qe. Nyob rau hauv cov ntaub ntawv ntawm corpus luteum insufficiency, cov kev taw qhia ntawm 5000 MO yog pom zoo, nyob rau hauv lub thib tsib thiab cuaj hnub tom qab ovulation."Profazi" muaj txiaj ntsig zoo hauv kev kho mob ntawm kev nchuav menyuam. Thov ntawm 10,000 MO thawj zaug, tom qab ntawd 5,000 MO ob zaug hauv ib lub lis piam mus txog 14 lub lis piam.
YContraindications
Contraindications rau kev siv tshuaj CG:
- Postmenopause.
- Hormone-produces qog of the gonads.
- Cov qog nqaij hlav ntawm hypothalamus thiab pituitary caj pas.
- Uterine qog incompatible nrog cev xeeb tub.
- Thrombophlebitis.
- Hypothyroidism.
- Keeb kwm ntawm tubal cev xeeb tub peb lub hlis ua ntej kho.
- Polycystic zes qe menyuam.
- Lub sijhawm lactation.
Side effects
Cov teebmeem ntawm tib neeg chorionic gonadotropin:
- Kev ntxhov siab ntau ntxiv, kev xav tsis zoo, mob taub hau, ntxhov siab.
- Cov kab mob dyspeptic (xeev siab, ntuav).
- Ntxim qab heev.
- Gynecomastia hauv txiv neej.
- pob khaus, khaus khaus.
- Ovarian hyperstimulation syndrome.
- Lub sijhawm noov o, erection txawv txav.
- Txo pituitary muaj nuj nqi.
- Txo cov ntshav ntim (hypovolemia).
- Cov ntshav ntim hauv plab.
- Thromboembolism.
- Ntau cev xeeb tub.
- Cov kua dej tuav, hais tawm, dav edema.
Analogue "Pregnil 1500" tsis muaj txiaj ntsig hauv kev xeeb tub hauv kev loj hlob ntawm lub tsev menyuam,Adnexa thiab qhov chaw mos, adhesions nyob rau hauv cov hlab ntsha fallopian, thawj zes qe menyuam tsis ua hauj lwm, loj fibrous hlav nyob rau hauv lub tsev menyuam.
Txhua txoj kev kho mob yuav tsum ua nruj me ntsis raws li kev saib xyuas ntawm tus kws tshaj lij thiab kev tswj hwm ntawm cov kev hloov pauv hauv kev tshuaj ntsuam, kev siv cov tshuaj no hauv tsev tsis tuaj yeem lees txais thiab tuaj yeem ua rau muaj txiaj ntsig zoo rau kev noj qab haus huv.
Kev kho mob ntawm anovulatory infertility yuav tsum tau ua raws li kev tswj hwm ultrasound ntawm cov follicle loj hlob thiab kev soj ntsuam tas li ntawm lub ncauj tsev menyuam.
Nws yog ib qho tseem ceeb los saib xyuas qib ntawm estradiol concentration txhua hnub. Nrog rau cov tsos mob ntawm qhov tsis xav tau ntawm zes qe menyuam hyperstimulation, chorionic gonadotropin txoj kev kho yog nres tam sim.
Peb tau tshuaj xyuas cov analogues rau kev npaj Pregnil, cov lus qhia siv rau lawv kuj tau piav qhia.
